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Fusion gene ID: 5437

FusionGeneSummary for CAP1_NFYC

Fusion gene summary

Fusion gene information	Fusion gene name: CAP1_NFYC
	Fusion gene ID: 5437
		Hgene	Tgene
	Gene symbol	CAP1	NFYC
	Gene ID	10487	4802
	Gene name	cyclase associated actin cytoskeleton regulatory protein 1	nuclear transcription factor Y subunit gamma
	Synonyms	CAP\|CAP1-PEN	CBF-C\|CBFC\|H1TF2A\|HAP5\|HSM\|NF-YC
	Cytomap	1p34.2	1p34.2
	Type of gene	protein-coding	protein-coding
	Description	adenylyl cyclase-associated protein 1CAP, adenylate cyclase-associated protein 1adenylate cyclase associated protein 1testis secretory sperm-binding protein Li 218p	nuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit CCCAAT binding factor subunit CCCAAT transcription binding factor subunit gammahistone H1 transcription factor large subunit 2Anuclear transcription factor Y subunit Cn
	Modification date	20180523	20180523
	UniProtAcc	Q01518	Q13952
	Ensembl transtripts involved in fusion gene	ENST00000372797, ENST00000372802, ENST00000372792, ENST00000372798, ENST00000340450, ENST00000372805, ENST00000479759,	ENST00000427410, ENST00000447388, ENST00000425457, ENST00000456393, ENST00000372654, ENST00000372653, ENST00000372652, ENST00000372651, ENST00000440226, ENST00000308733, ENST00000483091,
Fusion gene scores	* DoF score	5 X 4 X 5=100	8 X 5 X 6=240
	# samples	5	9
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CAP1 [Title/Abstract] AND NFYC [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NFYC	GO:0006355	regulation of transcription, DNA-templated	15243141

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BLCA	TCGA-KQ-A41P-01A	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-5UTR	ENST00000372797	ENST00000427410	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372797	ENST00000447388	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372797	ENST00000425457	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372797	ENST00000456393	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372797	ENST00000372654	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372797	ENST00000372653	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372797	ENST00000372652	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372797	ENST00000372651	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372797	ENST00000440226	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372797	ENST00000308733	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-intron	ENST00000372797	ENST00000483091	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372802	ENST00000427410	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372802	ENST00000447388	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372802	ENST00000425457	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372802	ENST00000456393	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372802	ENST00000372654	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372802	ENST00000372653	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372802	ENST00000372652	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372802	ENST00000372651	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372802	ENST00000440226	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000372802	ENST00000308733	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-intron	ENST00000372802	ENST00000483091	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372792	ENST00000427410	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372792	ENST00000447388	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372792	ENST00000425457	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372792	ENST00000456393	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372792	ENST00000372654	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372792	ENST00000372653	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372792	ENST00000372652	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372792	ENST00000372651	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372792	ENST00000440226	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372792	ENST00000308733	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-intron	ENST00000372792	ENST00000483091	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372798	ENST00000427410	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372798	ENST00000447388	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372798	ENST00000425457	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372798	ENST00000456393	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372798	ENST00000372654	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372798	ENST00000372653	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372798	ENST00000372652	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372798	ENST00000372651	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372798	ENST00000440226	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372798	ENST00000308733	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-intron	ENST00000372798	ENST00000483091	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000340450	ENST00000427410	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000340450	ENST00000447388	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000340450	ENST00000425457	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000340450	ENST00000456393	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000340450	ENST00000372654	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000340450	ENST00000372653	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000340450	ENST00000372652	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000340450	ENST00000372651	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000340450	ENST00000440226	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000340450	ENST00000308733	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-intron	ENST00000340450	ENST00000483091	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372805	ENST00000427410	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372805	ENST00000447388	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372805	ENST00000425457	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372805	ENST00000456393	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372805	ENST00000372654	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372805	ENST00000372653	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372805	ENST00000372652	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372805	ENST00000372651	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372805	ENST00000440226	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-5UTR	ENST00000372805	ENST00000308733	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
5UTR-intron	ENST00000372805	ENST00000483091	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000479759	ENST00000427410	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000479759	ENST00000447388	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000479759	ENST00000425457	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000479759	ENST00000456393	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000479759	ENST00000372654	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000479759	ENST00000372653	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000479759	ENST00000372652	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000479759	ENST00000372651	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000479759	ENST00000440226	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-5UTR	ENST00000479759	ENST00000308733	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+
intron-intron	ENST00000479759	ENST00000483091	CAP1	chr1	40506473	+	NFYC	chr1	41204508	+

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FusionProtFeatures for CAP1_NFYC

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAP1 Q01518	NFYC Q13952
Directly regulates filament dynamics and has beenimplicated in a number of complex developmental and morphologicalprocesses, including mRNA localization and the establishment ofcell polarity.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for CAP1_NFYC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CAP1_NFYC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
CAP1	CFL1, CAP1, CAP2, ACTG1, UCHL5, SIRT7, MYOC, PSME2, MYL12A, HTRA2, BARD1, LIG4, FMNL1, FN1, ATF2, ABI2, ACTBL2, HSP90B1, KIAA1598, MCM5, NEK9, SIRT1, TPM4, FASN, HSP90AA1, HSP90AB1, MCM2, MCM3, MCM4, MCM6, MGEA5, TPM3, PLA2G4A, PXN, UFD1L, DPH2, DPYSL2, NPLOC4, RNASEH2C, TTC38, NTRK1, U2AF2, ACTA1, POTEI, BCL7A, TWF2, ACTA2, BCL7C, ACTB, STYX, DLD, G3BP1, BRCA1	NFYC	MYC, SMAD3, SMAD2, TBP, ATF6, ATF6B, TP73, DST, CSN2, DR1, NFYA, NFYB, SP1, SREBF2, LMO4, ADNP2, POGZ, CIC, ZDHHC17, GLTSCR1L, GLTSCR1, ARID2, KIAA2018, TRIM27, TBPL2, HDAC1, TAF12, TAF11, TAF6, KAT2B, GAPDH, ELAVL1, CDK2, SNX2, FCGR2A, CORO1B, CORO1C, FOXJ2, FOXK2, NFATC2, PON1, ENDOG, PON3, NFKB1, COMMD1, PRR20E

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for CAP1_NFYC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CAP1_NFYC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CAP1	C0029456	Osteoporosis	1	CTD_human

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Fusion gene ID: 5437

FusionGeneSummary for CAP1_NFYC

FusionProtFeatures for CAP1_NFYC

FusionGeneSequence for CAP1_NFYC

FusionGenePPI for CAP1_NFYC

RelatedDrugs for CAP1_NFYC

RelatedDiseases for CAP1_NFYC