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Fusion gene ID: 5431 |
FusionGeneSummary for CANX_SNHG3 |
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Fusion gene information | Fusion gene name: CANX_SNHG3 | Fusion gene ID: 5431 | Hgene | Tgene | Gene symbol | CANX | SNHG3 | Gene ID | 821 | 8420 |
Gene name | calnexin | small nucleolar RNA host gene 3 | |
Synonyms | CNX|IP90|P90 | NCRNA00014|RNU17C|RNU17D|U17HG|U17HG-A|U17HG-AB | |
Cytomap | 5q35.3 | 1p35.3 | |
Type of gene | protein-coding | ncRNA | |
Description | calnexinmajor histocompatibility complex class I antigen-binding protein p88 | U17 small nucleolar RNA hostsmall nucleolar RNA host gene (non-protein coding) 3small nucleolar RNA host gene 3 (non-protein coding) | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P27824 | ||
Ensembl transtripts involved in fusion gene | ENST00000504734, ENST00000415618, ENST00000452673, ENST00000247461, ENST00000512607, ENST00000503126, | ENST00000364938, | |
Fusion gene scores | * DoF score | 9 X 11 X 4=396 | 2 X 2 X 1=4 |
# samples | 12 | 2 | |
** MAII score | log2(12/396*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: CANX [Title/Abstract] AND SNHG3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AU125279 | CANX | chr5 | 179157013 | + | SNHG3 | chr1 | 28833820 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000504734 | ENST00000364938 | CANX | chr5 | 179157013 | + | SNHG3 | chr1 | 28833820 | + |
intron-intron | ENST00000415618 | ENST00000364938 | CANX | chr5 | 179157013 | + | SNHG3 | chr1 | 28833820 | + |
3UTR-intron | ENST00000452673 | ENST00000364938 | CANX | chr5 | 179157013 | + | SNHG3 | chr1 | 28833820 | + |
3UTR-intron | ENST00000247461 | ENST00000364938 | CANX | chr5 | 179157013 | + | SNHG3 | chr1 | 28833820 | + |
intron-intron | ENST00000512607 | ENST00000364938 | CANX | chr5 | 179157013 | + | SNHG3 | chr1 | 28833820 | + |
intron-intron | ENST00000503126 | ENST00000364938 | CANX | chr5 | 179157013 | + | SNHG3 | chr1 | 28833820 | + |
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FusionProtFeatures for CANX_SNHG3 |
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Hgene | Tgene |
CANX | SNHG3 |
Calcium-binding protein that interacts with newlysynthesized glycoproteins in the endoplasmic reticulum. It may actin assisting protein assembly and/or in the retention within theER of unassembled protein subunits. It seems to play a major rolein the quality control apparatus of the ER by the retention ofincorrectly folded proteins. Associated with partial T-cellantigen receptor complexes that escape the ER of immaturethymocytes, it may function as a signaling complex regulatingthymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CANX_SNHG3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CANX_SNHG3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CANX_SNHG3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CANX | P27824 | DB00031 | Tenecteplase | Calnexin | biotech | approved |
Hgene | CANX | P27824 | DB11093 | Calcium Citrate | Calnexin | small molecule | approved |
Hgene | CANX | P27824 | DB11348 | Calcium Phosphate | Calnexin | small molecule | approved |
Hgene | CANX | P27824 | DB00025 | Antihemophilic factor, human recombinant | Calnexin | biotech | approved|investigational |
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RelatedDiseases for CANX_SNHG3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CANX | C0151744 | Myocardial Ischemia | 1 | CTD_human |