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Fusion gene ID: 5366 |
FusionGeneSummary for CAMK2N1_ABCD3 |
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Fusion gene information | Fusion gene name: CAMK2N1_ABCD3 | Fusion gene ID: 5366 | Hgene | Tgene | Gene symbol | CAMK2N1 | ABCD3 | Gene ID | 55450 | 5825 |
Gene name | calcium/calmodulin dependent protein kinase II inhibitor 1 | ATP binding cassette subfamily D member 3 | |
Synonyms | PRO1489 | ABC43|CBAS5|PMP70|PXMP1|ZWS2 | |
Cytomap | 1p36.12 | 1p21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | calcium/calmodulin-dependent protein kinase II inhibitor 1CaMKIINalphacaMKII inhibitory protein alphacaMKIIN-alpha | ATP-binding cassette sub-family D member 370 kDa peroxisomal membrane proteinATP-binding cassette, sub-family D (ALD), member 3Peroxisomal membrane protein-1 (70kD)dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))peroxiso | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q7Z7J9 | P28288 | |
Ensembl transtripts involved in fusion gene | ENST00000375078, ENST00000489020, | ENST00000394233, ENST00000454898, ENST00000536817, ENST00000370214, ENST00000315713, ENST00000484213, | |
Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 4 X 3 X 4=48 |
# samples | 4 | 4 | |
** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CAMK2N1 [Title/Abstract] AND ABCD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ABCD3 | GO:0007031 | peroxisome organization | 9425230 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI653395 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000375078 | ENST00000394233 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000375078 | ENST00000454898 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000375078 | ENST00000536817 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000375078 | ENST00000370214 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000375078 | ENST00000315713 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000375078 | ENST00000484213 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000489020 | ENST00000394233 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000489020 | ENST00000454898 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000489020 | ENST00000536817 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000489020 | ENST00000370214 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000489020 | ENST00000315713 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
intron-intron | ENST00000489020 | ENST00000484213 | CAMK2N1 | chr1 | 20809860 | + | ABCD3 | chr1 | 94945591 | - |
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FusionProtFeatures for CAMK2N1_ABCD3 |
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Hgene | Tgene |
CAMK2N1 | ABCD3 |
Potent and specific inhibitor of CaM-kinase II (CAMK2).{ECO:0000250, ECO:0000269|PubMed:18305109}. | Probable transporter involved in the transport ofbranched-chain fatty acids and C27 bile acids into the peroxisome;the latter function is a crucial step in bile acid biosynthesis(PubMed:25168382). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed:11248239).{ECO:0000269|PubMed:11248239, ECO:0000269|PubMed:25168382}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CAMK2N1_ABCD3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CAMK2N1_ABCD3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CAMK2N1_ABCD3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CAMK2N1_ABCD3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ABCD3 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | ABCD3 | C0043459 | Zellweger Syndrome | 1 | CTD_human |