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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5365

FusionGeneSummary for CAMK2G_SRP72

check button Fusion gene summary
Fusion gene informationFusion gene name: CAMK2G_SRP72
Fusion gene ID: 5365
HgeneTgene
Gene symbol

CAMK2G

SRP72

Gene ID

818

6731

Gene namecalcium/calmodulin dependent protein kinase II gammasignal recognition particle 72
SynonymsCAMK|CAMK-II|CAMKGBMFF|BMFS1|HEL103
Cytomap

10q22.2

4q12

Type of geneprotein-codingprotein-coding
Descriptioncalcium/calmodulin-dependent protein kinase type II subunit gammacaMK-II subunit gammacalcium/calmodulin-dependent protein kinase (CaM kinase) II gammasignal recognition particle subunit SRP72epididymis luminal protein 103signal recognition particle 72 kDa proteinsignal recognition particle 72kDsignal recognition particle 72kDa
Modification date2018052720180525
UniProtAcc

Q13555

O76094

Ensembl transtripts involved in fusion geneENST00000351293, ENST00000322635, 
ENST00000394762, ENST00000423381, 
ENST00000322680, ENST00000305762, 
ENST00000372765, ENST00000472912, 
ENST00000444854, 		ENST00000342756, 
ENST00000510663, ENST00000504757, 
Fusion gene scores* DoF score7 X 8 X 7=3922 X 2 X 1=4
# samples 92
** MAII scorelog2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: CAMK2G [Title/Abstract] AND SRP72 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAMK2G

GO:0051259

protein complex oligomerization

20668654

TgeneSRP72

GO:0042493

response to drug

18089836


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1U81554CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000351293ENST00000342756CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000351293ENST00000510663CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5CDS-intronENST00000351293ENST00000504757CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000322635ENST00000342756CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000322635ENST00000510663CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5CDS-intronENST00000322635ENST00000504757CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000394762ENST00000342756CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000394762ENST00000510663CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5CDS-intronENST00000394762ENST00000504757CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000423381ENST00000342756CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000423381ENST00000510663CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5CDS-intronENST00000423381ENST00000504757CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000322680ENST00000342756CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000322680ENST00000510663CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5CDS-intronENST00000322680ENST00000504757CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000305762ENST00000342756CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000305762ENST00000510663CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5CDS-intronENST00000305762ENST00000504757CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000372765ENST00000342756CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000372765ENST00000510663CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5CDS-intronENST00000372765ENST00000504757CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5UTR-3CDSENST00000472912ENST00000342756CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5UTR-3CDSENST00000472912ENST00000510663CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5UTR-intronENST00000472912ENST00000504757CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000444854ENST00000342756CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
Frame-shiftENST00000444854ENST00000510663CAMK2Gchr10

75597226

-SRP72chr4

57349375

+
5CDS-intronENST00000444854ENST00000504757CAMK2Gchr10

75597226

-SRP72chr4

57349375

+

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FusionProtFeatures for CAMK2G_SRP72


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAMK2G

Q13555

SRP72

O76094

Signal-recognition-particle assembly has a crucial rolein targeting secretory proteins to the rough endoplasmic reticulummembrane. Binds the 7S RNA only in presence of SRP68. Thisribonucleoprotein complex might interact directly with the dockingprotein in the ER membrane and possibly participate in theelongation arrest function.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CAMK2G_SRP72


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CAMK2G_SRP72


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CAMK2G_SRP72


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCAMK2GQ13555DB06616BosutinibCalcium/calmodulin-dependent protein kinase type II subunit gammasmall moleculeapproved

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RelatedDiseases for CAMK2G_SRP72


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSRP72C0008370Cholestasis1CTD_human
TgeneSRP72C3808553BONE MARROW FAILURE SYNDROME 11ORPHANET;UNIPROT
TgeneSRP72C4277682Chemical and Drug Induced Liver Injury1CTD_human