FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5345

FusionGeneSummary for CAMK1D_LRRFIP2

check button Fusion gene summary
Fusion gene informationFusion gene name: CAMK1D_LRRFIP2
Fusion gene ID: 5345
HgeneTgene
Gene symbol

CAMK1D

LRRFIP2

Gene ID

57118

9209

Gene namecalcium/calmodulin dependent protein kinase IDLRR binding FLII interacting protein 2
SynonymsCKLiK|CaM-K1|CaMKIDHUFI-2
Cytomap

10p13

3p22.2

Type of geneprotein-codingprotein-coding
Descriptioncalcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI deltaleucine-rich repeat flightless-interacting protein 2LRR FLII-interacting protein 2leucine rich repeat (in FLII) interacting protein 2
Modification date2018052320180522
UniProtAcc

Q8IU85

Q9Y608

Ensembl transtripts involved in fusion geneENST00000378847, ENST00000487696, 
ENST00000378845, 
ENST00000421307, 
ENST00000354379, ENST00000336686, 
ENST00000421276, ENST00000396428, 
ENST00000440230, ENST00000490597, 
Fusion gene scores* DoF score10 X 10 X 6=6004 X 4 X 2=32
# samples 144
** MAII scorelog2(14/600*10)=-2.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CAMK1D [Title/Abstract] AND LRRFIP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAMK1D

GO:0032793

positive regulation of CREB transcription factor activity

16324104


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF229112CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000378847ENST00000421307CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378847ENST00000354379CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378847ENST00000336686CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378847ENST00000421276CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378847ENST00000396428CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378847ENST00000440230CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-intronENST00000378847ENST00000490597CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000487696ENST00000421307CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000487696ENST00000354379CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000487696ENST00000336686CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000487696ENST00000421276CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000487696ENST00000396428CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000487696ENST00000440230CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-intronENST00000487696ENST00000490597CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378845ENST00000421307CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378845ENST00000354379CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378845ENST00000336686CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378845ENST00000421276CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378845ENST00000396428CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-3CDSENST00000378845ENST00000440230CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-
intron-intronENST00000378845ENST00000490597CAMK1Dchr10

12606364

-LRRFIP2chr3

37136355

-

Top

FusionProtFeatures for CAMK1D_LRRFIP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAMK1D

Q8IU85

LRRFIP2

Q9Y608

Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascadeand, upon calcium influx, activates CREB-dependent genetranscription, regulates calcium-mediated granulocyte function andrespiratory burst and promotes basal dendritic growth ofhippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratoryburst. Activates the transcription factor CREB1 in hippocampalneuron nuclei. May play a role in apoptosis of erythroleukemiacells. In vitro, phosphorylates transcription factor CREM isoformBeta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691,ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. May function as activator of the canonical Wnt signalingpathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signalingin response to agonist probably by competing with the negativeFLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333,ECO:0000269|PubMed:19265123}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CAMK1D_LRRFIP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CAMK1D_LRRFIP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CAMK1D_LRRFIP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CAMK1D_LRRFIP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource