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Fusion gene ID: 5344 |
FusionGeneSummary for CAMK1D_FRMD4A |
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Fusion gene information | Fusion gene name: CAMK1D_FRMD4A | Fusion gene ID: 5344 | Hgene | Tgene | Gene symbol | CAMK1D | FRMD4A | Gene ID | 57118 | 55691 |
Gene name | calcium/calmodulin dependent protein kinase ID | FERM domain containing 4A | |
Synonyms | CKLiK|CaM-K1|CaMKID | CCAFCA|FRMD4|bA295P9.4 | |
Cytomap | 10p13 | 10p13 | |
Type of gene | protein-coding | protein-coding | |
Description | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | FERM domain-containing protein 4AFERM domain containing 4 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q8IU85 | Q9P2Q2 | |
Ensembl transtripts involved in fusion gene | ENST00000378847, ENST00000487696, ENST00000378845, | ENST00000358621, ENST00000357447, ENST00000378503, ENST00000342409, ENST00000493380, ENST00000475141, ENST00000492155, | |
Fusion gene scores | * DoF score | 10 X 10 X 6=600 | 9 X 7 X 6=378 |
# samples | 14 | 10 | |
** MAII score | log2(14/600*10)=-2.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CAMK1D [Title/Abstract] AND FRMD4A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-86-8358-01A | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000378847 | ENST00000358621 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
Frame-shift | ENST00000378847 | ENST00000357447 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
Frame-shift | ENST00000378847 | ENST00000378503 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
Frame-shift | ENST00000378847 | ENST00000342409 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
5CDS-intron | ENST00000378847 | ENST00000493380 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
5CDS-intron | ENST00000378847 | ENST00000475141 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
5CDS-intron | ENST00000378847 | ENST00000492155 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
3UTR-3CDS | ENST00000487696 | ENST00000358621 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
3UTR-3CDS | ENST00000487696 | ENST00000357447 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
3UTR-3CDS | ENST00000487696 | ENST00000378503 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
3UTR-3CDS | ENST00000487696 | ENST00000342409 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
3UTR-intron | ENST00000487696 | ENST00000493380 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
3UTR-intron | ENST00000487696 | ENST00000475141 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
3UTR-intron | ENST00000487696 | ENST00000492155 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
Frame-shift | ENST00000378845 | ENST00000358621 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
Frame-shift | ENST00000378845 | ENST00000357447 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
Frame-shift | ENST00000378845 | ENST00000378503 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
Frame-shift | ENST00000378845 | ENST00000342409 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
5CDS-intron | ENST00000378845 | ENST00000493380 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
5CDS-intron | ENST00000378845 | ENST00000475141 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
5CDS-intron | ENST00000378845 | ENST00000492155 | CAMK1D | chr10 | 12708809 | + | FRMD4A | chr10 | 13900912 | - |
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FusionProtFeatures for CAMK1D_FRMD4A |
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Hgene | Tgene |
CAMK1D | FRMD4A |
Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascadeand, upon calcium influx, activates CREB-dependent genetranscription, regulates calcium-mediated granulocyte function andrespiratory burst and promotes basal dendritic growth ofhippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratoryburst. Activates the transcription factor CREB1 in hippocampalneuron nuclei. May play a role in apoptosis of erythroleukemiacells. In vitro, phosphorylates transcription factor CREM isoformBeta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691,ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. | Scaffolding protein that regulates epithelial cellpolarity by connecting ARF6 activation with the PAR3 complex (Bysimilarity). Plays a redundant role with FRMD4B in epithelialpolarization (By similarity). May regulate MAPT secretion byactivating ARF6-signaling (PubMed:27044754).{ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CAMK1D_FRMD4A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CAMK1D_FRMD4A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CAMK1D | NEDD4, NEDD4L, POT1, APP, BAG3, TNFSF13, ASAH1, CDC25A, CUL3, GMFG, BNIP3L, DCPS, HSPA1L, NAE1, NUCB2, PCYT2, TUBB6, TUFM, UBA3, XPO1, CAMK1, CAMK1G, ZG16B, QPCTL, MUC7, AMY1C, CKS2, CST4, XYLT2, CDH1, LAMP3, CST1, C9orf173, GNRHR, CALM3 | FRMD4A | HNRNPA1, TRAF3IP1, YEATS4, WDR83 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CAMK1D_FRMD4A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CAMK1D_FRMD4A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FRMD4A | C0236969 | Substance-Related Disorders | 1 | CTD_human |