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Fusion gene ID: 5340 |
FusionGeneSummary for CAMK1D_BNIP3L |
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Fusion gene information | Fusion gene name: CAMK1D_BNIP3L | Fusion gene ID: 5340 | Hgene | Tgene | Gene symbol | CAMK1D | BNIP3L | Gene ID | 57118 | 665 |
Gene name | calcium/calmodulin dependent protein kinase ID | BCL2 interacting protein 3 like | |
Synonyms | CKLiK|CaM-K1|CaMKID | BNIP3a|NIX | |
Cytomap | 10p13 | 8p21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likeBCL2/adenovirus E1B 19 kDa protein-interacting protein 3ABCL2/adenovirus E1B 19-kd protein-interacting protein 3aBCL2/adenovirus E1B 19kDa interacting protein 3 likeNIP-3-like protein XNIP3 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8IU85 | O60238 | |
Ensembl transtripts involved in fusion gene | ENST00000378847, ENST00000487696, ENST00000378845, | ENST00000380629, ENST00000523515, ENST00000520409, ENST00000518611, ENST00000521254, | |
Fusion gene scores | * DoF score | 10 X 10 X 6=600 | 5 X 3 X 5=75 |
# samples | 14 | 5 | |
** MAII score | log2(14/600*10)=-2.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CAMK1D [Title/Abstract] AND BNIP3L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
Tgene | BNIP3L | GO:0043065 | positive regulation of apoptotic process | 9973195 |
Tgene | BNIP3L | GO:0043066 | negative regulation of apoptotic process | 10381623 |
Tgene | BNIP3L | GO:0051607 | defense response to virus | 9973195 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-24-2288-01A | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000378847 | ENST00000380629 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
5CDS-5UTR | ENST00000378847 | ENST00000523515 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
5CDS-5UTR | ENST00000378847 | ENST00000520409 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
5CDS-5UTR | ENST00000378847 | ENST00000518611 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
5CDS-intron | ENST00000378847 | ENST00000521254 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
3UTR-3CDS | ENST00000487696 | ENST00000380629 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
3UTR-5UTR | ENST00000487696 | ENST00000523515 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
3UTR-5UTR | ENST00000487696 | ENST00000520409 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
3UTR-5UTR | ENST00000487696 | ENST00000518611 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
3UTR-intron | ENST00000487696 | ENST00000521254 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
Frame-shift | ENST00000378845 | ENST00000380629 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
5CDS-5UTR | ENST00000378845 | ENST00000523515 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
5CDS-5UTR | ENST00000378845 | ENST00000520409 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
5CDS-5UTR | ENST00000378845 | ENST00000518611 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
5CDS-intron | ENST00000378845 | ENST00000521254 | CAMK1D | chr10 | 12391909 | + | BNIP3L | chr8 | 26248759 | + |
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FusionProtFeatures for CAMK1D_BNIP3L |
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Hgene | Tgene |
CAMK1D | BNIP3L |
Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascadeand, upon calcium influx, activates CREB-dependent genetranscription, regulates calcium-mediated granulocyte function andrespiratory burst and promotes basal dendritic growth ofhippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratoryburst. Activates the transcription factor CREB1 in hippocampalneuron nuclei. May play a role in apoptosis of erythroleukemiacells. In vitro, phosphorylates transcription factor CREM isoformBeta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691,ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. | Induces apoptosis. Interacts with viral and cellularanti-apoptosis proteins. Can overcome the suppressors BCL-2 andBCL-XL, although high levels of BCL-XL expression will inhibitapoptosis. Inhibits apoptosis induced by BNIP3. Involved inmitochondrial quality control via its interaction withSPATA18/MIEAP: in response to mitochondrial damage, participatesin mitochondrial protein catabolic process (also named MALM)leading to the degradation of damaged proteins insidemitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 andBNIP3L/NIX at the mitochondrial outer membrane regulates theopening of a pore in the mitochondrial double membrane in order tomediate the translocation of lysosomal proteins from the cytoplasmto the mitochondrial matrix. May function as a tumor suppressor.{ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CAMK1D_BNIP3L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CAMK1D_BNIP3L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CAMK1D | NEDD4, NEDD4L, POT1, APP, BAG3, TNFSF13, ASAH1, CDC25A, CUL3, GMFG, BNIP3L, DCPS, HSPA1L, NAE1, NUCB2, PCYT2, TUBB6, TUFM, UBA3, XPO1, CAMK1, CAMK1G, ZG16B, QPCTL, MUC7, AMY1C, CKS2, CST4, XYLT2, CDH1, LAMP3, CST1, C9orf173, GNRHR, CALM3 | BNIP3L | DOK5, EWSR1, BNIP3L, BNIP3, TMEM11, STEAP3, BCL2, ROBO2, GNB5, KLHL23, GBP2, ATP13A2, RHEB, CLN8, MAP1LC3B, MAP1LC3A, GABARAP, GABARAPL1, GABARAPL2, CEP192, ECM1, CASK, CAMK1D, DUSP3, SMCO4, CLEC7A, FATE1, LDLRAD1, WIPI2, BCL2L1, PPTC7, LMNA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CAMK1D_BNIP3L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CAMK1D_BNIP3L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |