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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5340

FusionGeneSummary for CAMK1D_BNIP3L

check button Fusion gene summary
Fusion gene informationFusion gene name: CAMK1D_BNIP3L
Fusion gene ID: 5340
HgeneTgene
Gene symbol

CAMK1D

BNIP3L

Gene ID

57118

665

Gene namecalcium/calmodulin dependent protein kinase IDBCL2 interacting protein 3 like
SynonymsCKLiK|CaM-K1|CaMKIDBNIP3a|NIX
Cytomap

10p13

8p21.2

Type of geneprotein-codingprotein-coding
Descriptioncalcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI deltaBCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likeBCL2/adenovirus E1B 19 kDa protein-interacting protein 3ABCL2/adenovirus E1B 19-kd protein-interacting protein 3aBCL2/adenovirus E1B 19kDa interacting protein 3 likeNIP-3-like protein XNIP3
Modification date2018052320180523
UniProtAcc

Q8IU85

O60238

Ensembl transtripts involved in fusion geneENST00000378847, ENST00000487696, 
ENST00000378845, 
ENST00000380629, 
ENST00000523515, ENST00000520409, 
ENST00000518611, ENST00000521254, 
Fusion gene scores* DoF score10 X 10 X 6=6005 X 3 X 5=75
# samples 145
** MAII scorelog2(14/600*10)=-2.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAMK1D [Title/Abstract] AND BNIP3L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAMK1D

GO:0032793

positive regulation of CREB transcription factor activity

16324104

TgeneBNIP3L

GO:0043065

positive regulation of apoptotic process

9973195

TgeneBNIP3L

GO:0043066

negative regulation of apoptotic process

10381623

TgeneBNIP3L

GO:0051607

defense response to virus

9973195


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-2288-01ACAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000378847ENST00000380629CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
5CDS-5UTRENST00000378847ENST00000523515CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
5CDS-5UTRENST00000378847ENST00000520409CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
5CDS-5UTRENST00000378847ENST00000518611CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
5CDS-intronENST00000378847ENST00000521254CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
3UTR-3CDSENST00000487696ENST00000380629CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
3UTR-5UTRENST00000487696ENST00000523515CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
3UTR-5UTRENST00000487696ENST00000520409CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
3UTR-5UTRENST00000487696ENST00000518611CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
3UTR-intronENST00000487696ENST00000521254CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
Frame-shitENST00000378845ENST00000380629CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
5CDS-5UTRENST00000378845ENST00000523515CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
5CDS-5UTRENST00000378845ENST00000520409CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
5CDS-5UTRENST00000378845ENST00000518611CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+
5CDS-intronENST00000378845ENST00000521254CAMK1Dchr10

12391909

+BNIP3Lchr8

26248759

+

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FusionProtFeatures for CAMK1D_BNIP3L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAMK1D

Q8IU85

BNIP3L

O60238

Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascadeand, upon calcium influx, activates CREB-dependent genetranscription, regulates calcium-mediated granulocyte function andrespiratory burst and promotes basal dendritic growth ofhippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratoryburst. Activates the transcription factor CREB1 in hippocampalneuron nuclei. May play a role in apoptosis of erythroleukemiacells. In vitro, phosphorylates transcription factor CREM isoformBeta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691,ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. Induces apoptosis. Interacts with viral and cellularanti-apoptosis proteins. Can overcome the suppressors BCL-2 andBCL-XL, although high levels of BCL-XL expression will inhibitapoptosis. Inhibits apoptosis induced by BNIP3. Involved inmitochondrial quality control via its interaction withSPATA18/MIEAP: in response to mitochondrial damage, participatesin mitochondrial protein catabolic process (also named MALM)leading to the degradation of damaged proteins insidemitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 andBNIP3L/NIX at the mitochondrial outer membrane regulates theopening of a pore in the mitochondrial double membrane in order tomediate the translocation of lysosomal proteins from the cytoplasmto the mitochondrial matrix. May function as a tumor suppressor.{ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CAMK1D_BNIP3L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CAMK1D_BNIP3L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CAMK1DNEDD4, NEDD4L, POT1, APP, BAG3, TNFSF13, ASAH1, CDC25A, CUL3, GMFG, BNIP3L, DCPS, HSPA1L, NAE1, NUCB2, PCYT2, TUBB6, TUFM, UBA3, XPO1, CAMK1, CAMK1G, ZG16B, QPCTL, MUC7, AMY1C, CKS2, CST4, XYLT2, CDH1, LAMP3, CST1, C9orf173, GNRHR, CALM3BNIP3LDOK5, EWSR1, BNIP3L, BNIP3, TMEM11, STEAP3, BCL2, ROBO2, GNB5, KLHL23, GBP2, ATP13A2, RHEB, CLN8, MAP1LC3B, MAP1LC3A, GABARAP, GABARAPL1, GABARAPL2, CEP192, ECM1, CASK, CAMK1D, DUSP3, SMCO4, CLEC7A, FATE1, LDLRAD1, WIPI2, BCL2L1, PPTC7, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CAMK1D_BNIP3L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CAMK1D_BNIP3L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource