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Fusion gene ID: 5339 |
FusionGeneSummary for CAMK1D_ARL3 |
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Fusion gene information | Fusion gene name: CAMK1D_ARL3 | Fusion gene ID: 5339 | Hgene | Tgene | Gene symbol | CAMK1D | ARL3 | Gene ID | 57118 | 403 |
Gene name | calcium/calmodulin dependent protein kinase ID | ADP ribosylation factor like GTPase 3 | |
Synonyms | CKLiK|CaM-K1|CaMKID | ARFL3 | |
Cytomap | 10p13 | 10q24.32 | |
Type of gene | protein-coding | protein-coding | |
Description | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | ADP-ribosylation factor-like protein 3ADP-ribosylation factor-like 3ARF-like 3 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8IU85 | P36405 | |
Ensembl transtripts involved in fusion gene | ENST00000378847, ENST00000487696, ENST00000378845, | ENST00000260746, | |
Fusion gene scores | * DoF score | 10 X 10 X 6=600 | 6 X 4 X 5=120 |
# samples | 14 | 7 | |
** MAII score | log2(14/600*10)=-2.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CAMK1D [Title/Abstract] AND ARL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
Tgene | ARL3 | GO:0007264 | small GTPase mediated signal transduction | 22085962 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-44-3917-01A | CAMK1D | chr10 | 12833232 | + | ARL3 | chr10 | 104465246 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000378847 | ENST00000260746 | CAMK1D | chr10 | 12833232 | + | ARL3 | chr10 | 104465246 | - |
intron-3CDS | ENST00000487696 | ENST00000260746 | CAMK1D | chr10 | 12833232 | + | ARL3 | chr10 | 104465246 | - |
Frame-shift | ENST00000378845 | ENST00000260746 | CAMK1D | chr10 | 12833232 | + | ARL3 | chr10 | 104465246 | - |
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FusionProtFeatures for CAMK1D_ARL3 |
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Hgene | Tgene |
CAMK1D | ARL3 |
Calcium/calmodulin-dependent protein kinase thatoperates in the calcium-triggered CaMKK-CaMK1 signaling cascadeand, upon calcium influx, activates CREB-dependent genetranscription, regulates calcium-mediated granulocyte function andrespiratory burst and promotes basal dendritic growth ofhippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratoryburst. Activates the transcription factor CREB1 in hippocampalneuron nuclei. May play a role in apoptosis of erythroleukemiacells. In vitro, phosphorylates transcription factor CREM isoformBeta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691,ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. | Small GTP-binding protein which cycles between aninactive GDP-bound and an active GTP-bound form, and the rate ofcycling is regulated by guanine nucleotide exchange factors (GEF)and GTPase-activating proteins (GAP). Required for normalcytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cyclebetween inactive GDP-bound and active GTP-bound forms. Requiredfor targeting proteins such as NPHP3 to the ciliary membrane byreleasing myristoylated NPHP3 from UNC119B cargo adapter into thecilium. Does not act as an allosteric activator of the choleratoxin catalytic subunit. {ECO:0000269|PubMed:16525022,ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:22085962}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CAMK1D_ARL3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CAMK1D_ARL3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CAMK1D | NEDD4, NEDD4L, POT1, APP, BAG3, TNFSF13, ASAH1, CDC25A, CUL3, GMFG, BNIP3L, DCPS, HSPA1L, NAE1, NUCB2, PCYT2, TUBB6, TUFM, UBA3, XPO1, CAMK1, CAMK1G, ZG16B, QPCTL, MUC7, AMY1C, CKS2, CST4, XYLT2, CDH1, LAMP3, CST1, C9orf173, GNRHR, CALM3 | ARL3 | PDE6D, LRIF1, TLE1, TP53, UBR1, UNC119, RP2, GOLGA4, ARL2BP, ARL2, ALKBH2, SPRR2A, UNC119B, ESF1, WRN, NPHP3, CAMK2A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CAMK1D_ARL3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CAMK1D_ARL3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |