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Fusion gene ID: 5338 |
FusionGeneSummary for CALU_TRIAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CALU_TRIAP1 | Fusion gene ID: 5338 | Hgene | Tgene | Gene symbol | CALU | TRIAP1 | Gene ID | 813 | 51499 |
| Gene name | calumenin | TP53 regulated inhibitor of apoptosis 1 | |
| Synonyms | - | HSPC132|MDM35|P53CSV|WF-1 | |
| Cytomap | 7q32.1 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calumeninIEF SSP 9302crocalbin-like proteinmultiple EF-hand protein | TP53-regulated inhibitor of apoptosis 1mitochondrial distribution and morphology 35 homologp53-inducible cell-survival factorprotein 15E1.1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O43852 | O43715 | |
| Ensembl transtripts involved in fusion gene | ENST00000538546, ENST00000535623, ENST00000535011, ENST00000542996, ENST00000249364, ENST00000449187, ENST00000479257, | ENST00000546954, ENST00000302432, | |
| Fusion gene scores | * DoF score | 5 X 9 X 2=90 | 1 X 1 X 1=1 |
| # samples | 12 | 1 | |
| ** MAII score | log2(12/90*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CALU [Title/Abstract] AND TRIAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TRIAP1 | GO:0015914 | phospholipid transport | 26071602 |
| Tgene | TRIAP1 | GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 15735003 |
| Tgene | TRIAP1 | GO:0034644 | cellular response to UV | 15735003 |
| Tgene | TRIAP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15735003 |
| Tgene | TRIAP1 | GO:2001140 | positive regulation of phospholipid transport | 23931759 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CF135162 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000538546 | ENST00000546954 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 5CDS-intron | ENST00000538546 | ENST00000302432 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 3UTR-3UTR | ENST00000535623 | ENST00000546954 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 3UTR-intron | ENST00000535623 | ENST00000302432 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| intron-3UTR | ENST00000535011 | ENST00000546954 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| intron-intron | ENST00000535011 | ENST00000302432 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 5CDS-3UTR | ENST00000542996 | ENST00000546954 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 5CDS-intron | ENST00000542996 | ENST00000302432 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 5CDS-3UTR | ENST00000249364 | ENST00000546954 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 5CDS-intron | ENST00000249364 | ENST00000302432 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 5CDS-3UTR | ENST00000449187 | ENST00000546954 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 5CDS-intron | ENST00000449187 | ENST00000302432 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 5CDS-3UTR | ENST00000479257 | ENST00000546954 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
| 5CDS-intron | ENST00000479257 | ENST00000302432 | CALU | chr7 | 128407569 | - | TRIAP1 | chr12 | 120881856 | - |
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FusionProtFeatures for CALU_TRIAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CALU | TRIAP1 |
| Involved in the modulation of the mitochondrialapoptotic pathway by ensuring the accumulation of cardiolipin (CL)in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complexmediates the transfer of phosphatidic acid (PA) between liposomesand probably functions as a PA transporter across themitochondrion intermembrane space to provide PA for CL synthesisin the inner membrane (PubMed:23931759). Likewise, theTRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid(PA) between liposomes (in vitro) and probably functions as a PAtransporter across the mitochondrion intermembrane space (in vivo)(PubMed:26071602). Mediates cell survival by inhibiting activationof caspase-9 which prevents induction of apoptosis(PubMed:15735003). {ECO:0000269|PubMed:15735003,ECO:0000269|PubMed:23931759}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CALU_TRIAP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CALU_TRIAP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CALU_TRIAP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CALU_TRIAP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CALU | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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