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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5316

FusionGeneSummary for CALM3_MSN

check button Fusion gene summary
Fusion gene informationFusion gene name: CALM3_MSN
Fusion gene ID: 5316
HgeneTgene
Gene symbol

CALM3

MSN

Gene ID

808

4478

Gene namecalmodulin 3moesin
SynonymsCaM|CaMIII|HEL-S-72|PHKD|PHKD3HEL70|IMD50
Cytomap

19q13.32

Xq12

Type of geneprotein-codingprotein-coding
Descriptioncalmodulin-3epididymis secretory protein Li 72phosphorylase kinase subunit deltaprepro-calmodulin 3moesinepididymis luminal protein 70membrane-organizing extension spike protein
Modification date2018052320180527
UniProtAcc

P26038

Ensembl transtripts involved in fusion geneENST00000391918, ENST00000291295, 
ENST00000597743, ENST00000477244, 
ENST00000598871, ENST00000594523, 
ENST00000599839, ENST00000596362, 
ENST00000609205, ENST00000360270, 
Fusion gene scores* DoF score8 X 9 X 3=2166 X 6 X 2=72
# samples 117
** MAII scorelog2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALM3 [Title/Abstract] AND MSN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCALM3

GO:0010880

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

20226167

HgeneCALM3

GO:0030801

positive regulation of cyclic nucleotide metabolic process

8631777

HgeneCALM3

GO:0032516

positive regulation of phosphoprotein phosphatase activity

8631777

HgeneCALM3

GO:0035307

positive regulation of protein dephosphorylation

8631777

HgeneCALM3

GO:0051343

positive regulation of cyclic-nucleotide phosphodiesterase activity

8631777

HgeneCALM3

GO:0051592

response to calcium ion

7607248

HgeneCALM3

GO:0060316

positive regulation of ryanodine-sensitive calcium-release channel activity

20226167

TgeneMSN

GO:0001771

immunological synapse formation

27405666

TgeneMSN

GO:0042098

T cell proliferation

27405666

TgeneMSN

GO:0070489

T cell aggregation

27405666

TgeneMSN

GO:0071394

cellular response to testosterone stimulus

24065547

TgeneMSN

GO:0072678

T cell migration

27405666


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW867517CALM3chr19

47112203

+MSNchrX

64961187

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000391918ENST00000609205CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-3UTRENST00000391918ENST00000360270CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-intronENST00000291295ENST00000609205CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-3UTRENST00000291295ENST00000360270CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-intronENST00000597743ENST00000609205CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-3UTRENST00000597743ENST00000360270CALM3chr19

47112203

+MSNchrX

64961187

-
3UTR-intronENST00000477244ENST00000609205CALM3chr19

47112203

+MSNchrX

64961187

-
3UTR-3UTRENST00000477244ENST00000360270CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-intronENST00000598871ENST00000609205CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-3UTRENST00000598871ENST00000360270CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-intronENST00000594523ENST00000609205CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-3UTRENST00000594523ENST00000360270CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-intronENST00000599839ENST00000609205CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-3UTRENST00000599839ENST00000360270CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-intronENST00000596362ENST00000609205CALM3chr19

47112203

+MSNchrX

64961187

-
5CDS-3UTRENST00000596362ENST00000360270CALM3chr19

47112203

+MSNchrX

64961187

-

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FusionProtFeatures for CALM3_MSN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALM3

MSN

P26038

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Probably involved in connections of major cytoskeletalstructures to the plasma membrane. May inhibit herpes simplexvirus 1 infection at an early stage. Plays a role in regulatingthe proliferation, migration, and adhesion of human lymphoid cellsand participates in immunologic synapse formation(PubMed:27405666). {ECO:0000269|PubMed:21549406,ECO:0000269|PubMed:27405666}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CALM3_MSN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CALM3_MSN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CALM3_MSN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CALM3_MSN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMSNC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneMSNC0029408Degenerative polyarthritis1CTD_human
TgeneMSNC0151744Myocardial Ischemia1CTD_human
TgeneMSNC3495559Juvenile arthritis1CTD_human