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Fusion gene ID: 5316 |
FusionGeneSummary for CALM3_MSN |
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Fusion gene information | Fusion gene name: CALM3_MSN | Fusion gene ID: 5316 | Hgene | Tgene | Gene symbol | CALM3 | MSN | Gene ID | 808 | 4478 |
Gene name | calmodulin 3 | moesin | |
Synonyms | CaM|CaMIII|HEL-S-72|PHKD|PHKD3 | HEL70|IMD50 | |
Cytomap | 19q13.32 | Xq12 | |
Type of gene | protein-coding | protein-coding | |
Description | calmodulin-3epididymis secretory protein Li 72phosphorylase kinase subunit deltaprepro-calmodulin 3 | moesinepididymis luminal protein 70membrane-organizing extension spike protein | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | P26038 | ||
Ensembl transtripts involved in fusion gene | ENST00000391918, ENST00000291295, ENST00000597743, ENST00000477244, ENST00000598871, ENST00000594523, ENST00000599839, ENST00000596362, | ENST00000609205, ENST00000360270, | |
Fusion gene scores | * DoF score | 8 X 9 X 3=216 | 6 X 6 X 2=72 |
# samples | 11 | 7 | |
** MAII score | log2(11/216*10)=-0.973527788638809 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CALM3 [Title/Abstract] AND MSN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CALM3 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 20226167 |
Hgene | CALM3 | GO:0030801 | positive regulation of cyclic nucleotide metabolic process | 8631777 |
Hgene | CALM3 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 8631777 |
Hgene | CALM3 | GO:0035307 | positive regulation of protein dephosphorylation | 8631777 |
Hgene | CALM3 | GO:0051343 | positive regulation of cyclic-nucleotide phosphodiesterase activity | 8631777 |
Hgene | CALM3 | GO:0051592 | response to calcium ion | 7607248 |
Hgene | CALM3 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 20226167 |
Tgene | MSN | GO:0001771 | immunological synapse formation | 27405666 |
Tgene | MSN | GO:0042098 | T cell proliferation | 27405666 |
Tgene | MSN | GO:0070489 | T cell aggregation | 27405666 |
Tgene | MSN | GO:0071394 | cellular response to testosterone stimulus | 24065547 |
Tgene | MSN | GO:0072678 | T cell migration | 27405666 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW867517 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000391918 | ENST00000609205 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-3UTR | ENST00000391918 | ENST00000360270 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-intron | ENST00000291295 | ENST00000609205 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-3UTR | ENST00000291295 | ENST00000360270 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-intron | ENST00000597743 | ENST00000609205 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-3UTR | ENST00000597743 | ENST00000360270 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
3UTR-intron | ENST00000477244 | ENST00000609205 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
3UTR-3UTR | ENST00000477244 | ENST00000360270 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-intron | ENST00000598871 | ENST00000609205 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-3UTR | ENST00000598871 | ENST00000360270 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-intron | ENST00000594523 | ENST00000609205 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-3UTR | ENST00000594523 | ENST00000360270 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-intron | ENST00000599839 | ENST00000609205 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-3UTR | ENST00000599839 | ENST00000360270 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-intron | ENST00000596362 | ENST00000609205 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
5CDS-3UTR | ENST00000596362 | ENST00000360270 | CALM3 | chr19 | 47112203 | + | MSN | chrX | 64961187 | - |
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FusionProtFeatures for CALM3_MSN |
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Hgene | Tgene |
CALM3 | MSN |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Probably involved in connections of major cytoskeletalstructures to the plasma membrane. May inhibit herpes simplexvirus 1 infection at an early stage. Plays a role in regulatingthe proliferation, migration, and adhesion of human lymphoid cellsand participates in immunologic synapse formation(PubMed:27405666). {ECO:0000269|PubMed:21549406,ECO:0000269|PubMed:27405666}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CALM3_MSN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CALM3_MSN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CALM3_MSN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CALM3_MSN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MSN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | MSN | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | MSN | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | MSN | C3495559 | Juvenile arthritis | 1 | CTD_human |