FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 5295

FusionGeneSummary for CALD1_SREK1IP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CALD1_SREK1IP1
Fusion gene ID: 5295
HgeneTgene
Gene symbol

CALD1

SREK1IP1

Gene ID

800

285672

Gene namecaldesmon 1SREK1 interacting protein 1
SynonymsCDM|H-CAD|HCAD|L-CAD|LCAD|NAG22P18SRP|SFRS12IP1
Cytomap

7q33

5q12.3

Type of geneprotein-codingprotein-coding
Descriptioncaldesmontestis secretory sperm-binding protein Li 227nprotein SREK1IP1SFRS12-interacting protein 1p18 splicing regulatory proteinprotein SFRS12IP1splicing regulatory protein of 18 kDa
Modification date2018052220180519
UniProtAcc

Q05682

Q8N9Q2

Ensembl transtripts involved in fusion geneENST00000417172, ENST00000361388, 
ENST00000422748, ENST00000361675, 
ENST00000361901, ENST00000393118, 
ENST00000495522, ENST00000424922, 
ENST00000543443, ENST00000466704, 
ENST00000513458, ENST00000506252, 
Fusion gene scores* DoF score14 X 16 X 9=20161 X 1 X 1=1
# samples 201
** MAII scorelog2(20/2016*10)=-3.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: CALD1 [Title/Abstract] AND SREK1IP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW841250CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000417172ENST00000513458CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-intronENST00000417172ENST00000506252CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-3UTRENST00000361388ENST00000513458CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-intronENST00000361388ENST00000506252CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-3UTRENST00000422748ENST00000513458CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-intronENST00000422748ENST00000506252CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-3UTRENST00000361675ENST00000513458CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-intronENST00000361675ENST00000506252CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-3UTRENST00000361901ENST00000513458CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-intronENST00000361901ENST00000506252CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-3UTRENST00000393118ENST00000513458CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-intronENST00000393118ENST00000506252CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-3UTRENST00000495522ENST00000513458CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-intronENST00000495522ENST00000506252CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-3UTRENST00000424922ENST00000513458CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-intronENST00000424922ENST00000506252CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-3UTRENST00000543443ENST00000513458CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
5CDS-intronENST00000543443ENST00000506252CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
intron-3UTRENST00000466704ENST00000513458CALD1chr7

134618086

+SREK1IP1chr5

64016901

-
intron-intronENST00000466704ENST00000506252CALD1chr7

134618086

+SREK1IP1chr5

64016901

-

Top

FusionProtFeatures for CALD1_SREK1IP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALD1

Q05682

SREK1IP1

Q8N9Q2

Actin- and myosin-binding protein implicated in theregulation of actomyosin interactions in smooth muscle andnonmuscle cells (could act as a bridge between myosin and actinfilaments). Stimulates actin binding of tropomyosin whichincreases the stabilization of actin filament structure. In muscletissues, inhibits the actomyosin ATPase by binding to F-actin.This inhibition is attenuated by calcium-calmodulin and ispotentiated by tropomyosin. Interacts with actin, myosin, twomolecules of tropomyosin and with calmodulin. Also play anessential role during cellular mitosis and receptor capping.Involved in Schwann cell migration during peripheral nerveregeneration (By similarity). {ECO:0000250,ECO:0000269|PubMed:8227296}. Possible splicing regulator involved in the control ofcellular survival.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CALD1_SREK1IP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CALD1_SREK1IP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CALD1_SREK1IP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CALD1_SREK1IP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCALD1C0003873Rheumatoid Arthritis1CTD_human
HgeneCALD1C3495559Juvenile arthritis1CTD_human