![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 5295 |
FusionGeneSummary for CALD1_SREK1IP1 |
![]() |
Fusion gene information | Fusion gene name: CALD1_SREK1IP1 | Fusion gene ID: 5295 | Hgene | Tgene | Gene symbol | CALD1 | SREK1IP1 | Gene ID | 800 | 285672 |
Gene name | caldesmon 1 | SREK1 interacting protein 1 | |
Synonyms | CDM|H-CAD|HCAD|L-CAD|LCAD|NAG22 | P18SRP|SFRS12IP1 | |
Cytomap | 7q33 | 5q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | caldesmontestis secretory sperm-binding protein Li 227n | protein SREK1IP1SFRS12-interacting protein 1p18 splicing regulatory proteinprotein SFRS12IP1splicing regulatory protein of 18 kDa | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q05682 | Q8N9Q2 | |
Ensembl transtripts involved in fusion gene | ENST00000417172, ENST00000361388, ENST00000422748, ENST00000361675, ENST00000361901, ENST00000393118, ENST00000495522, ENST00000424922, ENST00000543443, ENST00000466704, | ENST00000513458, ENST00000506252, | |
Fusion gene scores | * DoF score | 14 X 16 X 9=2016 | 1 X 1 X 1=1 |
# samples | 20 | 1 | |
** MAII score | log2(20/2016*10)=-3.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CALD1 [Title/Abstract] AND SREK1IP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW841250 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000417172 | ENST00000513458 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-intron | ENST00000417172 | ENST00000506252 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-3UTR | ENST00000361388 | ENST00000513458 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-intron | ENST00000361388 | ENST00000506252 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-3UTR | ENST00000422748 | ENST00000513458 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-intron | ENST00000422748 | ENST00000506252 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-3UTR | ENST00000361675 | ENST00000513458 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-intron | ENST00000361675 | ENST00000506252 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-3UTR | ENST00000361901 | ENST00000513458 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-intron | ENST00000361901 | ENST00000506252 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-3UTR | ENST00000393118 | ENST00000513458 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-intron | ENST00000393118 | ENST00000506252 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-3UTR | ENST00000495522 | ENST00000513458 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-intron | ENST00000495522 | ENST00000506252 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-3UTR | ENST00000424922 | ENST00000513458 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-intron | ENST00000424922 | ENST00000506252 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-3UTR | ENST00000543443 | ENST00000513458 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
5CDS-intron | ENST00000543443 | ENST00000506252 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
intron-3UTR | ENST00000466704 | ENST00000513458 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
intron-intron | ENST00000466704 | ENST00000506252 | CALD1 | chr7 | 134618086 | + | SREK1IP1 | chr5 | 64016901 | - |
Top |
FusionProtFeatures for CALD1_SREK1IP1 |
![]() |
Hgene | Tgene |
CALD1 | SREK1IP1 |
Actin- and myosin-binding protein implicated in theregulation of actomyosin interactions in smooth muscle andnonmuscle cells (could act as a bridge between myosin and actinfilaments). Stimulates actin binding of tropomyosin whichincreases the stabilization of actin filament structure. In muscletissues, inhibits the actomyosin ATPase by binding to F-actin.This inhibition is attenuated by calcium-calmodulin and ispotentiated by tropomyosin. Interacts with actin, myosin, twomolecules of tropomyosin and with calmodulin. Also play anessential role during cellular mitosis and receptor capping.Involved in Schwann cell migration during peripheral nerveregeneration (By similarity). {ECO:0000250,ECO:0000269|PubMed:8227296}. | Possible splicing regulator involved in the control ofcellular survival. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CALD1_SREK1IP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CALD1_SREK1IP1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CALD1_SREK1IP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CALD1_SREK1IP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CALD1 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Hgene | CALD1 | C3495559 | Juvenile arthritis | 1 | CTD_human |