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Fusion gene ID: 528 |
FusionGeneSummary for ACTB_OSBPL3 |
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Fusion gene information | Fusion gene name: ACTB_OSBPL3 | Fusion gene ID: 528 | Hgene | Tgene | Gene symbol | ACTB | OSBPL3 | Gene ID | 60 | 26031 |
Gene name | actin beta | oxysterol binding protein like 3 | |
Synonyms | BRWS1|PS1TP5BP1 | ORP-3|ORP3|OSBP3 | |
Cytomap | 7p22.1 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | actin, cytoplasmic 1I(2)-actinPS1TP5-binding protein 1beta cytoskeletal actin | oxysterol-binding protein-related protein 3OSBP-related protein 3 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P60709 | Q9H4L5 | |
Ensembl transtripts involved in fusion gene | ENST00000464611, ENST00000331789, | ENST00000313367, ENST00000431825, ENST00000352860, ENST00000353930, ENST00000396431, ENST00000409069, ENST00000396429, ENST00000487020, | |
Fusion gene scores | * DoF score | 28 X 19 X 14=7448 | 5 X 5 X 4=100 |
# samples | 37 | 5 | |
** MAII score | log2(37/7448*10)=-4.33125589704248 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACTB [Title/Abstract] AND OSBPL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACTB | GO:0098974 | postsynaptic actin cytoskeleton organization | 18341992 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW949281 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000464611 | ENST00000313367 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000464611 | ENST00000431825 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000464611 | ENST00000352860 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000464611 | ENST00000353930 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000464611 | ENST00000396431 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000464611 | ENST00000409069 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000464611 | ENST00000396429 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000464611 | ENST00000487020 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000331789 | ENST00000313367 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000331789 | ENST00000431825 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000331789 | ENST00000352860 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000331789 | ENST00000353930 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000331789 | ENST00000396431 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000331789 | ENST00000409069 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000331789 | ENST00000396429 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
intron-intron | ENST00000331789 | ENST00000487020 | ACTB | chr7 | 5567263 | - | OSBPL3 | chr7 | 24969581 | - |
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FusionProtFeatures for ACTB_OSBPL3 |
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Hgene | Tgene |
ACTB | OSBPL3 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACTB_OSBPL3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACTB_OSBPL3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACTB_OSBPL3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACTB_OSBPL3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACTB | C2239176 | Liver carcinoma | 2 | CTD_human |
Hgene | ACTB | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | ACTB | C0009363 | Congenital ocular coloboma (disorder) | 1 | CTD_human |
Hgene | ACTB | C0013393 | Dysostoses | 1 | CTD_human |
Hgene | ACTB | C0013421 | Dystonia | 1 | CTD_human |
Hgene | ACTB | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0018784 | Sensorineural Hearing Loss (disorder) | 1 | CTD_human;HPO |
Hgene | ACTB | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | ACTB | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ACTB | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | ACTB | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ACTB | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | ACTB | C0242184 | Hypoxia | 1 | CTD_human |
Hgene | ACTB | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | ACTB | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
Hgene | ACTB | C1846331 | Juvenile-onset dystonia | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | ACTB | C1855722 | Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation | 1 | ORPHANET;UNIPROT |