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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5268

FusionGeneSummary for CADPS2_DNAH11

check button Fusion gene summary
Fusion gene informationFusion gene name: CADPS2_DNAH11
Fusion gene ID: 5268
HgeneTgene
Gene symbol

CADPS2

DNAH11

Gene ID

93664

8701

Gene namecalcium dependent secretion activator 2dynein axonemal heavy chain 11
SynonymsCAPS2CILD7|DNAHBL|DNAHC11|DNHBL|DPL11
Cytomap

7q31.32

7p15.3

Type of geneprotein-codingprotein-coding
Descriptioncalcium-dependent secretion activator 2CAPS-2Ca++-dependent secretion activator 2Ca2+ dependent secretion activator 2Ca2+-dependent activator protein for secretion 2calcium-dependent activator protein for secretion 2dynein heavy chain 11, axonemalaxonemal beta dynein heavy chain 11axonemal dynein heavy chain 11ciliary dynein heavy chain 11dynein, axonemal, heavy polypeptide 11dynein, ciliary, heavy chain 11
Modification date2018051920180523
UniProtAcc

Q86UW7

Q96DT5

Ensembl transtripts involved in fusion geneENST00000313070, ENST00000334010, 
ENST00000412584, ENST00000449022, 
ENST00000476131, 
ENST00000409508, 
ENST00000328843, ENST00000465593, 
Fusion gene scores* DoF score6 X 5 X 5=1504 X 4 X 4=64
# samples 64
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CADPS2 [Title/Abstract] AND DNAH11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7330-01ACADPS2chr7

122033495

-DNAH11chr7

21654732

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000313070ENST00000409508CADPS2chr7

122033495

-DNAH11chr7

21654732

+
Frame-shiftENST00000313070ENST00000328843CADPS2chr7

122033495

-DNAH11chr7

21654732

+
5CDS-intronENST00000313070ENST00000465593CADPS2chr7

122033495

-DNAH11chr7

21654732

+
Frame-shiftENST00000334010ENST00000409508CADPS2chr7

122033495

-DNAH11chr7

21654732

+
Frame-shiftENST00000334010ENST00000328843CADPS2chr7

122033495

-DNAH11chr7

21654732

+
5CDS-intronENST00000334010ENST00000465593CADPS2chr7

122033495

-DNAH11chr7

21654732

+
Frame-shiftENST00000412584ENST00000409508CADPS2chr7

122033495

-DNAH11chr7

21654732

+
Frame-shiftENST00000412584ENST00000328843CADPS2chr7

122033495

-DNAH11chr7

21654732

+
5CDS-intronENST00000412584ENST00000465593CADPS2chr7

122033495

-DNAH11chr7

21654732

+
Frame-shiftENST00000449022ENST00000409508CADPS2chr7

122033495

-DNAH11chr7

21654732

+
Frame-shiftENST00000449022ENST00000328843CADPS2chr7

122033495

-DNAH11chr7

21654732

+
5CDS-intronENST00000449022ENST00000465593CADPS2chr7

122033495

-DNAH11chr7

21654732

+
intron-3CDSENST00000476131ENST00000409508CADPS2chr7

122033495

-DNAH11chr7

21654732

+
intron-3CDSENST00000476131ENST00000328843CADPS2chr7

122033495

-DNAH11chr7

21654732

+
intron-intronENST00000476131ENST00000465593CADPS2chr7

122033495

-DNAH11chr7

21654732

+

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FusionProtFeatures for CADPS2_DNAH11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CADPS2

Q86UW7

DNAH11

Q96DT5

Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CADPS2_DNAH11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CADPS2_DNAH11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CADPS2UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2N, UBE2U, UBE2W, ASB6, ASB12, BZRAP1, SRPK2, C19orf45DNAH11ZDHHC17


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CADPS2_DNAH11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCADPS2Q86UW7DB11093Calcium CitrateCalcium-dependent secretion activator 2small moleculeapproved
HgeneCADPS2Q86UW7DB11348Calcium PhosphateCalcium-dependent secretion activator 2small moleculeapproved

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RelatedDiseases for CADPS2_DNAH11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCADPS2C0004352Autistic Disorder1CTD_human
HgeneCADPS2C0008370Cholestasis1CTD_human
HgeneCADPS2C0036341Schizophrenia1PSYGENET
HgeneCADPS2C0236969Substance-Related Disorders1CTD_human
HgeneCADPS2C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneDNAH11C0010068Coronary heart disease1CTD_human
TgeneDNAH11C0043094Weight Gain1CTD_human
TgeneDNAH11C0242339Dyslipidemias1CTD_human
TgeneDNAH11C2678473CILIARY DYSKINESIA, PRIMARY, 7 (disorder)1CTD_human;UNIPROT