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Fusion gene ID: 5268 |
FusionGeneSummary for CADPS2_DNAH11 |
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Fusion gene information | Fusion gene name: CADPS2_DNAH11 | Fusion gene ID: 5268 | Hgene | Tgene | Gene symbol | CADPS2 | DNAH11 | Gene ID | 93664 | 8701 |
Gene name | calcium dependent secretion activator 2 | dynein axonemal heavy chain 11 | |
Synonyms | CAPS2 | CILD7|DNAHBL|DNAHC11|DNHBL|DPL11 | |
Cytomap | 7q31.32 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | calcium-dependent secretion activator 2CAPS-2Ca++-dependent secretion activator 2Ca2+ dependent secretion activator 2Ca2+-dependent activator protein for secretion 2calcium-dependent activator protein for secretion 2 | dynein heavy chain 11, axonemalaxonemal beta dynein heavy chain 11axonemal dynein heavy chain 11ciliary dynein heavy chain 11dynein, axonemal, heavy polypeptide 11dynein, ciliary, heavy chain 11 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q86UW7 | Q96DT5 | |
Ensembl transtripts involved in fusion gene | ENST00000313070, ENST00000334010, ENST00000412584, ENST00000449022, ENST00000476131, | ENST00000409508, ENST00000328843, ENST00000465593, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 4 X 4 X 4=64 |
# samples | 6 | 4 | |
** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CADPS2 [Title/Abstract] AND DNAH11 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-EJ-7330-01A | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000313070 | ENST00000409508 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
Frame-shift | ENST00000313070 | ENST00000328843 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
5CDS-intron | ENST00000313070 | ENST00000465593 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
Frame-shift | ENST00000334010 | ENST00000409508 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
Frame-shift | ENST00000334010 | ENST00000328843 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
5CDS-intron | ENST00000334010 | ENST00000465593 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
Frame-shift | ENST00000412584 | ENST00000409508 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
Frame-shift | ENST00000412584 | ENST00000328843 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
5CDS-intron | ENST00000412584 | ENST00000465593 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
Frame-shift | ENST00000449022 | ENST00000409508 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
Frame-shift | ENST00000449022 | ENST00000328843 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
5CDS-intron | ENST00000449022 | ENST00000465593 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
intron-3CDS | ENST00000476131 | ENST00000409508 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
intron-3CDS | ENST00000476131 | ENST00000328843 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
intron-intron | ENST00000476131 | ENST00000465593 | CADPS2 | chr7 | 122033495 | - | DNAH11 | chr7 | 21654732 | + |
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FusionProtFeatures for CADPS2_DNAH11 |
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Hgene | Tgene |
CADPS2 | DNAH11 |
Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CADPS2_DNAH11 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CADPS2_DNAH11 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CADPS2 | UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2N, UBE2U, UBE2W, ASB6, ASB12, BZRAP1, SRPK2, C19orf45 | DNAH11 | ZDHHC17 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CADPS2_DNAH11 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CADPS2 | Q86UW7 | DB11093 | Calcium Citrate | Calcium-dependent secretion activator 2 | small molecule | approved |
Hgene | CADPS2 | Q86UW7 | DB11348 | Calcium Phosphate | Calcium-dependent secretion activator 2 | small molecule | approved |
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RelatedDiseases for CADPS2_DNAH11 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CADPS2 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | CADPS2 | C0008370 | Cholestasis | 1 | CTD_human |
Hgene | CADPS2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | CADPS2 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | CADPS2 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | DNAH11 | C0010068 | Coronary heart disease | 1 | CTD_human |
Tgene | DNAH11 | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | DNAH11 | C0242339 | Dyslipidemias | 1 | CTD_human |
Tgene | DNAH11 | C2678473 | CILIARY DYSKINESIA, PRIMARY, 7 (disorder) | 1 | CTD_human;UNIPROT |