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Fusion gene ID: 5266 |
FusionGeneSummary for CADPS2_ARMCX6 |
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Fusion gene information | Fusion gene name: CADPS2_ARMCX6 | Fusion gene ID: 5266 | Hgene | Tgene | Gene symbol | CADPS2 | ARMCX6 | Gene ID | 93664 | 54470 |
Gene name | calcium dependent secretion activator 2 | armadillo repeat containing X-linked 6 | |
Synonyms | CAPS2 | GASP10 | |
Cytomap | 7q31.32 | Xq22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | calcium-dependent secretion activator 2CAPS-2Ca++-dependent secretion activator 2Ca2+ dependent secretion activator 2Ca2+-dependent activator protein for secretion 2calcium-dependent activator protein for secretion 2 | protein ARMCX6 | |
Modification date | 20180519 | 20180429 | |
UniProtAcc | Q86UW7 | Q7L4S7 | |
Ensembl transtripts involved in fusion gene | ENST00000313070, ENST00000334010, ENST00000412584, ENST00000449022, ENST00000476131, | ENST00000497931, ENST00000361910, ENST00000538627, ENST00000539247, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CADPS2 [Title/Abstract] AND ARMCX6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK098170 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000313070 | ENST00000497931 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000313070 | ENST00000361910 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000313070 | ENST00000538627 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000313070 | ENST00000539247 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000334010 | ENST00000497931 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000334010 | ENST00000361910 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000334010 | ENST00000538627 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000334010 | ENST00000539247 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000412584 | ENST00000497931 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000412584 | ENST00000361910 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000412584 | ENST00000538627 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000412584 | ENST00000539247 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000449022 | ENST00000497931 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000449022 | ENST00000361910 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000449022 | ENST00000538627 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000449022 | ENST00000539247 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000476131 | ENST00000497931 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000476131 | ENST00000361910 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000476131 | ENST00000538627 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
intron-5UTR | ENST00000476131 | ENST00000539247 | CADPS2 | chr7 | 122153327 | - | ARMCX6 | chrX | 100870748 | - |
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FusionProtFeatures for CADPS2_ARMCX6 |
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Hgene | Tgene |
CADPS2 | ARMCX6 |
May regulate the dynamics and distribution ofmitochondria in neural cells. {ECO:0000250|UniProtKB:Q8K3A6}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CADPS2_ARMCX6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CADPS2_ARMCX6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CADPS2_ARMCX6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CADPS2 | Q86UW7 | DB11093 | Calcium Citrate | Calcium-dependent secretion activator 2 | small molecule | approved |
Hgene | CADPS2 | Q86UW7 | DB11348 | Calcium Phosphate | Calcium-dependent secretion activator 2 | small molecule | approved |
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RelatedDiseases for CADPS2_ARMCX6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CADPS2 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | CADPS2 | C0008370 | Cholestasis | 1 | CTD_human |
Hgene | CADPS2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | CADPS2 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | CADPS2 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |