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Fusion gene ID: 526 |
FusionGeneSummary for ACTB_HLA-DQB1 |
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Fusion gene information | Fusion gene name: ACTB_HLA-DQB1 | Fusion gene ID: 526 | Hgene | Tgene | Gene symbol | ACTB | HLA-DQB1 | Gene ID | 60 | 3120 |
Gene name | actin beta | major histocompatibility complex, class II, DQ beta 2 | |
Synonyms | BRWS1|PS1TP5BP1 | HLA-DQB1|HLA-DXB | |
Cytomap | 7p22.1 | 6p21.32 | |
Type of gene | protein-coding | protein-coding | |
Description | actin, cytoplasmic 1I(2)-actinPS1TP5-binding protein 1beta cytoskeletal actin | HLA class II histocompatibility antigen, DQ beta 2 chainDV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB))HLA class II histocompatibility antigen, DX beta chainMHC class II antigen DQB2 | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P60709 | P01920 | |
Ensembl transtripts involved in fusion gene | ENST00000464611, ENST00000331789, | ENST00000399082, ENST00000399079, ENST00000374943, ENST00000434651, ENST00000399084, ENST00000460185, ENST00000383121, ENST00000548953, ENST00000434886, ENST00000430790, ENST00000416192, ENST00000399074, ENST00000422950, ENST00000486521, ENST00000424530, ENST00000433936, ENST00000399088, ENST00000399065, ENST00000413089, ENST00000476430, ENST00000383247, ENST00000399670, ENST00000551970, ENST00000415926, ENST00000428219, ENST00000419914, ENST00000421888, ENST00000424806, ENST00000547498, ENST00000493020, ENST00000414518, ENST00000549367, ENST00000548083, | |
Fusion gene scores | * DoF score | 28 X 19 X 14=7448 | 1 X 1 X 1=1 |
# samples | 37 | 1 | |
** MAII score | log2(37/7448*10)=-4.33125589704248 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ACTB [Title/Abstract] AND HLA-DQB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACTB | GO:0098974 | postsynaptic actin cytoskeleton organization | 18341992 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-OL-A66I-01A | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000464611 | ENST00000399082 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000399079 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000374943 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-5UTR | ENST00000464611 | ENST00000434651 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000399084 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000460185 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000383121 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000548953 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000434886 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000430790 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000416192 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000399074 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000422950 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000486521 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000424530 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000433936 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000399088 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000399065 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000413089 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000476430 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000383247 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000399670 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000551970 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000415926 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000428219 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000419914 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000421888 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000424806 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000547498 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000493020 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000414518 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000549367 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000464611 | ENST00000548083 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000399082 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000399079 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000374943 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-5UTR | ENST00000331789 | ENST00000434651 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000399084 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000460185 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000383121 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000548953 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000434886 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000430790 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000416192 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000399074 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000422950 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000486521 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000424530 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000433936 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000399088 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000399065 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000413089 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000476430 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000383247 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000399670 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000551970 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000415926 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000428219 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000419914 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000421888 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000424806 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000547498 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000493020 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000414518 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000549367 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
intron-intron | ENST00000331789 | ENST00000548083 | ACTB | chr7 | 5567255 | - | HLA-DQB1 | chr6 | 32634461 | - |
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FusionProtFeatures for ACTB_HLA-DQB1 |
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Hgene | Tgene |
ACTB | HLA-DQB1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACTB_HLA-DQB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACTB_HLA-DQB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ACTB | CFL1, CFL2, ACTB, DSTN, ACTG1, NCALD, RAB8B, MYC, SMARCA4, SMARCE1, SMARCC2, NCF1, RAC1, RAC2, PFN1, PCYT1B, CCT5, CCT2, SSH1, SSH2, SPTBN2, RUVBL2, MEPCE, RUVBL1, PSTPIP1, INO80, BCL7C, MGMT, CENPA, CARM1, EMD, MORF4L1, MORF4L2, MRGBP, ESR1, ACTR3, ACTR2, DMAP1, KAT5, CBL, UCHL5, SMN1, AGO4, SMAD3, TJP1, YWHAQ, PSMA3, BCL2L1, H2AFX, AIMP2, TK1, CDKN1A, FABP4, RCC1, TTR, ANXA7, HMMR, CTGF, POLR2A, TAF11, PCK1, VHL, PROM1, ATF3, HNRNPU, ELAVL1, ARRB2, ANGPTL4, DHX9, ERG, FBXO25, TINF2, ACD, POT1, PPP1CC, PPP1CA, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, OSTF1, SHBG, MYOC, MKL1, LRRK2, SLC6A2, SNCA, UBASH3B, GRB2, PIK3R2, SHC1, CRK, EPS15, AP2M1, CYBB, IQGAP1, NSMAF, AKT1, ABLIM1, FPR1, A2M, MYH11, CORO1C, FHOD1, MAGOH, EIF4A3, HNF1A, SMURF1, VCP, TRAF3IP1, ERBB2, POLR1B, ESR2, FN1, VCAM1, HCK, DAB2, IQCB1, OTUB1, SMAD9, UBL4A, ITGA4, SVIL, PHB, BBS4, MAP1A, MAP2, NOS3, SLC12A3, DTNA, PAN2, PLG, ICAM1, CD81, ICAM3, MAPK7, AR, MYH9, ACE, RAD52, ENC1, CAV1, EP300, CSNK2B, KHDRBS1, PROSER2, RPL10A, COTL1, HNRNPD, PARK2, CDKN2A, RPA1, RPA2, RPA3, ASB9, ASB12, ZBTB1, HSPA5, ERRFI1, LGR4, CORO7, IVNS1ABP, STAU1, AMOT, HAUS1, CEP250, LGALS3BP, NEDD1, TP53, TUBG1, TUBGCP2, TUBGCP3, FUS, PA2G4, HDAC6, EHHADH, CAP2, WDYHV1, ALK, KAT2B, MDM2, ADA, MAGEA10, TPST1, LMX1B, USP46, DUSP19, HOXB5, HOMER1, PRSS23, HSD17B3, PNMA1, SLC30A6, HNRNPA1, SAMHD1, UNK, CORO1B, CAD, EEF1A1, EEF1A2, YARS, SCARNA22, HSPB2, TCP1, SRPK2, FLNA, PPP1CB, RAB2A, SYNPO, LIMA1, MYO18A, TRIM15, UBE3A, SKI, SNW1, CDC5L, ERBB3, EGFR, EPC1, MBTD1, PTPN1, GC, PHACTR2, PFN2, THRB, TMOD3, REG3A, DBN1, NEXN, TMCC2, COBL, CAP1, TWF2, RNASE3, SFXN5, NPB, SLC25A11, RPL15, PLEKHG6, PPIAL4G, CDK10, SCGB1A1, POLH, RIC3, NUS1, ACP1, IL1RL2, DUSP10, NXF5, THAP4, ZNF695, HTR1E, LSP1, RPS27, MEIS2, FBXL5, DEFA6, CLEC2D, UQCRB, TPGS2, CTNNB1, MTNR1A, CYLD, CCND2, FAM107A, HEY1, TES | HLA-DQB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACTB_HLA-DQB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | HLA-DQB1 | P01920 | DB00071 | Insulin Pork | HLA class II histocompatibility antigen, DQ beta 1 chain | biotech | approved |
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RelatedDiseases for ACTB_HLA-DQB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACTB | C2239176 | Liver carcinoma | 2 | CTD_human |
Hgene | ACTB | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | ACTB | C0009363 | Congenital ocular coloboma (disorder) | 1 | CTD_human |
Hgene | ACTB | C0013393 | Dysostoses | 1 | CTD_human |
Hgene | ACTB | C0013421 | Dystonia | 1 | CTD_human |
Hgene | ACTB | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0018784 | Sensorineural Hearing Loss (disorder) | 1 | CTD_human;HPO |
Hgene | ACTB | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | ACTB | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ACTB | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | ACTB | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ACTB | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | ACTB | C0242184 | Hypoxia | 1 | CTD_human |
Hgene | ACTB | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | ACTB | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
Hgene | ACTB | C1846331 | Juvenile-onset dystonia | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | ACTB | C1855722 | Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation | 1 | ORPHANET;UNIPROT |
Tgene | HLA-DQB1 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | HLA-DQB1 | C0002994 | Angioedema | 1 | CTD_human |
Tgene | HLA-DQB1 | C0004096 | Asthma | 1 | CTD_human |
Tgene | HLA-DQB1 | C0011609 | Drug Eruptions | 1 | CTD_human |
Tgene | HLA-DQB1 | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
Tgene | HLA-DQB1 | C0014848 | Esophageal Achalasia | 1 | CTD_human;HPO |
Tgene | HLA-DQB1 | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
Tgene | HLA-DQB1 | C0020517 | Hypersensitivity | 1 | CTD_human |
Tgene | HLA-DQB1 | C0027404 | Narcolepsy | 1 | CTD_human;ORPHANET |
Tgene | HLA-DQB1 | C0029295 | Oropharyngeal Neoplasms | 1 | CTD_human |
Tgene | HLA-DQB1 | C0036421 | Systemic Scleroderma | 1 | CTD_human |
Tgene | HLA-DQB1 | C0042109 | Urticaria | 1 | CTD_human;HPO |
Tgene | HLA-DQB1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |