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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 526

FusionGeneSummary for ACTB_HLA-DQB1

check button Fusion gene summary
Fusion gene informationFusion gene name: ACTB_HLA-DQB1
Fusion gene ID: 526
HgeneTgene
Gene symbol

ACTB

HLA-DQB1

Gene ID

60

3120

Gene nameactin betamajor histocompatibility complex, class II, DQ beta 2
SynonymsBRWS1|PS1TP5BP1HLA-DQB1|HLA-DXB
Cytomap

7p22.1

6p21.32

Type of geneprotein-codingprotein-coding
Descriptionactin, cytoplasmic 1I(2)-actinPS1TP5-binding protein 1beta cytoskeletal actinHLA class II histocompatibility antigen, DQ beta 2 chainDV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB))HLA class II histocompatibility antigen, DX beta chainMHC class II antigen DQB2
Modification date2018052220180522
UniProtAcc

P60709

P01920

Ensembl transtripts involved in fusion geneENST00000464611, ENST00000331789, 
ENST00000399082, ENST00000399079, 
ENST00000374943, ENST00000434651, 
ENST00000399084, ENST00000460185, 
ENST00000383121, ENST00000548953, 
ENST00000434886, ENST00000430790, 
ENST00000416192, ENST00000399074, 
ENST00000422950, ENST00000486521, 
ENST00000424530, ENST00000433936, 
ENST00000399088, ENST00000399065, 
ENST00000413089, ENST00000476430, 
ENST00000383247, ENST00000399670, 
ENST00000551970, ENST00000415926, 
ENST00000428219, ENST00000419914, 
ENST00000421888, ENST00000424806, 
ENST00000547498, ENST00000493020, 
ENST00000414518, ENST00000549367, 
ENST00000548083, 
Fusion gene scores* DoF score28 X 19 X 14=74481 X 1 X 1=1
# samples 371
** MAII scorelog2(37/7448*10)=-4.33125589704248
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ACTB [Title/Abstract] AND HLA-DQB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACTB

GO:0098974

postsynaptic actin cytoskeleton organization

18341992


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-OL-A66I-01AACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000464611ENST00000399082ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000399079ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000374943ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-5UTRENST00000464611ENST00000434651ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000399084ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000460185ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000383121ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000548953ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000434886ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000430790ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000416192ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000399074ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000422950ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000486521ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000424530ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000433936ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000399088ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000399065ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000413089ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000476430ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000383247ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000399670ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000551970ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000415926ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000428219ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000419914ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000421888ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000424806ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000547498ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000493020ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000414518ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000549367ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000464611ENST00000548083ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000399082ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000399079ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000374943ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-5UTRENST00000331789ENST00000434651ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000399084ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000460185ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000383121ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000548953ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000434886ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000430790ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000416192ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000399074ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000422950ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000486521ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000424530ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000433936ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000399088ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000399065ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000413089ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000476430ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000383247ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000399670ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000551970ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000415926ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000428219ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000419914ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000421888ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000424806ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000547498ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000493020ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000414518ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000549367ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-
intron-intronENST00000331789ENST00000548083ACTBchr7

5567255

-HLA-DQB1chr6

32634461

-

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FusionProtFeatures for ACTB_HLA-DQB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACTB

P60709

HLA-DQB1

P01920


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACTB_HLA-DQB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACTB_HLA-DQB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACTBCFL1, CFL2, ACTB, DSTN, ACTG1, NCALD, RAB8B, MYC, SMARCA4, SMARCE1, SMARCC2, NCF1, RAC1, RAC2, PFN1, PCYT1B, CCT5, CCT2, SSH1, SSH2, SPTBN2, RUVBL2, MEPCE, RUVBL1, PSTPIP1, INO80, BCL7C, MGMT, CENPA, CARM1, EMD, MORF4L1, MORF4L2, MRGBP, ESR1, ACTR3, ACTR2, DMAP1, KAT5, CBL, UCHL5, SMN1, AGO4, SMAD3, TJP1, YWHAQ, PSMA3, BCL2L1, H2AFX, AIMP2, TK1, CDKN1A, FABP4, RCC1, TTR, ANXA7, HMMR, CTGF, POLR2A, TAF11, PCK1, VHL, PROM1, ATF3, HNRNPU, ELAVL1, ARRB2, ANGPTL4, DHX9, ERG, FBXO25, TINF2, ACD, POT1, PPP1CC, PPP1CA, CUL3, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, OSTF1, SHBG, MYOC, MKL1, LRRK2, SLC6A2, SNCA, UBASH3B, GRB2, PIK3R2, SHC1, CRK, EPS15, AP2M1, CYBB, IQGAP1, NSMAF, AKT1, ABLIM1, FPR1, A2M, MYH11, CORO1C, FHOD1, MAGOH, EIF4A3, HNF1A, SMURF1, VCP, TRAF3IP1, ERBB2, POLR1B, ESR2, FN1, VCAM1, HCK, DAB2, IQCB1, OTUB1, SMAD9, UBL4A, ITGA4, SVIL, PHB, BBS4, MAP1A, MAP2, NOS3, SLC12A3, DTNA, PAN2, PLG, ICAM1, CD81, ICAM3, MAPK7, AR, MYH9, ACE, RAD52, ENC1, CAV1, EP300, CSNK2B, KHDRBS1, PROSER2, RPL10A, COTL1, HNRNPD, PARK2, CDKN2A, RPA1, RPA2, RPA3, ASB9, ASB12, ZBTB1, HSPA5, ERRFI1, LGR4, CORO7, IVNS1ABP, STAU1, AMOT, HAUS1, CEP250, LGALS3BP, NEDD1, TP53, TUBG1, TUBGCP2, TUBGCP3, FUS, PA2G4, HDAC6, EHHADH, CAP2, WDYHV1, ALK, KAT2B, MDM2, ADA, MAGEA10, TPST1, LMX1B, USP46, DUSP19, HOXB5, HOMER1, PRSS23, HSD17B3, PNMA1, SLC30A6, HNRNPA1, SAMHD1, UNK, CORO1B, CAD, EEF1A1, EEF1A2, YARS, SCARNA22, HSPB2, TCP1, SRPK2, FLNA, PPP1CB, RAB2A, SYNPO, LIMA1, MYO18A, TRIM15, UBE3A, SKI, SNW1, CDC5L, ERBB3, EGFR, EPC1, MBTD1, PTPN1, GC, PHACTR2, PFN2, THRB, TMOD3, REG3A, DBN1, NEXN, TMCC2, COBL, CAP1, TWF2, RNASE3, SFXN5, NPB, SLC25A11, RPL15, PLEKHG6, PPIAL4G, CDK10, SCGB1A1, POLH, RIC3, NUS1, ACP1, IL1RL2, DUSP10, NXF5, THAP4, ZNF695, HTR1E, LSP1, RPS27, MEIS2, FBXL5, DEFA6, CLEC2D, UQCRB, TPGS2, CTNNB1, MTNR1A, CYLD, CCND2, FAM107A, HEY1, TESHLA-DQB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACTB_HLA-DQB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHLA-DQB1P01920DB00071Insulin PorkHLA class II histocompatibility antigen, DQ beta 1 chainbiotechapproved

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RelatedDiseases for ACTB_HLA-DQB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACTBC2239176Liver carcinoma2CTD_human
HgeneACTBC0005586Bipolar Disorder1PSYGENET
HgeneACTBC0009363Congenital ocular coloboma (disorder)1CTD_human
HgeneACTBC0013393Dysostoses1CTD_human
HgeneACTBC0013421Dystonia1CTD_human
HgeneACTBC0014859Esophageal Neoplasms1CTD_human
HgeneACTBC0018784Sensorineural Hearing Loss (disorder)1CTD_human;HPO
HgeneACTBC0024121Lung Neoplasms1CTD_human
HgeneACTBC0024667Animal Mammary Neoplasms1CTD_human
HgeneACTBC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneACTBC0027626Neoplasm Invasiveness1CTD_human
HgeneACTBC0029408Degenerative polyarthritis1CTD_human
HgeneACTBC0036341Schizophrenia1PSYGENET
HgeneACTBC0151744Myocardial Ischemia1CTD_human
HgeneACTBC0242184Hypoxia1CTD_human
HgeneACTBC0376634Craniofacial Abnormalities1CTD_human
HgeneACTBC0497552Congenital neurologic anomalies1CTD_human
HgeneACTBC1846331Juvenile-onset dystonia1CTD_human;ORPHANET;UNIPROT
HgeneACTBC1855722Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation1ORPHANET;UNIPROT
TgeneHLA-DQB1C0036341Schizophrenia2PSYGENET
TgeneHLA-DQB1C0002994Angioedema1CTD_human
TgeneHLA-DQB1C0004096Asthma1CTD_human
TgeneHLA-DQB1C0011609Drug Eruptions1CTD_human
TgeneHLA-DQB1C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
TgeneHLA-DQB1C0014848Esophageal Achalasia1CTD_human;HPO
TgeneHLA-DQB1C0017661IGA Glomerulonephritis1CTD_human
TgeneHLA-DQB1C0020517Hypersensitivity1CTD_human
TgeneHLA-DQB1C0027404Narcolepsy1CTD_human;ORPHANET
TgeneHLA-DQB1C0029295Oropharyngeal Neoplasms1CTD_human
TgeneHLA-DQB1C0036421Systemic Scleroderma1CTD_human
TgeneHLA-DQB1C0042109Urticaria1CTD_human;HPO
TgeneHLA-DQB1C4277682Chemical and Drug Induced Liver Injury1CTD_human