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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5237

FusionGeneSummary for CACNB2_SPARCL1

check button Fusion gene summary
Fusion gene informationFusion gene name: CACNB2_SPARCL1
Fusion gene ID: 5237
HgeneTgene
Gene symbol

CACNB2

SPARCL1

Gene ID

783

8404

Gene namecalcium voltage-gated channel auxiliary subunit beta 2SPARC like 1
SynonymsCACNLB2|CAVB2|MYSBMAST 9|MAST9|PIG33|SC1
Cytomap

10p12.33-p12.31

4q22.1

Type of geneprotein-codingprotein-coding
Descriptionvoltage-dependent L-type calcium channel subunit beta-2CAB2calcium channel voltage-dependent subunit beta 2calcium channel, voltage-dependent, beta 2 subunitlambert-Eaton myasthenic syndrome antigen Bmyasthenic (Lambert-Eaton) syndrome antigen BSPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33
Modification date2018052320180523
UniProtAcc

Q08289

Q14515

Ensembl transtripts involved in fusion geneENST00000324631, ENST00000377328, 
ENST00000352115, ENST00000282343, 
ENST00000377331, ENST00000396576, 
ENST00000377319, ENST00000377329, 
ENST00000377315, ENST00000467034, 
ENST00000282470, ENST00000418378, 
ENST00000503414, 
Fusion gene scores* DoF score3 X 3 X 1=910 X 8 X 5=400
# samples 411
** MAII scorelog2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CACNB2 [Title/Abstract] AND SPARCL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCACNB2

GO:0051928

positive regulation of calcium ion transport

1309651

HgeneCACNB2

GO:0070509

calcium ion import

1309651


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB962120CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000324631ENST00000282470CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000324631ENST00000418378CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000324631ENST00000503414CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377328ENST00000282470CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377328ENST00000418378CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377328ENST00000503414CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000352115ENST00000282470CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000352115ENST00000418378CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000352115ENST00000503414CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000282343ENST00000282470CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000282343ENST00000418378CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000282343ENST00000503414CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377331ENST00000282470CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377331ENST00000418378CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377331ENST00000503414CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000396576ENST00000282470CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000396576ENST00000418378CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000396576ENST00000503414CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377319ENST00000282470CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377319ENST00000418378CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377319ENST00000503414CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377329ENST00000282470CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377329ENST00000418378CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377329ENST00000503414CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377315ENST00000282470CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377315ENST00000418378CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000377315ENST00000503414CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000467034ENST00000282470CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000467034ENST00000418378CACNB2chr10

18500360

+SPARCL1chr4

88403655

-
intron-3CDSENST00000467034ENST00000503414CACNB2chr10

18500360

+SPARCL1chr4

88403655

-

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FusionProtFeatures for CACNB2_SPARCL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CACNB2

Q08289

SPARCL1

Q14515


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CACNB2_SPARCL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CACNB2_SPARCL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CACNB2_SPARCL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCACNB2Q08289DB00381AmlodipineVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved
HgeneCACNB2Q08289DB00401NisoldipineVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved
HgeneCACNB2Q08289DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved
HgeneCACNB2Q08289DB01115NifedipineVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved
HgeneCACNB2Q08289DB04855DronedaroneVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved
HgeneCACNB2Q08289DB00270IsradipineVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved|investigational
HgeneCACNB2Q08289DB00393NimodipineVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved|investigational
HgeneCACNB2Q08289DB00622NicardipineVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved|investigational
HgeneCACNB2Q08289DB01023FelodipineVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved|investigational
HgeneCACNB2Q08289DB01054NitrendipineVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved|investigational
HgeneCACNB2Q08289DB06712NilvadipineVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved|investigational
HgeneCACNB2Q08289DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2small moleculeapproved|investigational|vet_approved

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RelatedDiseases for CACNB2_SPARCL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCACNB2C0005586Bipolar Disorder1PSYGENET
HgeneCACNB2C0036341Schizophrenia1PSYGENET
HgeneCACNB2C2678477Brugada Syndrome 41CTD_human;UNIPROT
TgeneSPARCL1C0014175Endometriosis1CTD_human
TgeneSPARCL1C0014544Epilepsy1CTD_human