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Fusion gene ID: 5237 |
FusionGeneSummary for CACNB2_SPARCL1 |
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Fusion gene information | Fusion gene name: CACNB2_SPARCL1 | Fusion gene ID: 5237 | Hgene | Tgene | Gene symbol | CACNB2 | SPARCL1 | Gene ID | 783 | 8404 |
Gene name | calcium voltage-gated channel auxiliary subunit beta 2 | SPARC like 1 | |
Synonyms | CACNLB2|CAVB2|MYSB | MAST 9|MAST9|PIG33|SC1 | |
Cytomap | 10p12.33-p12.31 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | voltage-dependent L-type calcium channel subunit beta-2CAB2calcium channel voltage-dependent subunit beta 2calcium channel, voltage-dependent, beta 2 subunitlambert-Eaton myasthenic syndrome antigen Bmyasthenic (Lambert-Eaton) syndrome antigen B | SPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q08289 | Q14515 | |
Ensembl transtripts involved in fusion gene | ENST00000324631, ENST00000377328, ENST00000352115, ENST00000282343, ENST00000377331, ENST00000396576, ENST00000377319, ENST00000377329, ENST00000377315, ENST00000467034, | ENST00000282470, ENST00000418378, ENST00000503414, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 10 X 8 X 5=400 |
# samples | 4 | 11 | |
** MAII score | log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/400*10)=-1.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CACNB2 [Title/Abstract] AND SPARCL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CACNB2 | GO:0051928 | positive regulation of calcium ion transport | 1309651 |
Hgene | CACNB2 | GO:0070509 | calcium ion import | 1309651 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB962120 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000324631 | ENST00000282470 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000324631 | ENST00000418378 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000324631 | ENST00000503414 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377328 | ENST00000282470 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377328 | ENST00000418378 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377328 | ENST00000503414 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000352115 | ENST00000282470 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000352115 | ENST00000418378 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000352115 | ENST00000503414 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000282343 | ENST00000282470 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000282343 | ENST00000418378 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000282343 | ENST00000503414 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377331 | ENST00000282470 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377331 | ENST00000418378 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377331 | ENST00000503414 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000396576 | ENST00000282470 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000396576 | ENST00000418378 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000396576 | ENST00000503414 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377319 | ENST00000282470 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377319 | ENST00000418378 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377319 | ENST00000503414 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377329 | ENST00000282470 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377329 | ENST00000418378 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377329 | ENST00000503414 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377315 | ENST00000282470 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377315 | ENST00000418378 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000377315 | ENST00000503414 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000467034 | ENST00000282470 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000467034 | ENST00000418378 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
intron-3CDS | ENST00000467034 | ENST00000503414 | CACNB2 | chr10 | 18500360 | + | SPARCL1 | chr4 | 88403655 | - |
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FusionProtFeatures for CACNB2_SPARCL1 |
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Hgene | Tgene |
CACNB2 | SPARCL1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CACNB2_SPARCL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CACNB2_SPARCL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CACNB2_SPARCL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CACNB2 | Q08289 | DB00381 | Amlodipine | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved |
Hgene | CACNB2 | Q08289 | DB00401 | Nisoldipine | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved |
Hgene | CACNB2 | Q08289 | DB00661 | Verapamil | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved |
Hgene | CACNB2 | Q08289 | DB01115 | Nifedipine | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved |
Hgene | CACNB2 | Q08289 | DB04855 | Dronedarone | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved |
Hgene | CACNB2 | Q08289 | DB00270 | Isradipine | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved|investigational |
Hgene | CACNB2 | Q08289 | DB00393 | Nimodipine | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved|investigational |
Hgene | CACNB2 | Q08289 | DB00622 | Nicardipine | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved|investigational |
Hgene | CACNB2 | Q08289 | DB01023 | Felodipine | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved|investigational |
Hgene | CACNB2 | Q08289 | DB01054 | Nitrendipine | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved|investigational |
Hgene | CACNB2 | Q08289 | DB06712 | Nilvadipine | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved|investigational |
Hgene | CACNB2 | Q08289 | DB00653 | Magnesium sulfate | Voltage-dependent L-type calcium channel subunit beta-2 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for CACNB2_SPARCL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CACNB2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | CACNB2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | CACNB2 | C2678477 | Brugada Syndrome 4 | 1 | CTD_human;UNIPROT |
Tgene | SPARCL1 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | SPARCL1 | C0014544 | Epilepsy | 1 | CTD_human |