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Fusion gene ID: 5215 |
FusionGeneSummary for CACNA2D3_DAP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CACNA2D3_DAP3 | Fusion gene ID: 5215 | Hgene | Tgene | Gene symbol | CACNA2D3 | DAP3 | Gene ID | 55799 | 58512 |
| Gene name | calcium voltage-gated channel auxiliary subunit alpha2delta 3 | DLG associated protein 3 | |
| Synonyms | HSA272268 | DAP3|SAPAP3 | |
| Cytomap | 3p21.1-p14.3 | 1p34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | voltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit a | disks large-associated protein 3DAP-3PSD-95/SAP90-binding protein 3SAP90/PSD-95-associated protein 3discs large homolog associated protein 3 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q8IZS8 | P51398 | |
| Ensembl transtripts involved in fusion gene | ENST00000415676, ENST00000288197, ENST00000474759, ENST00000490478, ENST00000478261, | ENST00000471642, ENST00000368336, ENST00000343043, ENST00000496863, ENST00000535183, ENST00000421487, ENST00000465375, | |
| Fusion gene scores | * DoF score | 7 X 7 X 5=245 | 3 X 2 X 2=12 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CACNA2D3 [Title/Abstract] AND DAP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-20-1684-01A | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000415676 | ENST00000471642 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| In-frame | ENST00000415676 | ENST00000368336 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| Frame-shift | ENST00000415676 | ENST00000343043 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000415676 | ENST00000496863 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000415676 | ENST00000535183 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000415676 | ENST00000421487 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000415676 | ENST00000465375 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| Frame-shift | ENST00000288197 | ENST00000471642 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| In-frame | ENST00000288197 | ENST00000368336 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| Frame-shift | ENST00000288197 | ENST00000343043 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000288197 | ENST00000496863 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000288197 | ENST00000535183 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000288197 | ENST00000421487 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000288197 | ENST00000465375 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| Frame-shift | ENST00000474759 | ENST00000471642 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| In-frame | ENST00000474759 | ENST00000368336 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| Frame-shift | ENST00000474759 | ENST00000343043 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000474759 | ENST00000496863 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000474759 | ENST00000535183 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000474759 | ENST00000421487 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000474759 | ENST00000465375 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| Frame-shift | ENST00000490478 | ENST00000471642 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| In-frame | ENST00000490478 | ENST00000368336 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| Frame-shift | ENST00000490478 | ENST00000343043 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000490478 | ENST00000496863 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000490478 | ENST00000535183 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000490478 | ENST00000421487 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| 5CDS-intron | ENST00000490478 | ENST00000465375 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| intron-3CDS | ENST00000478261 | ENST00000471642 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| intron-3CDS | ENST00000478261 | ENST00000368336 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| intron-3CDS | ENST00000478261 | ENST00000343043 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| intron-intron | ENST00000478261 | ENST00000496863 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| intron-intron | ENST00000478261 | ENST00000535183 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| intron-intron | ENST00000478261 | ENST00000421487 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
| intron-intron | ENST00000478261 | ENST00000465375 | CACNA2D3 | chr3 | 54676268 | + | DAP3 | chr1 | 155707948 | + |
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FusionProtFeatures for CACNA2D3_DAP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CACNA2D3 | DAP3 |
| The alpha-2/delta subunit of voltage-dependent calciumchannels regulates calcium current density andactivation/inactivation kinetics of the calcium channel. Acts as aregulatory subunit for P/Q-type calcium channel (CACNA1A), N-type(CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G)(By similarity). {ECO:0000250}. | Involved in mediating interferon-gamma-induced celldeath. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CACNA2D3_DAP3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CACNA2D3_ENST00000415676_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_417aa MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI >In-frame_CACNA2D3_ENST00000288197_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_417aa MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI >In-frame_CACNA2D3_ENST00000474759_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_417aa MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI >In-frame_CACNA2D3_ENST00000490478_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_323aa MEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPA IVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTI AKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CACNA2D3_ENST00000415676_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_1253nt ATGGCCGGGCCGGGCTCGCCGCGCCGCGCGTCCCGGGGGGCCTCGGCGCTTCTCGCTGCCGCGCTTCTCTACGCCGCGCTGGGGGACGTG GTGCGCTCGGAGCAGCAGATACCGCTCTCCGTGGTGAAGCTCTGGGCCTCGGCTTTTGGTGGGGAGATAAAATCCATTGCTGCTAAGTAC TCCGGTTCCCAGCTTCTGCAAAAGAAATACAAAGAGTATGAGAAAGACGTTGCCATAGAAGAAATTGATGGCCTCCAACTGGTAAAGAAG CTGGCAAAGAACATGGAAGAGATGTTTCACAAGAAGTCTGAGGCCGTCAGGCGTCTGGTGGAGGCTGCAGAAGAAGCACACCTGAAACAT GAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTGCTGATAAATGAAAGGGACAAAGACGGGAATTTTTTGGAGCTGGGAAAG GAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCTGTGAACATCAGTCTAAGTGACGTCCAAGTACCAACGAACATGTACAAC AAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCTCTAAACAAAGTTTTTGTAGATAACTTTGACCGTGACCCATCTCTCATA TGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTATCCGGGGATTAAATGGGAACCAGATGAGAATGGAGTCATTGCCTTCGAC TGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCGAAAGACGTGGTCATTTTAGTTGACGTCAGTGGCAGCATGAAAGGACTC CGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGATACACTTGGGGATGATGACTTCTTCAACATAATTGCTTATAATGAGGAG CTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAAGCCGACAGGACAAACAAAGAGCACTTCAGGGAGCATCTGGACAAACTT TTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAGGCCTTCAACATTCTGAGTGATTTCAACCACACGGGACAAGGAAGTATC TGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGACACCTATGATACAATCTTTGCAAAATACAATTGGCCAGATCGAAAGCTC >In-frame_CACNA2D3_ENST00000288197_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_1253nt ATGGCCGGGCCGGGCTCGCCGCGCCGCGCGTCCCGGGGGGCCTCGGCGCTTCTCGCTGCCGCGCTTCTCTACGCCGCGCTGGGGGACGTG GTGCGCTCGGAGCAGCAGATACCGCTCTCCGTGGTGAAGCTCTGGGCCTCGGCTTTTGGTGGGGAGATAAAATCCATTGCTGCTAAGTAC TCCGGTTCCCAGCTTCTGCAAAAGAAATACAAAGAGTATGAGAAAGACGTTGCCATAGAAGAAATTGATGGCCTCCAACTGGTAAAGAAG CTGGCAAAGAACATGGAAGAGATGTTTCACAAGAAGTCTGAGGCCGTCAGGCGTCTGGTGGAGGCTGCAGAAGAAGCACACCTGAAACAT GAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTGCTGATAAATGAAAGGGACAAAGACGGGAATTTTTTGGAGCTGGGAAAG GAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCTGTGAACATCAGTCTAAGTGACGTCCAAGTACCAACGAACATGTACAAC AAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCTCTAAACAAAGTTTTTGTAGATAACTTTGACCGTGACCCATCTCTCATA TGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTATCCGGGGATTAAATGGGAACCAGATGAGAATGGAGTCATTGCCTTCGAC TGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCGAAAGACGTGGTCATTTTAGTTGACGTCAGTGGCAGCATGAAAGGACTC CGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGATACACTTGGGGATGATGACTTCTTCAACATAATTGCTTATAATGAGGAG CTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAAGCCGACAGGACAAACAAAGAGCACTTCAGGGAGCATCTGGACAAACTT TTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAGGCCTTCAACATTCTGAGTGATTTCAACCACACGGGACAAGGAAGTATC TGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGACACCTATGATACAATCTTTGCAAAATACAATTGGCCAGATCGAAAGCTC >In-frame_CACNA2D3_ENST00000474759_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_1253nt ATGGCCGGGCCGGGCTCGCCGCGCCGCGCGTCCCGGGGGGCCTCGGCGCTTCTCGCTGCCGCGCTTCTCTACGCCGCGCTGGGGGACGTG GTGCGCTCGGAGCAGCAGATACCGCTCTCCGTGGTGAAGCTCTGGGCCTCGGCTTTTGGTGGGGAGATAAAATCCATTGCTGCTAAGTAC TCCGGTTCCCAGCTTCTGCAAAAGAAATACAAAGAGTATGAGAAAGACGTTGCCATAGAAGAAATTGATGGCCTCCAACTGGTAAAGAAG CTGGCAAAGAACATGGAAGAGATGTTTCACAAGAAGTCTGAGGCCGTCAGGCGTCTGGTGGAGGCTGCAGAAGAAGCACACCTGAAACAT GAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTGCTGATAAATGAAAGGGACAAAGACGGGAATTTTTTGGAGCTGGGAAAG GAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCTGTGAACATCAGTCTAAGTGACGTCCAAGTACCAACGAACATGTACAAC AAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCTCTAAACAAAGTTTTTGTAGATAACTTTGACCGTGACCCATCTCTCATA TGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTATCCGGGGATTAAATGGGAACCAGATGAGAATGGAGTCATTGCCTTCGAC TGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCGAAAGACGTGGTCATTTTAGTTGACGTCAGTGGCAGCATGAAAGGACTC CGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGATACACTTGGGGATGATGACTTCTTCAACATAATTGCTTATAATGAGGAG CTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAAGCCGACAGGACAAACAAAGAGCACTTCAGGGAGCATCTGGACAAACTT TTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAGGCCTTCAACATTCTGAGTGATTTCAACCACACGGGACAAGGAAGTATC TGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGACACCTATGATACAATCTTTGCAAAATACAATTGGCCAGATCGAAAGCTC >In-frame_CACNA2D3_ENST00000490478_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_971nt ATGGAAGAGATGTTTCACAAGAAGTCTGAGGCCGTCAGGCGTCTGGTGGAGGCTGCAGAAGAAGCACACCTGAAACATGAATTTGATGCA GACTTACAGTATGAATACTTCAATGCTGTGCTGATAAATGAAAGGGACAAAGACGGGAATTTTTTGGAGCTGGGAAAGGAATTCATCTTA GCCCCAAATGACCATTTTAATAATTTGCCTGTGAACATCAGTCTAAGTGACGTCCAAGTACCAACGAACATGTACAACAAAGACCCTGCA ATTGTCAATGGGGTTTATTGGTCTGAATCTCTAAACAAAGTTTTTGTAGATAACTTTGACCGTGACCCATCTCTCATATGGCAGTACTTT GGAAGTGCAAAGGGCTTTTTTAGGCAGTATCCGGGGATTAAATGGGAACCAGATGAGAATGGAGTCATTGCCTTCGACTGCAGGAACCGA AAATGGTACATCCAGGCAGCAACTTCTCCGAAAGACGTGGTCATTTTAGTTGACGTCAGTGGCAGCATGAAAGGACTCCGTCTGACTATC GCGAAGCAAACAGTCTCATCCATTTTGGATACACTTGGGGATGATGACTTCTTCAACATAATTGCTTATAATGAGGAGCTTCACTATGTG GAACCTTGCCTGAATGGAACTTTGGTGCAAGCCGACAGGACAAACAAAGAGCACTTCAGGGAGCATCTGGACAAACTTTTCGCCAAAGGA ATTGGAATGTTGGATATAGCTCTGAATGAGGCCTTCAACATTCTGAGTGATTTCAACCACACGGGACAAGGAAGTATCTGCAGTCAGGCC ATCATGCTCATAACTGATGGGGCGGTGGACACCTATGATACAATCTTTGCAAAATACAATTGGCCAGATCGAAAGCTCCTACAGAAGAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CACNA2D3_ENST00000415676_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_2139nt CACCCGCTCCTTTTTCTGCTCCCCAAGTGAGCCGGGCGCTCGCCCACCGCCCGCTCCGCGCAGCTCCCCGCGGCCGCTCTCGTCGCCGCC GCAGCGGGCGCGTCGGAGGGAGCCCAGCATGGCCGGGCCGGGCTCGCCGCGCCGCGCGTCCCGGGGGGCCTCGGCGCTTCTCGCTGCCGC GCTTCTCTACGCCGCGCTGGGGGACGTGGTGCGCTCGGAGCAGCAGATACCGCTCTCCGTGGTGAAGCTCTGGGCCTCGGCTTTTGGTGG GGAGATAAAATCCATTGCTGCTAAGTACTCCGGTTCCCAGCTTCTGCAAAAGAAATACAAAGAGTATGAGAAAGACGTTGCCATAGAAGA AATTGATGGCCTCCAACTGGTAAAGAAGCTGGCAAAGAACATGGAAGAGATGTTTCACAAGAAGTCTGAGGCCGTCAGGCGTCTGGTGGA GGCTGCAGAAGAAGCACACCTGAAACATGAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTGCTGATAAATGAAAGGGACAA AGACGGGAATTTTTTGGAGCTGGGAAAGGAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCTGTGAACATCAGTCTAAGTGA CGTCCAAGTACCAACGAACATGTACAACAAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCTCTAAACAAAGTTTTTGTAGA TAACTTTGACCGTGACCCATCTCTCATATGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTATCCGGGGATTAAATGGGAACC AGATGAGAATGGAGTCATTGCCTTCGACTGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCGAAAGACGTGGTCATTTTAGT TGACGTCAGTGGCAGCATGAAAGGACTCCGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGATACACTTGGGGATGATGACTT CTTCAACATAATTGCTTATAATGAGGAGCTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAAGCCGACAGGACAAACAAAGA GCACTTCAGGGAGCATCTGGACAAACTTTTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAGGCCTTCAACATTCTGAGTGA TTTCAACCACACGGGACAAGGAAGTATCTGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGACACCTATGATACAATCTTTGC AAAATACAATTGGCCAGATCGAAAGCTCCTACAGAAGAAGGGAAAAAAGAGCTGCTGTTCCTAAGTAACGCGAACCCCTCGCTGCTGGAG CGGCACTGTGCCTACCTCTAAGCCAAGATCACAGCATGTGAGGAAGACAGTGGACATCTGCTTTATGCTGGACCCAGTAAGATGAGGAAG TCGGGCAGTACACAGGAAGAGGAGCCAGGCCCTTGTACCTATGGGATTGGACAGGACTGCAGTTGGCTCTGGACCTGCATTAAAATGGGT TTCACTGTGAATGCGTGACAATAAGATATTCCCTTGTTCCTAAAACTTTATATCAGTTTATTGGATGTGGTTTTTCACATTTAAGATAAT TATGGCTCTTTTCCTAAAAAATAAAATATCTTTCTAAAGTGTTGTGTTAGATTAATAATATGGAAGGAGTCTTTAGATTGGCCAAATTGC ATTTCTCTGATATTCCTCTTGTTGCAGGTCAGAAGAGATCAATTCTACAGAAATTTCCAGTGGTTCTGTTGAGGCTTTATGGAATTCAGC ATGTCAAAATTCACAGCTGGCTGGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGAAGCCCAAGGCGGGCAGACTGCTTGAGTTC AGGAGTTTGCAACCAGCCTGGGCAACATGGTGAAAACCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCACGGTGGCATGCGCCTGTA ATCCAAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTCAACTTGGGAGGCGGATGTTGCAGTGAGCCAAAATTGCACCACTGCACTCC >In-frame_CACNA2D3_ENST00000288197_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_2069nt CGGCCGCTCTCGTCGCCGCCGCAGCGGGCGCGTCGGAGGGAGCCCAGCATGGCCGGGCCGGGCTCGCCGCGCCGCGCGTCCCGGGGGGCC TCGGCGCTTCTCGCTGCCGCGCTTCTCTACGCCGCGCTGGGGGACGTGGTGCGCTCGGAGCAGCAGATACCGCTCTCCGTGGTGAAGCTC TGGGCCTCGGCTTTTGGTGGGGAGATAAAATCCATTGCTGCTAAGTACTCCGGTTCCCAGCTTCTGCAAAAGAAATACAAAGAGTATGAG AAAGACGTTGCCATAGAAGAAATTGATGGCCTCCAACTGGTAAAGAAGCTGGCAAAGAACATGGAAGAGATGTTTCACAAGAAGTCTGAG GCCGTCAGGCGTCTGGTGGAGGCTGCAGAAGAAGCACACCTGAAACATGAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTG CTGATAAATGAAAGGGACAAAGACGGGAATTTTTTGGAGCTGGGAAAGGAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCT GTGAACATCAGTCTAAGTGACGTCCAAGTACCAACGAACATGTACAACAAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCT CTAAACAAAGTTTTTGTAGATAACTTTGACCGTGACCCATCTCTCATATGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTAT CCGGGGATTAAATGGGAACCAGATGAGAATGGAGTCATTGCCTTCGACTGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCG AAAGACGTGGTCATTTTAGTTGACGTCAGTGGCAGCATGAAAGGACTCCGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGAT ACACTTGGGGATGATGACTTCTTCAACATAATTGCTTATAATGAGGAGCTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAA GCCGACAGGACAAACAAAGAGCACTTCAGGGAGCATCTGGACAAACTTTTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAG GCCTTCAACATTCTGAGTGATTTCAACCACACGGGACAAGGAAGTATCTGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGAC ACCTATGATACAATCTTTGCAAAATACAATTGGCCAGATCGAAAGCTCCTACAGAAGAAGGGAAAAAAGAGCTGCTGTTCCTAAGTAACG CGAACCCCTCGCTGCTGGAGCGGCACTGTGCCTACCTCTAAGCCAAGATCACAGCATGTGAGGAAGACAGTGGACATCTGCTTTATGCTG GACCCAGTAAGATGAGGAAGTCGGGCAGTACACAGGAAGAGGAGCCAGGCCCTTGTACCTATGGGATTGGACAGGACTGCAGTTGGCTCT GGACCTGCATTAAAATGGGTTTCACTGTGAATGCGTGACAATAAGATATTCCCTTGTTCCTAAAACTTTATATCAGTTTATTGGATGTGG TTTTTCACATTTAAGATAATTATGGCTCTTTTCCTAAAAAATAAAATATCTTTCTAAAGTGTTGTGTTAGATTAATAATATGGAAGGAGT CTTTAGATTGGCCAAATTGCATTTCTCTGATATTCCTCTTGTTGCAGGTCAGAAGAGATCAATTCTACAGAAATTTCCAGTGGTTCTGTT GAGGCTTTATGGAATTCAGCATGTCAAAATTCACAGCTGGCTGGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGAAGCCCAAGG CGGGCAGACTGCTTGAGTTCAGGAGTTTGCAACCAGCCTGGGCAACATGGTGAAAACCTGTCTCTACTAAAAATACAAAAATTAGCCGGG CACGGTGGCATGCGCCTGTAATCCAAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTCAACTTGGGAGGCGGATGTTGCAGTGAGCCA >In-frame_CACNA2D3_ENST00000474759_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_2069nt CGGCCGCTCTCGTCGCCGCCGCAGCGGGCGCGTCGGAGGGAGCCCAGCATGGCCGGGCCGGGCTCGCCGCGCCGCGCGTCCCGGGGGGCC TCGGCGCTTCTCGCTGCCGCGCTTCTCTACGCCGCGCTGGGGGACGTGGTGCGCTCGGAGCAGCAGATACCGCTCTCCGTGGTGAAGCTC TGGGCCTCGGCTTTTGGTGGGGAGATAAAATCCATTGCTGCTAAGTACTCCGGTTCCCAGCTTCTGCAAAAGAAATACAAAGAGTATGAG AAAGACGTTGCCATAGAAGAAATTGATGGCCTCCAACTGGTAAAGAAGCTGGCAAAGAACATGGAAGAGATGTTTCACAAGAAGTCTGAG GCCGTCAGGCGTCTGGTGGAGGCTGCAGAAGAAGCACACCTGAAACATGAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTG CTGATAAATGAAAGGGACAAAGACGGGAATTTTTTGGAGCTGGGAAAGGAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCT GTGAACATCAGTCTAAGTGACGTCCAAGTACCAACGAACATGTACAACAAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCT CTAAACAAAGTTTTTGTAGATAACTTTGACCGTGACCCATCTCTCATATGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTAT CCGGGGATTAAATGGGAACCAGATGAGAATGGAGTCATTGCCTTCGACTGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCG AAAGACGTGGTCATTTTAGTTGACGTCAGTGGCAGCATGAAAGGACTCCGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGAT ACACTTGGGGATGATGACTTCTTCAACATAATTGCTTATAATGAGGAGCTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAA GCCGACAGGACAAACAAAGAGCACTTCAGGGAGCATCTGGACAAACTTTTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAG GCCTTCAACATTCTGAGTGATTTCAACCACACGGGACAAGGAAGTATCTGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGAC ACCTATGATACAATCTTTGCAAAATACAATTGGCCAGATCGAAAGCTCCTACAGAAGAAGGGAAAAAAGAGCTGCTGTTCCTAAGTAACG CGAACCCCTCGCTGCTGGAGCGGCACTGTGCCTACCTCTAAGCCAAGATCACAGCATGTGAGGAAGACAGTGGACATCTGCTTTATGCTG GACCCAGTAAGATGAGGAAGTCGGGCAGTACACAGGAAGAGGAGCCAGGCCCTTGTACCTATGGGATTGGACAGGACTGCAGTTGGCTCT GGACCTGCATTAAAATGGGTTTCACTGTGAATGCGTGACAATAAGATATTCCCTTGTTCCTAAAACTTTATATCAGTTTATTGGATGTGG TTTTTCACATTTAAGATAATTATGGCTCTTTTCCTAAAAAATAAAATATCTTTCTAAAGTGTTGTGTTAGATTAATAATATGGAAGGAGT CTTTAGATTGGCCAAATTGCATTTCTCTGATATTCCTCTTGTTGCAGGTCAGAAGAGATCAATTCTACAGAAATTTCCAGTGGTTCTGTT GAGGCTTTATGGAATTCAGCATGTCAAAATTCACAGCTGGCTGGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGAAGCCCAAGG CGGGCAGACTGCTTGAGTTCAGGAGTTTGCAACCAGCCTGGGCAACATGGTGAAAACCTGTCTCTACTAAAAATACAAAAATTAGCCGGG CACGGTGGCATGCGCCTGTAATCCAAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTCAACTTGGGAGGCGGATGTTGCAGTGAGCCA >In-frame_CACNA2D3_ENST00000490478_chr3_54676268_+_DAP3_ENST00000368336_chr1_155707948_+_1951nt GTTGACTGTGACACGGGTGTTACATATCTTCCTGTGCCCCTTCTCCCTGTAGGGTGAAGCTCTGGGCCTCGGCTTTTGGTGGGGAGATAA AATCCATTGCTGCTAAGTACTCCGGTTCCCAGCTTCTGCAAAAGAAATACAAAGAGTATGAGAAAGACGTTGCCATAGAAGAAATTGATG GCCTCCAACTGGTAAAGAAGCTGGCAAAGAACATGGAAGAGATGTTTCACAAGAAGTCTGAGGCCGTCAGGCGTCTGGTGGAGGCTGCAG AAGAAGCACACCTGAAACATGAATTTGATGCAGACTTACAGTATGAATACTTCAATGCTGTGCTGATAAATGAAAGGGACAAAGACGGGA ATTTTTTGGAGCTGGGAAAGGAATTCATCTTAGCCCCAAATGACCATTTTAATAATTTGCCTGTGAACATCAGTCTAAGTGACGTCCAAG TACCAACGAACATGTACAACAAAGACCCTGCAATTGTCAATGGGGTTTATTGGTCTGAATCTCTAAACAAAGTTTTTGTAGATAACTTTG ACCGTGACCCATCTCTCATATGGCAGTACTTTGGAAGTGCAAAGGGCTTTTTTAGGCAGTATCCGGGGATTAAATGGGAACCAGATGAGA ATGGAGTCATTGCCTTCGACTGCAGGAACCGAAAATGGTACATCCAGGCAGCAACTTCTCCGAAAGACGTGGTCATTTTAGTTGACGTCA GTGGCAGCATGAAAGGACTCCGTCTGACTATCGCGAAGCAAACAGTCTCATCCATTTTGGATACACTTGGGGATGATGACTTCTTCAACA TAATTGCTTATAATGAGGAGCTTCACTATGTGGAACCTTGCCTGAATGGAACTTTGGTGCAAGCCGACAGGACAAACAAAGAGCACTTCA GGGAGCATCTGGACAAACTTTTCGCCAAAGGAATTGGAATGTTGGATATAGCTCTGAATGAGGCCTTCAACATTCTGAGTGATTTCAACC ACACGGGACAAGGAAGTATCTGCAGTCAGGCCATCATGCTCATAACTGATGGGGCGGTGGACACCTATGATACAATCTTTGCAAAATACA ATTGGCCAGATCGAAAGCTCCTACAGAAGAAGGGAAAAAAGAGCTGCTGTTCCTAAGTAACGCGAACCCCTCGCTGCTGGAGCGGCACTG TGCCTACCTCTAAGCCAAGATCACAGCATGTGAGGAAGACAGTGGACATCTGCTTTATGCTGGACCCAGTAAGATGAGGAAGTCGGGCAG TACACAGGAAGAGGAGCCAGGCCCTTGTACCTATGGGATTGGACAGGACTGCAGTTGGCTCTGGACCTGCATTAAAATGGGTTTCACTGT GAATGCGTGACAATAAGATATTCCCTTGTTCCTAAAACTTTATATCAGTTTATTGGATGTGGTTTTTCACATTTAAGATAATTATGGCTC TTTTCCTAAAAAATAAAATATCTTTCTAAAGTGTTGTGTTAGATTAATAATATGGAAGGAGTCTTTAGATTGGCCAAATTGCATTTCTCT GATATTCCTCTTGTTGCAGGTCAGAAGAGATCAATTCTACAGAAATTTCCAGTGGTTCTGTTGAGGCTTTATGGAATTCAGCATGTCAAA ATTCACAGCTGGCTGGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGAAGCCCAAGGCGGGCAGACTGCTTGAGTTCAGGAGTTT GCAACCAGCCTGGGCAACATGGTGAAAACCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCACGGTGGCATGCGCCTGTAATCCAAGC TACTTGGGAGGCTGAGGCAGGAGAATTGCTTCAACTTGGGAGGCGGATGTTGCAGTGAGCCAAAATTGCACCACTGCACTCCAGCCTGGG |
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FusionGenePPI for CACNA2D3_DAP3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CACNA2D3 | DAP3 | CNBP, NR3C1, PPARA, HSP90AA1, HIF1A, AHR, ESR1, ESR2, PGR, THRA, AR, DAP3, TNFRSF10A, TNFRSF25, FADD, UBC, ICT1, DYRK2, MRPS27, STOML2, COX5A, YME1L1, C1QBP, SOX2, TARDBP, PARK2, GRSF1, CEP250, HAUS2, VCP, FBXW11, BTRC, TRA2A, RPL6, ZC3H3, RPS8, TRMT10B, HNRNPA1, ZNF707, MRPS31, MRPS35, MRPS10, WDFY2, MTIF2, PNMA6A, MRPS5, NTRK1, PTCD3, MRPS18B, MRPS2, MRPS22, MRPS23, MRPS28, MRPS9, LYST, COL4A5, CSNK1D, MBNL1, PYCR1, HNRNPU, MAGEA1, AP3D1, POC1A, MRPS11, ZNF746, DUSP11, MRPS34, MRPS15, AURKAIP1, RRS1, ZBTB48, E4F1, BHLHA15, FGF8, ZNF331, U2AF2, ZNF324B, ZNF133, ZNF408, SNRNP70, CCDC59, GLTSCR2, RBM3, NCL, DLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CACNA2D3_DAP3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CACNA2D3 | Q8IZS8 | DB00381 | Amlodipine | Voltage-dependent calcium channel subunit alpha-2/delta-3 | small molecule | approved |
| Hgene | CACNA2D3 | Q8IZS8 | DB06712 | Nilvadipine | Voltage-dependent calcium channel subunit alpha-2/delta-3 | small molecule | approved|investigational |
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RelatedDiseases for CACNA2D3_DAP3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DAP3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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