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Fusion gene ID: 5210 |
FusionGeneSummary for CACNA2D1_PTPN12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CACNA2D1_PTPN12 | Fusion gene ID: 5210 | Hgene | Tgene | Gene symbol | CACNA2D1 | PTPN12 | Gene ID | 781 | 5782 |
| Gene name | calcium voltage-gated channel auxiliary subunit alpha2delta 1 | protein tyrosine phosphatase, non-receptor type 12 | |
| Synonyms | CACNA2|CACNL2A|CCHL2A|LINC01112|lncRNA-N3 | PTP-PEST|PTPG1 | |
| Cytomap | 7q21.11 | 7q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | voltage-dependent calcium channel subunit alpha-2/delta-1calcium channel, L type, alpha 2 polypeptidecalcium channel, voltage-dependent, alpha 2/delta subunit 1dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunitvoltage-gated calciu | tyrosine-protein phosphatase non-receptor type 12protein-tyrosine phosphatase G1 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | P54289 | Q05209 | |
| Ensembl transtripts involved in fusion gene | ENST00000356860, ENST00000356253, ENST00000423588, ENST00000464354, ENST00000535308, | ENST00000248594, ENST00000415482, ENST00000435495, | |
| Fusion gene scores | * DoF score | 5 X 7 X 4=140 | 7 X 7 X 5=245 |
| # samples | 9 | 7 | |
| ** MAII score | log2(9/140*10)=-0.637429920615292 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CACNA2D1 [Title/Abstract] AND PTPN12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CACNA2D1 | GO:0006816 | calcium ion transport | 1309651|11160515 |
| Hgene | CACNA2D1 | GO:0051924 | regulation of calcium ion transport | 1309651 |
| Tgene | PTPN12 | GO:0006470 | protein dephosphorylation | 27134172 |
| Tgene | PTPN12 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 27134172 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-K1-A6RT-01A | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000356860 | ENST00000248594 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| 5CDS-5UTR | ENST00000356860 | ENST00000415482 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| 5CDS-5UTR | ENST00000356860 | ENST00000435495 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| In-frame | ENST00000356253 | ENST00000248594 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| 5CDS-5UTR | ENST00000356253 | ENST00000415482 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| 5CDS-5UTR | ENST00000356253 | ENST00000435495 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| In-frame | ENST00000423588 | ENST00000248594 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| 5CDS-5UTR | ENST00000423588 | ENST00000415482 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| 5CDS-5UTR | ENST00000423588 | ENST00000435495 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| intron-3CDS | ENST00000464354 | ENST00000248594 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| intron-5UTR | ENST00000464354 | ENST00000415482 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| intron-5UTR | ENST00000464354 | ENST00000435495 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| intron-3CDS | ENST00000535308 | ENST00000248594 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| intron-5UTR | ENST00000535308 | ENST00000415482 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
| intron-5UTR | ENST00000535308 | ENST00000435495 | CACNA2D1 | chr7 | 81964451 | - | PTPN12 | chr7 | 77200395 | + |
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FusionProtFeatures for CACNA2D1_PTPN12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CACNA2D1 | PTPN12 |
| The alpha-2/delta subunit of voltage-dependent calciumchannels regulates calcium current density andactivation/inactivation kinetics of the calcium channel. Plays animportant role in excitation-contraction coupling (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PTPN12 | chr7:81964451 | chr7:77200395 | ENST00000435495 | + | 0 | 17 | 28_293 | -65 | 651 | Domain | Tyrosine-protein phosphatase |
| Tgene | >PTPN12 | chr7:81964451 | chr7:77200395 | ENST00000248594 | + | 0 | 18 | 231_237 | 33 | 781 | Region | Substrate binding |
| Tgene | >PTPN12 | chr7:81964451 | chr7:77200395 | ENST00000248594 | + | 0 | 18 | 63_67 | 33 | 781 | Region | Substrate binding |
| Tgene | >PTPN12 | chr7:81964451 | chr7:77200395 | ENST00000435495 | + | 0 | 17 | 231_237 | -65 | 651 | Region | Substrate binding |
| Tgene | >PTPN12 | chr7:81964451 | chr7:77200395 | ENST00000435495 | + | 0 | 17 | 63_67 | -65 | 651 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356253 | - | 3 | 39 | 253_430 | 98 | 1104 | Domain | VWFA |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356253 | - | 3 | 39 | 446_556 | 98 | 1104 | Domain | Note=Cache |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356860 | - | 3 | 39 | 253_430 | 98 | 1092 | Domain | VWFA |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356860 | - | 3 | 39 | 446_556 | 98 | 1092 | Domain | Note=Cache |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356253 | - | 3 | 39 | 259_263 | 98 | 1104 | Motif | Note=MIDAS-like motif |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356860 | - | 3 | 39 | 259_263 | 98 | 1092 | Motif | Note=MIDAS-like motif |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356253 | - | 3 | 39 | 1095_1103 | 98 | 1104 | Topological domain | Cytoplasmic |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356253 | - | 3 | 39 | 25_1073 | 98 | 1104 | Topological domain | Extracellular |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356860 | - | 3 | 39 | 1095_1103 | 98 | 1092 | Topological domain | Cytoplasmic |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356860 | - | 3 | 39 | 25_1073 | 98 | 1092 | Topological domain | Extracellular |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356253 | - | 3 | 39 | 1074_1094 | 98 | 1104 | Transmembrane | Helical |
| Hgene | >CACNA2D1 | chr7:81964451 | chr7:77200395 | ENST00000356860 | - | 3 | 39 | 1074_1094 | 98 | 1092 | Transmembrane | Helical |
| Tgene | PTPN12 | chr7:81964451 | chr7:77200395 | ENST00000248594 | + | 0 | 18 | 28_293 | 33 | 781 | Domain | Tyrosine-protein phosphatase |
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FusionGeneSequence for CACNA2D1_PTPN12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CACNA2D1_ENST00000356860_chr7_81964451_-_PTPN12_ENST00000248594_chr7_77200395_+_846aa MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLL SNRSKALVRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVI DFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSS FDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE KQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDND RYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKI SKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKT VSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNI AGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSD >In-frame_CACNA2D1_ENST00000356253_chr7_81964451_-_PTPN12_ENST00000248594_chr7_77200395_+_846aa MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLL SNRSKALVRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVI DFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSS FDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE KQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDND RYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKI SKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKT VSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNI AGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSD >In-frame_CACNA2D1_ENST00000423588_chr7_81964451_-_PTPN12_ENST00000248594_chr7_77200395_+_846aa MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLL SNRSKALVRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVI DFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSS FDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFE KQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDND RYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKI SKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKT VSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNI AGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CACNA2D1_ENST00000356860_chr7_81964451_-_PTPN12_ENST00000248594_chr7_77200395_+_2538nt ATGGCTGCTGGCTGCCTGCTGGCCTTGACTCTGACACTTTTCCAATCTTTGCTCATCGGCCCCTCGTCGGAGGAGCCGTTCCCTTCGGCC GTCACTATCAAATCATGGGTGGATAAGATGCAAGAAGACCTTGTCACACTGGCAAAAACAGCAAGTGGAGTCAATCAGCTTGTTGATATT TATGAGAAATATCAAGATTTGTATACTGTGGAACCAAATAATGCACGCCAGCTGGTAGAAATTGCAGCCAGGGATATTGAGAAACTTCTG AGCAACAGATCTAAAGCCCTGGTGCGGTTAAGAAGATTGTCTACCAAATATAGAACAGAAAAGATATATCCCACAGCCACTGGAGAAAAA GAAGAAAATGTTAAAAAGAACAGATACAAGGACATACTGCCATTTGATCACAGCCGAGTTAAATTGACATTAAAGACTCCTTCACAAGAT TCAGACTATATCAATGCAAATTTTATAAAGGGCGTCTATGGGCCAAAAGCATATGTAGCAACTCAAGGACCTTTAGCAAATACAGTAATA GATTTTTGGAGGATGATATGGGAGTATAATGTTGTGATCATTGTAATGGCCTGCCGAGAATTTGAGATGGGAAGGAAAAAATGTGAGCGC TATTGGCCTTTGTATGGAGAAGACCCCATAACGTTTGCACCATTTAAAATTTCTTGTGAGGATGAACAAGCAAGAACAGACTACTTCATC AGGACACTCTTACTTGAATTTCAAAATGAATCTCGTAGGCTGTATCAGTTTCATTATGTGAACTGGCCAGACCATGATGTTCCTTCATCA TTTGATTCTATTCTGGACATGATAAGCTTAATGAGGAAATATCAAGAACATGAAGATGTTCCTATTTGTATTCATTGCAGTGCAGGCTGT GGAAGAACAGGTGCCATTTGTGCCATAGATTATACGTGGAATTTACTAAAAGCTGGGAAAATACCAGAGGAATTTAATGTATTTAATTTA ATACAAGAAATGAGAACACAAAGGCATTCTGCAGTACAAACAAAGGAGCAATATGAACTTGTTCATAGAGCTATTGCCCAACTGTTTGAA AAACAGCTACAACTATATGAAATTCATGGAGCTCAGAAAATTGCTGATGGAGTGAATGAAATTAACACTGAAAACATGGTCAGCTCCATA GAGCCTGAAAAACAAGATTCTCCTCCTCCAAAACCACCAAGGACCCGCAGTTGCCTTGTTGAAGGGGATGCTAAAGAAGAAATACTGCAG CCACCGGAACCTCATCCAGTGCCACCCATCTTGACACCTTCTCCCCCTTCAGCTTTTCCAACAGTCACTACTGTGTGGCAGGACAATGAT AGATACCATCCAAAGCCAGTGTTGCATATGGTTTCATCAGAACAACATTCAGCAGACCTCAACAGAAACTATAGTAAATCAACAGAACTT CCAGGGAAAAATGAATCAACAATTGAACAGATAGATAAAAAATTGGAACGAAATTTAAGTTTTGAGATTAAGAAGGTCCCTCTCCAAGAG GGACCAAAAAGTTTTGATGGGAACACACTTTTGAATAGGGGACATGCAATTAAAATTAAATCTGCTTCACCTTGTATAGCTGATAAAATC TCTAAGCCACAGGAATTAAGTTCAGATCTAAATGTCGGTGATACTTCCCAGAATTCTTGTGTGGACTGCAGTGTAACACAATCAAACAAA GTTTCAGTTACTCCACCAGAAGAATCCCAGAATTCAGACACACCTCCAAGGCCAGACCGCTTGCCTCTTGATGAGAAAGGACATGTAACG TGGTCATTTCATGGACCTGAAAATGCCATACCCATACCTGATTTATCTGAAGGCAATTCCTCAGATATCAACTATCAAACTAGGAAAACT GTGAGTTTAACACCAAGTCCTACAACACAAGTTGAAACACCTGATCTTGTGGATCATGATAACACTTCACCACTCTTCAGAACACCCCTC AGTTTTACTAATCCACTTCACTCTGATGACTCAGACTCAGATGAAAGAAACTCTGATGGTGCTGTGACCCAGAATAAAACTAATATTTCA ACAGCAAGTGCCACAGTTTCTGCTGCCACTAGTACTGAAAGCATTTCTACTAGGAAAGTATTGCCAATGTCCATTGCTAGACATAATATA GCAGGAACAACACATTCAGGTGCTGAAAAAGATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTT GTGTTAGCAAGTGAACATAATACACCTGTAAGATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGC TTGATAACCTCTGAAAATGAGAAATGTGATCATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGAC AAGAGAGAACAAATATCAGAAAATCCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATCCA >In-frame_CACNA2D1_ENST00000356253_chr7_81964451_-_PTPN12_ENST00000248594_chr7_77200395_+_2538nt ATGGCTGCTGGCTGCCTGCTGGCCTTGACTCTGACACTTTTCCAATCTTTGCTCATCGGCCCCTCGTCGGAGGAGCCGTTCCCTTCGGCC GTCACTATCAAATCATGGGTGGATAAGATGCAAGAAGACCTTGTCACACTGGCAAAAACAGCAAGTGGAGTCAATCAGCTTGTTGATATT TATGAGAAATATCAAGATTTGTATACTGTGGAACCAAATAATGCACGCCAGCTGGTAGAAATTGCAGCCAGGGATATTGAGAAACTTCTG AGCAACAGATCTAAAGCCCTGGTGCGGTTAAGAAGATTGTCTACCAAATATAGAACAGAAAAGATATATCCCACAGCCACTGGAGAAAAA GAAGAAAATGTTAAAAAGAACAGATACAAGGACATACTGCCATTTGATCACAGCCGAGTTAAATTGACATTAAAGACTCCTTCACAAGAT TCAGACTATATCAATGCAAATTTTATAAAGGGCGTCTATGGGCCAAAAGCATATGTAGCAACTCAAGGACCTTTAGCAAATACAGTAATA GATTTTTGGAGGATGATATGGGAGTATAATGTTGTGATCATTGTAATGGCCTGCCGAGAATTTGAGATGGGAAGGAAAAAATGTGAGCGC TATTGGCCTTTGTATGGAGAAGACCCCATAACGTTTGCACCATTTAAAATTTCTTGTGAGGATGAACAAGCAAGAACAGACTACTTCATC AGGACACTCTTACTTGAATTTCAAAATGAATCTCGTAGGCTGTATCAGTTTCATTATGTGAACTGGCCAGACCATGATGTTCCTTCATCA TTTGATTCTATTCTGGACATGATAAGCTTAATGAGGAAATATCAAGAACATGAAGATGTTCCTATTTGTATTCATTGCAGTGCAGGCTGT GGAAGAACAGGTGCCATTTGTGCCATAGATTATACGTGGAATTTACTAAAAGCTGGGAAAATACCAGAGGAATTTAATGTATTTAATTTA ATACAAGAAATGAGAACACAAAGGCATTCTGCAGTACAAACAAAGGAGCAATATGAACTTGTTCATAGAGCTATTGCCCAACTGTTTGAA AAACAGCTACAACTATATGAAATTCATGGAGCTCAGAAAATTGCTGATGGAGTGAATGAAATTAACACTGAAAACATGGTCAGCTCCATA GAGCCTGAAAAACAAGATTCTCCTCCTCCAAAACCACCAAGGACCCGCAGTTGCCTTGTTGAAGGGGATGCTAAAGAAGAAATACTGCAG CCACCGGAACCTCATCCAGTGCCACCCATCTTGACACCTTCTCCCCCTTCAGCTTTTCCAACAGTCACTACTGTGTGGCAGGACAATGAT AGATACCATCCAAAGCCAGTGTTGCATATGGTTTCATCAGAACAACATTCAGCAGACCTCAACAGAAACTATAGTAAATCAACAGAACTT CCAGGGAAAAATGAATCAACAATTGAACAGATAGATAAAAAATTGGAACGAAATTTAAGTTTTGAGATTAAGAAGGTCCCTCTCCAAGAG GGACCAAAAAGTTTTGATGGGAACACACTTTTGAATAGGGGACATGCAATTAAAATTAAATCTGCTTCACCTTGTATAGCTGATAAAATC TCTAAGCCACAGGAATTAAGTTCAGATCTAAATGTCGGTGATACTTCCCAGAATTCTTGTGTGGACTGCAGTGTAACACAATCAAACAAA GTTTCAGTTACTCCACCAGAAGAATCCCAGAATTCAGACACACCTCCAAGGCCAGACCGCTTGCCTCTTGATGAGAAAGGACATGTAACG TGGTCATTTCATGGACCTGAAAATGCCATACCCATACCTGATTTATCTGAAGGCAATTCCTCAGATATCAACTATCAAACTAGGAAAACT GTGAGTTTAACACCAAGTCCTACAACACAAGTTGAAACACCTGATCTTGTGGATCATGATAACACTTCACCACTCTTCAGAACACCCCTC AGTTTTACTAATCCACTTCACTCTGATGACTCAGACTCAGATGAAAGAAACTCTGATGGTGCTGTGACCCAGAATAAAACTAATATTTCA ACAGCAAGTGCCACAGTTTCTGCTGCCACTAGTACTGAAAGCATTTCTACTAGGAAAGTATTGCCAATGTCCATTGCTAGACATAATATA GCAGGAACAACACATTCAGGTGCTGAAAAAGATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTT GTGTTAGCAAGTGAACATAATACACCTGTAAGATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGC TTGATAACCTCTGAAAATGAGAAATGTGATCATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGAC AAGAGAGAACAAATATCAGAAAATCCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATCCA >In-frame_CACNA2D1_ENST00000423588_chr7_81964451_-_PTPN12_ENST00000248594_chr7_77200395_+_2538nt ATGGCTGCTGGCTGCCTGCTGGCCTTGACTCTGACACTTTTCCAATCTTTGCTCATCGGCCCCTCGTCGGAGGAGCCGTTCCCTTCGGCC GTCACTATCAAATCATGGGTGGATAAGATGCAAGAAGACCTTGTCACACTGGCAAAAACAGCAAGTGGAGTCAATCAGCTTGTTGATATT TATGAGAAATATCAAGATTTGTATACTGTGGAACCAAATAATGCACGCCAGCTGGTAGAAATTGCAGCCAGGGATATTGAGAAACTTCTG AGCAACAGATCTAAAGCCCTGGTGCGGTTAAGAAGATTGTCTACCAAATATAGAACAGAAAAGATATATCCCACAGCCACTGGAGAAAAA GAAGAAAATGTTAAAAAGAACAGATACAAGGACATACTGCCATTTGATCACAGCCGAGTTAAATTGACATTAAAGACTCCTTCACAAGAT TCAGACTATATCAATGCAAATTTTATAAAGGGCGTCTATGGGCCAAAAGCATATGTAGCAACTCAAGGACCTTTAGCAAATACAGTAATA GATTTTTGGAGGATGATATGGGAGTATAATGTTGTGATCATTGTAATGGCCTGCCGAGAATTTGAGATGGGAAGGAAAAAATGTGAGCGC TATTGGCCTTTGTATGGAGAAGACCCCATAACGTTTGCACCATTTAAAATTTCTTGTGAGGATGAACAAGCAAGAACAGACTACTTCATC AGGACACTCTTACTTGAATTTCAAAATGAATCTCGTAGGCTGTATCAGTTTCATTATGTGAACTGGCCAGACCATGATGTTCCTTCATCA TTTGATTCTATTCTGGACATGATAAGCTTAATGAGGAAATATCAAGAACATGAAGATGTTCCTATTTGTATTCATTGCAGTGCAGGCTGT GGAAGAACAGGTGCCATTTGTGCCATAGATTATACGTGGAATTTACTAAAAGCTGGGAAAATACCAGAGGAATTTAATGTATTTAATTTA ATACAAGAAATGAGAACACAAAGGCATTCTGCAGTACAAACAAAGGAGCAATATGAACTTGTTCATAGAGCTATTGCCCAACTGTTTGAA AAACAGCTACAACTATATGAAATTCATGGAGCTCAGAAAATTGCTGATGGAGTGAATGAAATTAACACTGAAAACATGGTCAGCTCCATA GAGCCTGAAAAACAAGATTCTCCTCCTCCAAAACCACCAAGGACCCGCAGTTGCCTTGTTGAAGGGGATGCTAAAGAAGAAATACTGCAG CCACCGGAACCTCATCCAGTGCCACCCATCTTGACACCTTCTCCCCCTTCAGCTTTTCCAACAGTCACTACTGTGTGGCAGGACAATGAT AGATACCATCCAAAGCCAGTGTTGCATATGGTTTCATCAGAACAACATTCAGCAGACCTCAACAGAAACTATAGTAAATCAACAGAACTT CCAGGGAAAAATGAATCAACAATTGAACAGATAGATAAAAAATTGGAACGAAATTTAAGTTTTGAGATTAAGAAGGTCCCTCTCCAAGAG GGACCAAAAAGTTTTGATGGGAACACACTTTTGAATAGGGGACATGCAATTAAAATTAAATCTGCTTCACCTTGTATAGCTGATAAAATC TCTAAGCCACAGGAATTAAGTTCAGATCTAAATGTCGGTGATACTTCCCAGAATTCTTGTGTGGACTGCAGTGTAACACAATCAAACAAA GTTTCAGTTACTCCACCAGAAGAATCCCAGAATTCAGACACACCTCCAAGGCCAGACCGCTTGCCTCTTGATGAGAAAGGACATGTAACG TGGTCATTTCATGGACCTGAAAATGCCATACCCATACCTGATTTATCTGAAGGCAATTCCTCAGATATCAACTATCAAACTAGGAAAACT GTGAGTTTAACACCAAGTCCTACAACACAAGTTGAAACACCTGATCTTGTGGATCATGATAACACTTCACCACTCTTCAGAACACCCCTC AGTTTTACTAATCCACTTCACTCTGATGACTCAGACTCAGATGAAAGAAACTCTGATGGTGCTGTGACCCAGAATAAAACTAATATTTCA ACAGCAAGTGCCACAGTTTCTGCTGCCACTAGTACTGAAAGCATTTCTACTAGGAAAGTATTGCCAATGTCCATTGCTAGACATAATATA GCAGGAACAACACATTCAGGTGCTGAAAAAGATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTT GTGTTAGCAAGTGAACATAATACACCTGTAAGATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGC TTGATAACCTCTGAAAATGAGAAATGTGATCATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGAC AAGAGAGAACAAATATCAGAAAATCCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CACNA2D1_ENST00000356860_chr7_81964451_-_PTPN12_ENST00000248594_chr7_77200395_+_3668nt AGGGAGGAAACCGAGAGGGAGAGCGAGAGCGCGCGAGCGCCGGCGGGCTCGCCGAGGTCTGTTTCCAAAGTCGCCCTTGATGGCGGCGGA GGCAAGGCGGCCGCGGCGCGGAGCAGCCGACGCACGCTAGTGGGTCCGCCCGCCACCGCCCCTTCCTCGGCGTCCGCTCCCGCCCTTGCC GTCCCCCGCGCGGCTCCGCGCCTCGGGCCCCGGGCGCAGCCAGCCCTCCAGACGCCCGCGGTCCCGGCGGCGTGTGCTGCTCTTCCTCCG CCCGCGGTTTCCAGCGCCGCTCCTTCCCCCGCTTGGGCAGGGAGGGGGCATTGATCTTCGATCGCGAAGATGGCTGCTGGCTGCCTGCTG GCCTTGACTCTGACACTTTTCCAATCTTTGCTCATCGGCCCCTCGTCGGAGGAGCCGTTCCCTTCGGCCGTCACTATCAAATCATGGGTG GATAAGATGCAAGAAGACCTTGTCACACTGGCAAAAACAGCAAGTGGAGTCAATCAGCTTGTTGATATTTATGAGAAATATCAAGATTTG TATACTGTGGAACCAAATAATGCACGCCAGCTGGTAGAAATTGCAGCCAGGGATATTGAGAAACTTCTGAGCAACAGATCTAAAGCCCTG GTGCGGTTAAGAAGATTGTCTACCAAATATAGAACAGAAAAGATATATCCCACAGCCACTGGAGAAAAAGAAGAAAATGTTAAAAAGAAC AGATACAAGGACATACTGCCATTTGATCACAGCCGAGTTAAATTGACATTAAAGACTCCTTCACAAGATTCAGACTATATCAATGCAAAT TTTATAAAGGGCGTCTATGGGCCAAAAGCATATGTAGCAACTCAAGGACCTTTAGCAAATACAGTAATAGATTTTTGGAGGATGATATGG GAGTATAATGTTGTGATCATTGTAATGGCCTGCCGAGAATTTGAGATGGGAAGGAAAAAATGTGAGCGCTATTGGCCTTTGTATGGAGAA GACCCCATAACGTTTGCACCATTTAAAATTTCTTGTGAGGATGAACAAGCAAGAACAGACTACTTCATCAGGACACTCTTACTTGAATTT CAAAATGAATCTCGTAGGCTGTATCAGTTTCATTATGTGAACTGGCCAGACCATGATGTTCCTTCATCATTTGATTCTATTCTGGACATG ATAAGCTTAATGAGGAAATATCAAGAACATGAAGATGTTCCTATTTGTATTCATTGCAGTGCAGGCTGTGGAAGAACAGGTGCCATTTGT GCCATAGATTATACGTGGAATTTACTAAAAGCTGGGAAAATACCAGAGGAATTTAATGTATTTAATTTAATACAAGAAATGAGAACACAA AGGCATTCTGCAGTACAAACAAAGGAGCAATATGAACTTGTTCATAGAGCTATTGCCCAACTGTTTGAAAAACAGCTACAACTATATGAA ATTCATGGAGCTCAGAAAATTGCTGATGGAGTGAATGAAATTAACACTGAAAACATGGTCAGCTCCATAGAGCCTGAAAAACAAGATTCT CCTCCTCCAAAACCACCAAGGACCCGCAGTTGCCTTGTTGAAGGGGATGCTAAAGAAGAAATACTGCAGCCACCGGAACCTCATCCAGTG CCACCCATCTTGACACCTTCTCCCCCTTCAGCTTTTCCAACAGTCACTACTGTGTGGCAGGACAATGATAGATACCATCCAAAGCCAGTG TTGCATATGGTTTCATCAGAACAACATTCAGCAGACCTCAACAGAAACTATAGTAAATCAACAGAACTTCCAGGGAAAAATGAATCAACA ATTGAACAGATAGATAAAAAATTGGAACGAAATTTAAGTTTTGAGATTAAGAAGGTCCCTCTCCAAGAGGGACCAAAAAGTTTTGATGGG AACACACTTTTGAATAGGGGACATGCAATTAAAATTAAATCTGCTTCACCTTGTATAGCTGATAAAATCTCTAAGCCACAGGAATTAAGT TCAGATCTAAATGTCGGTGATACTTCCCAGAATTCTTGTGTGGACTGCAGTGTAACACAATCAAACAAAGTTTCAGTTACTCCACCAGAA GAATCCCAGAATTCAGACACACCTCCAAGGCCAGACCGCTTGCCTCTTGATGAGAAAGGACATGTAACGTGGTCATTTCATGGACCTGAA AATGCCATACCCATACCTGATTTATCTGAAGGCAATTCCTCAGATATCAACTATCAAACTAGGAAAACTGTGAGTTTAACACCAAGTCCT ACAACACAAGTTGAAACACCTGATCTTGTGGATCATGATAACACTTCACCACTCTTCAGAACACCCCTCAGTTTTACTAATCCACTTCAC TCTGATGACTCAGACTCAGATGAAAGAAACTCTGATGGTGCTGTGACCCAGAATAAAACTAATATTTCAACAGCAAGTGCCACAGTTTCT GCTGCCACTAGTACTGAAAGCATTTCTACTAGGAAAGTATTGCCAATGTCCATTGCTAGACATAATATAGCAGGAACAACACATTCAGGT GCTGAAAAAGATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGAACATAAT ACACCTGTAAGATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAG AAATGTGATCATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAATATCAGAA AATCCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATCCACCTTCAGAATGGACATGATTC AGGGAGCTAGAAGACACTTTAAGTTATACTGGAAAATTCAGGTGCCACTGAAAGCCAGATTTATAGTATTCCATCTTTAATATGTGGGAC TAACAGCAGTGTAGATTGTTACCTTAATATTTTTTGCTGGGACCATCTACCTGCCTTATACTACACTTAGGAAAAAGTATTACATATGGT TTATTTTGAAACTTCAAGTATTATTGCCTTAATGTCTCTTAACCCTGTTACACGCTGCTTGTAGACATGTTAATATAGTAATACCTTTAT GATATATTGAGTTTAAGGACTACTCTTTTTCTGTTTTATCATGTATGCATTATTTTGTATATGTACAGGGCAAGTAGGTATATAATTTGA TAAAGTTGCAATTGAAATATTATTAACAGAAGATGTAAGAAATTTCTGCATGGTCTAAATCTTTGTGTACTTTATTTGTAAATTATTTGC CCTGGAGTTTTAGAAAATAGTTTCTGAATTTTAAACTTGCTGGATTCATGCAGCCAGCTTTGCAGGTTATCAGAGATCAAAGATTGTAAT AATAATTTTGTAAATTGTAAGCAAAAAGTTATTTTTATATTATATACAGTCTAATTGTTCATCCTAATTGTTCCTGTTTTCATCTAGTCA GAGATTCAGTAAGTGCCTTGGAACAATATTGAATTCTCTTAGCTTGTGTGTGTTTCTTTAATATTTGAACTCAAGTGGGATTAGAAGACT >In-frame_CACNA2D1_ENST00000356253_chr7_81964451_-_PTPN12_ENST00000248594_chr7_77200395_+_3585nt CGGCGGAGGCAAGGCGGCCGCGGCGCGGAGCAGCCGACGCACGCTAGTGGGTCCGCCCGCCACCGCCCCTTCCTCGGCGTCCGCTCCCGC CCTTGCCGTCCCCCGCGCGGCTCCGCGCCTCGGGCCCCGGGCGCAGCCAGCCCTCCAGACGCCCGCGGTCCCGGCGGCGTGTGCTGCTCT TCCTCCGCCCGCGGTTTCCAGCGCCGCTCCTTCCCCCGCTTGGGCAGGGAGGGGGCATTGATCTTCGATCGCGAAGATGGCTGCTGGCTG CCTGCTGGCCTTGACTCTGACACTTTTCCAATCTTTGCTCATCGGCCCCTCGTCGGAGGAGCCGTTCCCTTCGGCCGTCACTATCAAATC ATGGGTGGATAAGATGCAAGAAGACCTTGTCACACTGGCAAAAACAGCAAGTGGAGTCAATCAGCTTGTTGATATTTATGAGAAATATCA AGATTTGTATACTGTGGAACCAAATAATGCACGCCAGCTGGTAGAAATTGCAGCCAGGGATATTGAGAAACTTCTGAGCAACAGATCTAA AGCCCTGGTGCGGTTAAGAAGATTGTCTACCAAATATAGAACAGAAAAGATATATCCCACAGCCACTGGAGAAAAAGAAGAAAATGTTAA AAAGAACAGATACAAGGACATACTGCCATTTGATCACAGCCGAGTTAAATTGACATTAAAGACTCCTTCACAAGATTCAGACTATATCAA TGCAAATTTTATAAAGGGCGTCTATGGGCCAAAAGCATATGTAGCAACTCAAGGACCTTTAGCAAATACAGTAATAGATTTTTGGAGGAT GATATGGGAGTATAATGTTGTGATCATTGTAATGGCCTGCCGAGAATTTGAGATGGGAAGGAAAAAATGTGAGCGCTATTGGCCTTTGTA TGGAGAAGACCCCATAACGTTTGCACCATTTAAAATTTCTTGTGAGGATGAACAAGCAAGAACAGACTACTTCATCAGGACACTCTTACT TGAATTTCAAAATGAATCTCGTAGGCTGTATCAGTTTCATTATGTGAACTGGCCAGACCATGATGTTCCTTCATCATTTGATTCTATTCT GGACATGATAAGCTTAATGAGGAAATATCAAGAACATGAAGATGTTCCTATTTGTATTCATTGCAGTGCAGGCTGTGGAAGAACAGGTGC CATTTGTGCCATAGATTATACGTGGAATTTACTAAAAGCTGGGAAAATACCAGAGGAATTTAATGTATTTAATTTAATACAAGAAATGAG AACACAAAGGCATTCTGCAGTACAAACAAAGGAGCAATATGAACTTGTTCATAGAGCTATTGCCCAACTGTTTGAAAAACAGCTACAACT ATATGAAATTCATGGAGCTCAGAAAATTGCTGATGGAGTGAATGAAATTAACACTGAAAACATGGTCAGCTCCATAGAGCCTGAAAAACA AGATTCTCCTCCTCCAAAACCACCAAGGACCCGCAGTTGCCTTGTTGAAGGGGATGCTAAAGAAGAAATACTGCAGCCACCGGAACCTCA TCCAGTGCCACCCATCTTGACACCTTCTCCCCCTTCAGCTTTTCCAACAGTCACTACTGTGTGGCAGGACAATGATAGATACCATCCAAA GCCAGTGTTGCATATGGTTTCATCAGAACAACATTCAGCAGACCTCAACAGAAACTATAGTAAATCAACAGAACTTCCAGGGAAAAATGA ATCAACAATTGAACAGATAGATAAAAAATTGGAACGAAATTTAAGTTTTGAGATTAAGAAGGTCCCTCTCCAAGAGGGACCAAAAAGTTT TGATGGGAACACACTTTTGAATAGGGGACATGCAATTAAAATTAAATCTGCTTCACCTTGTATAGCTGATAAAATCTCTAAGCCACAGGA ATTAAGTTCAGATCTAAATGTCGGTGATACTTCCCAGAATTCTTGTGTGGACTGCAGTGTAACACAATCAAACAAAGTTTCAGTTACTCC ACCAGAAGAATCCCAGAATTCAGACACACCTCCAAGGCCAGACCGCTTGCCTCTTGATGAGAAAGGACATGTAACGTGGTCATTTCATGG ACCTGAAAATGCCATACCCATACCTGATTTATCTGAAGGCAATTCCTCAGATATCAACTATCAAACTAGGAAAACTGTGAGTTTAACACC AAGTCCTACAACACAAGTTGAAACACCTGATCTTGTGGATCATGATAACACTTCACCACTCTTCAGAACACCCCTCAGTTTTACTAATCC ACTTCACTCTGATGACTCAGACTCAGATGAAAGAAACTCTGATGGTGCTGTGACCCAGAATAAAACTAATATTTCAACAGCAAGTGCCAC AGTTTCTGCTGCCACTAGTACTGAAAGCATTTCTACTAGGAAAGTATTGCCAATGTCCATTGCTAGACATAATATAGCAGGAACAACACA TTCAGGTGCTGAAAAAGATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGA ACATAATACACCTGTAAGATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGA AAATGAGAAATGTGATCATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAAT ATCAGAAAATCCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATCCACCTTCAGAATGGAC ATGATTCAGGGAGCTAGAAGACACTTTAAGTTATACTGGAAAATTCAGGTGCCACTGAAAGCCAGATTTATAGTATTCCATCTTTAATAT GTGGGACTAACAGCAGTGTAGATTGTTACCTTAATATTTTTTGCTGGGACCATCTACCTGCCTTATACTACACTTAGGAAAAAGTATTAC ATATGGTTTATTTTGAAACTTCAAGTATTATTGCCTTAATGTCTCTTAACCCTGTTACACGCTGCTTGTAGACATGTTAATATAGTAATA CCTTTATGATATATTGAGTTTAAGGACTACTCTTTTTCTGTTTTATCATGTATGCATTATTTTGTATATGTACAGGGCAAGTAGGTATAT AATTTGATAAAGTTGCAATTGAAATATTATTAACAGAAGATGTAAGAAATTTCTGCATGGTCTAAATCTTTGTGTACTTTATTTGTAAAT TATTTGCCCTGGAGTTTTAGAAAATAGTTTCTGAATTTTAAACTTGCTGGATTCATGCAGCCAGCTTTGCAGGTTATCAGAGATCAAAGA TTGTAATAATAATTTTGTAAATTGTAAGCAAAAAGTTATTTTTATATTATATACAGTCTAATTGTTCATCCTAATTGTTCCTGTTTTCAT CTAGTCAGAGATTCAGTAAGTGCCTTGGAACAATATTGAATTCTCTTAGCTTGTGTGTGTTTCTTTAATATTTGAACTCAAGTGGGATTA >In-frame_CACNA2D1_ENST00000423588_chr7_81964451_-_PTPN12_ENST00000248594_chr7_77200395_+_3586nt GCGGCGGAGGCAAGGCGGCCGCGGCGCGGAGCAGCCGACGCACGCTAGTGGGTCCGCCCGCCACCGCCCCTTCCTCGGCGTCCGCTCCCG CCCTTGCCGTCCCCCGCGCGGCTCCGCGCCTCGGGCCCCGGGCGCAGCCAGCCCTCCAGACGCCCGCGGTCCCGGCGGCGTGTGCTGCTC TTCCTCCGCCCGCGGTTTCCAGCGCCGCTCCTTCCCCCGCTTGGGCAGGGAGGGGGCATTGATCTTCGATCGCGAAGATGGCTGCTGGCT GCCTGCTGGCCTTGACTCTGACACTTTTCCAATCTTTGCTCATCGGCCCCTCGTCGGAGGAGCCGTTCCCTTCGGCCGTCACTATCAAAT CATGGGTGGATAAGATGCAAGAAGACCTTGTCACACTGGCAAAAACAGCAAGTGGAGTCAATCAGCTTGTTGATATTTATGAGAAATATC AAGATTTGTATACTGTGGAACCAAATAATGCACGCCAGCTGGTAGAAATTGCAGCCAGGGATATTGAGAAACTTCTGAGCAACAGATCTA AAGCCCTGGTGCGGTTAAGAAGATTGTCTACCAAATATAGAACAGAAAAGATATATCCCACAGCCACTGGAGAAAAAGAAGAAAATGTTA AAAAGAACAGATACAAGGACATACTGCCATTTGATCACAGCCGAGTTAAATTGACATTAAAGACTCCTTCACAAGATTCAGACTATATCA ATGCAAATTTTATAAAGGGCGTCTATGGGCCAAAAGCATATGTAGCAACTCAAGGACCTTTAGCAAATACAGTAATAGATTTTTGGAGGA TGATATGGGAGTATAATGTTGTGATCATTGTAATGGCCTGCCGAGAATTTGAGATGGGAAGGAAAAAATGTGAGCGCTATTGGCCTTTGT ATGGAGAAGACCCCATAACGTTTGCACCATTTAAAATTTCTTGTGAGGATGAACAAGCAAGAACAGACTACTTCATCAGGACACTCTTAC TTGAATTTCAAAATGAATCTCGTAGGCTGTATCAGTTTCATTATGTGAACTGGCCAGACCATGATGTTCCTTCATCATTTGATTCTATTC TGGACATGATAAGCTTAATGAGGAAATATCAAGAACATGAAGATGTTCCTATTTGTATTCATTGCAGTGCAGGCTGTGGAAGAACAGGTG CCATTTGTGCCATAGATTATACGTGGAATTTACTAAAAGCTGGGAAAATACCAGAGGAATTTAATGTATTTAATTTAATACAAGAAATGA GAACACAAAGGCATTCTGCAGTACAAACAAAGGAGCAATATGAACTTGTTCATAGAGCTATTGCCCAACTGTTTGAAAAACAGCTACAAC TATATGAAATTCATGGAGCTCAGAAAATTGCTGATGGAGTGAATGAAATTAACACTGAAAACATGGTCAGCTCCATAGAGCCTGAAAAAC AAGATTCTCCTCCTCCAAAACCACCAAGGACCCGCAGTTGCCTTGTTGAAGGGGATGCTAAAGAAGAAATACTGCAGCCACCGGAACCTC ATCCAGTGCCACCCATCTTGACACCTTCTCCCCCTTCAGCTTTTCCAACAGTCACTACTGTGTGGCAGGACAATGATAGATACCATCCAA AGCCAGTGTTGCATATGGTTTCATCAGAACAACATTCAGCAGACCTCAACAGAAACTATAGTAAATCAACAGAACTTCCAGGGAAAAATG AATCAACAATTGAACAGATAGATAAAAAATTGGAACGAAATTTAAGTTTTGAGATTAAGAAGGTCCCTCTCCAAGAGGGACCAAAAAGTT TTGATGGGAACACACTTTTGAATAGGGGACATGCAATTAAAATTAAATCTGCTTCACCTTGTATAGCTGATAAAATCTCTAAGCCACAGG AATTAAGTTCAGATCTAAATGTCGGTGATACTTCCCAGAATTCTTGTGTGGACTGCAGTGTAACACAATCAAACAAAGTTTCAGTTACTC CACCAGAAGAATCCCAGAATTCAGACACACCTCCAAGGCCAGACCGCTTGCCTCTTGATGAGAAAGGACATGTAACGTGGTCATTTCATG GACCTGAAAATGCCATACCCATACCTGATTTATCTGAAGGCAATTCCTCAGATATCAACTATCAAACTAGGAAAACTGTGAGTTTAACAC CAAGTCCTACAACACAAGTTGAAACACCTGATCTTGTGGATCATGATAACACTTCACCACTCTTCAGAACACCCCTCAGTTTTACTAATC CACTTCACTCTGATGACTCAGACTCAGATGAAAGAAACTCTGATGGTGCTGTGACCCAGAATAAAACTAATATTTCAACAGCAAGTGCCA CAGTTTCTGCTGCCACTAGTACTGAAAGCATTTCTACTAGGAAAGTATTGCCAATGTCCATTGCTAGACATAATATAGCAGGAACAACAC ATTCAGGTGCTGAAAAAGATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTG AACATAATACACCTGTAAGATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTG AAAATGAGAAATGTGATCATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAA TATCAGAAAATCCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATCCACCTTCAGAATGGA CATGATTCAGGGAGCTAGAAGACACTTTAAGTTATACTGGAAAATTCAGGTGCCACTGAAAGCCAGATTTATAGTATTCCATCTTTAATA TGTGGGACTAACAGCAGTGTAGATTGTTACCTTAATATTTTTTGCTGGGACCATCTACCTGCCTTATACTACACTTAGGAAAAAGTATTA CATATGGTTTATTTTGAAACTTCAAGTATTATTGCCTTAATGTCTCTTAACCCTGTTACACGCTGCTTGTAGACATGTTAATATAGTAAT ACCTTTATGATATATTGAGTTTAAGGACTACTCTTTTTCTGTTTTATCATGTATGCATTATTTTGTATATGTACAGGGCAAGTAGGTATA TAATTTGATAAAGTTGCAATTGAAATATTATTAACAGAAGATGTAAGAAATTTCTGCATGGTCTAAATCTTTGTGTACTTTATTTGTAAA TTATTTGCCCTGGAGTTTTAGAAAATAGTTTCTGAATTTTAAACTTGCTGGATTCATGCAGCCAGCTTTGCAGGTTATCAGAGATCAAAG ATTGTAATAATAATTTTGTAAATTGTAAGCAAAAAGTTATTTTTATATTATATACAGTCTAATTGTTCATCCTAATTGTTCCTGTTTTCA TCTAGTCAGAGATTCAGTAAGTGCCTTGGAACAATATTGAATTCTCTTAGCTTGTGTGTGTTTCTTTAATATTTGAACTCAAGTGGGATT |
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FusionGenePPI for CACNA2D1_PTPN12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CACNA2D1 | RAB11A, NDUFS4, STT3B, CCDC8, ABCE1, TAZ, ITM2B, DNAAF2, SUSD4, GLT8D2, LMAN2, TMEM185A, BTNL8, PTCH1, PTPRK, ISLR, ERLIN2, PON2, USP7, HNRNPU, CNOT2, MYH7B, SCGB1D4, PRSS33, DEFA1, LMAN2L, SCGB1D1, C7orf69, LYZL1, FUT3, SLC34A2, CYP19A1, TRIM25 | PTPN12 | PSTPIP1, SHC1, PXN, BCAR1, JAK2, NEDD9, EFS, TGFB1I1, GSN, GRB2, PTK2B, EGFR, SORBS2, WASF1, APP, STX16, CGA, CSH1, CSH2, BAG6, UTRN, PSG9, ZFP2, IFT20, THAP2, TEX10, RBM19, SMAD5, ANKS1A, EPN1, NUSAP1, PACSIN2, PLOD2, DEK, DNPEP, GANAB, TNS3, TRIM47, UGP2, VASN, NTRK1, CENPJ, NANOG, ERBB4, FGFR2, FGFR4, IGF1R, KDR, PSTPIP2, ARHGAP10, ASAP1, NCK2, CSK, LPXN, PTPN6, AIFM1, VAPA, LMTK2, AATK, ERBB3, ROR2, PTK7, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | PTPN12 | chr7:81964451 | chr7:77200395 | ENST00000248594 | + | 0 | 18 | 345_438 | 33 | 781 | TGFB1I1 |
| Tgene | PTPN12 | chr7:81964451 | chr7:77200395 | ENST00000435495 | + | 0 | 17 | 345_438 | -65 | 651 | TGFB1I1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CACNA2D1_PTPN12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CACNA2D1 | P54289 | DB00308 | Ibutilide | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved |
| Hgene | CACNA2D1 | P54289 | DB00381 | Amlodipine | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved |
| Hgene | CACNA2D1 | P54289 | DB00401 | Nisoldipine | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved |
| Hgene | CACNA2D1 | P54289 | DB01115 | Nifedipine | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved |
| Hgene | CACNA2D1 | P54289 | DB04838 | Cyclandelate | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved |
| Hgene | CACNA2D1 | P54289 | DB00270 | Isradipine | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved|investigational |
| Hgene | CACNA2D1 | P54289 | DB00622 | Nicardipine | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved|investigational |
| Hgene | CACNA2D1 | P54289 | DB00996 | Gabapentin | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved|investigational |
| Hgene | CACNA2D1 | P54289 | DB01023 | Felodipine | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved|investigational |
| Hgene | CACNA2D1 | P54289 | DB01054 | Nitrendipine | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved|investigational |
| Hgene | CACNA2D1 | P54289 | DB06712 | Nilvadipine | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved|investigational |
| Hgene | CACNA2D1 | P54289 | DB00653 | Magnesium sulfate | Voltage-dependent calcium channel subunit alpha-2/delta-1 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for CACNA2D1_PTPN12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CACNA2D1 | C0027796 | Neuralgia | 4 | CTD_human |
| Hgene | CACNA2D1 | C0020429 | Hyperalgesia | 3 | CTD_human |
| Hgene | CACNA2D1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | CACNA2D1 | C0020538 | Hypertensive disease | 1 | CTD_human |
| Hgene | CACNA2D1 | C0030193 | Pain | 1 | CTD_human |
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