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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 5191

FusionGeneSummary for CACNA1D_PRKCD

check button Fusion gene summary
Fusion gene informationFusion gene name: CACNA1D_PRKCD
Fusion gene ID: 5191
HgeneTgene
Gene symbol

CACNA1D

PRKCD

Gene ID

776

5580

Gene namecalcium voltage-gated channel subunit alpha1 Dprotein kinase C delta
SynonymsCACH3|CACN4|CACNL1A2|CCHL1A2|Cav1.3|PASNA|SANDDALPS3|CVID9|MAY1|PKCD|nPKC-delta
Cytomap

3p21.1

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionvoltage-dependent L-type calcium channel subunit alpha-1Dcalcium channel, L type, alpha-1 polypeptidecalcium channel, neuroendocrine/brain-type, alpha 1 subunitcalcium channel, voltage-dependent, L type, alpha 1D subunitvoltage-gated calcium channel aprotein kinase C delta typeprotein kinase C delta VIIItyrosine-protein kinase PRKCD
Modification date2018052320180523
UniProtAcc

Q01668

Q05655

Ensembl transtripts involved in fusion geneENST00000350061, ENST00000288139, 
ENST00000422281, ENST00000498251, 
ENST00000540742, ENST00000544977, 
ENST00000394729, ENST00000330452, 
ENST00000477794, 
Fusion gene scores* DoF score5 X 5 X 4=1003 X 4 X 3=36
# samples 64
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CACNA1D [Title/Abstract] AND PRKCD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCACNA1D

GO:0006816

calcium ion transport

11160515

HgeneCACNA1D

GO:0051928

positive regulation of calcium ion transport

1309651

HgeneCACNA1D

GO:0070509

calcium ion import

1309651

TgenePRKCD

GO:0006468

protein phosphorylation

10713049|16611985

TgenePRKCD

GO:0006915

apoptotic process

10770950

TgenePRKCD

GO:0016572

histone phosphorylation

19059439

TgenePRKCD

GO:0018105

peptidyl-serine phosphorylation

18285462

TgenePRKCD

GO:0018107

peptidyl-threonine phosphorylation

10770950

TgenePRKCD

GO:0032147

activation of protein kinase activity

10713049

TgenePRKCD

GO:0042119

neutrophil activation

10770950

TgenePRKCD

GO:0070301

cellular response to hydrogen peroxide

10713049

TgenePRKCD

GO:0071447

cellular response to hydroperoxide

19059439

TgenePRKCD

GO:1904385

cellular response to angiotensin

18285462


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-GM-A2DD-01ACACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000350061ENST00000394729CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
In-frameENST00000350061ENST00000330452CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
5CDS-intronENST00000350061ENST00000477794CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
In-frameENST00000288139ENST00000394729CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
In-frameENST00000288139ENST00000330452CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
5CDS-intronENST00000288139ENST00000477794CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
In-frameENST00000422281ENST00000394729CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
In-frameENST00000422281ENST00000330452CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
5CDS-intronENST00000422281ENST00000477794CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
intron-3CDSENST00000498251ENST00000394729CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
intron-3CDSENST00000498251ENST00000330452CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
intron-intronENST00000498251ENST00000477794CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
intron-3CDSENST00000540742ENST00000394729CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
intron-3CDSENST00000540742ENST00000330452CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
intron-intronENST00000540742ENST00000477794CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
intron-3CDSENST00000544977ENST00000394729CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
intron-3CDSENST00000544977ENST00000330452CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+
intron-intronENST00000544977ENST00000477794CACNA1Dchr3

53535747

+PRKCDchr3

53217468

+

Top

FusionProtFeatures for CACNA1D_PRKCD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CACNA1D

Q01668

PRKCD

Q05655

Voltage-sensitive calcium channels (VSCC) mediate theentry of calcium ions into excitable cells and are also involvedin a variety of calcium-dependent processes, including musclecontraction, hormone or neurotransmitter release, gene expression,cell motility, cell division and cell death. The isoform alpha-1Dgives rise to L-type calcium currents. Long-lasting (L-type)calcium channels belong to the 'high-voltage activated' (HVA)group. They are blocked by dihydropyridines (DHP),phenylalkylamines, and by benzothiazepines.{ECO:0000269|PubMed:18482979, ECO:0000269|PubMed:25620733,ECO:0000269|PubMed:28472301}. Calcium-independent, phospholipid- and diacylglycerol(DAG)-dependent serine/threonine-protein kinase that playscontrasting roles in cell death and cell survival by functioningas a pro-apoptotic protein during DNA damage-induced apoptosis,but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well assurvival of several cancers, is required for oxygen radicalproduction by NADPH oxidase and acts as positive or negativeregulator in platelet functional responses. Negatively regulates Bcell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage,activates the promoter of the death-promoting transcription factorBCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcriptionand apoptosis. In response to oxidative stress, interact with andactivate CHUK/IKKA in the nucleus, causing the phosphorylation ofp53/TP53. In the case of ER stress or DNA damage-inducedapoptosis, can form a complex with the tyrosine-protein kinaseABL1 which trigger apoptosis independently of p53/TP53. In cytosolcan trigger apoptosis by activating MAPK11 or MAPK14, inhibitingAKT1 and decreasing the level of X-linked inhibitor of apoptosisprotein (XIAP), whereas in nucleus induces apoptosis via theactivation of MAPK8 or MAPK9. Upon ionizing radiation treatment,is required for the activation of the apoptosis regulators BAX andBAK, which trigger the mitochondrial cell death pathway. Canphosphorylate MCL1 and target it for degradation which issufficient to trigger for BAX activation and apoptosis. Isrequired for the control of cell cycle progression both at G1/Sand G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclinCCNA2 promoter activity. In response to UV irradiation canphosphorylate CDK1, which is important for the G2/M DNA damagecheckpoint activation. Can protect glioma cells from the apoptosisinduced by TNFSF10/TRAIL, probably by inducing increasedphosphorylation and subsequent activation of AKT1. Is highlyexpressed in a number of cancer cells and promotes cell survivaland resistance against chemotherapeutic drugs by inducing cyclinD1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3(ERK1/2). Can also act as tumor suppressor upon mitogenicstimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity,and regulates TNF-elicited superoxide anion production inneutrophils, by direct phosphorylation and activation of NCF1 orindirectly through MAPK1/3 (ERK1/2) signaling pathways. May alsoplay a role in the regulation of NADPH oxidase activity ineosinophil after stimulation with IL5, leukotriene B4 or PMA. Incollagen-induced platelet aggregation, acts a negative regulatorof filopodia formation and actin polymerization by interactingwith and negatively regulating VASP phosphorylation. Downstream ofPAR1, PAR4 and CD36/GP4 receptors, regulates differentiallyplatelet dense granule secretion; acts as a positive regulator inPAR-mediated granule secretion, whereas it negatively regulatesCD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins(YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (Bysimilarity). Phosphorylates ELAVL1 in response to angiotensin-2treatment (PubMed:18285462). {ECO:0000250,ECO:0000269|PubMed:11748588, ECO:0000269|PubMed:11877440,ECO:0000269|PubMed:15774464, ECO:0000269|PubMed:16940418,ECO:0000269|PubMed:18285462, ECO:0000269|PubMed:19587372,ECO:0000269|PubMed:19801500}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491_71612182Compositional biasNote=Poly-Met
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481_71612162Compositional biasNote=Poly-Met
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461_71612138Compositional biasNote=Poly-Met
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349146_1631612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491_1261612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348146_1631612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481_1261612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346146_1631612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461_1261612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349127_1451612182TransmembraneHelical%3B Name%3DS1 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348127_1451612162TransmembraneHelical%3B Name%3DS1 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346127_1451612138TransmembraneHelical%3B Name%3DS1 of repeat I
TgenePRKCDchr3:53535747chr3:53217468ENST00000330452+719349_603219677DomainProtein kinase
TgenePRKCDchr3:53535747chr3:53217468ENST00000330452+719604_675219677DomainNote=AGC-kinase C-terminal
TgenePRKCDchr3:53535747chr3:53217468ENST00000394729+618349_603219677DomainProtein kinase
TgenePRKCDchr3:53535747chr3:53217468ENST00000394729+618604_675219677DomainNote=AGC-kinase C-terminal
TgenePRKCDchr3:53535747chr3:53217468ENST00000330452+719355_363219677Nucleotide bindingATP
TgenePRKCDchr3:53535747chr3:53217468ENST00000394729+618355_363219677Nucleotide bindingATP
TgenePRKCDchr3:53535747chr3:53217468ENST00000330452+719230_280219677Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCDchr3:53535747chr3:53217468ENST00000394729+618230_280219677Zinc fingerPhorbol-ester/DAG-type 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491493_15041612182Calcium bindingOntology_term=ECO:0000250
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481493_15041612162Calcium bindingOntology_term=ECO:0000250
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461493_15041612138Calcium bindingOntology_term=ECO:0000250
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349653_6591612182Compositional biasNote=Poly-Leu
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349827_8381612182Compositional biasNote=Poly-Glu
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348653_6591612162Compositional biasNote=Poly-Leu
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348827_8381612162Compositional biasNote=Poly-Glu
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346653_6591612138Compositional biasNote=Poly-Leu
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346827_8381612138Compositional biasNote=Poly-Glu
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491075_11651612182RegionDihydropyridine binding
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491420_14861612182RegionDihydropyridine binding
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491432_14751612182RegionPhenylalkylamine binding
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349429_4461612182RegionBinding to the beta subunit
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481075_11651612162RegionDihydropyridine binding
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481420_14861612162RegionDihydropyridine binding
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481432_14751612162RegionPhenylalkylamine binding
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348429_4461612162RegionBinding to the beta subunit
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461075_11651612138RegionDihydropyridine binding
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461420_14861612138RegionDihydropyridine binding
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461432_14751612138RegionPhenylalkylamine binding
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346429_4461612138RegionBinding to the beta subunit
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349113_4091612182RepeatNote=I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491192_14671612182RepeatNote=IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349509_7551612182RepeatNote=II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349873_11551612182RepeatNote=III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348113_4091612162RepeatNote=I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481192_14671612162RepeatNote=IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348509_7551612162RepeatNote=II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348873_11551612162RepeatNote=III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346113_4091612138RepeatNote=I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461192_14671612138RepeatNote=IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346509_7551612138RepeatNote=II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346873_11551612138RepeatNote=III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491038_11271612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491149_12051612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491225_12391612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491260_12661612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491289_13131612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491334_13521612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491373_14391612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491465_21611612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349184_1951612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349215_2351612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349255_2731612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349294_3811612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349407_5231612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349544_5581612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349578_5851612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349605_6141612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349634_6521612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349674_7271612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349753_8861612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349906_9211612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349942_9531612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349973_9781612182Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349999_10171612182Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481038_11271612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481149_12051612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481225_12391612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481260_12661612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481289_13131612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481334_13521612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481373_14391612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481465_21611612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348184_1951612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348215_2351612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348255_2731612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348294_3811612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348407_5231612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348544_5581612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348578_5851612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348605_6141612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348634_6521612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348674_7271612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348753_8861612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348906_9211612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348942_9531612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348973_9781612162Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348999_10171612162Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461038_11271612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461149_12051612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461225_12391612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461260_12661612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461289_13131612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461334_13521612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461373_14391612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461465_21611612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346184_1951612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346215_2351612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346255_2731612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346294_3811612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346407_5231612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346544_5581612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346578_5851612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346605_6141612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346634_6521612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346674_7271612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346753_8861612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346906_9211612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346942_9531612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346973_9781612138Topological domainExtracellular
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346999_10171612138Topological domainCytoplasmic
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491018_10371612182TransmembraneHelical%3B Name%3DS5 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491128_11481612182TransmembraneHelical%3B Name%3DS6 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491206_12241612182TransmembraneHelical%3B Name%3DS1 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491240_12591612182TransmembraneHelical%3B Name%3DS2 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491267_12881612182TransmembraneHelical%3B Name%3DS3 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491314_13331612182TransmembraneHelical%3B Name%3DS4 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491353_13721612182TransmembraneHelical%3B Name%3DS5 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+3491440_14641612182TransmembraneHelical%3B Name%3DS6 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349164_1831612182TransmembraneHelical%3B Name%3DS2 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349196_2141612182TransmembraneHelical%3B Name%3DS3 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349236_2541612182TransmembraneHelical%3B Name%3DS4 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349274_2931612182TransmembraneHelical%3B Name%3DS5 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349382_4061612182TransmembraneHelical%3B Name%3DS6 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349524_5431612182TransmembraneHelical%3B Name%3DS1 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349559_5771612182TransmembraneHelical%3B Name%3DS2 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349586_6041612182TransmembraneHelical%3B Name%3DS3 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349615_6331612182TransmembraneHelical%3B Name%3DS4 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349653_6731612182TransmembraneHelical%3B Name%3DS5 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349728_7521612182TransmembraneHelical%3B Name%3DS6 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349887_9051612182TransmembraneHelical%3B Name%3DS1 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349922_9411612182TransmembraneHelical%3B Name%3DS2 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349954_9721612182TransmembraneHelical%3B Name%3DS3 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000288139+349979_9981612182TransmembraneHelical%3B Name%3DS4 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481018_10371612162TransmembraneHelical%3B Name%3DS5 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481128_11481612162TransmembraneHelical%3B Name%3DS6 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481206_12241612162TransmembraneHelical%3B Name%3DS1 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481240_12591612162TransmembraneHelical%3B Name%3DS2 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481267_12881612162TransmembraneHelical%3B Name%3DS3 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481314_13331612162TransmembraneHelical%3B Name%3DS4 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481353_13721612162TransmembraneHelical%3B Name%3DS5 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+3481440_14641612162TransmembraneHelical%3B Name%3DS6 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348164_1831612162TransmembraneHelical%3B Name%3DS2 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348196_2141612162TransmembraneHelical%3B Name%3DS3 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348236_2541612162TransmembraneHelical%3B Name%3DS4 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348274_2931612162TransmembraneHelical%3B Name%3DS5 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348382_4061612162TransmembraneHelical%3B Name%3DS6 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348524_5431612162TransmembraneHelical%3B Name%3DS1 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348559_5771612162TransmembraneHelical%3B Name%3DS2 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348586_6041612162TransmembraneHelical%3B Name%3DS3 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348615_6331612162TransmembraneHelical%3B Name%3DS4 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348653_6731612162TransmembraneHelical%3B Name%3DS5 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348728_7521612162TransmembraneHelical%3B Name%3DS6 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348887_9051612162TransmembraneHelical%3B Name%3DS1 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348922_9411612162TransmembraneHelical%3B Name%3DS2 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348954_9721612162TransmembraneHelical%3B Name%3DS3 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000350061+348979_9981612162TransmembraneHelical%3B Name%3DS4 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461018_10371612138TransmembraneHelical%3B Name%3DS5 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461128_11481612138TransmembraneHelical%3B Name%3DS6 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461206_12241612138TransmembraneHelical%3B Name%3DS1 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461240_12591612138TransmembraneHelical%3B Name%3DS2 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461267_12881612138TransmembraneHelical%3B Name%3DS3 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461314_13331612138TransmembraneHelical%3B Name%3DS4 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461353_13721612138TransmembraneHelical%3B Name%3DS5 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+3461440_14641612138TransmembraneHelical%3B Name%3DS6 of repeat IV
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346164_1831612138TransmembraneHelical%3B Name%3DS2 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346196_2141612138TransmembraneHelical%3B Name%3DS3 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346236_2541612138TransmembraneHelical%3B Name%3DS4 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346274_2931612138TransmembraneHelical%3B Name%3DS5 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346382_4061612138TransmembraneHelical%3B Name%3DS6 of repeat I
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346524_5431612138TransmembraneHelical%3B Name%3DS1 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346559_5771612138TransmembraneHelical%3B Name%3DS2 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346586_6041612138TransmembraneHelical%3B Name%3DS3 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346615_6331612138TransmembraneHelical%3B Name%3DS4 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346653_6731612138TransmembraneHelical%3B Name%3DS5 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346728_7521612138TransmembraneHelical%3B Name%3DS6 of repeat II
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346887_9051612138TransmembraneHelical%3B Name%3DS1 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346922_9411612138TransmembraneHelical%3B Name%3DS2 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346954_9721612138TransmembraneHelical%3B Name%3DS3 of repeat III
HgeneCACNA1Dchr3:53535747chr3:53217468ENST00000422281+346979_9981612138TransmembraneHelical%3B Name%3DS4 of repeat III
TgenePRKCDchr3:53535747chr3:53217468ENST00000330452+7191_90219677DomainNote=C2
TgenePRKCDchr3:53535747chr3:53217468ENST00000394729+6181_90219677DomainNote=C2
TgenePRKCDchr3:53535747chr3:53217468ENST00000330452+719158_208219677Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCDchr3:53535747chr3:53217468ENST00000394729+618158_208219677Zinc fingerPhorbol-ester/DAG-type 1


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FusionGeneSequence for CACNA1D_PRKCD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CACNA1D_ENST00000350061_chr3_53535747_+_PRKCD_ENST00000394729_chr3_53217468_+_619aa
MMMMMMMKKMQHQRQQQADHANEANTARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK
SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLFQKERFNIDMPHRFKVHNY
MSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGITQGFEKKTGVAGEDMQ
DNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQ
TKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFTAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTF
CGTPDTIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHTPRWITKESKDILEKLFEREPTKRLGVTGNIK

>In-frame_CACNA1D_ENST00000350061_chr3_53535747_+_PRKCD_ENST00000330452_chr3_53217468_+_619aa
MMMMMMMKKMQHQRQQQADHANEANTARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK
SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLFQKERFNIDMPHRFKVHNY
MSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGITQGFEKKTGVAGEDMQ
DNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQ
TKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFTAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTF
CGTPDTIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHTPRWITKESKDILEKLFEREPTKRLGVTGNIK

>In-frame_CACNA1D_ENST00000288139_chr3_53535747_+_PRKCD_ENST00000394729_chr3_53217468_+_619aa
MMMMMMMKKMQHQRQQQADHANEANTARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK
SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLFQKERFNIDMPHRFKVHNY
MSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGITQGFEKKTGVAGEDMQ
DNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQ
TKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFTAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTF
CGTPDTIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHTPRWITKESKDILEKLFEREPTKRLGVTGNIK

>In-frame_CACNA1D_ENST00000288139_chr3_53535747_+_PRKCD_ENST00000330452_chr3_53217468_+_619aa
MMMMMMMKKMQHQRQQQADHANEANTARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK
SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLFQKERFNIDMPHRFKVHNY
MSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGITQGFEKKTGVAGEDMQ
DNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQ
TKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFTAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTF
CGTPDTIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHTPRWITKESKDILEKLFEREPTKRLGVTGNIK

>In-frame_CACNA1D_ENST00000422281_chr3_53535747_+_PRKCD_ENST00000394729_chr3_53217468_+_619aa
MMMMMMMKKMQHQRQQQADHANEANTARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK
SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLFQKERFNIDMPHRFKVHNY
MSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGITQGFEKKTGVAGEDMQ
DNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQ
TKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFTAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTF
CGTPDTIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHTPRWITKESKDILEKLFEREPTKRLGVTGNIK

>In-frame_CACNA1D_ENST00000422281_chr3_53535747_+_PRKCD_ENST00000330452_chr3_53217468_+_619aa
MMMMMMMKKMQHQRQQQADHANEANTARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAK
SKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLFQKERFNIDMPHRFKVHNY
MSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGITQGFEKKTGVAGEDMQ
DNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQ
TKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFTAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTF
CGTPDTIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHTPRWITKESKDILEKLFEREPTKRLGVTGNIK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CACNA1D_ENST00000350061_chr3_53535747_+_PRKCD_ENST00000394729_chr3_53217468_+_1857nt
ATGATGATGATGATGATGATGAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGCAAGAGGCACC
AGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCCGAATAGCTCCAAGCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCT
AGACAGGCCAAGGCTGCCCAAACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCAATACGCCAAG
AGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTTCTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATT
AGTATAGTGGAATGGAAACCATTTGACATATTTATATTATTGGCTATTTTTGCCAATTGTGTGGCCTTAGCTATTTACATCCCATTCCCT
GAAGATGATTCTAATTCAACAAATCATAACTTGTTCCAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTAC
ATGAGCCCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAGTGTGAAGACTGCGGCATGAATGTG
CACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGCGGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCC
TCCCGGAGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACCGGAGTTGCTGGGGAGGACATGCAA
GACAACAGTGGGACCTACGGCAAGATCTGGGAGGGCAGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGC
AGCTTCGGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTTTGCCATCAAGGCCCTCAAGAAGGATGTGGTCCTGATCGAC
GACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTGCTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAG
ACCAAGGACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACATCCAGGACAAAGGCCGCTTTGAACTCTAC
CGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGACTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAAT
GTGCTGCTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACATATTCGGGGAGAGCCGGGCCAGCACCTTC
TGCGGCACCCCTGACTATATCGCCCCTGAGATCCTACAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTG
TACGAGATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTCCATCCGTGTGGACACGCCACATTATCCC
CGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAGAAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAGTGACCGGAAACATCAAA
ATCCACCCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCTTTCAGGCCCAAAGTGAAGTCACCCAGA
GACTACAGTAACTTTGACCAGGAGTTCCTGAACGAGAAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCT

>In-frame_CACNA1D_ENST00000350061_chr3_53535747_+_PRKCD_ENST00000330452_chr3_53217468_+_1857nt
ATGATGATGATGATGATGATGAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGCAAGAGGCACC
AGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCCGAATAGCTCCAAGCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCT
AGACAGGCCAAGGCTGCCCAAACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCAATACGCCAAG
AGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTTCTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATT
AGTATAGTGGAATGGAAACCATTTGACATATTTATATTATTGGCTATTTTTGCCAATTGTGTGGCCTTAGCTATTTACATCCCATTCCCT
GAAGATGATTCTAATTCAACAAATCATAACTTGTTCCAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTAC
ATGAGCCCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAGTGTGAAGACTGCGGCATGAATGTG
CACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGCGGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCC
TCCCGGAGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACCGGAGTTGCTGGGGAGGACATGCAA
GACAACAGTGGGACCTACGGCAAGATCTGGGAGGGCAGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGC
AGCTTCGGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTTTGCCATCAAGGCCCTCAAGAAGGATGTGGTCCTGATCGAC
GACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTGCTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAG
ACCAAGGACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACATCCAGGACAAAGGCCGCTTTGAACTCTAC
CGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGACTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAAT
GTGCTGCTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACATATTCGGGGAGAGCCGGGCCAGCACCTTC
TGCGGCACCCCTGACTATATCGCCCCTGAGATCCTACAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTG
TACGAGATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTCCATCCGTGTGGACACGCCACATTATCCC
CGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAGAAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAGTGACCGGAAACATCAAA
ATCCACCCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCTTTCAGGCCCAAAGTGAAGTCACCCAGA
GACTACAGTAACTTTGACCAGGAGTTCCTGAACGAGAAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCT

>In-frame_CACNA1D_ENST00000288139_chr3_53535747_+_PRKCD_ENST00000394729_chr3_53217468_+_1857nt
ATGATGATGATGATGATGATGAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGCAAGAGGCACC
AGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCCGAATAGCTCCAAGCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCT
AGACAGGCCAAGGCTGCCCAAACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCAATACGCCAAG
AGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTTCTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATT
AGTATAGTGGAATGGAAACCATTTGACATATTTATATTATTGGCTATTTTTGCCAATTGTGTGGCCTTAGCTATTTACATCCCATTCCCT
GAAGATGATTCTAATTCAACAAATCATAACTTGTTCCAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTAC
ATGAGCCCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAGTGTGAAGACTGCGGCATGAATGTG
CACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGCGGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCC
TCCCGGAGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACCGGAGTTGCTGGGGAGGACATGCAA
GACAACAGTGGGACCTACGGCAAGATCTGGGAGGGCAGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGC
AGCTTCGGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTTTGCCATCAAGGCCCTCAAGAAGGATGTGGTCCTGATCGAC
GACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTGCTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAG
ACCAAGGACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACATCCAGGACAAAGGCCGCTTTGAACTCTAC
CGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGACTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAAT
GTGCTGCTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACATATTCGGGGAGAGCCGGGCCAGCACCTTC
TGCGGCACCCCTGACTATATCGCCCCTGAGATCCTACAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTG
TACGAGATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTCCATCCGTGTGGACACGCCACATTATCCC
CGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAGAAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAGTGACCGGAAACATCAAA
ATCCACCCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCTTTCAGGCCCAAAGTGAAGTCACCCAGA
GACTACAGTAACTTTGACCAGGAGTTCCTGAACGAGAAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCT

>In-frame_CACNA1D_ENST00000288139_chr3_53535747_+_PRKCD_ENST00000330452_chr3_53217468_+_1857nt
ATGATGATGATGATGATGATGAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGCAAGAGGCACC
AGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCCGAATAGCTCCAAGCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCT
AGACAGGCCAAGGCTGCCCAAACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCAATACGCCAAG
AGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTTCTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATT
AGTATAGTGGAATGGAAACCATTTGACATATTTATATTATTGGCTATTTTTGCCAATTGTGTGGCCTTAGCTATTTACATCCCATTCCCT
GAAGATGATTCTAATTCAACAAATCATAACTTGTTCCAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTAC
ATGAGCCCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAGTGTGAAGACTGCGGCATGAATGTG
CACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGCGGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCC
TCCCGGAGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACCGGAGTTGCTGGGGAGGACATGCAA
GACAACAGTGGGACCTACGGCAAGATCTGGGAGGGCAGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGC
AGCTTCGGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTTTGCCATCAAGGCCCTCAAGAAGGATGTGGTCCTGATCGAC
GACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTGCTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAG
ACCAAGGACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACATCCAGGACAAAGGCCGCTTTGAACTCTAC
CGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGACTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAAT
GTGCTGCTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACATATTCGGGGAGAGCCGGGCCAGCACCTTC
TGCGGCACCCCTGACTATATCGCCCCTGAGATCCTACAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTG
TACGAGATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTCCATCCGTGTGGACACGCCACATTATCCC
CGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAGAAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAGTGACCGGAAACATCAAA
ATCCACCCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCTTTCAGGCCCAAAGTGAAGTCACCCAGA
GACTACAGTAACTTTGACCAGGAGTTCCTGAACGAGAAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCT

>In-frame_CACNA1D_ENST00000422281_chr3_53535747_+_PRKCD_ENST00000394729_chr3_53217468_+_1857nt
ATGATGATGATGATGATGATGAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGCAAGAGGCACC
AGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCCGAATAGCTCCAAGCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCT
AGACAGGCCAAGGCTGCCCAAACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCAATACGCCAAG
AGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTTCTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATT
AGTATAGTGGAATGGAAACCATTTGACATATTTATATTATTGGCTATTTTTGCCAATTGTGTGGCCTTAGCTATTTACATCCCATTCCCT
GAAGATGATTCTAATTCAACAAATCATAACTTGTTCCAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTAC
ATGAGCCCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAGTGTGAAGACTGCGGCATGAATGTG
CACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGCGGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCC
TCCCGGAGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACCGGAGTTGCTGGGGAGGACATGCAA
GACAACAGTGGGACCTACGGCAAGATCTGGGAGGGCAGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGC
AGCTTCGGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTTTGCCATCAAGGCCCTCAAGAAGGATGTGGTCCTGATCGAC
GACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTGCTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAG
ACCAAGGACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACATCCAGGACAAAGGCCGCTTTGAACTCTAC
CGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGACTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAAT
GTGCTGCTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACATATTCGGGGAGAGCCGGGCCAGCACCTTC
TGCGGCACCCCTGACTATATCGCCCCTGAGATCCTACAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTG
TACGAGATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTCCATCCGTGTGGACACGCCACATTATCCC
CGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAGAAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAGTGACCGGAAACATCAAA
ATCCACCCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCTTTCAGGCCCAAAGTGAAGTCACCCAGA
GACTACAGTAACTTTGACCAGGAGTTCCTGAACGAGAAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCT

>In-frame_CACNA1D_ENST00000422281_chr3_53535747_+_PRKCD_ENST00000330452_chr3_53217468_+_1857nt
ATGATGATGATGATGATGATGAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGCAAGAGGCACC
AGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCCGAATAGCTCCAAGCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCT
AGACAGGCCAAGGCTGCCCAAACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCAATACGCCAAG
AGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTTCTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATT
AGTATAGTGGAATGGAAACCATTTGACATATTTATATTATTGGCTATTTTTGCCAATTGTGTGGCCTTAGCTATTTACATCCCATTCCCT
GAAGATGATTCTAATTCAACAAATCATAACTTGTTCCAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTAC
ATGAGCCCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAGTGTGAAGACTGCGGCATGAATGTG
CACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGCGGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCC
TCCCGGAGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACCGGAGTTGCTGGGGAGGACATGCAA
GACAACAGTGGGACCTACGGCAAGATCTGGGAGGGCAGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGC
AGCTTCGGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTTTGCCATCAAGGCCCTCAAGAAGGATGTGGTCCTGATCGAC
GACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTGCTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAG
ACCAAGGACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACATCCAGGACAAAGGCCGCTTTGAACTCTAC
CGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGACTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAAT
GTGCTGCTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACATATTCGGGGAGAGCCGGGCCAGCACCTTC
TGCGGCACCCCTGACTATATCGCCCCTGAGATCCTACAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTG
TACGAGATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTCCATCCGTGTGGACACGCCACATTATCCC
CGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAGAAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAGTGACCGGAAACATCAAA
ATCCACCCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCTTTCAGGCCCAAAGTGAAGTCACCCAGA
GACTACAGTAACTTTGACCAGGAGTTCCTGAACGAGAAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_CACNA1D_ENST00000350061_chr3_53535747_+_PRKCD_ENST00000394729_chr3_53217468_+_2819nt
GGGCGAGCGCCTCCGTCCCCGGATGTGAGCTCCGGCTGCCCGCGGTCCCGAGCCAGCGGCGGCGCGGGCGGCGGCGGCGGGCACCGGGCA
CCGCGGCGGGCGGGCAGACGGGCGGGCATGGGGGGAGCGCCGAGCGGCCCCGGCGGCCGGGCCGGCATCACCGCGGCGTCTCTCCGCTAG
AGGAGGGGACAAGCCAGTTCTCCTTTGCAGCAAAAAATTACATGTATATATTATTAAGATAATATATACATTGGATTTTATTTTTTTAAA
AAGTTTATTTTGCTCCATTTTTGAAAAAGAGAGAGCTTGGGTGGCGAGCGGTTTTTTTTTTAAATCAATTATCCTTATTTTCTGTTATTT
GTCCCCGTCCCTCCCCACCCCCCTGCTGAAGCGAGAATAAGGGCAGGGACCGCGGCTCCTACCTCTTGGTGATCCCCTTCCCCATTCCGC
CCCCGCCTCAACGCCCAGCACAGTGCCCTGCACACAGTAGTCGCTCAATAAATGTTCGTGGATGATGATGATGATGATGATGAAAAAAAT
GCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGCAAGAGGCACCAGACTTCCTCTTTCTGGTGAAGGACCAAC
TTCTCAGCCGAATAGCTCCAAGCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCTAGACAGGCCAAGGCTGCCCAAACTATGAG
CACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCAATACGCCAAGAGCAAAAAACAGGGTAACTCGTCCAACAG
CCGACCTGCCCGCGCCCTTTTCTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATTAGTATAGTGGAATGGAAACCATTTGACAT
ATTTATATTATTGGCTATTTTTGCCAATTGTGTGGCCTTAGCTATTTACATCCCATTCCCTGAAGATGATTCTAATTCAACAAATCATAA
CTTGTTCCAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTACATGAGCCCCACCTTCTGTGACCACTGCGG
CAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAGTGTGAAGACTGCGGCATGAATGTGCACCATAAATGCCGGGAGAAGGTGGCCAA
CCTCTGCGGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCCTCCCGGAGATCAGACTCAGCCTCCTCAGA
GCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACCGGAGTTGCTGGGGAGGACATGCAAGACAACAGTGGGACCTACGGCAAGATCTG
GGAGGGCAGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGCAGCTTCGGGAAGGTGCTGCTTGGAGAGCT
GAAGGGCAGAGGAGAGTACTTTGCCATCAAGGCCCTCAAGAAGGATGTGGTCCTGATCGACGACGACGTGGAGTGCACCATGGTTGAGAA
GCGGGTGCTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAGACCAAGGACCACCTGTTCTTTGTGATGGA
GTTCCTCAACGGGGGGGACCTGATGTACCACATCCAGGACAAAGGCCGCTTTGAACTCTACCGTGCCACGTTTTATGCCGCTGAGATAAT
GTGTGGACTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAATGTGCTGCTGGACCGGGATGGCCACATCAA
GATTGCCGACTTTGGGATGTGCAAAGAGAACATATTCGGGGAGAGCCGGGCCAGCACCTTCTGCGGCACCCCTGACTATATCGCCCCTGA
GATCCTACAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTGTACGAGATGCTCATTGGCCAGTCCCCCTT
CCATGGTGATGATGAGGATGAACTCTTCGAGTCCATCCGTGTGGACACGCCACATTATCCCCGCTGGATCACCAAGGAGTCCAAGGACAT
CCTGGAGAAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAGTGACCGGAAACATCAAAATCCACCCCTTCTTCAAGACCATAAACTG
GACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCTTTCAGGCCCAAAGTGAAGTCACCCAGAGACTACAGTAACTTTGACCAGGAGTTCCT
GAACGAGAAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCTGCATTCGCTGGCTTCTCCTTTGTGAACCC
CAAATTCGAGCACCTCCTGGAAGATTGAGGTTCCTGGACAGATCAGGCTAGCCCTGCCCTCCACCCACACCTGCCCGCTCCCCACGATAA
GCACCAGTGGGACTGTGGTGACTTCTGCTGCTGGCCCCGCCCCTGCCCCCAGAGCGTCCTTGGCTGCCGTCTGGCCGGGCTCTCATGGTA
CTTCCTCTGTGAACTGTGTGTGAATCTGCTTTTCCTCTGCCTTCGGAGGGAAATTGTAAATCCTGTGTTTCATTACTTGAATGTAGTTAT
CTATTGAAAATATATATTATATACATAGACATATATATATATATAATAGGCTGTATATATTGCTCAGTAGAGAAAAACCATGGGGGACTG
GTGATATGTTGATCTTTTTCAAAAAAATATATATATGACAAAAAAAAAAAAAAAGGAGCACAAGCTGTTTGAACCACCAGGTTTATTTGT

>In-frame_CACNA1D_ENST00000350061_chr3_53535747_+_PRKCD_ENST00000330452_chr3_53217468_+_2656nt
GGGCGAGCGCCTCCGTCCCCGGATGTGAGCTCCGGCTGCCCGCGGTCCCGAGCCAGCGGCGGCGCGGGCGGCGGCGGCGGGCACCGGGCA
CCGCGGCGGGCGGGCAGACGGGCGGGCATGGGGGGAGCGCCGAGCGGCCCCGGCGGCCGGGCCGGCATCACCGCGGCGTCTCTCCGCTAG
AGGAGGGGACAAGCCAGTTCTCCTTTGCAGCAAAAAATTACATGTATATATTATTAAGATAATATATACATTGGATTTTATTTTTTTAAA
AAGTTTATTTTGCTCCATTTTTGAAAAAGAGAGAGCTTGGGTGGCGAGCGGTTTTTTTTTTAAATCAATTATCCTTATTTTCTGTTATTT
GTCCCCGTCCCTCCCCACCCCCCTGCTGAAGCGAGAATAAGGGCAGGGACCGCGGCTCCTACCTCTTGGTGATCCCCTTCCCCATTCCGC
CCCCGCCTCAACGCCCAGCACAGTGCCCTGCACACAGTAGTCGCTCAATAAATGTTCGTGGATGATGATGATGATGATGATGAAAAAAAT
GCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGCAAGAGGCACCAGACTTCCTCTTTCTGGTGAAGGACCAAC
TTCTCAGCCGAATAGCTCCAAGCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCTAGACAGGCCAAGGCTGCCCAAACTATGAG
CACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCAATACGCCAAGAGCAAAAAACAGGGTAACTCGTCCAACAG
CCGACCTGCCCGCGCCCTTTTCTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATTAGTATAGTGGAATGGAAACCATTTGACAT
ATTTATATTATTGGCTATTTTTGCCAATTGTGTGGCCTTAGCTATTTACATCCCATTCCCTGAAGATGATTCTAATTCAACAAATCATAA
CTTGTTCCAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTACATGAGCCCCACCTTCTGTGACCACTGCGG
CAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAGTGTGAAGACTGCGGCATGAATGTGCACCATAAATGCCGGGAGAAGGTGGCCAA
CCTCTGCGGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCCTCCCGGAGATCAGACTCAGCCTCCTCAGA
GCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACCGGAGTTGCTGGGGAGGACATGCAAGACAACAGTGGGACCTACGGCAAGATCTG
GGAGGGCAGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGCAGCTTCGGGAAGGTGCTGCTTGGAGAGCT
GAAGGGCAGAGGAGAGTACTTTGCCATCAAGGCCCTCAAGAAGGATGTGGTCCTGATCGACGACGACGTGGAGTGCACCATGGTTGAGAA
GCGGGTGCTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAGACCAAGGACCACCTGTTCTTTGTGATGGA
GTTCCTCAACGGGGGGGACCTGATGTACCACATCCAGGACAAAGGCCGCTTTGAACTCTACCGTGCCACGTTTTATGCCGCTGAGATAAT
GTGTGGACTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAATGTGCTGCTGGACCGGGATGGCCACATCAA
GATTGCCGACTTTGGGATGTGCAAAGAGAACATATTCGGGGAGAGCCGGGCCAGCACCTTCTGCGGCACCCCTGACTATATCGCCCCTGA
GATCCTACAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTGTACGAGATGCTCATTGGCCAGTCCCCCTT
CCATGGTGATGATGAGGATGAACTCTTCGAGTCCATCCGTGTGGACACGCCACATTATCCCCGCTGGATCACCAAGGAGTCCAAGGACAT
CCTGGAGAAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAGTGACCGGAAACATCAAAATCCACCCCTTCTTCAAGACCATAAACTG
GACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCTTTCAGGCCCAAAGTGAAGTCACCCAGAGACTACAGTAACTTTGACCAGGAGTTCCT
GAACGAGAAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCTGCATTCGCTGGCTTCTCCTTTGTGAACCC
CAAATTCGAGCACCTCCTGGAAGATTGAGGTTCCTGGACAGATCAGGCTAGCCCTGCCCTCCACCCACACCTGCCCGCTCCCCACGATAA
GCACCAGTGGGACTGTGGTGACTTCTGCTGCTGGCCCCGCCCCTGCCCCCAGAGCGTCCTTGGCTGCCGTCTGGCCGGGCTCTCATGGTA
CTTCCTCTGTGAACTGTGTGTGAATCTGCTTTTCCTCTGCCTTCGGAGGGAAATTGTAAATCCTGTGTTTCATTACTTGAATGTAGTTAT

>In-frame_CACNA1D_ENST00000288139_chr3_53535747_+_PRKCD_ENST00000394729_chr3_53217468_+_2426nt
AGAATAAGGGCAGGGACCGCGGCTCCTACCTCTTGGTGATCCCCTTCCCCATTCCGCCCCCGCCTCAACGCCCAGCACAGTGCCCTGCAC
ACAGTAGTCGCTCAATAAATGTTCGTGGATGATGATGATGATGATGATGAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGC
GAACGAGGCAAACTATGCAAGAGGCACCAGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCCGAATAGCTCCAAGCAAACTGTCCT
GTCTTGGCAAGCTGCAATCGATGCTGCTAGACAGGCCAAGGCTGCCCAAACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTC
CCAAAGAAAACGTCAGCAATACGCCAAGAGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTTCTGTTTATCACT
CAATAACCCCATCCGAAGAGCCTGCATTAGTATAGTGGAATGGAAACCATTTGACATATTTATATTATTGGCTATTTTTGCCAATTGTGT
GGCCTTAGCTATTTACATCCCATTCCCTGAAGATGATTCTAATTCAACAAATCATAACTTGTTCCAGAAAGAACGCTTCAACATCGACAT
GCCGCACCGCTTCAAGGTTCACAACTACATGAGCCCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATT
AAAGTGTGAAGACTGCGGCATGAATGTGCACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGCGGCATCAACCAGAAGCTTTTGGCTGA
GGCCTTGAACCAAGTCACCCAGAGAGCCTCCCGGAGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAA
GACCGGAGTTGCTGGGGAGGACATGCAAGACAACAGTGGGACCTACGGCAAGATCTGGGAGGGCAGCAGCAAGTGCAACATCAACAACTT
CATCTTCCACAAGGTCCTGGGCAAAGGCAGCTTCGGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTTTGCCATCAAGGC
CCTCAAGAAGGATGTGGTCCTGATCGACGACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTGCTGACACTTGCCGCAGAGAATCCCTT
TCTCACCCACCTCATCTGCACCTTCCAGACCAAGGACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACAT
CCAGGACAAAGGCCGCTTTGAACTCTACCGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGACTGCAGTTTCTACACAGCAAGGGCAT
CATTTACAGGGACCTCAAACTGGACAATGTGCTGCTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACAT
ATTCGGGGAGAGCCGGGCCAGCACCTTCTGCGGCACCCCTGACTATATCGCCCCTGAGATCCTACAGGGCCTGAAGTACACATTCTCTGT
GGACTGGTGGTCTTTCGGGGTCCTTCTGTACGAGATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTC
CATCCGTGTGGACACGCCACATTATCCCCGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAGAAGCTCTTTGAAAGGGAACCAACCAA
GAGGCTGGGAGTGACCGGAAACATCAAAATCCACCCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACC
TTTCAGGCCCAAAGTGAAGTCACCCAGAGACTACAGTAACTTTGACCAGGAGTTCCTGAACGAGAAGGCGCGCCTCTCCTACAGCGACAA
GAACCTCATCGACTCCATGGACCAGTCTGCATTCGCTGGCTTCTCCTTTGTGAACCCCAAATTCGAGCACCTCCTGGAAGATTGAGGTTC
CTGGACAGATCAGGCTAGCCCTGCCCTCCACCCACACCTGCCCGCTCCCCACGATAAGCACCAGTGGGACTGTGGTGACTTCTGCTGCTG
GCCCCGCCCCTGCCCCCAGAGCGTCCTTGGCTGCCGTCTGGCCGGGCTCTCATGGTACTTCCTCTGTGAACTGTGTGTGAATCTGCTTTT
CCTCTGCCTTCGGAGGGAAATTGTAAATCCTGTGTTTCATTACTTGAATGTAGTTATCTATTGAAAATATATATTATATACATAGACATA
TATATATATATAATAGGCTGTATATATTGCTCAGTAGAGAAAAACCATGGGGGACTGGTGATATGTTGATCTTTTTCAAAAAAATATATA

>In-frame_CACNA1D_ENST00000288139_chr3_53535747_+_PRKCD_ENST00000330452_chr3_53217468_+_2263nt
AGAATAAGGGCAGGGACCGCGGCTCCTACCTCTTGGTGATCCCCTTCCCCATTCCGCCCCCGCCTCAACGCCCAGCACAGTGCCCTGCAC
ACAGTAGTCGCTCAATAAATGTTCGTGGATGATGATGATGATGATGATGAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGC
GAACGAGGCAAACTATGCAAGAGGCACCAGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCCGAATAGCTCCAAGCAAACTGTCCT
GTCTTGGCAAGCTGCAATCGATGCTGCTAGACAGGCCAAGGCTGCCCAAACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTC
CCAAAGAAAACGTCAGCAATACGCCAAGAGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTTCTGTTTATCACT
CAATAACCCCATCCGAAGAGCCTGCATTAGTATAGTGGAATGGAAACCATTTGACATATTTATATTATTGGCTATTTTTGCCAATTGTGT
GGCCTTAGCTATTTACATCCCATTCCCTGAAGATGATTCTAATTCAACAAATCATAACTTGTTCCAGAAAGAACGCTTCAACATCGACAT
GCCGCACCGCTTCAAGGTTCACAACTACATGAGCCCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATT
AAAGTGTGAAGACTGCGGCATGAATGTGCACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGCGGCATCAACCAGAAGCTTTTGGCTGA
GGCCTTGAACCAAGTCACCCAGAGAGCCTCCCGGAGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAA
GACCGGAGTTGCTGGGGAGGACATGCAAGACAACAGTGGGACCTACGGCAAGATCTGGGAGGGCAGCAGCAAGTGCAACATCAACAACTT
CATCTTCCACAAGGTCCTGGGCAAAGGCAGCTTCGGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTTTGCCATCAAGGC
CCTCAAGAAGGATGTGGTCCTGATCGACGACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTGCTGACACTTGCCGCAGAGAATCCCTT
TCTCACCCACCTCATCTGCACCTTCCAGACCAAGGACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACAT
CCAGGACAAAGGCCGCTTTGAACTCTACCGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGACTGCAGTTTCTACACAGCAAGGGCAT
CATTTACAGGGACCTCAAACTGGACAATGTGCTGCTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACAT
ATTCGGGGAGAGCCGGGCCAGCACCTTCTGCGGCACCCCTGACTATATCGCCCCTGAGATCCTACAGGGCCTGAAGTACACATTCTCTGT
GGACTGGTGGTCTTTCGGGGTCCTTCTGTACGAGATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTC
CATCCGTGTGGACACGCCACATTATCCCCGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAGAAGCTCTTTGAAAGGGAACCAACCAA
GAGGCTGGGAGTGACCGGAAACATCAAAATCCACCCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACC
TTTCAGGCCCAAAGTGAAGTCACCCAGAGACTACAGTAACTTTGACCAGGAGTTCCTGAACGAGAAGGCGCGCCTCTCCTACAGCGACAA
GAACCTCATCGACTCCATGGACCAGTCTGCATTCGCTGGCTTCTCCTTTGTGAACCCCAAATTCGAGCACCTCCTGGAAGATTGAGGTTC
CTGGACAGATCAGGCTAGCCCTGCCCTCCACCCACACCTGCCCGCTCCCCACGATAAGCACCAGTGGGACTGTGGTGACTTCTGCTGCTG
GCCCCGCCCCTGCCCCCAGAGCGTCCTTGGCTGCCGTCTGGCCGGGCTCTCATGGTACTTCCTCTGTGAACTGTGTGTGAATCTGCTTTT
CCTCTGCCTTCGGAGGGAAATTGTAAATCCTGTGTTTCATTACTTGAATGTAGTTATCTATTGAAAATATATATTATATACATAGACATA

>In-frame_CACNA1D_ENST00000422281_chr3_53535747_+_PRKCD_ENST00000394729_chr3_53217468_+_2308nt
ATGATGATGATGATGATGATGAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGCAAGAGGCACC
AGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCCGAATAGCTCCAAGCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCT
AGACAGGCCAAGGCTGCCCAAACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCAATACGCCAAG
AGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTTCTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATT
AGTATAGTGGAATGGAAACCATTTGACATATTTATATTATTGGCTATTTTTGCCAATTGTGTGGCCTTAGCTATTTACATCCCATTCCCT
GAAGATGATTCTAATTCAACAAATCATAACTTGTTCCAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTAC
ATGAGCCCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAGTGTGAAGACTGCGGCATGAATGTG
CACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGCGGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCC
TCCCGGAGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACCGGAGTTGCTGGGGAGGACATGCAA
GACAACAGTGGGACCTACGGCAAGATCTGGGAGGGCAGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGC
AGCTTCGGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTTTGCCATCAAGGCCCTCAAGAAGGATGTGGTCCTGATCGAC
GACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTGCTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAG
ACCAAGGACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACATCCAGGACAAAGGCCGCTTTGAACTCTAC
CGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGACTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAAT
GTGCTGCTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACATATTCGGGGAGAGCCGGGCCAGCACCTTC
TGCGGCACCCCTGACTATATCGCCCCTGAGATCCTACAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTG
TACGAGATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTCCATCCGTGTGGACACGCCACATTATCCC
CGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAGAAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAGTGACCGGAAACATCAAA
ATCCACCCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCTTTCAGGCCCAAAGTGAAGTCACCCAGA
GACTACAGTAACTTTGACCAGGAGTTCCTGAACGAGAAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCT
GCATTCGCTGGCTTCTCCTTTGTGAACCCCAAATTCGAGCACCTCCTGGAAGATTGAGGTTCCTGGACAGATCAGGCTAGCCCTGCCCTC
CACCCACACCTGCCCGCTCCCCACGATAAGCACCAGTGGGACTGTGGTGACTTCTGCTGCTGGCCCCGCCCCTGCCCCCAGAGCGTCCTT
GGCTGCCGTCTGGCCGGGCTCTCATGGTACTTCCTCTGTGAACTGTGTGTGAATCTGCTTTTCCTCTGCCTTCGGAGGGAAATTGTAAAT
CCTGTGTTTCATTACTTGAATGTAGTTATCTATTGAAAATATATATTATATACATAGACATATATATATATATAATAGGCTGTATATATT
GCTCAGTAGAGAAAAACCATGGGGGACTGGTGATATGTTGATCTTTTTCAAAAAAATATATATATGACAAAAAAAAAAAAAAAGGAGCAC

>In-frame_CACNA1D_ENST00000422281_chr3_53535747_+_PRKCD_ENST00000330452_chr3_53217468_+_2145nt
ATGATGATGATGATGATGATGAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGCAAGAGGCACC
AGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCCGAATAGCTCCAAGCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCT
AGACAGGCCAAGGCTGCCCAAACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCAATACGCCAAG
AGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTTCTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATT
AGTATAGTGGAATGGAAACCATTTGACATATTTATATTATTGGCTATTTTTGCCAATTGTGTGGCCTTAGCTATTTACATCCCATTCCCT
GAAGATGATTCTAATTCAACAAATCATAACTTGTTCCAGAAAGAACGCTTCAACATCGACATGCCGCACCGCTTCAAGGTTCACAACTAC
ATGAGCCCCACCTTCTGTGACCACTGCGGCAGCCTGCTCTGGGGACTGGTGAAGCAGGGATTAAAGTGTGAAGACTGCGGCATGAATGTG
CACCATAAATGCCGGGAGAAGGTGGCCAACCTCTGCGGCATCAACCAGAAGCTTTTGGCTGAGGCCTTGAACCAAGTCACCCAGAGAGCC
TCCCGGAGATCAGACTCAGCCTCCTCAGAGCCTGTTGGGATATATCAGGGTTTCGAGAAGAAGACCGGAGTTGCTGGGGAGGACATGCAA
GACAACAGTGGGACCTACGGCAAGATCTGGGAGGGCAGCAGCAAGTGCAACATCAACAACTTCATCTTCCACAAGGTCCTGGGCAAAGGC
AGCTTCGGGAAGGTGCTGCTTGGAGAGCTGAAGGGCAGAGGAGAGTACTTTGCCATCAAGGCCCTCAAGAAGGATGTGGTCCTGATCGAC
GACGACGTGGAGTGCACCATGGTTGAGAAGCGGGTGCTGACACTTGCCGCAGAGAATCCCTTTCTCACCCACCTCATCTGCACCTTCCAG
ACCAAGGACCACCTGTTCTTTGTGATGGAGTTCCTCAACGGGGGGGACCTGATGTACCACATCCAGGACAAAGGCCGCTTTGAACTCTAC
CGTGCCACGTTTTATGCCGCTGAGATAATGTGTGGACTGCAGTTTCTACACAGCAAGGGCATCATTTACAGGGACCTCAAACTGGACAAT
GTGCTGCTGGACCGGGATGGCCACATCAAGATTGCCGACTTTGGGATGTGCAAAGAGAACATATTCGGGGAGAGCCGGGCCAGCACCTTC
TGCGGCACCCCTGACTATATCGCCCCTGAGATCCTACAGGGCCTGAAGTACACATTCTCTGTGGACTGGTGGTCTTTCGGGGTCCTTCTG
TACGAGATGCTCATTGGCCAGTCCCCCTTCCATGGTGATGATGAGGATGAACTCTTCGAGTCCATCCGTGTGGACACGCCACATTATCCC
CGCTGGATCACCAAGGAGTCCAAGGACATCCTGGAGAAGCTCTTTGAAAGGGAACCAACCAAGAGGCTGGGAGTGACCGGAAACATCAAA
ATCCACCCCTTCTTCAAGACCATAAACTGGACTCTGCTGGAAAAGCGGAGGTTGGAGCCACCTTTCAGGCCCAAAGTGAAGTCACCCAGA
GACTACAGTAACTTTGACCAGGAGTTCCTGAACGAGAAGGCGCGCCTCTCCTACAGCGACAAGAACCTCATCGACTCCATGGACCAGTCT
GCATTCGCTGGCTTCTCCTTTGTGAACCCCAAATTCGAGCACCTCCTGGAAGATTGAGGTTCCTGGACAGATCAGGCTAGCCCTGCCCTC
CACCCACACCTGCCCGCTCCCCACGATAAGCACCAGTGGGACTGTGGTGACTTCTGCTGCTGGCCCCGCCCCTGCCCCCAGAGCGTCCTT
GGCTGCCGTCTGGCCGGGCTCTCATGGTACTTCCTCTGTGAACTGTGTGTGAATCTGCTTTTCCTCTGCCTTCGGAGGGAAATTGTAAAT


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FusionGenePPI for CACNA1D_PRKCD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CACNA1DCALB1PRKCDRASGRP3, PLSCR3, INPP5D, SHC1, RIPK4, YWHAG, PDPK1, C1QBP, GNA12, GNA13, MTOR, STAT1, PTK2B, ADAM9, INSR, PDP1, PDP2, PPP2CA, IRS1, PIK3CB, PTPN6, YWHAZ, TIAM1, PLD2, AFAP1, IL6ST, MUC1, GABRA1, CHUK, IKBKB, SP1, NFE2L2, PRKCD, HDAC5, STAT3, TRIM41, HSPB1, KLF4, VHL, HIST1H1A, TP53, IBTK, IRAK1, TRO, HIST1H1B, SNCA, NCF1, APP, ITGB2, TNFRSF1A, GSK3A, ELAVL1, PHB, SQSTM1, PRKCB, PRKCQ, DYNC1H1, HSPA4, HSP90AA1, ITPR1, MACF1, ART3, VCP, RANBP10, RANBP9, IL32, EP300, FLI1, DIABLO, PTGES3, MYC, DAB2, RPL37A, TKT, ZNF131, FXR1, DHX16, PRPF4B, PPRC1, CWC15, H2BFS, TRAPPC13, FAM192A, CHD9, BUD13, LYSMD2, ACTBL2, FYN, GRM5, NOTCH1, CARD11, TRAF6, MALT1, NGEF, TP73, MBP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CACNA1D_PRKCD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCACNA1DQ01668DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved
HgeneCACNA1DQ01668DB00401NisoldipineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved
HgeneCACNA1DQ01668DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved
HgeneCACNA1DQ01668DB00898EthanolVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved
HgeneCACNA1DQ01668DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved
HgeneCACNA1DQ01668DB04855DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved
HgeneCACNA1DQ01668DB00270IsradipineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved|investigational
HgeneCACNA1DQ01668DB00393NimodipineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved|investigational
HgeneCACNA1DQ01668DB00568CinnarizineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved|investigational
HgeneCACNA1DQ01668DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved|investigational
HgeneCACNA1DQ01668DB01023FelodipineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved|investigational
HgeneCACNA1DQ01668DB01054NitrendipineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved|investigational
HgeneCACNA1DQ01668DB04920ClevidipineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved|investigational
HgeneCACNA1DQ01668DB06712NilvadipineVoltage-dependent L-type calcium channel subunit alpha-1Dsmall moleculeapproved|investigational
TgenePRKCDQ05655DB05013Ingenol MebutateProtein kinase C delta typesmall moleculeapproved

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RelatedDiseases for CACNA1D_PRKCD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCACNA1DC0001430Adenoma2CTD_human
HgeneCACNA1DC0011053Deafness1CTD_human;HPO
HgeneCACNA1DC0020428Hyperaldosteronism1CTD_human;HPO
HgeneCACNA1DC0525045Mood Disorders1PSYGENET
HgeneCACNA1DC3809609PRIMARY ALDOSTERONISM, SEIZURES, AND NEUROLOGIC ABNORMALITIES1ORPHANET;UNIPROT
TgenePRKCDC0011853Diabetes Mellitus, Experimental1CTD_human
TgenePRKCDC0020538Hypertensive disease1CTD_human
TgenePRKCDC0021841Intestinal Neoplasms1CTD_human
TgenePRKCDC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePRKCDC0036572Seizures1CTD_human
TgenePRKCDC0235032Neurotoxicity Syndromes1CTD_human
TgenePRKCDC0242422Parkinsonian Disorders1CTD_human