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Fusion gene ID: 514 |
FusionGeneSummary for ACTB_BSG |
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Fusion gene information | Fusion gene name: ACTB_BSG | Fusion gene ID: 514 | Hgene | Tgene | Gene symbol | ACTB | BSG | Gene ID | 60 | 682 |
Gene name | actin beta | basigin (Ok blood group) | |
Synonyms | BRWS1|PS1TP5BP1 | 5F7|CD147|EMMPRIN|EMPRIN|OK|TCSF | |
Cytomap | 7p22.1 | 19p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | actin, cytoplasmic 1I(2)-actinPS1TP5-binding protein 1beta cytoskeletal actin | basiginOK blood group antigencollagenase stimulatory factorextracellular matrix metalloproteinase inducerleukocyte activation antigen M6tumor cell-derived collagenase stimulatory factor | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | P60709 | P35613 | |
Ensembl transtripts involved in fusion gene | ENST00000464611, ENST00000331789, | ENST00000346916, ENST00000545507, ENST00000333511, ENST00000353555, ENST00000574970, | |
Fusion gene scores | * DoF score | 28 X 19 X 14=7448 | 4 X 7 X 3=84 |
# samples | 37 | 10 | |
** MAII score | log2(37/7448*10)=-4.33125589704248 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/84*10)=0.251538766995964 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ACTB [Title/Abstract] AND BSG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACTB | GO:0098974 | postsynaptic actin cytoskeleton organization | 18341992 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP379102 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000464611 | ENST00000346916 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
intron-3CDS | ENST00000464611 | ENST00000545507 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
intron-3CDS | ENST00000464611 | ENST00000333511 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
intron-3CDS | ENST00000464611 | ENST00000353555 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
intron-intron | ENST00000464611 | ENST00000574970 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
intron-3CDS | ENST00000331789 | ENST00000346916 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
intron-3CDS | ENST00000331789 | ENST00000545507 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
intron-3CDS | ENST00000331789 | ENST00000333511 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
intron-3CDS | ENST00000331789 | ENST00000353555 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
intron-intron | ENST00000331789 | ENST00000574970 | ACTB | chr7 | 5568820 | - | BSG | chr19 | 580716 | + |
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FusionProtFeatures for ACTB_BSG |
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Hgene | Tgene |
ACTB | BSG |
Plays an important role in targeting the monocarboxylatetransporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasmamembrane. Plays pivotal roles in spermatogenesis, embryoimplantation, neural network formation and tumor progression.Stimulates adjacent fibroblasts to produce matrixmetalloproteinases (MMPS). Seems to be a receptor foroligomannosidic glycans. In vitro, promotes outgrowth ofastrocytic processes. {ECO:0000269|PubMed:17127621,ECO:0000269|PubMed:28666119}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACTB_BSG |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACTB_BSG |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACTB_BSG |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACTB_BSG |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACTB | C2239176 | Liver carcinoma | 2 | CTD_human |
Hgene | ACTB | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | ACTB | C0009363 | Congenital ocular coloboma (disorder) | 1 | CTD_human |
Hgene | ACTB | C0013393 | Dysostoses | 1 | CTD_human |
Hgene | ACTB | C0013421 | Dystonia | 1 | CTD_human |
Hgene | ACTB | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0018784 | Sensorineural Hearing Loss (disorder) | 1 | CTD_human;HPO |
Hgene | ACTB | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | ACTB | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ACTB | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | ACTB | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ACTB | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | ACTB | C0242184 | Hypoxia | 1 | CTD_human |
Hgene | ACTB | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | ACTB | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
Hgene | ACTB | C1846331 | Juvenile-onset dystonia | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | ACTB | C1855722 | Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation | 1 | ORPHANET;UNIPROT |
Tgene | BSG | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | BSG | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | BSG | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Tgene | BSG | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | BSG | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
Tgene | BSG | C2936350 | Plaque, Atherosclerotic | 1 | CTD_human |