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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 5138

FusionGeneSummary for CAAP1_TNNI3K

check button Fusion gene summary
Fusion gene informationFusion gene name: CAAP1_TNNI3K
Fusion gene ID: 5138
HgeneTgene
Gene symbol

CAAP1

TNNI3K

Gene ID

79886

51086

Gene namecaspase activity and apoptosis inhibitor 1TNNI3 interacting kinase
SynonymsC9orf82|CAAPCARK|CCDD
Cytomap

9p21.2

1p31.1

Type of geneprotein-codingprotein-coding
Descriptioncaspase activity and apoptosis inhibitor 1conserved anti-apoptotic proteinserine/threonine-protein kinase TNNI3Kcardiac ankyrin repeat kinasecardiac troponin I-interacting kinase
Modification date2018052220180522
UniProtAcc

Q9H8G2

Q59H18

Ensembl transtripts involved in fusion geneENST00000333916, ENST00000535437, 
ENST00000520187, ENST00000495958, 
ENST00000370891, ENST00000326637, 
ENST00000465473, 
Fusion gene scores* DoF score3 X 2 X 3=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: CAAP1 [Title/Abstract] AND TNNI3K [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNNI3K

GO:0006468

protein phosphorylation

12721663


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-2095-01ACAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000333916ENST00000370891CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
In-frameENST00000333916ENST00000326637CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
5CDS-intronENST00000333916ENST00000465473CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
Frame-shiftENST00000535437ENST00000370891CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
Frame-shiftENST00000535437ENST00000326637CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
5CDS-intronENST00000535437ENST00000465473CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
intron-3CDSENST00000520187ENST00000370891CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
intron-3CDSENST00000520187ENST00000326637CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
intron-intronENST00000520187ENST00000465473CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
intron-3CDSENST00000495958ENST00000370891CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
intron-3CDSENST00000495958ENST00000326637CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+
intron-intronENST00000495958ENST00000465473CAAP1chr9

26861064

-TNNI3Kchr1

74832940

+

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FusionProtFeatures for CAAP1_TNNI3K


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAAP1

Q9H8G2

TNNI3K

Q59H18

Anti-apoptotic protein that modulates a caspase-10dependent mitochondrial caspase-3/9 feedback amplification loop.{ECO:0000269|PubMed:21980415}. May play a role in cardiac physiology.{ECO:0000303|PubMed:12721663}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAAP1chr9:26861064chr1:74832940ENST00000333916-5619_25246362Compositional biasNote=Poly-Ala
HgeneCAAP1chr9:26861064chr1:74832940ENST00000535437-5619_25101217Compositional biasNote=Poly-Ala
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025733_746392836Compositional biasNote=Poly-Ser
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227733_746493937Compositional biasNote=Poly-Ser
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025463_723392836DomainProtein kinase
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025469_477392836Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAAP1chr9:26861064chr1:74832940ENST00000333916-56281_311246362Coiled coilOntology_term=ECO:0000255
HgeneCAAP1chr9:26861064chr1:74832940ENST00000535437-56281_311101217Coiled coilOntology_term=ECO:0000255
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+102521_51392836Coiled coilOntology_term=ECO:0000255
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+122721_51493937Coiled coilOntology_term=ECO:0000255
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227463_723493937DomainProtein kinase
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227469_477493937Nucleotide bindingATP
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025100_129392836RepeatNote=ANK 2
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025133_162392836RepeatNote=ANK 3
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025166_195392836RepeatNote=ANK 4
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025199_228392836RepeatNote=ANK 5
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025234_263392836RepeatNote=ANK 6
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025269_298392836RepeatNote=ANK 7
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025304_335392836RepeatNote=ANK 8
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025339_368392836RepeatNote=ANK 9
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+1025381_410392836RepeatNote=ANK 10
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000326637+102566_96392836RepeatNote=ANK 1
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227100_129493937RepeatNote=ANK 2
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227133_162493937RepeatNote=ANK 3
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227166_195493937RepeatNote=ANK 4
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227199_228493937RepeatNote=ANK 5
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227234_263493937RepeatNote=ANK 6
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227269_298493937RepeatNote=ANK 7
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227304_335493937RepeatNote=ANK 8
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227339_368493937RepeatNote=ANK 9
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+1227381_410493937RepeatNote=ANK 10
TgeneTNNI3Kchr9:26861064chr1:74832940ENST00000370891+122766_96493937RepeatNote=ANK 1


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FusionGeneSequence for CAAP1_TNNI3K


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CAAP1_ENST00000333916_chr9_26861064_-_TNNI3K_ENST00000370891_chr1_74832940_+_690aa
MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRST
DSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQ
EQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGHDAIVTLLKHYKRPQDELPCNEY
SQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMF
CREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILL
YEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPI
GYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNAR

>In-frame_CAAP1_ENST00000333916_chr9_26861064_-_TNNI3K_ENST00000326637_chr1_74832940_+_690aa
MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRST
DSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQ
EQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGHDAIVTLLKHYKRPQDELPCNEY
SQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMF
CREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILL
YEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPI
GYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNAR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CAAP1_ENST00000333916_chr9_26861064_-_TNNI3K_ENST00000370891_chr1_74832940_+_2070nt
ATGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCC
GCGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTT
AGTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACC
GACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGT
GACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGC
TTCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAG
GAACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGAT
GATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAA
GGTTTGGAATTAAAACAAGGGCATGATGCCATTGTCACACTCCTGAAGCATTATAAGAGACCACAAGATGAATTGCCCTGTAATGAATAT
TCTCAGCCTGGAGGAGATGGCTCCTATGTGTCTGTTCCATCACCCTTGGGGAAGATTAAAAGCATGACAAAAGAGAAGGCAGATATTCTC
CTCCTAAGAGCTGGATTGCCTTCACATTTCCATCTTCAGCTCTCAGAAATTGAGTTCCATGAGATTATTGGCTCAGGTTCTTTTGGGAAA
GTATATAAAGGACGATGCAGAAATAAAATAGTGGCTATAAAACGTTATCGAGCCAATACCTACTGCTCCAAGTCAGATGTGGATATGTTT
TGCCGAGAGGTGTCCATTCTCTGCCAGCTCAATCATCCCTGCGTAATTCAGTTTGTGGGTGCTTGCTTGAATGATCCCAGCCAGTTTGCC
ATTGTCACTCAATACATATCAGGGGGTTCTCTGTTCTCCCTCCTTCATGAGCAGAAGAGGATTCTTGATTTGCAGTCTAAATTAATTATT
GCAGTAGATGTTGCCAAAGGCATGGAGTACCTTCACAACCTGACACAGCCAATTATACATCGTGACTTGAACAGTCACAATATTCTTCTC
TATGAGGATGGGCATGCTGTGGTGGCAGATTTTGGAGAATCAAGATTTCTACAGTCTCTGGATGAAGACAACATGACAAAACAACCTGGG
AACCTCCGTTGGATGGCTCCTGAGGTGTTCACGCAGTGCACTCGGTACACCATCAAAGCAGATGTCTTCAGCTATGCTCTGTGTCTGTGG
GAAATTCTCACTGGCGAAATTCCATTCGCTCATCTCAAGCCAGCGGCTGCGGCAGCAGACATGGCTTACCACCACATCAGACCTCCCATT
GGCTATTCCATTCCCAAGCCCATATCATCTCTGCTGATACGAGGGTGGAACGCATGTCCTGAAGGAAGACCCGAATTTTCTGAAGTTGTC
ATGAAGTTAGAAGAGTGTCTCTGCAACATTGAGCTGATGTCTCCTGCATCAAGTAACAGCAGTGGGTCTCTCTCACCTTCTTCTTCTTCT
GATTGCCTGGTGAACCGGGGAGGACCTGGCCGGAGTCATGTGGCAGCATTAAGAAGTCGTTTCGAATTGGAATATGCTCTAAATGCAAGG
TCCTATGCTGCTTTGTCCCAAAGTGCTGGACAATATTCCTCTCAAGGTCTGTCTTTGGAGGAGATGAAAAGAAGTCTTCAATACACACCC
ATTGACAAATATGGCTATGTATCCGATCCCATGAGCTCAATGCATTTTCATTCTTGCCGAAATAGTAGCAGCTTTGAGGACAGCAGCTGA

>In-frame_CAAP1_ENST00000333916_chr9_26861064_-_TNNI3K_ENST00000326637_chr1_74832940_+_2070nt
ATGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCC
GCGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTT
AGTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACC
GACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGT
GACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGC
TTCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAG
GAACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGAT
GATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAA
GGTTTGGAATTAAAACAAGGGCATGATGCCATTGTCACACTCCTGAAGCATTATAAGAGACCACAAGATGAATTGCCCTGTAATGAATAT
TCTCAGCCTGGAGGAGATGGCTCCTATGTGTCTGTTCCATCACCCTTGGGGAAGATTAAAAGCATGACAAAAGAGAAGGCAGATATTCTC
CTCCTAAGAGCTGGATTGCCTTCACATTTCCATCTTCAGCTCTCAGAAATTGAGTTCCATGAGATTATTGGCTCAGGTTCTTTTGGGAAA
GTATATAAAGGACGATGCAGAAATAAAATAGTGGCTATAAAACGTTATCGAGCCAATACCTACTGCTCCAAGTCAGATGTGGATATGTTT
TGCCGAGAGGTGTCCATTCTCTGCCAGCTCAATCATCCCTGCGTAATTCAGTTTGTGGGTGCTTGCTTGAATGATCCCAGCCAGTTTGCC
ATTGTCACTCAATACATATCAGGGGGTTCTCTGTTCTCCCTCCTTCATGAGCAGAAGAGGATTCTTGATTTGCAGTCTAAATTAATTATT
GCAGTAGATGTTGCCAAAGGCATGGAGTACCTTCACAACCTGACACAGCCAATTATACATCGTGACTTGAACAGTCACAATATTCTTCTC
TATGAGGATGGGCATGCTGTGGTGGCAGATTTTGGAGAATCAAGATTTCTACAGTCTCTGGATGAAGACAACATGACAAAACAACCTGGG
AACCTCCGTTGGATGGCTCCTGAGGTGTTCACGCAGTGCACTCGGTACACCATCAAAGCAGATGTCTTCAGCTATGCTCTGTGTCTGTGG
GAAATTCTCACTGGCGAAATTCCATTCGCTCATCTCAAGCCAGCGGCTGCGGCAGCAGACATGGCTTACCACCACATCAGACCTCCCATT
GGCTATTCCATTCCCAAGCCCATATCATCTCTGCTGATACGAGGGTGGAACGCATGTCCTGAAGGAAGACCCGAATTTTCTGAAGTTGTC
ATGAAGTTAGAAGAGTGTCTCTGCAACATTGAGCTGATGTCTCCTGCATCAAGTAACAGCAGTGGGTCTCTCTCACCTTCTTCTTCTTCT
GATTGCCTGGTGAACCGGGGAGGACCTGGCCGGAGTCATGTGGCAGCATTAAGAAGTCGTTTCGAATTGGAATATGCTCTAAATGCAAGG
TCCTATGCTGCTTTGTCCCAAAGTGCTGGACAATATTCCTCTCAAGGTCTGTCTTTGGAGGAGATGAAAAGAAGTCTTCAATACACACCC
ATTGACAAATATGGCTATGTATCCGATCCCATGAGCTCAATGCATTTTCATTCTTGCCGAAATAGTAGCAGCTTTGAGGACAGCAGCTGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CAAP1_ENST00000333916_chr9_26861064_-_TNNI3K_ENST00000370891_chr1_74832940_+_2601nt
CCAGTGCCTGCCGCCCACGGCCGCAGGAGTCGGGCTTCGGTCGCACCAGAGACAGCGGACTTTCCTCCGATGGTTGCAGCAGAGGGATCA
TGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCCG
CGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTTA
GTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACCG
ACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTG
ACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCT
TCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGG
AACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATG
ATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAAG
GTTTGGAATTAAAACAAGGGCATGATGCCATTGTCACACTCCTGAAGCATTATAAGAGACCACAAGATGAATTGCCCTGTAATGAATATT
CTCAGCCTGGAGGAGATGGCTCCTATGTGTCTGTTCCATCACCCTTGGGGAAGATTAAAAGCATGACAAAAGAGAAGGCAGATATTCTCC
TCCTAAGAGCTGGATTGCCTTCACATTTCCATCTTCAGCTCTCAGAAATTGAGTTCCATGAGATTATTGGCTCAGGTTCTTTTGGGAAAG
TATATAAAGGACGATGCAGAAATAAAATAGTGGCTATAAAACGTTATCGAGCCAATACCTACTGCTCCAAGTCAGATGTGGATATGTTTT
GCCGAGAGGTGTCCATTCTCTGCCAGCTCAATCATCCCTGCGTAATTCAGTTTGTGGGTGCTTGCTTGAATGATCCCAGCCAGTTTGCCA
TTGTCACTCAATACATATCAGGGGGTTCTCTGTTCTCCCTCCTTCATGAGCAGAAGAGGATTCTTGATTTGCAGTCTAAATTAATTATTG
CAGTAGATGTTGCCAAAGGCATGGAGTACCTTCACAACCTGACACAGCCAATTATACATCGTGACTTGAACAGTCACAATATTCTTCTCT
ATGAGGATGGGCATGCTGTGGTGGCAGATTTTGGAGAATCAAGATTTCTACAGTCTCTGGATGAAGACAACATGACAAAACAACCTGGGA
ACCTCCGTTGGATGGCTCCTGAGGTGTTCACGCAGTGCACTCGGTACACCATCAAAGCAGATGTCTTCAGCTATGCTCTGTGTCTGTGGG
AAATTCTCACTGGCGAAATTCCATTCGCTCATCTCAAGCCAGCGGCTGCGGCAGCAGACATGGCTTACCACCACATCAGACCTCCCATTG
GCTATTCCATTCCCAAGCCCATATCATCTCTGCTGATACGAGGGTGGAACGCATGTCCTGAAGGAAGACCCGAATTTTCTGAAGTTGTCA
TGAAGTTAGAAGAGTGTCTCTGCAACATTGAGCTGATGTCTCCTGCATCAAGTAACAGCAGTGGGTCTCTCTCACCTTCTTCTTCTTCTG
ATTGCCTGGTGAACCGGGGAGGACCTGGCCGGAGTCATGTGGCAGCATTAAGAAGTCGTTTCGAATTGGAATATGCTCTAAATGCAAGGT
CCTATGCTGCTTTGTCCCAAAGTGCTGGACAATATTCCTCTCAAGGTCTGTCTTTGGAGGAGATGAAAAGAAGTCTTCAATACACACCCA
TTGACAAATATGGCTATGTATCCGATCCCATGAGCTCAATGCATTTTCATTCTTGCCGAAATAGTAGCAGCTTTGAGGACAGCAGCTGAC
AGCATTCGGCGTATACCTAAGGAGAGTTTTTTCCCCGAACTGACAGCAACGATTCCAACCACGGCAAGCTGGCTTCCAACTATAACATTT
TACTCTCAAAGGTCTCCTTAAATTGGGCTTGTTTTTACTTGTCCTATTTAATTCCCCACTATTAGCAGGCTTTGGATTTGTGCCTAAGGA
ATAATATGCAAAAGAACCAAGACAGAATGTATATGAAGAATTGTTTTTAATTTTGTAAATTAAAAAAAAATTTAGATCGTTACTTGGAAA
TGGAGCCTAAGTCTGTGGTGGACAGATAATAATTATGTTTTCCTGGGCTGAATTATGTAGACTTGTGTTTGACAGCTATGGGTTTATTTC

>In-frame_CAAP1_ENST00000333916_chr9_26861064_-_TNNI3K_ENST00000326637_chr1_74832940_+_2601nt
CCAGTGCCTGCCGCCCACGGCCGCAGGAGTCGGGCTTCGGTCGCACCAGAGACAGCGGACTTTCCTCCGATGGTTGCAGCAGAGGGATCA
TGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCCG
CGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTTA
GTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACCG
ACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTG
ACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCT
TCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGG
AACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATG
ATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAAG
GTTTGGAATTAAAACAAGGGCATGATGCCATTGTCACACTCCTGAAGCATTATAAGAGACCACAAGATGAATTGCCCTGTAATGAATATT
CTCAGCCTGGAGGAGATGGCTCCTATGTGTCTGTTCCATCACCCTTGGGGAAGATTAAAAGCATGACAAAAGAGAAGGCAGATATTCTCC
TCCTAAGAGCTGGATTGCCTTCACATTTCCATCTTCAGCTCTCAGAAATTGAGTTCCATGAGATTATTGGCTCAGGTTCTTTTGGGAAAG
TATATAAAGGACGATGCAGAAATAAAATAGTGGCTATAAAACGTTATCGAGCCAATACCTACTGCTCCAAGTCAGATGTGGATATGTTTT
GCCGAGAGGTGTCCATTCTCTGCCAGCTCAATCATCCCTGCGTAATTCAGTTTGTGGGTGCTTGCTTGAATGATCCCAGCCAGTTTGCCA
TTGTCACTCAATACATATCAGGGGGTTCTCTGTTCTCCCTCCTTCATGAGCAGAAGAGGATTCTTGATTTGCAGTCTAAATTAATTATTG
CAGTAGATGTTGCCAAAGGCATGGAGTACCTTCACAACCTGACACAGCCAATTATACATCGTGACTTGAACAGTCACAATATTCTTCTCT
ATGAGGATGGGCATGCTGTGGTGGCAGATTTTGGAGAATCAAGATTTCTACAGTCTCTGGATGAAGACAACATGACAAAACAACCTGGGA
ACCTCCGTTGGATGGCTCCTGAGGTGTTCACGCAGTGCACTCGGTACACCATCAAAGCAGATGTCTTCAGCTATGCTCTGTGTCTGTGGG
AAATTCTCACTGGCGAAATTCCATTCGCTCATCTCAAGCCAGCGGCTGCGGCAGCAGACATGGCTTACCACCACATCAGACCTCCCATTG
GCTATTCCATTCCCAAGCCCATATCATCTCTGCTGATACGAGGGTGGAACGCATGTCCTGAAGGAAGACCCGAATTTTCTGAAGTTGTCA
TGAAGTTAGAAGAGTGTCTCTGCAACATTGAGCTGATGTCTCCTGCATCAAGTAACAGCAGTGGGTCTCTCTCACCTTCTTCTTCTTCTG
ATTGCCTGGTGAACCGGGGAGGACCTGGCCGGAGTCATGTGGCAGCATTAAGAAGTCGTTTCGAATTGGAATATGCTCTAAATGCAAGGT
CCTATGCTGCTTTGTCCCAAAGTGCTGGACAATATTCCTCTCAAGGTCTGTCTTTGGAGGAGATGAAAAGAAGTCTTCAATACACACCCA
TTGACAAATATGGCTATGTATCCGATCCCATGAGCTCAATGCATTTTCATTCTTGCCGAAATAGTAGCAGCTTTGAGGACAGCAGCTGAC
AGCATTCGGCGTATACCTAAGGAGAGTTTTTTCCCCGAACTGACAGCAACGATTCCAACCACGGCAAGCTGGCTTCCAACTATAACATTT
TACTCTCAAAGGTCTCCTTAAATTGGGCTTGTTTTTACTTGTCCTATTTAATTCCCCACTATTAGCAGGCTTTGGATTTGTGCCTAAGGA
ATAATATGCAAAAGAACCAAGACAGAATGTATATGAAGAATTGTTTTTAATTTTGTAAATTAAAAAAAAATTTAGATCGTTACTTGGAAA
TGGAGCCTAAGTCTGTGGTGGACAGATAATAATTATGTTTTCCTGGGCTGAATTATGTAGACTTGTGTTTGACAGCTATGGGTTTATTTC


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FusionGenePPI for CAAP1_TNNI3K


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CAAP1XRCC4, KAT7, PTN, ELAVL1, APP, VCP, IKBKG, THOC1, AKAP17A, JMJD6, DLSTTNNI3KTNNI3, MYBPC3, ACTC1, ACTA1, FABP3, HADHB, AIP, HSP90AA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CAAP1_TNNI3K


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CAAP1_TNNI3K


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTNNI3KC4015285CARDIAC CONDUCTION DISEASE WITH OR WITHOUT DILATED CARDIOMYOPATHY1ORPHANET;UNIPROT