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Fusion gene ID: 5123 |
FusionGeneSummary for C9orf85_ARHGAP10 |
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Fusion gene information | Fusion gene name: C9orf85_ARHGAP10 | Fusion gene ID: 5123 | Hgene | Tgene | Gene symbol | C9orf85 | ARHGAP10 | Gene ID | 138241 | 79658 |
Gene name | chromosome 9 open reading frame 85 | Rho GTPase activating protein 10 | |
Synonyms | - | GRAF2|PS-GAP|PSGAP | |
Cytomap | 9q21.13 | 4q31.23 | |
Type of gene | protein-coding | protein-coding | |
Description | uncharacterized protein C9orf85 | rho GTPase-activating protein 10GTPase regulator associated with focal adhesion kinase 2graf-related protein 2rho-type GTPase-activating protein 10 | |
Modification date | 20180403 | 20180523 | |
UniProtAcc | Q96MD7 | A1A4S6 | |
Ensembl transtripts involved in fusion gene | ENST00000334731, ENST00000377031, ENST00000486911, | ENST00000336498, ENST00000414545, ENST00000510076, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 6 X 3=108 |
# samples | 3 | 6 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C9orf85 [Title/Abstract] AND ARHGAP10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE931282 | C9orf85 | chr9 | 74587484 | - | ARHGAP10 | chr4 | 148886241 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000334731 | ENST00000336498 | C9orf85 | chr9 | 74587484 | - | ARHGAP10 | chr4 | 148886241 | + |
intron-3CDS | ENST00000334731 | ENST00000414545 | C9orf85 | chr9 | 74587484 | - | ARHGAP10 | chr4 | 148886241 | + |
intron-intron | ENST00000334731 | ENST00000510076 | C9orf85 | chr9 | 74587484 | - | ARHGAP10 | chr4 | 148886241 | + |
intron-3CDS | ENST00000377031 | ENST00000336498 | C9orf85 | chr9 | 74587484 | - | ARHGAP10 | chr4 | 148886241 | + |
intron-3CDS | ENST00000377031 | ENST00000414545 | C9orf85 | chr9 | 74587484 | - | ARHGAP10 | chr4 | 148886241 | + |
intron-intron | ENST00000377031 | ENST00000510076 | C9orf85 | chr9 | 74587484 | - | ARHGAP10 | chr4 | 148886241 | + |
intron-3CDS | ENST00000486911 | ENST00000336498 | C9orf85 | chr9 | 74587484 | - | ARHGAP10 | chr4 | 148886241 | + |
intron-3CDS | ENST00000486911 | ENST00000414545 | C9orf85 | chr9 | 74587484 | - | ARHGAP10 | chr4 | 148886241 | + |
intron-intron | ENST00000486911 | ENST00000510076 | C9orf85 | chr9 | 74587484 | - | ARHGAP10 | chr4 | 148886241 | + |
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FusionProtFeatures for C9orf85_ARHGAP10 |
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Hgene | Tgene |
C9orf85 | ARHGAP10 |
GTPase activator for the small GTPases RhoA and Cdc42 byconverting them to an inactive GDP-bound state. Essential forPTKB2 regulation of cytoskeletal organization via Rho familyGTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinaseactivity and changes its localization from the nucleus to theperinuclear region. Stabilizes PAK-2p34 thereby increasingstimulation of cell death (By similarity). {ECO:0000250,ECO:0000269|PubMed:11432776}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C9orf85_ARHGAP10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for C9orf85_ARHGAP10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C9orf85_ARHGAP10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C9orf85_ARHGAP10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |