![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 512 |
FusionGeneSummary for ACTB_AGAP1 |
![]() |
Fusion gene information | Fusion gene name: ACTB_AGAP1 | Fusion gene ID: 512 | Hgene | Tgene | Gene symbol | ACTB | AGAP1 | Gene ID | 60 | 116987 |
Gene name | actin beta | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | |
Synonyms | BRWS1|PS1TP5BP1 | AGAP-1|CENTG2|GGAP1|cnt-g2 | |
Cytomap | 7p22.1 | 2q37.2 | |
Type of gene | protein-coding | protein-coding | |
Description | actin, cytoplasmic 1I(2)-actinPS1TP5-binding protein 1beta cytoskeletal actin | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P60709 | Q9UPQ3 | |
Ensembl transtripts involved in fusion gene | ENST00000464611, ENST00000331789, | ENST00000336665, ENST00000304032, ENST00000409538, ENST00000428334, ENST00000409457, | |
Fusion gene scores | * DoF score | 28 X 19 X 14=7448 | 5 X 5 X 3=75 |
# samples | 37 | 5 | |
** MAII score | log2(37/7448*10)=-4.33125589704248 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACTB [Title/Abstract] AND AGAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACTB | GO:0098974 | postsynaptic actin cytoskeleton organization | 18341992 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE707882 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000464611 | ENST00000336665 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
intron-intron | ENST00000464611 | ENST00000304032 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
intron-intron | ENST00000464611 | ENST00000409538 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
intron-intron | ENST00000464611 | ENST00000428334 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
intron-intron | ENST00000464611 | ENST00000409457 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
intron-intron | ENST00000331789 | ENST00000336665 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
intron-intron | ENST00000331789 | ENST00000304032 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
intron-intron | ENST00000331789 | ENST00000409538 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
intron-intron | ENST00000331789 | ENST00000428334 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
intron-intron | ENST00000331789 | ENST00000409457 | ACTB | chr7 | 5568826 | - | AGAP1 | chr2 | 237015903 | + |
Top |
FusionProtFeatures for ACTB_AGAP1 |
![]() |
Hgene | Tgene |
ACTB | AGAP1 |
GTPase-activating protein for ARF1 and, to a lesserextent, ARF5. Directly and specifically regulates the adapterprotein 3 (AP-3)-dependent trafficking of proteins in theendosomal-lysosomal system. {ECO:0000269|PubMed:12640130}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ACTB_AGAP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ACTB_AGAP1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ACTB_AGAP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ACTB_AGAP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACTB | C2239176 | Liver carcinoma | 2 | CTD_human |
Hgene | ACTB | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | ACTB | C0009363 | Congenital ocular coloboma (disorder) | 1 | CTD_human |
Hgene | ACTB | C0013393 | Dysostoses | 1 | CTD_human |
Hgene | ACTB | C0013421 | Dystonia | 1 | CTD_human |
Hgene | ACTB | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0018784 | Sensorineural Hearing Loss (disorder) | 1 | CTD_human;HPO |
Hgene | ACTB | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | ACTB | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Hgene | ACTB | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ACTB | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | ACTB | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ACTB | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | ACTB | C0242184 | Hypoxia | 1 | CTD_human |
Hgene | ACTB | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | ACTB | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
Hgene | ACTB | C1846331 | Juvenile-onset dystonia | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | ACTB | C1855722 | Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation | 1 | ORPHANET;UNIPROT |
Tgene | AGAP1 | C0004352 | Autistic Disorder | 1 | CTD_human |