	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 5099

FusionGeneSummary for C8orf44_RAD17

Fusion gene summary

Fusion gene information	Fusion gene name: C8orf44_RAD17
	Fusion gene ID: 5099
		Hgene	Tgene
	Gene symbol	C8orf44	RAD17
	Gene ID	56260	5884
	Gene name	chromosome 8 open reading frame 44	RAD17 checkpoint clamp loader component
	Synonyms	-	CCYC\|HRAD17\|R24L\|RAD17SP\|RAD24
	Cytomap	8q13.1	5q13.2
	Type of gene	protein-coding	protein-coding
	Description	putative uncharacterized protein C8orf44	cell cycle checkpoint protein RAD17RAD1 homologRAD17 homologRF-C activator 1 homologRad17-like proteincell cycle checkpoint protein (RAD17)
	Modification date	20180519	20180523
	UniProtAcc	Q96CB5	O75943
	Ensembl transtripts involved in fusion gene	ENST00000519561, ENST00000521889, ENST00000390159, ENST00000518860,	ENST00000361732, ENST00000509734, ENST00000354868, ENST00000521422, ENST00000504177, ENST00000354312, ENST00000345306, ENST00000305138, ENST00000282891, ENST00000358030, ENST00000380774,
Fusion gene scores	* DoF score	2 X 2 X 2=8	5 X 5 X 4=100
	# samples	2	5
	** MAII score	log2(2/8*10)=1.32192809488736	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: C8orf44 [Title/Abstract] AND RAD17 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AK123514	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000519561	ENST00000361732	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000519561	ENST00000509734	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000519561	ENST00000354868	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000519561	ENST00000521422	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000519561	ENST00000504177	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000519561	ENST00000354312	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000519561	ENST00000345306	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000519561	ENST00000305138	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000519561	ENST00000282891	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000519561	ENST00000358030	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000519561	ENST00000380774	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000361732	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000509734	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000354868	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000521422	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000504177	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000354312	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000345306	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000305138	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000282891	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000358030	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000521889	ENST00000380774	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000361732	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000509734	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000354868	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000521422	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000504177	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000354312	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000345306	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000305138	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000282891	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000358030	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000390159	ENST00000380774	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000361732	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000509734	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000354868	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000521422	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000504177	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000354312	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000345306	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000305138	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000282891	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000358030	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+
intron-intron	ENST00000518860	ENST00000380774	C8orf44	chr8	67580665	+	RAD17	chr5	68666385	+

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FusionProtFeatures for C8orf44_RAD17

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
C8orf44 Q96CB5	RAD17 O75943

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for C8orf44_RAD17

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C8orf44_RAD17

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for C8orf44_RAD17

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for C8orf44_RAD17

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 5099

FusionGeneSummary for C8orf44_RAD17

FusionProtFeatures for C8orf44_RAD17

FusionGeneSequence for C8orf44_RAD17

FusionGenePPI for C8orf44_RAD17

RelatedDrugs for C8orf44_RAD17

RelatedDiseases for C8orf44_RAD17