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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5043

FusionGeneSummary for C6orf106_SORBS2

check button Fusion gene summary
Fusion gene informationFusion gene name: C6orf106_SORBS2
Fusion gene ID: 5043
HgeneTgene
Gene symbol

C6orf106

SORBS2

Gene ID

64771

8470

Gene namechromosome 6 open reading frame 106sorbin and SH3 domain containing 2
SynonymsFP852|dJ391O22.4ARGBP2|PRO0618
Cytomap

6p21.31

4q35.1

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C6orf106sorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2
Modification date2018052320180523
UniProtAcc

Q9H6K1

O94875

Ensembl transtripts involved in fusion geneENST00000374023, ENST00000374026, 
ENST00000374021, 
ENST00000448662, 
ENST00000431808, ENST00000284776, 
ENST00000437304, ENST00000319471, 
ENST00000449407, ENST00000355634, 
ENST00000393528, ENST00000418609, 
ENST00000498125, 
Fusion gene scores* DoF score8 X 3 X 7=16811 X 12 X 7=924
# samples 815
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/924*10)=-2.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C6orf106 [Title/Abstract] AND SORBS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM969290C6orf106chr6

34555147

+SORBS2chr4

186686434

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000374023ENST00000448662C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374023ENST00000431808C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374023ENST00000284776C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374023ENST00000437304C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374023ENST00000319471C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374023ENST00000449407C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374023ENST00000355634C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374023ENST00000393528C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374023ENST00000418609C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374023ENST00000498125C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374026ENST00000448662C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374026ENST00000431808C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374026ENST00000284776C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374026ENST00000437304C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374026ENST00000319471C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374026ENST00000449407C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374026ENST00000355634C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374026ENST00000393528C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374026ENST00000418609C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374026ENST00000498125C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374021ENST00000448662C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374021ENST00000431808C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374021ENST00000284776C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374021ENST00000437304C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374021ENST00000319471C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374021ENST00000449407C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374021ENST00000355634C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374021ENST00000393528C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374021ENST00000418609C6orf106chr6

34555147

+SORBS2chr4

186686434

+
intron-intronENST00000374021ENST00000498125C6orf106chr6

34555147

+SORBS2chr4

186686434

+

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FusionProtFeatures for C6orf106_SORBS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C6orf106

Q9H6K1

SORBS2

O94875


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C6orf106_SORBS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C6orf106_SORBS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C6orf106_SORBS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C6orf106_SORBS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSORBS2C0043094Weight Gain1CTD_human