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Fusion gene ID: 5017 |
FusionGeneSummary for C5AR1_SSR1 |
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Fusion gene information | Fusion gene name: C5AR1_SSR1 | Fusion gene ID: 5017 | Hgene | Tgene | Gene symbol | C5AR1 | SSR1 | Gene ID | 728 | 6745 |
Gene name | complement C5a receptor 1 | signal sequence receptor subunit 1 | |
Synonyms | C5A|C5AR|C5R1|CD88 | TRAPA | |
Cytomap | 19q13.32 | 6p24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | C5a anaphylatoxin chemotactic receptor 1C5a anaphylatoxin receptorC5a ligandC5a-Rcomplement component 5 receptor 1complement component 5a receptor 1 | translocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunit | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P21730 | P43307 | |
Ensembl transtripts involved in fusion gene | ENST00000595501, ENST00000355085, | ENST00000488834, ENST00000474597, ENST00000244763, ENST00000397511, ENST00000534851, ENST00000489567, ENST00000479365, ENST00000462112, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 6 X 3=90 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C5AR1 [Title/Abstract] AND SSR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | C5AR1 | GO:0038178 | complement component C5a signaling pathway | 10571060 |
Hgene | C5AR1 | GO:0042789 | mRNA transcription by RNA polymerase II | 22496247 |
Hgene | C5AR1 | GO:0050679 | positive regulation of epithelial cell proliferation | 22496247 |
Hgene | C5AR1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22496247 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ353656 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000595501 | ENST00000488834 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
intron-intron | ENST00000595501 | ENST00000474597 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
intron-3UTR | ENST00000595501 | ENST00000244763 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
intron-3UTR | ENST00000595501 | ENST00000397511 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
intron-3UTR | ENST00000595501 | ENST00000534851 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
intron-intron | ENST00000595501 | ENST00000489567 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
intron-intron | ENST00000595501 | ENST00000479365 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
intron-intron | ENST00000595501 | ENST00000462112 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
3UTR-intron | ENST00000355085 | ENST00000488834 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
3UTR-intron | ENST00000355085 | ENST00000474597 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
3UTR-3UTR | ENST00000355085 | ENST00000244763 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
3UTR-3UTR | ENST00000355085 | ENST00000397511 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
3UTR-3UTR | ENST00000355085 | ENST00000534851 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
3UTR-intron | ENST00000355085 | ENST00000489567 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
3UTR-intron | ENST00000355085 | ENST00000479365 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
3UTR-intron | ENST00000355085 | ENST00000462112 | C5AR1 | chr19 | 47824151 | + | SSR1 | chr6 | 7288877 | - |
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FusionProtFeatures for C5AR1_SSR1 |
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Hgene | Tgene |
C5AR1 | SSR1 |
Receptor for the chemotactic and inflammatory peptideanaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471,PubMed:9553099, PubMed:10636859, PubMed:15153520,PubMed:29300009). The ligand interacts with at least two sites onthe receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region whichactivates downstream signaling events (PubMed:8182049,PubMed:7622471, PubMed:9553099). Receptor activation stimulateschemotaxis, granule enzyme release, intracellular calcium releaseand superoxide anion production (PubMed:10636859,PubMed:15153520). {ECO:0000269|PubMed:10636859,ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994,ECO:0000269|PubMed:29300009, ECO:0000269|PubMed:7622471,ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C5AR1_SSR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for C5AR1_SSR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C5AR1_SSR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C5AR1_SSR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | C5AR1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | C5AR1 | C0036983 | Septic Shock | 1 | CTD_human |