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Fusion gene ID: 5015 |
FusionGeneSummary for C4orf46_FAM188A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C4orf46_FAM188A | Fusion gene ID: 5015 | Hgene | Tgene | Gene symbol | C4orf46 | FAM188A | Gene ID | 201725 | 80013 |
| Gene name | chromosome 4 open reading frame 46 | MINDY lysine 48 deubiquitinase 3 | |
| Synonyms | RCDG1 | C10orf97|CARP|DERP5|FAM188A|MST126|MSTP126|my042 | |
| Cytomap | 4q32.1 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | renal cancer differentiation gene 1 protein | ubiquitin carboxyl-terminal hydrolase MINDY-3CARD-containing proteinMINDY deubiquitinase 3caspase recruitment domain containing pro-apoptotic proteindermal papilla-derived protein 5deubiquitinating enzyme MINDY-3family with sequence similarity 188 m | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q504U0 | ||
| Ensembl transtripts involved in fusion gene | ENST00000379205, ENST00000508457, ENST00000508836, | ENST00000378036, ENST00000477891, ENST00000277632, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 4=48 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C4orf46 [Title/Abstract] AND FAM188A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF695980 | C4orf46 | chr4 | 159592767 | - | FAM188A | chr10 | 15824225 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000379205 | ENST00000378036 | C4orf46 | chr4 | 159592767 | - | FAM188A | chr10 | 15824225 | - |
| 5CDS-5UTR | ENST00000379205 | ENST00000477891 | C4orf46 | chr4 | 159592767 | - | FAM188A | chr10 | 15824225 | - |
| 5CDS-5UTR | ENST00000379205 | ENST00000277632 | C4orf46 | chr4 | 159592767 | - | FAM188A | chr10 | 15824225 | - |
| In-frame | ENST00000508457 | ENST00000378036 | C4orf46 | chr4 | 159592767 | - | FAM188A | chr10 | 15824225 | - |
| 5CDS-5UTR | ENST00000508457 | ENST00000477891 | C4orf46 | chr4 | 159592767 | - | FAM188A | chr10 | 15824225 | - |
| 5CDS-5UTR | ENST00000508457 | ENST00000277632 | C4orf46 | chr4 | 159592767 | - | FAM188A | chr10 | 15824225 | - |
| intron-3CDS | ENST00000508836 | ENST00000378036 | C4orf46 | chr4 | 159592767 | - | FAM188A | chr10 | 15824225 | - |
| intron-5UTR | ENST00000508836 | ENST00000477891 | C4orf46 | chr4 | 159592767 | - | FAM188A | chr10 | 15824225 | - |
| intron-5UTR | ENST00000508836 | ENST00000277632 | C4orf46 | chr4 | 159592767 | - | FAM188A | chr10 | 15824225 | - |
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FusionProtFeatures for C4orf46_FAM188A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C4orf46 | FAM188A |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C4orf46_FAM188A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_C4orf46_ENST00000379205_chr4_159592767_-_FAM188A_ENST00000378036_chr10_15824225_-_136aa MADPEELQVSSPPPPPPSSPSSSDASAASSPGGPVSLGWPVPSRSSGPTVDQLEEVELQIGDGSSGPESFTVYHYNGLKQSNYNEKVMYV >In-frame_C4orf46_ENST00000508457_chr4_159592767_-_FAM188A_ENST00000378036_chr10_15824225_-_136aa MADPEELQVSSPPPPPPSSPSSSDASAASSPGGPVSLGWPVPSRSSGPTVDQLEEVELQIGDGSSGPESFTVYHYNGLKQSNYNEKVMYV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_C4orf46_ENST00000379205_chr4_159592767_-_FAM188A_ENST00000378036_chr10_15824225_-_408nt ATGGCCGACCCTGAGGAGTTGCAGGTTTCTTCGCCGCCCCCGCCGCCTCCCTCTTCTCCCTCCTCTTCAGACGCCTCTGCAGCATCTTCC CCGGGCGGCCCAGTGAGTTTGGGCTGGCCAGTTCCGAGCAGGAGCAGCGGCCCAACGGTGGACCAGCTGGAGGAAGTGGAGCTGCAGATC GGAGACGGCTCCAGTGGTCCAGAATCTTTTACTGTCTACCACTACAATGGATTGAAGCAGTCAAATTATAATGAAAAGGTCATGTACGTA GAAGGGACTGCAGTTGTGATGGGTTTTGAAGATCCCATGCTACAGACAGATGACACTCCTATTAAACGCTGTCTGCAAACCAAATGGCCA >In-frame_C4orf46_ENST00000508457_chr4_159592767_-_FAM188A_ENST00000378036_chr10_15824225_-_408nt ATGGCCGACCCTGAGGAGTTGCAGGTTTCTTCGCCGCCCCCGCCGCCTCCCTCTTCTCCCTCCTCTTCAGACGCCTCTGCAGCATCTTCC CCGGGCGGCCCAGTGAGTTTGGGCTGGCCAGTTCCGAGCAGGAGCAGCGGCCCAACGGTGGACCAGCTGGAGGAAGTGGAGCTGCAGATC GGAGACGGCTCCAGTGGTCCAGAATCTTTTACTGTCTACCACTACAATGGATTGAAGCAGTCAAATTATAATGAAAAGGTCATGTACGTA GAAGGGACTGCAGTTGTGATGGGTTTTGAAGATCCCATGCTACAGACAGATGACACTCCTATTAAACGCTGTCTGCAAACCAAATGGCCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_C4orf46_ENST00000379205_chr4_159592767_-_FAM188A_ENST00000378036_chr10_15824225_-_1475nt GCCCTTCGAGATCGATTGGAGGCTCGCGCAGGAGCCGTGAGTTGCCTAAGGTGAATTGACTCATATGATTGGCTGTCCCGAAAAATGAAA CGTCTTTGTGGTCCGGGGCTGAGACCCACGAGGAGACTGGGCGGGATTTCTGGCGTTAGGAGGCGGGGCCTTTCGGCTTTGGGCGCGAGT GGTTAAAAGACAGTTGGTGTCGGTTCGGCTTCTCGGGTCGGATTCCGCGGTCCCAACCCTTCCCCATGGCCGACCCTGAGGAGTTGCAGG TTTCTTCGCCGCCCCCGCCGCCTCCCTCTTCTCCCTCCTCTTCAGACGCCTCTGCAGCATCTTCCCCGGGCGGCCCAGTGAGTTTGGGCT GGCCAGTTCCGAGCAGGAGCAGCGGCCCAACGGTGGACCAGCTGGAGGAAGTGGAGCTGCAGATCGGAGACGGCTCCAGTGGTCCAGAAT CTTTTACTGTCTACCACTACAATGGATTGAAGCAGTCAAATTATAATGAAAAGGTCATGTACGTAGAAGGGACTGCAGTTGTGATGGGTT TTGAAGATCCCATGCTACAGACAGATGACACTCCTATTAAACGCTGTCTGCAAACCAAATGGCCATACATTGAGTTACTCTGGACCACAG ATCGCTCTCCTTCACTAAATTAATTTGTCTAAGTATTTATAAGGAAGATCTTAATAACAGATGTTGAAAGAAGGAGTCAAGACTGGCAAT TGGCTGGATTAAGCTAAACACTGGTATCACTGATTAACTGTAAATAACAATTAAAAACACATTTTCAGTGTTTATGATATGTTTAAATTA TTTGTCCTAAAGCTTTATGTTAAAGATTATCCTATTTTACCCCTTCGTGTGAAATTTACTAGCAAAATTAAGCTTTCATCAAAGTTCATC ACTTTTGCATTCAGATACTTGGTCATTTACTTACCAAATTACAAACGCAATACTACAGCATTTGTATATTAAGTATCACAGTTACTATTG ATAAACTACTTTTGGGTTTTATTTCATTGAGGCACTTTTTTTATTGTTTGAATGATTCCGGCTTGTAATATATCAGCCTCTACAATGAAA TGCAGAAGAGTTCATTTTTCTAAGATCTGTTTTTCATTAGAAATATTGACAAATAACACATTGTCAACCTGGATCCTTTGACAATTTACT TAACTCTGGCATGTTCACAAAAAGTAGAAACTCTAAGAGACCATTACCATTTATTCACAGATGTATAGGGGATGTATTCTAAAAACTGAC AGAAAAGAGAATCTGATAGTCAACACTGTTAACTTTTACTGTGTAATTGCCAAATACACTTTTCCAAATTTGTCCCAACAGCCCTGTAAG CCAGCTTTCTTCTATATTTATAAACACGATAAATGCATGAGAAGATCTGTTATTACATTAGTATATTACGTTATTTATTATGATCCTAGT >In-frame_C4orf46_ENST00000508457_chr4_159592767_-_FAM188A_ENST00000378036_chr10_15824225_-_1321nt GGGGCCTTTCGGCTTTGGGCGCGAGTGGTTAAAAGACAGTTGGTGTCGGTTCGGCTTCTCGGGTCGGATTCCGCGGTCCCAACCCTTCCC CATGGCCGACCCTGAGGAGTTGCAGGTTTCTTCGCCGCCCCCGCCGCCTCCCTCTTCTCCCTCCTCTTCAGACGCCTCTGCAGCATCTTC CCCGGGCGGCCCAGTGAGTTTGGGCTGGCCAGTTCCGAGCAGGAGCAGCGGCCCAACGGTGGACCAGCTGGAGGAAGTGGAGCTGCAGAT CGGAGACGGCTCCAGTGGTCCAGAATCTTTTACTGTCTACCACTACAATGGATTGAAGCAGTCAAATTATAATGAAAAGGTCATGTACGT AGAAGGGACTGCAGTTGTGATGGGTTTTGAAGATCCCATGCTACAGACAGATGACACTCCTATTAAACGCTGTCTGCAAACCAAATGGCC ATACATTGAGTTACTCTGGACCACAGATCGCTCTCCTTCACTAAATTAATTTGTCTAAGTATTTATAAGGAAGATCTTAATAACAGATGT TGAAAGAAGGAGTCAAGACTGGCAATTGGCTGGATTAAGCTAAACACTGGTATCACTGATTAACTGTAAATAACAATTAAAAACACATTT TCAGTGTTTATGATATGTTTAAATTATTTGTCCTAAAGCTTTATGTTAAAGATTATCCTATTTTACCCCTTCGTGTGAAATTTACTAGCA AAATTAAGCTTTCATCAAAGTTCATCACTTTTGCATTCAGATACTTGGTCATTTACTTACCAAATTACAAACGCAATACTACAGCATTTG TATATTAAGTATCACAGTTACTATTGATAAACTACTTTTGGGTTTTATTTCATTGAGGCACTTTTTTTATTGTTTGAATGATTCCGGCTT GTAATATATCAGCCTCTACAATGAAATGCAGAAGAGTTCATTTTTCTAAGATCTGTTTTTCATTAGAAATATTGACAAATAACACATTGT CAACCTGGATCCTTTGACAATTTACTTAACTCTGGCATGTTCACAAAAAGTAGAAACTCTAAGAGACCATTACCATTTATTCACAGATGT ATAGGGGATGTATTCTAAAAACTGACAGAAAAGAGAATCTGATAGTCAACACTGTTAACTTTTACTGTGTAATTGCCAAATACACTTTTC CAAATTTGTCCCAACAGCCCTGTAAGCCAGCTTTCTTCTATATTTATAAACACGATAAATGCATGAGAAGATCTGTTATTACATTAGTAT |
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FusionGenePPI for C4orf46_FAM188A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C4orf46_FAM188A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C4orf46_FAM188A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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