![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 5012 |
FusionGeneSummary for C4orf32_ARHGEF38 |
![]() |
Fusion gene information | Fusion gene name: C4orf32_ARHGEF38 | Fusion gene ID: 5012 | Hgene | Tgene | Gene symbol | C4orf32 | ARHGEF38 | Gene ID | 54848 |
Gene name | Rho guanine nucleotide exchange factor 38 | ||
Synonyms | - | ||
Cytomap | 4q24 | ||
Type of gene | protein-coding | ||
Description | rho guanine nucleotide exchange factor 38Rho guanine nucleotide exchange factor (GEF) 38 | ||
Modification date | 20180523 | ||
UniProtAcc | Q9NXL2 | ||
Ensembl transtripts involved in fusion gene | ENST00000309733, | ENST00000420470, ENST00000508036, ENST00000265154, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 4 X 4=48 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C4orf32 [Title/Abstract] AND ARHGEF38 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A3U5-01A | C4orf32 | chr4 | 113066889 | + | ARHGEF38 | chr4 | 106627460 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000309733 | ENST00000420470 | C4orf32 | chr4 | 113066889 | + | ARHGEF38 | chr4 | 106627460 | + |
5CDS-intron | ENST00000309733 | ENST00000508036 | C4orf32 | chr4 | 113066889 | + | ARHGEF38 | chr4 | 106627460 | + |
5CDS-intron | ENST00000309733 | ENST00000265154 | C4orf32 | chr4 | 113066889 | + | ARHGEF38 | chr4 | 106627460 | + |
Top |
FusionProtFeatures for C4orf32_ARHGEF38 |
![]() |
Hgene | Tgene |
C4orf32 | ARHGEF38 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May act as a guanine-nucleotide releasing factor.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for C4orf32_ARHGEF38 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for C4orf32_ARHGEF38 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
C4orf32 | ELAVL1, CD27, SGCZ, ATP1B3, CLEC10A, SGCD, RTN4, ZACN, LPAR1, TMEM258, RPN2, REEP5, RTN1, FPR2, C3AR1, ZDHHC11, IPPK, TSPAN2, FZD10, LINGO1, PLP1, VIPR2 | ARHGEF38 | CLASP1, TMEM261 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for C4orf32_ARHGEF38 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for C4orf32_ARHGEF38 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |