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Fusion gene ID: 5011 |
FusionGeneSummary for C4orf29_SLC25A31 |
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Fusion gene information | Fusion gene name: C4orf29_SLC25A31 | Fusion gene ID: 5011 | Hgene | Tgene | Gene symbol | C4orf29 | SLC25A31 | Gene ID | 80167 | 83447 |
Gene name | abhydrolase domain containing 18 | solute carrier family 25 member 31 | |
Synonyms | C4orf29 | AAC4|ANT 4|ANT4|SFEC35kDa | |
Cytomap | 4q28.2 | 4q28.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein ABHD18abhydrolase domain-containing protein 18alpha/beta hydrolase domain-containing protein 18 | ADP/ATP translocase 4ADP,ATP carrier protein 4adenine nucleotide translocase 4adenine nucleotide translocator 4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31sperm flagellar energy carrier protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9H0C2 | ||
Ensembl transtripts involved in fusion gene | ENST00000398965, ENST00000444616, ENST00000388795, | ENST00000281154, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
# samples | 1 | 3 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: C4orf29 [Title/Abstract] AND SLC25A31 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-J9-A8CL-01A | C4orf29 | chr4 | 128910976 | + | SLC25A31 | chr4 | 128694541 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000398965 | ENST00000281154 | C4orf29 | chr4 | 128910976 | + | SLC25A31 | chr4 | 128694541 | + |
Frame-shift | ENST00000444616 | ENST00000281154 | C4orf29 | chr4 | 128910976 | + | SLC25A31 | chr4 | 128694541 | + |
intron-3CDS | ENST00000388795 | ENST00000281154 | C4orf29 | chr4 | 128910976 | + | SLC25A31 | chr4 | 128694541 | + |
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FusionProtFeatures for C4orf29_SLC25A31 |
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Hgene | Tgene |
C4orf29 | SLC25A31 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Catalyzes the exchange of cytoplasmic ADP withmitochondrial ATP across the mitochondrial inner membrane. Mayserve to mediate energy generating and energy consuming processesin the distal flagellum, possibly as a nucleotide shuttle betweenflagellar glycolysis, protein phosphorylation and mechanisms ofmotility. {ECO:0000269|PubMed:17137571}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C4orf29_SLC25A31 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for C4orf29_SLC25A31 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
C4orf29 | SELO, VSIG4, HSPD1, IMPDH1, C1orf85, PDCD1, BPNT1, MGAT5B, LAMP2, YBEY, CD79A, SLC2A12, APLNR, TOR1AIP2, PRIMPOL | SLC25A31 | PPP4C, ZDHHC17 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C4orf29_SLC25A31 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C4orf29_SLC25A31 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |