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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5011

FusionGeneSummary for C4orf29_SLC25A31

check button Fusion gene summary
Fusion gene informationFusion gene name: C4orf29_SLC25A31
Fusion gene ID: 5011
HgeneTgene
Gene symbol

C4orf29

SLC25A31

Gene ID

80167

83447

Gene nameabhydrolase domain containing 18solute carrier family 25 member 31
SynonymsC4orf29AAC4|ANT 4|ANT4|SFEC35kDa
Cytomap

4q28.2

4q28.1

Type of geneprotein-codingprotein-coding
Descriptionprotein ABHD18abhydrolase domain-containing protein 18alpha/beta hydrolase domain-containing protein 18ADP/ATP translocase 4ADP,ATP carrier protein 4adenine nucleotide translocase 4adenine nucleotide translocator 4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31sperm flagellar energy carrier protein
Modification date2018051920180523
UniProtAcc

Q9H0C2

Ensembl transtripts involved in fusion geneENST00000398965, ENST00000444616, 
ENST00000388795, 
ENST00000281154, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C4orf29 [Title/Abstract] AND SLC25A31 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-J9-A8CL-01AC4orf29chr4

128910976

+SLC25A31chr4

128694541

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000398965ENST00000281154C4orf29chr4

128910976

+SLC25A31chr4

128694541

+
Frame-shiftENST00000444616ENST00000281154C4orf29chr4

128910976

+SLC25A31chr4

128694541

+
intron-3CDSENST00000388795ENST00000281154C4orf29chr4

128910976

+SLC25A31chr4

128694541

+

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FusionProtFeatures for C4orf29_SLC25A31


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C4orf29

SLC25A31

Q9H0C2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Catalyzes the exchange of cytoplasmic ADP withmitochondrial ATP across the mitochondrial inner membrane. Mayserve to mediate energy generating and energy consuming processesin the distal flagellum, possibly as a nucleotide shuttle betweenflagellar glycolysis, protein phosphorylation and mechanisms ofmotility. {ECO:0000269|PubMed:17137571}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C4orf29_SLC25A31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C4orf29_SLC25A31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C4orf29SELO, VSIG4, HSPD1, IMPDH1, C1orf85, PDCD1, BPNT1, MGAT5B, LAMP2, YBEY, CD79A, SLC2A12, APLNR, TOR1AIP2, PRIMPOLSLC25A31PPP4C, ZDHHC17


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C4orf29_SLC25A31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C4orf29_SLC25A31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource