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Fusion gene ID: 5009 |
FusionGeneSummary for C4orf22_MYH13 |
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Fusion gene information | Fusion gene name: C4orf22_MYH13 | Fusion gene ID: 5009 | Hgene | Tgene | Gene symbol | C4orf22 | MYH13 | Gene ID | 8735 |
Gene name | myosin heavy chain 13 | ||
Synonyms | MyHC-IIL|MyHC-eo | ||
Cytomap | 17p13.1 | ||
Type of gene | protein-coding | ||
Description | myosin-13extraocular muscle myosin heavy chainextraocular myosin heavy chainmyosin heavy chain, skeletal muscle, extraocularmyosin heavy chain, skeletal muscle, laryngealmyosin, heavy chain 13, skeletal musclemyosin, heavy polypeptide 13, skeletal m | ||
Modification date | 20180519 | ||
UniProtAcc | Q6V702 | Q9UKX3 | |
Ensembl transtripts involved in fusion gene | ENST00000358105, ENST00000508675, ENST00000512931, | ENST00000418404, ENST00000252172, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: C4orf22 [Title/Abstract] AND MYH13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CA335494 | C4orf22 | chr4 | 81580773 | + | MYH13 | chr17 | 10541244 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000358105 | ENST00000418404 | C4orf22 | chr4 | 81580773 | + | MYH13 | chr17 | 10541244 | - |
intron-intron | ENST00000358105 | ENST00000252172 | C4orf22 | chr4 | 81580773 | + | MYH13 | chr17 | 10541244 | - |
intron-intron | ENST00000508675 | ENST00000418404 | C4orf22 | chr4 | 81580773 | + | MYH13 | chr17 | 10541244 | - |
intron-intron | ENST00000508675 | ENST00000252172 | C4orf22 | chr4 | 81580773 | + | MYH13 | chr17 | 10541244 | - |
intron-intron | ENST00000512931 | ENST00000418404 | C4orf22 | chr4 | 81580773 | + | MYH13 | chr17 | 10541244 | - |
intron-intron | ENST00000512931 | ENST00000252172 | C4orf22 | chr4 | 81580773 | + | MYH13 | chr17 | 10541244 | - |
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FusionProtFeatures for C4orf22_MYH13 |
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Hgene | Tgene |
C4orf22 | MYH13 |
Fast twitching myosin mediating the high-velocity andlow-tension contractions of specific striated muscles.{ECO:0000269|PubMed:23908353}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C4orf22_MYH13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for C4orf22_MYH13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C4orf22_MYH13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C4orf22_MYH13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MYH13 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |