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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 5006

FusionGeneSummary for C4orf19_C4orf19

check button Fusion gene summary
Fusion gene informationFusion gene name: C4orf19_C4orf19
Fusion gene ID: 5006
HgeneTgene
Gene symbol

C4orf19

C4orf19

Gene ID

55286

55286

Gene namechromosome 4 open reading frame 19chromosome 4 open reading frame 19
Synonyms--
Cytomap

4p14

4p14

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C4orf19uncharacterized protein C4orf19
Modification date2018051920180519
UniProtAcc

Q8IY42

Q8IY42

Ensembl transtripts involved in fusion geneENST00000381980, ENST00000508175, 
ENST00000284437, 
ENST00000381980, 
ENST00000508175, ENST00000284437, 
Fusion gene scores* DoF score3 X 4 X 3=362 X 3 X 1=6
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/6*10)=2.32192809488736
Context

PubMed: C4orf19 [Title/Abstract] AND C4orf19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG011027C4orf19chr4

37455621

-C4orf19chr4

37592483

-
ChiTaRS3.1CA450533C4orf19chr4

37594571

-C4orf19chr4

37594260

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000381980ENST00000381980C4orf19chr4

37455621

-C4orf19chr4

37592483

-
5UTR-intronENST00000381980ENST00000508175C4orf19chr4

37455621

-C4orf19chr4

37592483

-
5UTR-intronENST00000381980ENST00000284437C4orf19chr4

37455621

-C4orf19chr4

37592483

-
5UTR-3CDSENST00000508175ENST00000381980C4orf19chr4

37455621

-C4orf19chr4

37592483

-
5UTR-intronENST00000508175ENST00000508175C4orf19chr4

37455621

-C4orf19chr4

37592483

-
5UTR-intronENST00000508175ENST00000284437C4orf19chr4

37455621

-C4orf19chr4

37592483

-
intron-3CDSENST00000284437ENST00000381980C4orf19chr4

37455621

-C4orf19chr4

37592483

-
intron-intronENST00000284437ENST00000508175C4orf19chr4

37455621

-C4orf19chr4

37592483

-
intron-intronENST00000284437ENST00000284437C4orf19chr4

37455621

-C4orf19chr4

37592483

-
intron-intronENST00000381980ENST00000381980C4orf19chr4

37594571

-C4orf19chr4

37594260

+
intron-intronENST00000381980ENST00000508175C4orf19chr4

37594571

-C4orf19chr4

37594260

+
intron-intronENST00000381980ENST00000284437C4orf19chr4

37594571

-C4orf19chr4

37594260

+
intron-intronENST00000508175ENST00000381980C4orf19chr4

37594571

-C4orf19chr4

37594260

+
intron-intronENST00000508175ENST00000508175C4orf19chr4

37594571

-C4orf19chr4

37594260

+
intron-intronENST00000508175ENST00000284437C4orf19chr4

37594571

-C4orf19chr4

37594260

+
intron-intronENST00000284437ENST00000381980C4orf19chr4

37594571

-C4orf19chr4

37594260

+
intron-intronENST00000284437ENST00000508175C4orf19chr4

37594571

-C4orf19chr4

37594260

+
intron-intronENST00000284437ENST00000284437C4orf19chr4

37594571

-C4orf19chr4

37594260

+

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FusionProtFeatures for C4orf19_C4orf19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C4orf19

Q8IY42

C4orf19

Q8IY42


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C4orf19_C4orf19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C4orf19_C4orf19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C4orf19_C4orf19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C4orf19_C4orf19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource