![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 5000 |
FusionGeneSummary for C3orf70_TPRG1 |
![]() |
Fusion gene information | Fusion gene name: C3orf70_TPRG1 | Fusion gene ID: 5000 | Hgene | Tgene | Gene symbol | C3orf70 | TPRG1 | Gene ID | 285382 | 285386 |
Gene name | chromosome 3 open reading frame 70 | tumor protein p63 regulated 1 | |
Synonyms | - | FAM79B | |
Cytomap | 3q27.2 | 3q28 | |
Type of gene | protein-coding | protein-coding | |
Description | UPF0524 protein C3orf70 | tumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B | |
Modification date | 20180519 | 20180403 | |
UniProtAcc | A6NLC5 | Q6ZUI0 | |
Ensembl transtripts involved in fusion gene | ENST00000335012, | ENST00000433971, ENST00000345063, ENST00000488841, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 12 X 6 X 6=432 |
# samples | 4 | 13 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/432*10)=-1.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C3orf70 [Title/Abstract] AND TPRG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-E2-A1L7-01A | C3orf70 | chr3 | 184870416 | - | TPRG1 | chr3 | 188844846 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000335012 | ENST00000433971 | C3orf70 | chr3 | 184870416 | - | TPRG1 | chr3 | 188844846 | + |
5CDS-intron | ENST00000335012 | ENST00000345063 | C3orf70 | chr3 | 184870416 | - | TPRG1 | chr3 | 188844846 | + |
5CDS-intron | ENST00000335012 | ENST00000488841 | C3orf70 | chr3 | 184870416 | - | TPRG1 | chr3 | 188844846 | + |
Top |
FusionProtFeatures for C3orf70_TPRG1 |
![]() |
Hgene | Tgene |
C3orf70 | TPRG1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for C3orf70_TPRG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for C3orf70_TPRG1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
C3orf70 | RBM3 | TPRG1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for C3orf70_TPRG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for C3orf70_TPRG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |