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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4969

FusionGeneSummary for C3_ALB

check button Fusion gene summary
Fusion gene informationFusion gene name: C3_ALB
Fusion gene ID: 4969
HgeneTgene
Gene symbol

C3

ALB

Gene ID

718

213

Gene namecomplement C3albumin
SynonymsAHUS5|ARMD9|ASP|C3a|C3b|CPAMD1|HEL-S-62pHSA|PRO0883|PRO0903|PRO1341
Cytomap

19p13.3

4q13.3

Type of geneprotein-codingprotein-coding
Descriptioncomplement C3C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1C3a anaphylatoxinacylation-stimulating protein cleavage productcomplement component 3complement component C3acomplement component C3bepididymis secretory sperm binding prserum albumin
Modification date2018051920180522
UniProtAcc

P01024

P02768

Ensembl transtripts involved in fusion geneENST00000245907, ENST00000599668, 
ENST00000295897, ENST00000415165, 
ENST00000503124, ENST00000509063, 
ENST00000401494, ENST00000505649, 
Fusion gene scores* DoF score20 X 13 X 8=208027 X 26 X 2=1404
# samples 2133
** MAII scorelog2(21/2080*10)=-3.30812229536233
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/1404*10)=-2.08900500605874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C3 [Title/Abstract] AND ALB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC3

GO:0001934

positive regulation of protein phosphorylation

15833747

HgeneC3

GO:0010575

positive regulation of vascular endothelial growth factor production

16452172

HgeneC3

GO:0010828

positive regulation of glucose transmembrane transport

9059512|15833747

HgeneC3

GO:0010866

regulation of triglyceride biosynthetic process

10432298

HgeneC3

GO:0010884

positive regulation of lipid storage

9555951

HgeneC3

GO:0045745

positive regulation of G-protein coupled receptor protein signaling pathway

15833747

TgeneALB

GO:0009267

cellular response to starvation

16245148

TgeneALB

GO:0019836

hemolysis by symbiont of host erythrocytes

16394536

TgeneALB

GO:0043066

negative regulation of apoptotic process

16153637

TgeneALB

GO:0051659

maintenance of mitochondrion location

16153637


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI305112C3chr19

6682029

+ALBchr4

74270017

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000245907ENST00000295897C3chr19

6682029

+ALBchr4

74270017

+
intron-5UTRENST00000245907ENST00000415165C3chr19

6682029

+ALBchr4

74270017

+
intron-5UTRENST00000245907ENST00000503124C3chr19

6682029

+ALBchr4

74270017

+
intron-5UTRENST00000245907ENST00000509063C3chr19

6682029

+ALBchr4

74270017

+
intron-intronENST00000245907ENST00000401494C3chr19

6682029

+ALBchr4

74270017

+
intron-intronENST00000245907ENST00000505649C3chr19

6682029

+ALBchr4

74270017

+
intron-5UTRENST00000599668ENST00000295897C3chr19

6682029

+ALBchr4

74270017

+
intron-5UTRENST00000599668ENST00000415165C3chr19

6682029

+ALBchr4

74270017

+
intron-5UTRENST00000599668ENST00000503124C3chr19

6682029

+ALBchr4

74270017

+
intron-5UTRENST00000599668ENST00000509063C3chr19

6682029

+ALBchr4

74270017

+
intron-intronENST00000599668ENST00000401494C3chr19

6682029

+ALBchr4

74270017

+
intron-intronENST00000599668ENST00000505649C3chr19

6682029

+ALBchr4

74270017

+

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FusionProtFeatures for C3_ALB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C3

P01024

ALB

P02768

C3 plays a central role in the activation of thecomplement system. Its processing by C3 convertase is the centralreaction in both classical and alternative complement pathways.After activation C3b can bind covalently, via its reactivethioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3,C3a anaphylatoxin is a mediator of local inflammatory process. Inchronic inflammation, acts as a chemoattractant for neutrophils(By similarity). It induces the contraction of smooth muscle,increases vascular permeability and causes histamine release frommast cells and basophilic leukocytes. {ECO:0000250}. C3-beta-c: Acts as a chemoattractant for neutrophils inchronic inflammation. {ECO:0000250}. Acylation stimulating protein: adipogenic hormone thatstimulates triglyceride (TG) synthesis and glucose transport inadipocytes, regulating fat storage and playing a role inpostprandial TG clearance. Appears to stimulate TG synthesis viaactivation of the PLC, MAPK and AKT signaling pathways. Ligand forC5AR2. Promotes the phosphorylation, ARRB2-mediatedinternalization and recycling of C5AR2 (PubMed:8376604,PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747,PubMed:16333141, PubMed:19615750). {ECO:0000269|PubMed:10432298,ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:16333141,ECO:0000269|PubMed:19615750, ECO:0000269|PubMed:2909530,ECO:0000269|PubMed:8376604, ECO:0000269|PubMed:9059512}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C3_ALB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C3_ALB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C3_ALB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneC3P01024DB01593ZincComplement C3small moleculeapproved|investigational
TgeneALBP02768DB00493CefotaximeSerum albuminsmall moleculeapproved
TgeneALBP02768DB01045RifampicinSerum albuminsmall moleculeapproved
TgeneALBP02768DB03255PhenolSerum albuminsmall moleculeapproved|experimental
TgeneALBP02768DB00276AmsacrineSerum albuminsmall moleculeapproved|investigational
TgeneALBP02768DB00545PyridostigmineSerum albuminsmall moleculeapproved|investigational
TgeneALBP02768DB06713NorelgestrominSerum albuminsmall moleculeapproved|investigational
TgeneALBP02768DB11638ArtenimolSerum albuminsmall moleculeapproved|investigational
TgeneALBP02768DB00199ErythromycinSerum albuminsmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for C3_ALB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneC3C0242383Age related macular degeneration4CTD_human
HgeneC3C2752037HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 52ORPHANET;UNIPROT
HgeneC3C3151071COMPLEMENT COMPONENT 3 DEFICIENCY, AUTOSOMAL RECESSIVE2ORPHANET;UNIPROT
HgeneC3C0007787Transient Ischemic Attack1CTD_human
HgeneC3C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneC3C0017665Membranous glomerulonephritis1CTD_human
HgeneC3C0021051Immunologic Deficiency Syndromes1CTD_human
HgeneC3C0021655Insulin Resistance1CTD_human
HgeneC3C0030524Paratuberculosis1CTD_human
HgeneC3C0030807Pemphigus1CTD_human
HgeneC3C0034152Henoch-Schoenlein Purpura1CTD_human
HgeneC3C0740392Infarction, Middle Cerebral Artery1CTD_human
HgeneC3C1969651Macular Degeneration, Age-Related, 91CTD_human;UNIPROT
HgeneC3C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneALBC0033687Proteinuria9CTD_human
TgeneALBC0017658Glomerulonephritis8CTD_human
TgeneALBC0022658Kidney Diseases8CTD_human
TgeneALBC0017665Membranous glomerulonephritis6CTD_human
TgeneALBC0027697Nephritis6CTD_human
TgeneALBC0027707Nephritis, Interstitial4CTD_human
TgeneALBC0038454Cerebrovascular accident4CTD_human
TgeneALBC0342185Hyperthyroxinemia, Familial Dysalbuminemic4CTD_human;UNIPROT
TgeneALBC0023893Liver Cirrhosis, Experimental3CTD_human
TgeneALBC0025290Aseptic Meningitis3CTD_human
TgeneALBC2609414Acute kidney injury3CTD_human
TgeneALBC0014544Epilepsy2CTD_human
TgeneALBC0020649Hypotension2CTD_human;HPO
TgeneALBC0023890Liver Cirrhosis2CTD_human
TgeneALBC0027726Nephrotic Syndrome2CTD_human
TgeneALBC0036830Serum Sickness2CTD_human
TgeneALBC0162557Liver Failure, Acute2CTD_human
TgeneALBC4277682Chemical and Drug Induced Liver Injury2CTD_human
TgeneALBC0002994Angioedema1CTD_human
TgeneALBC0003460Anuria1CTD_human
TgeneALBC0004509Azoospermia1CTD_human
TgeneALBC0006111Brain Diseases1CTD_human
TgeneALBC0007222Cardiovascular Diseases1CTD_human
TgeneALBC0007786Brain Ischemia1CTD_human
TgeneALBC0011581Depressive disorder1CTD_human
TgeneALBC0011875Diabetic Angiopathies1CTD_human
TgeneALBC0011881Diabetic Nephropathy1CTD_human
TgeneALBC0013502Echinococcosis1CTD_human
TgeneALBC0016059Fibrosis1CTD_human
TgeneALBC0017662Glomerulonephritis, Membranoproliferative1CTD_human
TgeneALBC0018799Heart Diseases1CTD_human
TgeneALBC0018801Heart failure1CTD_human
TgeneALBC0019061Hemolytic-Uremic Syndrome1CTD_human
TgeneALBC0019158Hepatitis1CTD_human
TgeneALBC0019693HIV Infections1CTD_human
TgeneALBC0019699HIV Seropositivity1CTD_human
TgeneALBC0020517Hypersensitivity1CTD_human
TgeneALBC0020522Delayed Hypersensitivity1CTD_human
TgeneALBC0020538Hypertensive disease1CTD_human
TgeneALBC0022548Keloid1CTD_human
TgeneALBC0022661Kidney Failure, Chronic1CTD_human
TgeneALBC0026848Myopathy1CTD_human
TgeneALBC0027055Myocardial Reperfusion Injury1CTD_human
TgeneALBC0027720Nephrosis1CTD_human
TgeneALBC0028797Occupational Diseases1CTD_human
TgeneALBC0030193Pain1CTD_human
TgeneALBC0030286Pancreatic Diseases1CTD_human
TgeneALBC0030305Pancreatitis1CTD_human
TgeneALBC0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneALBC0035242Respiratory Tract Diseases1CTD_human
TgeneALBC0035457Rhinitis, Allergic, Perennial1CTD_human
TgeneALBC0038325Stevens-Johnson Syndrome1CTD_human
TgeneALBC0038356Stomach Neoplasms1CTD_human
TgeneALBC0040034Thrombocytopenia1CTD_human
TgeneALBC0041755Adverse reaction to drug1CTD_human
TgeneALBC0042109Urticaria1CTD_human
TgeneALBC0042164Uveitis1CTD_human
TgeneALBC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneALBC0239981Hypoalbuminemia1CTD_human;HPO
TgeneALBC0993582Arthritis, Experimental1CTD_human