![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 4924 |
FusionGeneSummary for C2CD2_MID2 |
![]() |
Fusion gene information | Fusion gene name: C2CD2_MID2 | Fusion gene ID: 4924 | Hgene | Tgene | Gene symbol | C2CD2 | MID2 | Gene ID | 25966 | 11043 |
Gene name | C2 calcium dependent domain containing 2 | midline 2 | |
Synonyms | C21orf25|C21orf258|TMEM24L | FXY2|MRX101|RNF60|TRIM1 | |
Cytomap | 21q22.3 | Xq22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | C2 domain-containing protein 2TMEM24 related gemetransmembrane protein 24-like | probable E3 ubiquitin-protein ligase MID2RING finger protein 60RING-type E3 ubiquitin transferase MID2midin 2midline defect 2tripartite motif protein 1tripartite motif-containing protein 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9Y426 | Q9UJV3 | |
Ensembl transtripts involved in fusion gene | ENST00000329623, ENST00000380486, ENST00000478372, | ENST00000262843, ENST00000443968, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 3 X 4 X 5=60 |
# samples | 4 | 5 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C2CD2 [Title/Abstract] AND MID2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MID2 | GO:0032897 | negative regulation of viral transcription | 18248090 |
Tgene | MID2 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 23077300 |
Tgene | MID2 | GO:0045087 | innate immune response | 18248090 |
Tgene | MID2 | GO:0046597 | negative regulation of viral entry into host cell | 18248090 |
Tgene | MID2 | GO:1902187 | negative regulation of viral release from host cell | 18248090 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRC | TCGA-CJ-5681-01A | C2CD2 | chr21 | 43373479 | - | MID2 | chrX | 107083900 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000329623 | ENST00000262843 | C2CD2 | chr21 | 43373479 | - | MID2 | chrX | 107083900 | + |
intron-3CDS | ENST00000329623 | ENST00000443968 | C2CD2 | chr21 | 43373479 | - | MID2 | chrX | 107083900 | + |
Frame-shift | ENST00000380486 | ENST00000262843 | C2CD2 | chr21 | 43373479 | - | MID2 | chrX | 107083900 | + |
Frame-shift | ENST00000380486 | ENST00000443968 | C2CD2 | chr21 | 43373479 | - | MID2 | chrX | 107083900 | + |
5UTR-3CDS | ENST00000478372 | ENST00000262843 | C2CD2 | chr21 | 43373479 | - | MID2 | chrX | 107083900 | + |
5UTR-3CDS | ENST00000478372 | ENST00000443968 | C2CD2 | chr21 | 43373479 | - | MID2 | chrX | 107083900 | + |
Top |
FusionProtFeatures for C2CD2_MID2 |
![]() |
Hgene | Tgene |
C2CD2 | MID2 |
May play a role in microtubule stabilization.{ECO:0000303|PubMed:24115387}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for C2CD2_MID2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for C2CD2_MID2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
C2CD2 | ELAVL1, DYNC1LI2, ARHGAP10, SEC14L1, ARHGAP26, DYNC1LI1 | MID2 | DYDC1, MID2, MID1, TRIM29, TRIM32, IGBP1, UBE2D4, UBE2N, UBE2U, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E2, UBE2E3, GFI1B, DGCR6, KIF1A, MVP, SLC25A6, AQP1, BYSL, RUNX1T1, CHD2, CTSZ, DCX, GOLGA2, HOXB9, KIFC3, LGALS8, MFAP1, MOS, PSMA1, TRIM27, SDCBP, SNAI1, TCEA2, TCEB3, ZNF24, ZNF165, STX11, TOP3B, RPH3AL, ZSCAN12, ZBTB24, JOSD1, NR1D2, CALCOCO2, SPRY2, NXF1, FARS2, FAM107A, ISCU, GORASP2, PRPF31, DIEXF, SPG21, WT1-AS, SYT17, ADAMTSL4, CCHCR1, MAGOHB, FAM90A1, C19orf66, TRPV6, RCOR3, UNC45A, FAM214A, LGALS14, TRIM54, CBX8, ZNF250, DMRT3, MID1IP1, GMCL1, METTL17, AEN, OTUB2, SCNM1, ZFYVE21, LENG1, ZC2HC1C, PTCD2, UBTD1, FBXL18, TSGA10, KIAA1683, THAP7, ATRIP, FAM161A, UTP23, BRMS1L, ZGPAT, ZNF587, FBF1, DGCR6L, CCDC120, SNAP47, FRMD6, ZNF440, ZNF792, RPP25L, ZNF785, CCDC42, ZNF417, SLC25A48, ZNF564, PPP1R18, SPATA24, BCL6B, CEP57L1, TRIM42, BRCA1, UBXN1, EPN3, COX5B, ZNF774, TMEM14B, FAM115A, HIF1A, CDKN2AIP, SPAG5, TUBB, TUBA1B, TUBB4B, CEP128, ASPM, PSMD3, PSMC2, PSMD11, PSMD2, PSMB5, GMNN |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for C2CD2_MID2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for C2CD2_MID2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MID2 | C3890168 | MENTAL RETARDATION, X-LINKED 101 | 1 | UNIPROT |