![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 491 |
FusionGeneSummary for ACSM2B_CYP3A4 |
![]() |
Fusion gene information | Fusion gene name: ACSM2B_CYP3A4 | Fusion gene ID: 491 | Hgene | Tgene | Gene symbol | ACSM2B | CYP3A4 | Gene ID | 348158 | 1576 |
Gene name | acyl-CoA synthetase medium chain family member 2B | cytochrome P450 family 3 subfamily A member 4 | |
Synonyms | ACSM2|HXMA|HYST1046 | CP33|CP34|CYP3A|CYP3A3|CYPIIIA3|CYPIIIA4|HLP|NF-25|P450C3|P450PCN1 | |
Cytomap | 16p12.3 | 7q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | acyl-coenzyme A synthetase ACSM2B, mitochondrialacyl-CoA synthetase medium-chain family member 2butyrate--CoA ligase 2Bbutyryl-coenzyme A synthetase 2Bmiddle-chain acyl-CoA synthetase 2Bxenobiotic/medium-chain fatty acid-CoA ligase HXM-Axenobiotic/m | cytochrome P450 3A41,8-cineole 2-exo-monooxygenaseP450-III, steroid induciblealbendazole monooxygenasealbendazole sulfoxidasecholesterol 25-hydroxylasecytochrome P450 3A3cytochrome P450 HLpcytochrome P450 NF-25cytochrome P450, family 3, subfamily | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q68CK6 | P08684 | |
Ensembl transtripts involved in fusion gene | ENST00000329697, ENST00000565322, ENST00000565232, ENST00000567001, ENST00000414188, ENST00000567288, | ENST00000354593, ENST00000336411, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 3=48 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACSM2B [Title/Abstract] AND CYP3A4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CYP3A4 | GO:0002933 | lipid hydroxylation | 14559847 |
Tgene | CYP3A4 | GO:0008202 | steroid metabolic process | 14559847 |
Tgene | CYP3A4 | GO:0009822 | alkaloid catabolic process | 15039299 |
Tgene | CYP3A4 | GO:0016098 | monoterpenoid metabolic process | 16401082 |
Tgene | CYP3A4 | GO:0017144 | drug metabolic process | 15327587|19219744 |
Tgene | CYP3A4 | GO:0042737 | drug catabolic process | 15039299 |
Tgene | CYP3A4 | GO:0042738 | exogenous drug catabolic process | 18619574 |
Tgene | CYP3A4 | GO:0046483 | heterocycle metabolic process | 15327587 |
Tgene | CYP3A4 | GO:0055114 | oxidation-reduction process | 16401082|19219744 |
Tgene | CYP3A4 | GO:0070989 | oxidative demethylation | 15039299|18619574 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB162303 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000329697 | ENST00000354593 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000329697 | ENST00000336411 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000565322 | ENST00000354593 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000565322 | ENST00000336411 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000565232 | ENST00000354593 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000565232 | ENST00000336411 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000567001 | ENST00000354593 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000567001 | ENST00000336411 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000414188 | ENST00000354593 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000414188 | ENST00000336411 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000567288 | ENST00000354593 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
intron-intron | ENST00000567288 | ENST00000336411 | ACSM2B | chr16 | 20548553 | + | CYP3A4 | chr7 | 99359055 | - |
Top |
FusionProtFeatures for ACSM2B_CYP3A4 |
![]() |
Hgene | Tgene |
ACSM2B | CYP3A4 |
Has medium-chain fatty acid:CoA ligase activity withbroad substrate specificity (in vitro). Acts on acids from C(4) toC(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro). {ECO:0000269|PubMed:12616642}. | Cytochromes P450 are a group of heme-thiolatemonooxygenases. In liver microsomes, this enzyme is involved in anNADPH-dependent electron transport pathway. It performs a varietyof oxidation reactions (e.g. caffeine 8-oxidation, omeprazolesulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, includingsteroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide(PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol.May catalyze 25-hydroxylation of cholesterol in vitro(PubMed:21576599). {ECO:0000269|PubMed:11159812,ECO:0000269|PubMed:21576599}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ACSM2B_CYP3A4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ACSM2B_CYP3A4 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ACSM2B_CYP3A4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CYP3A4 | P08684 | DB01267 | Paliperidone | Cytochrome P450 3A4 | small molecule | approved |
Tgene | CYP3A4 | P08684 | DB00951 | Isoniazid | Cytochrome P450 3A4 | small molecule | approved|investigational |
Tgene | CYP3A4 | P08684 | DB11994 | Diacerein | Cytochrome P450 3A4 | small molecule | approved|investigational |
Tgene | CYP3A4 | P08684 | DB00143 | Glutathione | Cytochrome P450 3A4 | small molecule | approved|investigational|nutraceutical |
Top |
RelatedDiseases for ACSM2B_CYP3A4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CYP3A4 | C0019196 | Hepatitis C | 1 | CTD_human |
Tgene | CYP3A4 | C0029463 | Osteosarcoma | 1 | CTD_human |
Tgene | CYP3A4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | CYP3A4 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | CYP3A4 | C0040479 | Torsades de Pointes | 1 | CTD_human |
Tgene | CYP3A4 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
Tgene | CYP3A4 | C0221765 | Chronic schizophrenia | 1 | PSYGENET |
Tgene | CYP3A4 | C1458155 | Mammary Neoplasms | 1 | CTD_human |