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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4883

FusionGeneSummary for C1orf86_ZC3H11A

check button Fusion gene summary
Fusion gene informationFusion gene name: C1orf86_ZC3H11A
Fusion gene ID: 4883
HgeneTgene
Gene symbol

C1orf86

ZC3H11A

Gene ID

199990

9877

Gene nameFA core complex associated protein 20zinc finger CCCH-type containing 11A
SynonymsC1orf86|FP7162ZC3HDC11A
Cytomap

1p36.33

1q32.1

Type of geneprotein-codingprotein-coding
DescriptionFanconi anemia core complex-associated protein 20FANCA-associated protein of 20 kDaFanconi anemia core complex associated protein 20Fanconi anemia-associated protein of 20 kDazinc finger CCCH domain-containing protein 11Azinc finger CCCH-type domain containing 11A
Modification date2018052320180523
UniProtAcc

O75152

Ensembl transtripts involved in fusion geneENST00000400919, ENST00000378546, 
ENST00000487186, ENST00000378545, 
ENST00000367214, ENST00000367212, 
ENST00000332127, ENST00000545588, 
ENST00000367210, ENST00000466470, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: C1orf86 [Title/Abstract] AND ZC3H11A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC1orf86

GO:0006974

cellular response to DNA damage stimulus

22266823|22343915|22396592|22705371


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-G9-6353-01AC1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000400919ENST00000367214C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
intron-3CDSENST00000400919ENST00000367212C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
intron-3CDSENST00000400919ENST00000332127C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
intron-3CDSENST00000400919ENST00000545588C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
intron-3CDSENST00000400919ENST00000367210C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
intron-intronENST00000400919ENST00000466470C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000378546ENST00000367214C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000378546ENST00000367212C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000378546ENST00000332127C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000378546ENST00000545588C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000378546ENST00000367210C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
5CDS-intronENST00000378546ENST00000466470C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000487186ENST00000367214C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000487186ENST00000367212C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000487186ENST00000332127C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000487186ENST00000545588C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000487186ENST00000367210C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
5CDS-intronENST00000487186ENST00000466470C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000378545ENST00000367214C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000378545ENST00000367212C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000378545ENST00000332127C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000378545ENST00000545588C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
Frame-shiftENST00000378545ENST00000367210C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+
5CDS-intronENST00000378545ENST00000466470C1orf86chr1

2120987

-ZC3H11Achr1

203797427

+

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FusionProtFeatures for C1orf86_ZC3H11A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C1orf86

ZC3H11A

O75152

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Involved in nuclear mRNA export; probably mediated byassoociation with the TREX complex. {ECO:0000269|PubMed:22928037}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C1orf86_ZC3H11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C1orf86_ZC3H11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C1orf86ELAVL1, FANCA, FANCM, C17orf70, FANCB, FANCG, FANCL, FANCF, C19orf40, APITD1, FANCC, FANCE, REV1, UBC, CEP170, SOD1, GAR1, FANCI, FBXW7, NT5CZC3H11AMLH1, SIRT7, MRPL53, PQBP1, NDUFA2, SF1, SUGP1, SARNP, PPIF, SOD2, NDUFA7, RBM27, SERPINH1, UQCRFS1P1, RBMS1, NONO, PPIB, SRP19, TXLNG, SF3B4, SNX3, KIAA0101, HDAC9, TARDBP, LIN28A, RAPGEF4, BRCA1, CUL7, OBSL1, BMI1, SERPINB5, TRA2A, IER2, USP7, NTRK1, PFKFB2, XRCC3, THOC5, BCLAF1, THOC1, C17orf85, THOC2, THOC7, FOXM1, ELAVL2, C11orf57, KBTBD7, APOBEC3D, ZC3H18, GSPT2, XAGE1B, MTNR1A, SMARCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C1orf86_ZC3H11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C1orf86_ZC3H11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZC3H11AC1458155Mammary Neoplasms1CTD_human