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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4880

FusionGeneSummary for C1orf61_ADD1

check button Fusion gene summary
Fusion gene informationFusion gene name: C1orf61_ADD1
Fusion gene ID: 4880
HgeneTgene
Gene symbol

C1orf61

ADD1

Gene ID

10485

118

Gene namechromosome 1 open reading frame 61adducin 1
SynonymsCROC4ADDA
Cytomap

1q22

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionprotein CROC-4contingent replication of cDNA 4transcriptional activator of the c-fos promoteralpha-adducinadducin 1 (alpha)erythrocyte adducin alpha subunit
Modification date2018032920180523
UniProtAcc

Q13536

P35611

Ensembl transtripts involved in fusion geneENST00000488498, ENST00000368243, 
ENST00000446856, ENST00000264758, 
ENST00000398125, ENST00000513328, 
ENST00000503455, ENST00000355842, 
ENST00000398123, ENST00000398129, 
ENST00000538860, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 5 X 3=75
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C1orf61 [Title/Abstract] AND ADD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC1orf61

GO:0045944

positive regulation of transcription by RNA polymerase II

10995546

TgeneADD1

GO:0032092

positive regulation of protein binding

3693401|7642559

TgeneADD1

GO:0051016

barbed-end actin filament capping

8626479

TgeneADD1

GO:0051017

actin filament bundle assembly

3693401

TgeneADD1

GO:0071277

cellular response to calcium ion

25978380

TgeneADD1

GO:1903142

positive regulation of establishment of endothelial barrier

25978380

TgeneADD1

GO:1903393

positive regulation of adherens junction organization

25978380


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1D44764C1orf61chr1

156378403

+ADD1chr4

2895934

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000488498ENST00000446856C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000488498ENST00000264758C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000488498ENST00000398125C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000488498ENST00000513328C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000488498ENST00000503455C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000488498ENST00000355842C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000488498ENST00000398123C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000488498ENST00000398129C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000488498ENST00000538860C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000368243ENST00000446856C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000368243ENST00000264758C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000368243ENST00000398125C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000368243ENST00000513328C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000368243ENST00000503455C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000368243ENST00000355842C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000368243ENST00000398123C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000368243ENST00000398129C1orf61chr1

156378403

+ADD1chr4

2895934

-
intron-intronENST00000368243ENST00000538860C1orf61chr1

156378403

+ADD1chr4

2895934

-

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FusionProtFeatures for C1orf61_ADD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C1orf61

Q13536

ADD1

P35611

May play a role in FOS signaling pathways involved indevelopment and remodeling of neurons. Promotes transcription ofthe FOS promoter. {ECO:0000269|PubMed:10995546}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C1orf61_ADD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C1orf61_ADD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C1orf61_ADD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C1orf61_ADD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADD1C0020538Hypertensive disease2CTD_human
TgeneADD1C2239176Liver carcinoma1CTD_human