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Fusion gene ID: 4853 |
FusionGeneSummary for C1orf132_TSC22D3 |
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Fusion gene information | Fusion gene name: C1orf132_TSC22D3 | Fusion gene ID: 4853 | Hgene | Tgene | Gene symbol | C1orf132 | TSC22D3 | Gene ID | 1831 |
Gene name | TSC22 domain family member 3 | ||
Synonyms | DIP|DSIPI|GILZ|TSC-22R | ||
Cytomap | Xq22.3 | ||
Type of gene | protein-coding | ||
Description | TSC22 domain family protein 3DSIP-immunoreactive leucine zipper proteinDSIP-immunoreactive peptideTSC-22 related proteinTSC-22-like proteindelta sleep-inducing peptide immunoreactorglucocorticoid-induced leucine zipper protein | ||
Modification date | 20180519 | ||
UniProtAcc | Q99576 | ||
Ensembl transtripts involved in fusion gene | ENST00000385231, ENST00000385055, | ENST00000372390, ENST00000372397, ENST00000315660, ENST00000372383, ENST00000372384, ENST00000372382, ENST00000506081, ENST00000514426, | |
Fusion gene scores | * DoF score | 6 X 3 X 4=72 | 4 X 4 X 2=32 |
# samples | 6 | 5 | |
** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: C1orf132 [Title/Abstract] AND TSC22D3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-V1-A8WN-01A | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000385231 | ENST00000372390 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385231 | ENST00000372397 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385231 | ENST00000315660 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385231 | ENST00000372383 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385231 | ENST00000372384 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385231 | ENST00000372382 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385231 | ENST00000506081 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385231 | ENST00000514426 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385055 | ENST00000372390 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385055 | ENST00000372397 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385055 | ENST00000315660 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385055 | ENST00000372383 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385055 | ENST00000372384 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385055 | ENST00000372382 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385055 | ENST00000506081 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
intron-5UTR | ENST00000385055 | ENST00000514426 | C1orf132 | chr1 | 207989274 | - | TSC22D3 | chrX | 106959180 | - |
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FusionProtFeatures for C1orf132_TSC22D3 |
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Hgene | Tgene |
C1orf132 | TSC22D3 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Protects T-cells from IL2 deprivation-induced apoptosisthrough the inhibition of FOXO3A transcriptional activity thatleads to the down-regulation of the pro-apoptotic factor BCL2L11.In macrophages, plays a role in the anti-inflammatory andimmunosuppressive effects of glucocorticoids and IL10. In T-cells,inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro,suppresses AP1 and NFKB1 DNA-binding activities (By similarity).Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulatingMYOD1 and HDAC1 transcriptional activity resulting in reducedexpression of MYOG (By similarity). {ECO:0000250,ECO:0000269|PubMed:15031210}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C1orf132_TSC22D3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for C1orf132_TSC22D3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
C1orf132 | TSC22D3 | PLEKHF2, HPCAL4, RAF1, FOS, JUN, TSC22D3, NFKB1, NFKB2, MYOD1, HDAC1, HDAC2, UBC, SGK1, UBE2I, SUMO1, CASP8, PCK1, ELAVL1, SCNN1B, NEDD4L, MTA2, DCLK2, TP53, MDM2, MAD1L1, C19orf57, ENDOV, EID3, TSC22D4, ALDH3B1, FIGNL1, TSC22D2, TSC22D1, RCCD1, FAM117B, NRBP1, KIAA1683, CEP55, CDC42SE2, SIRT6, UBE3D, NUFIP2, AGAP3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C1orf132_TSC22D3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C1orf132_TSC22D3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TSC22D3 | C0020459 | Hyperinsulinism | 1 | CTD_human |
Tgene | TSC22D3 | C0021364 | Male infertility | 1 | CTD_human |
Tgene | TSC22D3 | C0039584 | Testicular Diseases | 1 | CTD_human |
Tgene | TSC22D3 | C1262477 | Weight decreased | 1 | CTD_human |