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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 485

FusionGeneSummary for ACSL4_ARRDC3

check button Fusion gene summary
Fusion gene informationFusion gene name: ACSL4_ARRDC3
Fusion gene ID: 485
HgeneTgene
Gene symbol

ACSL4

ARRDC3

Gene ID

2182

57561

Gene nameacyl-CoA synthetase long chain family member 4arrestin domain containing 3
SynonymsACS4|FACL4|LACS4|MRX63|MRX68TLIMP
Cytomap

Xq23

5q14.3

Type of geneprotein-codingprotein-coding
Descriptionlong-chain-fatty-acid--CoA ligase 4LACS 4acyl-CoA synthetase 4fatty-acid-Coenzyme A ligase, long-chain 4lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 4long-chain fatty-acid-Coenzyme A ligase 4arrestin domain-containing protein 3TBP-2-like inducible membrane proteinalpha-arrestin 3
Modification date2018052720180519
UniProtAcc

O60488

Q96B67

Ensembl transtripts involved in fusion geneENST00000469796, ENST00000340800, 
ENST00000348502, ENST00000504383, 
ENST00000265138, ENST00000503192, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 1=4
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: ACSL4 [Title/Abstract] AND ARRDC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACSL4

GO:0006629

lipid metabolic process

9598324


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF116642ACSL4chrX

108971287

+ARRDC3chr5

90678709

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000469796ENST00000265138ACSL4chrX

108971287

+ARRDC3chr5

90678709

-
intron-intronENST00000469796ENST00000503192ACSL4chrX

108971287

+ARRDC3chr5

90678709

-
intron-3CDSENST00000340800ENST00000265138ACSL4chrX

108971287

+ARRDC3chr5

90678709

-
intron-intronENST00000340800ENST00000503192ACSL4chrX

108971287

+ARRDC3chr5

90678709

-
intron-3CDSENST00000348502ENST00000265138ACSL4chrX

108971287

+ARRDC3chr5

90678709

-
intron-intronENST00000348502ENST00000503192ACSL4chrX

108971287

+ARRDC3chr5

90678709

-
intron-3CDSENST00000504383ENST00000265138ACSL4chrX

108971287

+ARRDC3chr5

90678709

-
intron-intronENST00000504383ENST00000503192ACSL4chrX

108971287

+ARRDC3chr5

90678709

-

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FusionProtFeatures for ACSL4_ARRDC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACSL4

O60488

ARRDC3

Q96B67

Activation of long-chain fatty acids for both synthesisof cellular lipids, and degradation via beta-oxidation.Preferentially uses arachidonate and eicosapentaenoate assubstrates. Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also otherG protein-coupled receptors (PubMed:20559325, PubMed:21982743,PubMed:23208550). Plays a role in NEDD4-mediated ubiquitinationand endocytosis af activated ADRB2 and subsequent ADRB2degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4to ADRB2 (PubMed:20559325). Alternatively, may function as adapterprotein that does not play a major role in recruiting NEDD4 toADRB2, but rather plays a role in a targeting ADRB2 to endosomes(PubMed:23208550). {ECO:0000269|PubMed:20559325,ECO:0000269|PubMed:23208550}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACSL4_ARRDC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACSL4_ARRDC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACSL4_ARRDC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneACSL4O60488DB00412RosiglitazoneLong-chain-fatty-acid--CoA ligase 4small moleculeapproved|investigational

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RelatedDiseases for ACSL4_ARRDC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACSL4C0011581Depressive disorder1CTD_human
HgeneACSL4C0033578Prostatic Neoplasms1CTD_human
HgeneACSL4C0036341Schizophrenia1PSYGENET
HgeneACSL4C0041834Erythema1CTD_human
HgeneACSL4C0993582Arthritis, Experimental1CTD_human
HgeneACSL4C1845672Mental Retardation, X-Linked 631CTD_human;UNIPROT
HgeneACSL4C2239176Liver carcinoma1CTD_human
TgeneARRDC3C1458155Mammary Neoplasms1CTD_human