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Fusion gene ID: 485 |
FusionGeneSummary for ACSL4_ARRDC3 |
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Fusion gene information | Fusion gene name: ACSL4_ARRDC3 | Fusion gene ID: 485 | Hgene | Tgene | Gene symbol | ACSL4 | ARRDC3 | Gene ID | 2182 | 57561 |
Gene name | acyl-CoA synthetase long chain family member 4 | arrestin domain containing 3 | |
Synonyms | ACS4|FACL4|LACS4|MRX63|MRX68 | TLIMP | |
Cytomap | Xq23 | 5q14.3 | |
Type of gene | protein-coding | protein-coding | |
Description | long-chain-fatty-acid--CoA ligase 4LACS 4acyl-CoA synthetase 4fatty-acid-Coenzyme A ligase, long-chain 4lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 4long-chain fatty-acid-Coenzyme A ligase 4 | arrestin domain-containing protein 3TBP-2-like inducible membrane proteinalpha-arrestin 3 | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | O60488 | Q96B67 | |
Ensembl transtripts involved in fusion gene | ENST00000469796, ENST00000340800, ENST00000348502, ENST00000504383, | ENST00000265138, ENST00000503192, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 1=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: ACSL4 [Title/Abstract] AND ARRDC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACSL4 | GO:0006629 | lipid metabolic process | 9598324 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AF116642 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000469796 | ENST00000265138 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
intron-intron | ENST00000469796 | ENST00000503192 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
intron-3CDS | ENST00000340800 | ENST00000265138 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
intron-intron | ENST00000340800 | ENST00000503192 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
intron-3CDS | ENST00000348502 | ENST00000265138 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
intron-intron | ENST00000348502 | ENST00000503192 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
intron-3CDS | ENST00000504383 | ENST00000265138 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
intron-intron | ENST00000504383 | ENST00000503192 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
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FusionProtFeatures for ACSL4_ARRDC3 |
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Hgene | Tgene |
ACSL4 | ARRDC3 |
Activation of long-chain fatty acids for both synthesisof cellular lipids, and degradation via beta-oxidation.Preferentially uses arachidonate and eicosapentaenoate assubstrates. | Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also otherG protein-coupled receptors (PubMed:20559325, PubMed:21982743,PubMed:23208550). Plays a role in NEDD4-mediated ubiquitinationand endocytosis af activated ADRB2 and subsequent ADRB2degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4to ADRB2 (PubMed:20559325). Alternatively, may function as adapterprotein that does not play a major role in recruiting NEDD4 toADRB2, but rather plays a role in a targeting ADRB2 to endosomes(PubMed:23208550). {ECO:0000269|PubMed:20559325,ECO:0000269|PubMed:23208550}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACSL4_ARRDC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACSL4_ARRDC3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACSL4_ARRDC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ACSL4 | O60488 | DB00412 | Rosiglitazone | Long-chain-fatty-acid--CoA ligase 4 | small molecule | approved|investigational |
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RelatedDiseases for ACSL4_ARRDC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACSL4 | C0011581 | Depressive disorder | 1 | CTD_human |
Hgene | ACSL4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | ACSL4 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | ACSL4 | C0041834 | Erythema | 1 | CTD_human |
Hgene | ACSL4 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Hgene | ACSL4 | C1845672 | Mental Retardation, X-Linked 63 | 1 | CTD_human;UNIPROT |
Hgene | ACSL4 | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | ARRDC3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |