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Fusion gene ID: 485 |
FusionGeneSummary for ACSL4_ARRDC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACSL4_ARRDC3 | Fusion gene ID: 485 | Hgene | Tgene | Gene symbol | ACSL4 | ARRDC3 | Gene ID | 2182 | 57561 |
| Gene name | acyl-CoA synthetase long chain family member 4 | arrestin domain containing 3 | |
| Synonyms | ACS4|FACL4|LACS4|MRX63|MRX68 | TLIMP | |
| Cytomap | Xq23 | 5q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | long-chain-fatty-acid--CoA ligase 4LACS 4acyl-CoA synthetase 4fatty-acid-Coenzyme A ligase, long-chain 4lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 4long-chain fatty-acid-Coenzyme A ligase 4 | arrestin domain-containing protein 3TBP-2-like inducible membrane proteinalpha-arrestin 3 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | O60488 | Q96B67 | |
| Ensembl transtripts involved in fusion gene | ENST00000469796, ENST00000340800, ENST00000348502, ENST00000504383, | ENST00000265138, ENST00000503192, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 1=4 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: ACSL4 [Title/Abstract] AND ARRDC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACSL4 | GO:0006629 | lipid metabolic process | 9598324 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AF116642 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000469796 | ENST00000265138 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
| intron-intron | ENST00000469796 | ENST00000503192 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
| intron-3CDS | ENST00000340800 | ENST00000265138 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
| intron-intron | ENST00000340800 | ENST00000503192 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
| intron-3CDS | ENST00000348502 | ENST00000265138 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
| intron-intron | ENST00000348502 | ENST00000503192 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
| intron-3CDS | ENST00000504383 | ENST00000265138 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
| intron-intron | ENST00000504383 | ENST00000503192 | ACSL4 | chrX | 108971287 | + | ARRDC3 | chr5 | 90678709 | - |
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FusionProtFeatures for ACSL4_ARRDC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACSL4 | ARRDC3 |
| Activation of long-chain fatty acids for both synthesisof cellular lipids, and degradation via beta-oxidation.Preferentially uses arachidonate and eicosapentaenoate assubstrates. | Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also otherG protein-coupled receptors (PubMed:20559325, PubMed:21982743,PubMed:23208550). Plays a role in NEDD4-mediated ubiquitinationand endocytosis af activated ADRB2 and subsequent ADRB2degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4to ADRB2 (PubMed:20559325). Alternatively, may function as adapterprotein that does not play a major role in recruiting NEDD4 toADRB2, but rather plays a role in a targeting ADRB2 to endosomes(PubMed:23208550). {ECO:0000269|PubMed:20559325,ECO:0000269|PubMed:23208550}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACSL4_ARRDC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACSL4_ARRDC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACSL4_ARRDC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ACSL4 | O60488 | DB00412 | Rosiglitazone | Long-chain-fatty-acid--CoA ligase 4 | small molecule | approved|investigational |
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RelatedDiseases for ACSL4_ARRDC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACSL4 | C0011581 | Depressive disorder | 1 | CTD_human |
| Hgene | ACSL4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | ACSL4 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | ACSL4 | C0041834 | Erythema | 1 | CTD_human |
| Hgene | ACSL4 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
| Hgene | ACSL4 | C1845672 | Mental Retardation, X-Linked 63 | 1 | CTD_human;UNIPROT |
| Hgene | ACSL4 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Tgene | ARRDC3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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