![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 4819 |
FusionGeneSummary for C1QTNF1_AFF1 |
![]() |
Fusion gene information | Fusion gene name: C1QTNF1_AFF1 | Fusion gene ID: 4819 | Hgene | Tgene | Gene symbol | C1QTNF1 | AFF1 | Gene ID | 114897 | 4299 |
Gene name | C1q and TNF related 1 | AF4/FMR2 family member 1 | |
Synonyms | CTRP1|GIP|ZSIG37 | AF4|MLLT2|PBM1 | |
Cytomap | 17q25.3 | 4q21.3-q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | complement C1q tumor necrosis factor-related protein 1C1q and tumor necrosis factor related protein 1G protein coupled receptor interacting proteing protein-coupled receptor-interacting protein | AF4/FMR2 family member 1ALL1-fused gene from chromosome 4 proteinmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2pre-B-cell monocytic leukemia partner 1proto-oncogene AF4 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9BXJ1 | P51825 | |
Ensembl transtripts involved in fusion gene | ENST00000578229, ENST00000580454, ENST00000579760, ENST00000339142, ENST00000311661, ENST00000354124, ENST00000392445, ENST00000581774, ENST00000583904, ENST00000580474, ENST00000582625, | ENST00000395146, ENST00000307808, ENST00000544085, ENST00000511996, | |
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 10 X 25 X 4=1000 |
# samples | 3 | 31 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(31/1000*10)=-1.68965987938785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C1QTNF1 [Title/Abstract] AND AFF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | C1QTNF1 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 18171693 |
Hgene | C1QTNF1 | GO:0010544 | negative regulation of platelet activation | 16195328 |
Hgene | C1QTNF1 | GO:0010628 | positive regulation of gene expression | 18171693 |
Hgene | C1QTNF1 | GO:0090331 | negative regulation of platelet aggregation | 16195328 |
Hgene | C1QTNF1 | GO:2000860 | positive regulation of aldosterone secretion | 18171693 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF064219 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000578229 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000578229 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000578229 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000578229 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000580454 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000580454 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000580454 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000580454 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000579760 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000579760 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000579760 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000579760 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-3CDS | ENST00000339142 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-3CDS | ENST00000339142 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-intron | ENST00000339142 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-intron | ENST00000339142 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-3CDS | ENST00000311661 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-3CDS | ENST00000311661 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-intron | ENST00000311661 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-intron | ENST00000311661 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000354124 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000354124 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000354124 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000354124 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-3CDS | ENST00000392445 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-3CDS | ENST00000392445 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-intron | ENST00000392445 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
3UTR-intron | ENST00000392445 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000581774 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000581774 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000581774 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000581774 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000583904 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000583904 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000583904 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000583904 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000580474 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000580474 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000580474 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000580474 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000582625 | ENST00000395146 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-3CDS | ENST00000582625 | ENST00000307808 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000582625 | ENST00000544085 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
intron-intron | ENST00000582625 | ENST00000511996 | C1QTNF1 | chr17 | 77045803 | - | AFF1 | chr4 | 87968067 | - |
Top |
FusionProtFeatures for C1QTNF1_AFF1 |
![]() |
Hgene | Tgene |
C1QTNF1 | AFF1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for C1QTNF1_AFF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for C1QTNF1_AFF1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for C1QTNF1_AFF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for C1QTNF1_AFF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |