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Fusion gene ID: 4814 |
FusionGeneSummary for C1QA_CD74 |
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Fusion gene information | Fusion gene name: C1QA_CD74 | Fusion gene ID: 4814 | Hgene | Tgene | Gene symbol | C1QA | CD74 | Gene ID | 712 | 972 |
Gene name | complement C1q A chain | CD74 molecule | |
Synonyms | - | DHLAG|HLADG|II|Ia-GAMMA | |
Cytomap | 1p36.12 | 5q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | complement C1q subcomponent subunit Acomplement C1q chain Acomplement component 1, q subcomponent, A chaincomplement component 1, q subcomponent, alpha polypeptidecomplement component C1q, A chain | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P02745 | P04233 | |
Ensembl transtripts involved in fusion gene | ENST00000374642, ENST00000402322, | ENST00000377795, ENST00000353334, ENST00000524315, ENST00000009530, | |
Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 16 X 15 X 5=1200 |
# samples | 3 | 27 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(27/1200*10)=-2.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C1QA [Title/Abstract] AND CD74 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
Tgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
Tgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
Tgene | CD74 | GO:0007165 | signal transduction | 12782713 |
Tgene | CD74 | GO:0008283 | cell proliferation | 12782713 |
Tgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
Tgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
Tgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
Tgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
Tgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
Tgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
Tgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
Tgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
Tgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
Tgene | CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
Tgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-91-6835-01A | C1QA | chr1 | 22965442 | + | CD74 | chr5 | 149792314 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000374642 | ENST00000377795 | C1QA | chr1 | 22965442 | + | CD74 | chr5 | 149792314 | - |
5CDS-5UTR | ENST00000374642 | ENST00000353334 | C1QA | chr1 | 22965442 | + | CD74 | chr5 | 149792314 | - |
5CDS-5UTR | ENST00000374642 | ENST00000524315 | C1QA | chr1 | 22965442 | + | CD74 | chr5 | 149792314 | - |
5CDS-5UTR | ENST00000374642 | ENST00000009530 | C1QA | chr1 | 22965442 | + | CD74 | chr5 | 149792314 | - |
5CDS-5UTR | ENST00000402322 | ENST00000377795 | C1QA | chr1 | 22965442 | + | CD74 | chr5 | 149792314 | - |
5CDS-5UTR | ENST00000402322 | ENST00000353334 | C1QA | chr1 | 22965442 | + | CD74 | chr5 | 149792314 | - |
5CDS-5UTR | ENST00000402322 | ENST00000524315 | C1QA | chr1 | 22965442 | + | CD74 | chr5 | 149792314 | - |
5CDS-5UTR | ENST00000402322 | ENST00000009530 | C1QA | chr1 | 22965442 | + | CD74 | chr5 | 149792314 | - |
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FusionProtFeatures for C1QA_CD74 |
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Hgene | Tgene |
C1QA | CD74 |
C1q associates with the proenzymes C1r and C1s to yieldC1, the first component of the serum complement system. Thecollagen-like regions of C1q interact with the Ca(2+)-dependentC1r(2)C1s(2) proenzyme complex, and efficient activation of C1takes place on interaction of the globular heads of C1q with theFc regions of IgG or IgM antibody present in immune complexes. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C1QA_CD74 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for C1QA_CD74 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
C1QA | CRP, DCN, C1S, C1R, FN1, PPP1CA, PPP1CC, APOA1, HIPK3, SLC25A47, BAG6, UBQLN2, SGTA, PIAS2, UBQLN1, GNPNAT1, RAC1, HSPB2, NLGN3 | CD74 | MIF, CD74, APP, HADHA, LAMTOR5, MAP3K1, TM4SF20, COPG1, COPG2, HLA-DPB1, HLA-DQA1, CD44 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C1QA_CD74 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | C1QA | P02745 | DB00002 | Cetuximab | Complement C1q subcomponent subunit A | biotech | approved |
Hgene | C1QA | P02745 | DB00051 | Adalimumab | Complement C1q subcomponent subunit A | biotech | approved |
Hgene | C1QA | P02745 | DB00054 | Abciximab | Complement C1q subcomponent subunit A | biotech | approved |
Hgene | C1QA | P02745 | DB00073 | Rituximab | Complement C1q subcomponent subunit A | biotech | approved |
Hgene | C1QA | P02745 | DB00005 | Etanercept | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00056 | Gemtuzumab ozogamicin | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00072 | Trastuzumab | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00074 | Basiliximab | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00075 | Muromonab | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00078 | Ibritumomab tiuxetan | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00081 | Tositumomab | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00087 | Alemtuzumab | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00095 | Efalizumab | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00108 | Natalizumab | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00110 | Palivizumab | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00112 | Bevacizumab | Complement C1q subcomponent subunit A | biotech | approved|investigational |
Hgene | C1QA | P02745 | DB00092 | Alefacept | Complement C1q subcomponent subunit A | biotech | approved|investigational|withdrawn |
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RelatedDiseases for C1QA_CD74 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | C1QA | C0017661 | IGA Glomerulonephritis | 2 | CTD_human |
Hgene | C1QA | C0015230 | Exanthema | 1 | CTD_human |
Hgene | C1QA | C0017662 | Glomerulonephritis, Membranoproliferative | 1 | CTD_human |
Hgene | C1QA | C0020951 | Immune Complex Diseases | 1 | CTD_human |
Hgene | C1QA | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | C1QA | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
Hgene | C1QA | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | CD74 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | CD74 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CD74 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Tgene | CD74 | C1458155 | Mammary Neoplasms | 1 | CTD_human |