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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4761

FusionGeneSummary for C17orf62_ABCA7

check button Fusion gene summary
Fusion gene informationFusion gene name: C17orf62_ABCA7
Fusion gene ID: 4761
HgeneTgene
Gene symbol

C17orf62

ABCA7

Gene ID

10347

Gene nameATP binding cassette subfamily A member 7
SynonymsABCA-SSN|ABCX|AD9
Cytomap

19p13.3

Type of geneprotein-coding
DescriptionATP-binding cassette sub-family A member 7ATP-binding cassette, sub-family A (ABC1), member 7autoantigen SS-Nmacrophage ABC transporter
Modification date20180523
UniProtAcc

Q8IZY2

Ensembl transtripts involved in fusion geneENST00000342572, ENST00000306645, 
ENST00000437807, ENST00000336995, 
ENST00000434650, ENST00000583617, 
ENST00000577436, ENST00000585064, 
ENST00000577732, ENST00000578919, 
ENST00000585080, ENST00000578913, 
ENST00000583359, 		ENST00000263094, 
ENST00000433129, ENST00000435683, 
ENST00000533574, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 4 X 4=80
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C17orf62 [Title/Abstract] AND ABCA7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneABCA7

GO:0033344

cholesterol efflux

14570867

TgeneABCA7

GO:0033700

phospholipid efflux

14570867

TgeneABCA7

GO:0034380

high-density lipoprotein particle assembly

14570867

TgeneABCA7

GO:0038027

apolipoprotein A-I-mediated signaling pathway

14570867

TgeneABCA7

GO:0045332

phospholipid translocation

24097981


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A138-01AC17orf62chr17

80408576

-ABCA7chr19

1048894

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000342572ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000342572ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000342572ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-intronENST00000342572ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000306645ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000306645ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000306645ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-intronENST00000306645ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000437807ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000437807ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000437807ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-intronENST00000437807ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000336995ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000336995ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000336995ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-intronENST00000336995ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000434650ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000434650ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000434650ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-intronENST00000434650ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000583617ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000583617ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000583617ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-intronENST00000583617ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000577436ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000577436ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000577436ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-intronENST00000577436ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000585064ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000585064ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000585064ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-intronENST00000585064ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000577732ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000577732ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-3CDSENST00000577732ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
intron-intronENST00000577732ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000578919ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000578919ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000578919ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-intronENST00000578919ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000585080ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000585080ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000585080ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-intronENST00000585080ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000578913ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000578913ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000578913ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-intronENST00000578913ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000583359ENST00000263094C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000583359ENST00000433129C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-3CDSENST00000583359ENST00000435683C17orf62chr17

80408576

-ABCA7chr19

1048894

+
5UTR-intronENST00000583359ENST00000533574C17orf62chr17

80408576

-ABCA7chr19

1048894

+

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FusionProtFeatures for C17orf62_ABCA7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C17orf62

ABCA7

Q8IZY2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Plays a role in phagocytosis by macrophages of apoptoticcells. Binds APOA1 and may function in apolipoprotein-mediatedphospholipid efflux from cells. May also mediate cholesterolefflux. May regulate cellular ceramide homeostasis duringkeratinocytes differentiation. {ECO:0000269|PubMed:12917409,ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867,ECO:0000269|PubMed:14592415}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C17orf62_ABCA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C17orf62_ABCA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C17orf62ETS1, CCDC155, P2RX4, GTF2A1, CREB3, CREB3L1, DUSP6, CD79B, LMNAABCA7HNRNPD, LLGL2, SORT1, SYNCRIP, SGTB, HTR3A, GABRA3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C17orf62_ABCA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C17orf62_ABCA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABCA7C0002395Alzheimer's Disease2CTD_human