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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4754

FusionGeneSummary for C16orf87_ATXN2

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf87_ATXN2
Fusion gene ID: 4754
HgeneTgene
Gene symbol

C16orf87

ATXN2

Gene ID

388272

6311

Gene namechromosome 16 open reading frame 87ataxin 2
Synonyms-ATX2|SCA2|TNRC13
Cytomap

16q11.2

12q24.12

Type of geneprotein-codingprotein-coding
DescriptionUPF0547 protein C16orf87ataxin-2spinocerebellar ataxia type 2 proteintrinucleotide repeat-containing gene 13 protein
Modification date2018051920180523
UniProtAcc

Q6PH81

Q99700

Ensembl transtripts involved in fusion geneENST00000394806, ENST00000285697, 
ENST00000564250, 		ENST00000389153, 
ENST00000608853, ENST00000377617, 
ENST00000550104, ENST00000542287, 
ENST00000535949, ENST00000549455, 
Fusion gene scores* DoF score2 X 1 X 2=410 X 10 X 5=500
# samples 213
** MAII scorelog2(2/4*10)=2.32192809488736log2(13/500*10)=-1.94341647163363
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C16orf87 [Title/Abstract] AND ATXN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A7-A425-01AC16orf87chr16

46864996

-ATXN2chr12

111891649

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000394806ENST00000389153C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000394806ENST00000608853C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000394806ENST00000377617C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000394806ENST00000550104C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000394806ENST00000542287C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000394806ENST00000535949C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-intronENST00000394806ENST00000549455C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000285697ENST00000389153C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000285697ENST00000608853C16orf87chr16

46864996

-ATXN2chr12

111891649

-
In-frameENST00000285697ENST00000377617C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000285697ENST00000550104C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000285697ENST00000542287C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-3UTRENST00000285697ENST00000535949C16orf87chr16

46864996

-ATXN2chr12

111891649

-
5CDS-intronENST00000285697ENST00000549455C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3CDSENST00000564250ENST00000389153C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3CDSENST00000564250ENST00000608853C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3CDSENST00000564250ENST00000377617C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3UTRENST00000564250ENST00000550104C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3UTRENST00000564250ENST00000542287C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-3UTRENST00000564250ENST00000535949C16orf87chr16

46864996

-ATXN2chr12

111891649

-
intron-intronENST00000564250ENST00000549455C16orf87chr16

46864996

-ATXN2chr12

111891649

-

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FusionProtFeatures for C16orf87_ATXN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C16orf87

Q6PH81

ATXN2

Q99700

Involved in EGFR trafficking, acting as negativeregulator of endocytic EGFR internalization at the plasmamembrane. {ECO:0000269|PubMed:18602463}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC16orf87chr16:46864996chr12:111891649ENST00000285697-14104_13222155Coiled coilOntology_term=ECO:0000255
HgeneC16orf87chr16:46864996chr12:111891649ENST00000394806-13104_1322294Coiled coilOntology_term=ECO:0000255
TgeneATXN2chr16:46864996chr12:111891649ENST00000377617-2225166_18712481314Compositional biasNote=Poly-Gln
TgeneATXN2chr16:46864996chr12:111891649ENST00000377617-2225213_22312481314Compositional biasNote=Poly-Ser
TgeneATXN2chr16:46864996chr12:111891649ENST00000377617-222547_15812481314Compositional biasNote=Pro-rich
TgeneATXN2chr16:46864996chr12:111891649ENST00000377617-2225551_73412481314Compositional biasNote=Pro-rich
TgeneATXN2chr16:46864996chr12:111891649ENST00000377617-222555_6412481314Compositional biasNote=Poly-Pro
TgeneATXN2chr16:46864996chr12:111891649ENST00000377617-2225929_108512481314Compositional biasNote=Pro-rich
TgeneATXN2chr16:46864996chr12:111891649ENST00000550104-2124166_18712271015Compositional biasNote=Poly-Gln
TgeneATXN2chr16:46864996chr12:111891649ENST00000550104-2124213_22312271015Compositional biasNote=Poly-Ser
TgeneATXN2chr16:46864996chr12:111891649ENST00000550104-212447_15812271015Compositional biasNote=Pro-rich
TgeneATXN2chr16:46864996chr12:111891649ENST00000550104-2124551_73412271015Compositional biasNote=Pro-rich
TgeneATXN2chr16:46864996chr12:111891649ENST00000550104-212455_6412271015Compositional biasNote=Poly-Pro
TgeneATXN2chr16:46864996chr12:111891649ENST00000550104-2124929_108512271015Compositional biasNote=Pro-rich


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FusionGeneSequence for C16orf87_ATXN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_C16orf87_ENST00000394806_chr16_46864996_-_ATXN2_ENST00000389153_chr12_111891649_-_88aa

>In-frame_C16orf87_ENST00000394806_chr16_46864996_-_ATXN2_ENST00000608853_chr12_111891649_-_88aa

>In-frame_C16orf87_ENST00000394806_chr16_46864996_-_ATXN2_ENST00000377617_chr12_111891649_-_88aa

>In-frame_C16orf87_ENST00000285697_chr16_46864996_-_ATXN2_ENST00000389153_chr12_111891649_-_88aa

>In-frame_C16orf87_ENST00000285697_chr16_46864996_-_ATXN2_ENST00000608853_chr12_111891649_-_88aa

>In-frame_C16orf87_ENST00000285697_chr16_46864996_-_ATXN2_ENST00000377617_chr12_111891649_-_88aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_C16orf87_ENST00000394806_chr16_46864996_-_ATXN2_ENST00000389153_chr12_111891649_-_264nt
ATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTT
CCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTA

>In-frame_C16orf87_ENST00000394806_chr16_46864996_-_ATXN2_ENST00000608853_chr12_111891649_-_264nt
ATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTT
CCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTA

>In-frame_C16orf87_ENST00000394806_chr16_46864996_-_ATXN2_ENST00000377617_chr12_111891649_-_264nt
ATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTT
CCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTA

>In-frame_C16orf87_ENST00000285697_chr16_46864996_-_ATXN2_ENST00000389153_chr12_111891649_-_264nt
ATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTT
CCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTA

>In-frame_C16orf87_ENST00000285697_chr16_46864996_-_ATXN2_ENST00000608853_chr12_111891649_-_264nt
ATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTT
CCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTA

>In-frame_C16orf87_ENST00000285697_chr16_46864996_-_ATXN2_ENST00000377617_chr12_111891649_-_264nt
ATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTT
CCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTA


* Fusion transcript sequences (Full-length transcript).
>In-frame_C16orf87_ENST00000394806_chr16_46864996_-_ATXN2_ENST00000389153_chr12_111891649_-_875nt
AAGGGAGAGGAGCATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACA
GTCAGGAATGGTTCCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGC
TCAAAGTGCACTACAGCCCATTCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCA
GTTGTAAGGCTGCCCTGGAGGAACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATT
TCATTTATTTTGTTTTTAAAATATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGG
ACCGAGTAGAGGCATTTAGGAACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCG
AAACTGGAAGTTATTTATTTTTTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTA
TTACTGCTAAAAAAAAAAAAAAAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAA
ACTGACGGATTATTATTTATAAATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACT

>In-frame_C16orf87_ENST00000394806_chr16_46864996_-_ATXN2_ENST00000608853_chr12_111891649_-_875nt
AAGGGAGAGGAGCATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACA
GTCAGGAATGGTTCCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGC
TCAAAGTGCACTACAGCCCATTCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCA
GTTGTAAGGCTGCCCTGGAGGAACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATT
TCATTTATTTTGTTTTTAAAATATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGG
ACCGAGTAGAGGCATTTAGGAACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCG
AAACTGGAAGTTATTTATTTTTTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTA
TTACTGCTAAAAAAAAAAAAAAAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAA
ACTGACGGATTATTATTTATAAATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACT

>In-frame_C16orf87_ENST00000394806_chr16_46864996_-_ATXN2_ENST00000377617_chr12_111891649_-_875nt
AAGGGAGAGGAGCATGTCTGCAACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACA
GTCAGGAATGGTTCCTTCTCATCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGC
TCAAAGTGCACTACAGCCCATTCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCA
GTTGTAAGGCTGCCCTGGAGGAACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATT
TCATTTATTTTGTTTTTAAAATATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGG
ACCGAGTAGAGGCATTTAGGAACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCG
AAACTGGAAGTTATTTATTTTTTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTA
TTACTGCTAAAAAAAAAAAAAAAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAA
ACTGACGGATTATTATTTATAAATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACT

>In-frame_C16orf87_ENST00000285697_chr16_46864996_-_ATXN2_ENST00000389153_chr12_111891649_-_1124nt
GATACTCTGGGCGAGCTCGCGGGCGGGCTGTGGGTCGCGAGCCGCCGTGGGAGCGCGTGTCGCGGTCCCCAGGAGCCGCCGGCCGACGCT
CCGCCCCGCCCCCTTGGCGCCCAGGTCCCGCGCGAGCTCGCGCACGCGCGCGCGCGCACCCGCCAGAGGCTTGTTTGAGGCCCGCGGGGA
CTGGGCGGGCGGAGGCCGGGCTGCCGAAGTGTGAGGGGAGGAGCCCGAGCCGTCGCTGCTGCCGCCGCTAAGGGAGAGGAGCATGTCTGC
AACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTTCCTTCTCA
TCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTACAGCCCAT
TCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCAGTTGTAAGGCTGCCCTGGAGG
AACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATTTCATTTATTTTGTTTTTAAAA
TATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGGACCGAGTAGAGGCATTTAGGA
ACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCGAAACTGGAAGTTATTTATTTT
TTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTATTACTGCTAAAAAAAAAAAAA
AAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAAACTGACGGATTATTATTTATA
AATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACTTTGTAGATAATATAAAATAAA

>In-frame_C16orf87_ENST00000285697_chr16_46864996_-_ATXN2_ENST00000608853_chr12_111891649_-_1124nt
GATACTCTGGGCGAGCTCGCGGGCGGGCTGTGGGTCGCGAGCCGCCGTGGGAGCGCGTGTCGCGGTCCCCAGGAGCCGCCGGCCGACGCT
CCGCCCCGCCCCCTTGGCGCCCAGGTCCCGCGCGAGCTCGCGCACGCGCGCGCGCGCACCCGCCAGAGGCTTGTTTGAGGCCCGCGGGGA
CTGGGCGGGCGGAGGCCGGGCTGCCGAAGTGTGAGGGGAGGAGCCCGAGCCGTCGCTGCTGCCGCCGCTAAGGGAGAGGAGCATGTCTGC
AACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTTCCTTCTCA
TCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTACAGCCCAT
TCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCAGTTGTAAGGCTGCCCTGGAGG
AACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATTTCATTTATTTTGTTTTTAAAA
TATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGGACCGAGTAGAGGCATTTAGGA
ACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCGAAACTGGAAGTTATTTATTTT
TTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTATTACTGCTAAAAAAAAAAAAA
AAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAAACTGACGGATTATTATTTATA
AATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACTTTGTAGATAATATAAAATAAA

>In-frame_C16orf87_ENST00000285697_chr16_46864996_-_ATXN2_ENST00000377617_chr12_111891649_-_1124nt
GATACTCTGGGCGAGCTCGCGGGCGGGCTGTGGGTCGCGAGCCGCCGTGGGAGCGCGTGTCGCGGTCCCCAGGAGCCGCCGGCCGACGCT
CCGCCCCGCCCCCTTGGCGCCCAGGTCCCGCGCGAGCTCGCGCACGCGCGCGCGCGCACCCGCCAGAGGCTTGTTTGAGGCCCGCGGGGA
CTGGGCGGGCGGAGGCCGGGCTGCCGAAGTGTGAGGGGAGGAGCCCGAGCCGTCGCTGCTGCCGCCGCTAAGGGAGAGGAGCATGTCTGC
AACTCGAGCCAAGAAAGTGAAGATGGCCACCAAATCATGCCCCGAGTGCGACCAACAGGCTCATGTACAGTCAGGAATGGTTCCTTCTCA
TCCAACTGCCCATGCGCCAATGATGCTAATGACGACACAGCCACCCGGCGGTCCCCAGGCCGCCCTCGCTCAAAGTGCACTACAGCCCAT
TCCAGTCTCGACAACAGCGCATTTCCCCTATATGACGCACCCTTCAGTACAAGCCCACCACCAACAGCAGTTGTAAGGCTGCCCTGGAGG
AACCGAAAGGCCAAATTCCCTCCTCCCTTCTACTGCTTCTACCAACTGGAAGCACAGAAAACTAGAATTTCATTTATTTTGTTTTTAAAA
TATATATGTTGATTTCTTGTAACATCCAATAGGAATGCTAACAGTTCACTTGCAGTGGAAGATACTTGGACCGAGTAGAGGCATTTAGGA
ACTTGGGGGCTATTCCATAATTCCATATGCTGTTTCAGAGTCCCGCAGGTACCCCAGCTCTGCTTGCCGAAACTGGAAGTTATTTATTTT
TTAATAACCCTTGAAAGTCATGAACACATCAGCTAGCAAAAGAAGTAACAAGAGTGATTCTTGCTGCTATTACTGCTAAAAAAAAAAAAA
AAAAAAAATCAAGACTTGGAACGCCCTTTTACTAAACTTGACAAAGTTTCAGTAAATTCTTACCGTCAAACTGACGGATTATTATTTATA
AATCAAGTTTGATGAGGTGATCACTGTCTACAGTGGTTCAACTTTTAAGTTAAGGGAAAAACTTTTACTTTGTAGATAATATAAAATAAA


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FusionGenePPI for C16orf87_ATXN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C16orf87ELAVL1, HDAC1, HDAC2, MAGEA12, MOV10, HIST1H2BA, MIER3, ANAPC2, MIER1, CDC16, ARID5B, NEK2, ANAPC4, CDC23, CDC27, MIER2, ANAPC5, ANAPC1, FZR1, H2AFX, ANAPC7, ANAPC16ATXN2VHL, CHGB, SH3KBP1, SH3GL2, SH3GL3, EGFR, TSG101, PABPC1, ISG15, PARK2, CUL3, CAND1, IDH3B, NCOA4, ZNRD1, RBFOX1, ATXN1, ACTN1, ACTN2, GOLGA6L5P, KIAA1279, TDRD7, BAG6, GFI1B, GPKOW, CCT5, MDC1, SHFM1, WWOX, DDX6, MOV10, NXF1, BMI1, CELA2B, FGL1, BCAT1, SKAP1, RBFOX2, CARD8, CCNDBP1, ADA, DDX17, DDX5, DHX15, KHDRBS1, KHDRBS2, KHDRBS3, TARDBP, LSM12, PABPC4, NTRK1, RPL10, YEATS4, SEC16A, PTPN18, PTPRA, LPXN, CELF5, ELAVL2, NME2P1, ESRP1, NUFIP2, APOBEC3D, NXF2, P4HA2, FAM98A, CLASRP, ASB3, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C16orf87_ATXN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C16orf87_ATXN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATXN2C0087012Ataxia, Spinocerebellar2CTD_human
TgeneATXN2C0036341Schizophrenia1PSYGENET
TgeneATXN2C0339573Glaucoma, Primary Open Angle1CTD_human