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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4752

FusionGeneSummary for C16orf74_SLPI

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf74_SLPI
Fusion gene ID: 4752
HgeneTgene
Gene symbol

C16orf74

SLPI

Gene ID

404550

6590

Gene namechromosome 16 open reading frame 74secretory leukocyte peptidase inhibitor
Synonyms-ALK1|ALP|BLPI|HUSI|HUSI-I|MPI|WAP4|WFDC4
Cytomap

16q24.1

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C16orf74hypothetical protein 1hypothetical protein 2hypothetical protein 3antileukoproteinaseHUSI-1WAP four-disulfide core domain protein 4mucus proteinase inhibitorprotease inhibitor WAP4secretory leukocyte protease inhibitor (antileukoproteinase)seminal proteinase inhibitor
Modification date2018051920180519
UniProtAcc

Q96GX8

P03973

Ensembl transtripts involved in fusion geneENST00000602758, ENST00000602719, 
ENST00000602583, ENST00000602675, 
ENST00000284245, ENST00000602914, 
ENST00000602766, 
ENST00000338380, 
Fusion gene scores* DoF score3 X 3 X 4=363 X 3 X 2=18
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C16orf74 [Title/Abstract] AND SLPI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLPI

GO:0019731

antibacterial humoral response

18714013

TgeneSLPI

GO:0032091

negative regulation of protein binding

19333378

TgeneSLPI

GO:0035821

modification of morphology or physiology of other organism

2467900

TgeneSLPI

GO:0045071

negative regulation of viral genome replication

19333378


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI063065C16orf74chr16

85759593

+SLPIchr20

43881039

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000602758ENST00000338380C16orf74chr16

85759593

+SLPIchr20

43881039

+
intron-3UTRENST00000602719ENST00000338380C16orf74chr16

85759593

+SLPIchr20

43881039

+
intron-3UTRENST00000602583ENST00000338380C16orf74chr16

85759593

+SLPIchr20

43881039

+
intron-3UTRENST00000602675ENST00000338380C16orf74chr16

85759593

+SLPIchr20

43881039

+
intron-3UTRENST00000284245ENST00000338380C16orf74chr16

85759593

+SLPIchr20

43881039

+
intron-3UTRENST00000602914ENST00000338380C16orf74chr16

85759593

+SLPIchr20

43881039

+
intron-3UTRENST00000602766ENST00000338380C16orf74chr16

85759593

+SLPIchr20

43881039

+

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FusionProtFeatures for C16orf74_SLPI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C16orf74

Q96GX8

SLPI

P03973

Acid-stable proteinase inhibitor with strong affinitiesfor trypsin, chymotrypsin, elastase, and cathepsin G(PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563,PubMed:10702419, PubMed:24121345). Modulates the inflammatory andimmune responses after bacterial infection, and after infection bythe intracellular parasite L.major. Down-regulates responses tobacterial lipopolysaccharide (LPS) (By similarity). Plays a rolein regulating the activation of NF-kappa-B and inflammatoryresponses (PubMed:10702419, PubMed:24352879). Has antimicrobialactivity against mycobacteria, but not against salmonella.Contributes to normal resistance against infection byM.tuberculosis. Required for normal resistance to infection byL.major. Required for normal wound healing, probably by preventingtissue damage by limiting protease activity (By similarity).Together with ELANE, required for normal differentiation andproliferation of bone marrow myeloid cells (PubMed:24352879).{ECO:0000250|UniProtKB:P97430, ECO:0000269|PubMed:10702419,ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:2110563,ECO:0000269|PubMed:24121345, ECO:0000269|PubMed:24352879,ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3533531,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C16orf74_SLPI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C16orf74_SLPI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C16orf74_SLPI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C16orf74_SLPI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLPIC0035126Reperfusion Injury1CTD_human
TgeneSLPIC4277682Chemical and Drug Induced Liver Injury1CTD_human