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Fusion gene ID: 4746 |
FusionGeneSummary for C16orf72_ACSM2A |
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Fusion gene information | Fusion gene name: C16orf72_ACSM2A | Fusion gene ID: 4746 | Hgene | Tgene | Gene symbol | C16orf72 | ACSM2A | Gene ID | 29035 | 123876 |
Gene name | chromosome 16 open reading frame 72 | acyl-CoA synthetase medium chain family member 2A | |
Synonyms | PRO0149 | A-923A4.1|ACSM2 | |
Cytomap | 16p13.2 | 16p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | UPF0472 protein C16orf72 | acyl-coenzyme A synthetase ACSM2A, mitochondrialacyl-CoA synthetase medium-chain family member 2butyrate--CoA ligase 2Abutyryl-coenzyme A synthetase 2Amiddle-chain acyl-CoA synthetase 2A | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q14CZ0 | Q08AH3 | |
Ensembl transtripts involved in fusion gene | ENST00000327827, | ENST00000417235, ENST00000424070, ENST00000575558, ENST00000536134, ENST00000573854, ENST00000219054, ENST00000575690, ENST00000396104, | |
Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: C16orf72 [Title/Abstract] AND ACSM2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ACSM2A | GO:0036112 | medium-chain fatty-acyl-CoA metabolic process | 19345228 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-C8-A278-01A | C16orf72 | chr16 | 9186858 | + | ACSM2A | chr16 | 20471429 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000327827 | ENST00000417235 | C16orf72 | chr16 | 9186858 | + | ACSM2A | chr16 | 20471429 | + |
5CDS-5UTR | ENST00000327827 | ENST00000424070 | C16orf72 | chr16 | 9186858 | + | ACSM2A | chr16 | 20471429 | + |
5CDS-intron | ENST00000327827 | ENST00000575558 | C16orf72 | chr16 | 9186858 | + | ACSM2A | chr16 | 20471429 | + |
5CDS-5UTR | ENST00000327827 | ENST00000536134 | C16orf72 | chr16 | 9186858 | + | ACSM2A | chr16 | 20471429 | + |
5CDS-5UTR | ENST00000327827 | ENST00000573854 | C16orf72 | chr16 | 9186858 | + | ACSM2A | chr16 | 20471429 | + |
5CDS-5UTR | ENST00000327827 | ENST00000219054 | C16orf72 | chr16 | 9186858 | + | ACSM2A | chr16 | 20471429 | + |
5CDS-5UTR | ENST00000327827 | ENST00000575690 | C16orf72 | chr16 | 9186858 | + | ACSM2A | chr16 | 20471429 | + |
5CDS-5UTR | ENST00000327827 | ENST00000396104 | C16orf72 | chr16 | 9186858 | + | ACSM2A | chr16 | 20471429 | + |
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FusionProtFeatures for C16orf72_ACSM2A |
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Hgene | Tgene |
C16orf72 | ACSM2A |
Has medium-chain fatty acid:CoA ligase activity withbroad substrate specificity (in vitro). Acts on acids from C(4) toC(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C16orf72_ACSM2A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for C16orf72_ACSM2A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
C16orf72 | ELAVL1, FAM9B, HUWE1, UNK, KRAS | ACSM2A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C16orf72_ACSM2A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C16orf72_ACSM2A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |