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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4746

FusionGeneSummary for C16orf72_ACSM2A

check button Fusion gene summary
Fusion gene informationFusion gene name: C16orf72_ACSM2A
Fusion gene ID: 4746
HgeneTgene
Gene symbol

C16orf72

ACSM2A

Gene ID

29035

123876

Gene namechromosome 16 open reading frame 72acyl-CoA synthetase medium chain family member 2A
SynonymsPRO0149A-923A4.1|ACSM2
Cytomap

16p13.2

16p12.3

Type of geneprotein-codingprotein-coding
DescriptionUPF0472 protein C16orf72acyl-coenzyme A synthetase ACSM2A, mitochondrialacyl-CoA synthetase medium-chain family member 2butyrate--CoA ligase 2Abutyryl-coenzyme A synthetase 2Amiddle-chain acyl-CoA synthetase 2A
Modification date2018051920180523
UniProtAcc

Q14CZ0

Q08AH3

Ensembl transtripts involved in fusion geneENST00000327827, ENST00000417235, 
ENST00000424070, ENST00000575558, 
ENST00000536134, ENST00000573854, 
ENST00000219054, ENST00000575690, 
ENST00000396104, 
Fusion gene scores* DoF score5 X 5 X 3=751 X 1 X 1=1
# samples 61
** MAII scorelog2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: C16orf72 [Title/Abstract] AND ACSM2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACSM2A

GO:0036112

medium-chain fatty-acyl-CoA metabolic process

19345228


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A278-01AC16orf72chr16

9186858

+ACSM2Achr16

20471429

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000327827ENST00000417235C16orf72chr16

9186858

+ACSM2Achr16

20471429

+
5CDS-5UTRENST00000327827ENST00000424070C16orf72chr16

9186858

+ACSM2Achr16

20471429

+
5CDS-intronENST00000327827ENST00000575558C16orf72chr16

9186858

+ACSM2Achr16

20471429

+
5CDS-5UTRENST00000327827ENST00000536134C16orf72chr16

9186858

+ACSM2Achr16

20471429

+
5CDS-5UTRENST00000327827ENST00000573854C16orf72chr16

9186858

+ACSM2Achr16

20471429

+
5CDS-5UTRENST00000327827ENST00000219054C16orf72chr16

9186858

+ACSM2Achr16

20471429

+
5CDS-5UTRENST00000327827ENST00000575690C16orf72chr16

9186858

+ACSM2Achr16

20471429

+
5CDS-5UTRENST00000327827ENST00000396104C16orf72chr16

9186858

+ACSM2Achr16

20471429

+

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FusionProtFeatures for C16orf72_ACSM2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C16orf72

Q14CZ0

ACSM2A

Q08AH3

Has medium-chain fatty acid:CoA ligase activity withbroad substrate specificity (in vitro). Acts on acids from C(4) toC(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for C16orf72_ACSM2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for C16orf72_ACSM2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
C16orf72ELAVL1, FAM9B, HUWE1, UNK, KRASACSM2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for C16orf72_ACSM2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for C16orf72_ACSM2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource