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Fusion gene ID: 4741 |
FusionGeneSummary for C16orf70_DNAAF1 |
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Fusion gene information | Fusion gene name: C16orf70_DNAAF1 | Fusion gene ID: 4741 | Hgene | Tgene | Gene symbol | C16orf70 | DNAAF1 | Gene ID | 80262 | 123872 |
Gene name | chromosome 16 open reading frame 70 | dynein axonemal assembly factor 1 | |
Synonyms | C16orf6|LIN10|lin-10 | CILD13|LRRC50|ODA7|swt | |
Cytomap | 16q22.1 | 16q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | UPF0183 protein C16orf70lin-10 homolog | dynein assembly factor 1, axonemalleucine-rich repeat-containing protein 50outer row dynein assembly 7 homologtesticular tissue protein Li 110 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9BSU1 | Q8NEP3 | |
Ensembl transtripts involved in fusion gene | ENST00000569600, ENST00000219139, ENST00000569683, | ENST00000334315, ENST00000378553, ENST00000563818, | |
Fusion gene scores | * DoF score | 7 X 6 X 7=294 | 2 X 2 X 2=8 |
# samples | 7 | 2 | |
** MAII score | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: C16orf70 [Title/Abstract] AND DNAAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-LN-A49L-01A | C16orf70 | chr16 | 67144142 | + | DNAAF1 | chr16 | 84193280 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000569600 | ENST00000334315 | C16orf70 | chr16 | 67144142 | + | DNAAF1 | chr16 | 84193280 | + |
Frame-shift | ENST00000569600 | ENST00000378553 | C16orf70 | chr16 | 67144142 | + | DNAAF1 | chr16 | 84193280 | + |
5CDS-3UTR | ENST00000569600 | ENST00000563818 | C16orf70 | chr16 | 67144142 | + | DNAAF1 | chr16 | 84193280 | + |
Frame-shift | ENST00000219139 | ENST00000334315 | C16orf70 | chr16 | 67144142 | + | DNAAF1 | chr16 | 84193280 | + |
Frame-shift | ENST00000219139 | ENST00000378553 | C16orf70 | chr16 | 67144142 | + | DNAAF1 | chr16 | 84193280 | + |
5CDS-3UTR | ENST00000219139 | ENST00000563818 | C16orf70 | chr16 | 67144142 | + | DNAAF1 | chr16 | 84193280 | + |
3UTR-3CDS | ENST00000569683 | ENST00000334315 | C16orf70 | chr16 | 67144142 | + | DNAAF1 | chr16 | 84193280 | + |
3UTR-3CDS | ENST00000569683 | ENST00000378553 | C16orf70 | chr16 | 67144142 | + | DNAAF1 | chr16 | 84193280 | + |
3UTR-3UTR | ENST00000569683 | ENST00000563818 | C16orf70 | chr16 | 67144142 | + | DNAAF1 | chr16 | 84193280 | + |
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FusionProtFeatures for C16orf70_DNAAF1 |
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Hgene | Tgene |
C16orf70 | DNAAF1 |
Cilium-specific protein required for the stability ofthe ciliary architecture. Plays a role in cytoplasmic preassemblyof dynein arms. Involved in regulation of microtubule-based ciliaand actin-based brush border microvilli.{ECO:0000269|PubMed:18385425, ECO:0000269|PubMed:19944400,ECO:0000269|PubMed:19944405}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for C16orf70_DNAAF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for C16orf70_DNAAF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
C16orf70 | ATXN3, APP, SERPINB6, BCAS3, CELA2B, SERPINA3, NEFH, NEFL, CALML5, OCRL, APPL1, SBSN, CST6, NUP35, ANK3, MASTL, SERPINB4, SERPINB3, TGM3, POMP, POF1B, CALML3, PSMG2, GM2A, FBXO30, PPFIA1, S100A7, ZBTB16, WIPI2, MAGEE1, AZGP1 | DNAAF1 | OBSL1, GLRX3, ANKMY2, XPNPEP3, STOM |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C16orf70_DNAAF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C16orf70_DNAAF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DNAAF1 | C2750790 | CILIARY DYSKINESIA, PRIMARY, 13 | 1 | CTD_human;UNIPROT |