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Fusion gene ID: 469 |
FusionGeneSummary for ACSBG1_ABCG1 |
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Fusion gene information | Fusion gene name: ACSBG1_ABCG1 | Fusion gene ID: 469 | Hgene | Tgene | Gene symbol | ACSBG1 | ABCG1 | Gene ID | 23205 | 9619 |
Gene name | acyl-CoA synthetase bubblegum family member 1 | ATP binding cassette subfamily G member 1 | |
Synonyms | BG|BG1|BGM|GR-LACS|LPD | ABC8|WHITE1 | |
Cytomap | 15q25.1 | 21q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | long-chain-fatty-acid--CoA ligase ACSBG1bubblegumlipidosinvery long-chain acyl-CoA synthetase | ATP-binding cassette sub-family G member 1ABC transporter 8ATP-binding cassette transporter 8ATP-binding cassette transporter member 1 of subfamily GATP-binding cassette, sub-family G (WHITE), member 1homolog of Drosophila whitewhite protein homolog | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96GR2 | P45844 | |
Ensembl transtripts involved in fusion gene | ENST00000258873, ENST00000541759, ENST00000560817, ENST00000558828, | ENST00000398457, ENST00000462050, ENST00000347800, ENST00000398449, ENST00000361802, ENST00000343687, ENST00000398437, ENST00000340588, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 3 X 7=168 |
# samples | 1 | 8 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACSBG1 [Title/Abstract] AND ABCG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACSBG1 | GO:0000038 | very long-chain fatty acid metabolic process | 10954726 |
Hgene | ACSBG1 | GO:0001676 | long-chain fatty acid metabolic process | 10954726 |
Tgene | ABCG1 | GO:0008203 | cholesterol metabolic process | 15994327 |
Tgene | ABCG1 | GO:0010033 | response to organic substance | 11500512 |
Tgene | ABCG1 | GO:0033344 | cholesterol efflux | 15994327 |
Tgene | ABCG1 | GO:0033993 | response to lipid | 16556852 |
Tgene | ABCG1 | GO:0034436 | glycoprotein transport | 17293612 |
Tgene | ABCG1 | GO:0042632 | cholesterol homeostasis | 15994327 |
Tgene | ABCG1 | GO:0042987 | amyloid precursor protein catabolic process | 17293612 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | U34919 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000258873 | ENST00000398457 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000258873 | ENST00000462050 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000258873 | ENST00000347800 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000258873 | ENST00000398449 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000258873 | ENST00000361802 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000258873 | ENST00000343687 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-intron | ENST00000258873 | ENST00000398437 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-intron | ENST00000258873 | ENST00000340588 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3CDS | ENST00000541759 | ENST00000398457 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000541759 | ENST00000462050 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000541759 | ENST00000347800 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000541759 | ENST00000398449 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000541759 | ENST00000361802 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000541759 | ENST00000343687 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-intron | ENST00000541759 | ENST00000398437 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-intron | ENST00000541759 | ENST00000340588 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3CDS | ENST00000560817 | ENST00000398457 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000560817 | ENST00000462050 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000560817 | ENST00000347800 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000560817 | ENST00000398449 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000560817 | ENST00000361802 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000560817 | ENST00000343687 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-intron | ENST00000560817 | ENST00000398437 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-intron | ENST00000560817 | ENST00000340588 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3CDS | ENST00000558828 | ENST00000398457 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000558828 | ENST00000462050 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000558828 | ENST00000347800 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000558828 | ENST00000398449 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000558828 | ENST00000361802 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-3UTR | ENST00000558828 | ENST00000343687 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-intron | ENST00000558828 | ENST00000398437 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
intron-intron | ENST00000558828 | ENST00000340588 | ACSBG1 | chr15 | 78521562 | - | ABCG1 | chr21 | 43645835 | + |
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FusionProtFeatures for ACSBG1_ABCG1 |
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Hgene | Tgene |
ACSBG1 | ABCG1 |
Mediates activation of long-chain fatty acids for bothsynthesis of cellular lipids, and degradation via beta-oxidation.Able to activate long-chain fatty acids. Also able to activatevery long-chain fatty acids; however, the relevance of suchactivity is unclear in vivo. Can activate diverse saturated,monosaturated and polyunsaturated fatty acids.{ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACSBG1_ABCG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACSBG1_ABCG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACSBG1_ABCG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACSBG1_ABCG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ABCG1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | ABCG1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Tgene | ABCG1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ABCG1 | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | ABCG1 | C0525045 | Mood Disorders | 1 | PSYGENET |