FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 469

FusionGeneSummary for ACSBG1_ABCG1

check button Fusion gene summary
Fusion gene informationFusion gene name: ACSBG1_ABCG1
Fusion gene ID: 469
HgeneTgene
Gene symbol

ACSBG1

ABCG1

Gene ID

23205

9619

Gene nameacyl-CoA synthetase bubblegum family member 1ATP binding cassette subfamily G member 1
SynonymsBG|BG1|BGM|GR-LACS|LPDABC8|WHITE1
Cytomap

15q25.1

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionlong-chain-fatty-acid--CoA ligase ACSBG1bubblegumlipidosinvery long-chain acyl-CoA synthetaseATP-binding cassette sub-family G member 1ABC transporter 8ATP-binding cassette transporter 8ATP-binding cassette transporter member 1 of subfamily GATP-binding cassette, sub-family G (WHITE), member 1homolog of Drosophila whitewhite protein homolog
Modification date2018051920180523
UniProtAcc

Q96GR2

P45844

Ensembl transtripts involved in fusion geneENST00000258873, ENST00000541759, 
ENST00000560817, ENST00000558828, 
ENST00000398457, ENST00000462050, 
ENST00000347800, ENST00000398449, 
ENST00000361802, ENST00000343687, 
ENST00000398437, ENST00000340588, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 3 X 7=168
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACSBG1 [Title/Abstract] AND ABCG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACSBG1

GO:0000038

very long-chain fatty acid metabolic process

10954726

HgeneACSBG1

GO:0001676

long-chain fatty acid metabolic process

10954726

TgeneABCG1

GO:0008203

cholesterol metabolic process

15994327

TgeneABCG1

GO:0010033

response to organic substance

11500512

TgeneABCG1

GO:0033344

cholesterol efflux

15994327

TgeneABCG1

GO:0033993

response to lipid

16556852

TgeneABCG1

GO:0034436

glycoprotein transport

17293612

TgeneABCG1

GO:0042632

cholesterol homeostasis

15994327

TgeneABCG1

GO:0042987

amyloid precursor protein catabolic process

17293612


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1U34919ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000258873ENST00000398457ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000258873ENST00000462050ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000258873ENST00000347800ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000258873ENST00000398449ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000258873ENST00000361802ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000258873ENST00000343687ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-intronENST00000258873ENST00000398437ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-intronENST00000258873ENST00000340588ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3CDSENST00000541759ENST00000398457ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000541759ENST00000462050ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000541759ENST00000347800ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000541759ENST00000398449ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000541759ENST00000361802ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000541759ENST00000343687ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-intronENST00000541759ENST00000398437ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-intronENST00000541759ENST00000340588ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3CDSENST00000560817ENST00000398457ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000560817ENST00000462050ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000560817ENST00000347800ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000560817ENST00000398449ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000560817ENST00000361802ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000560817ENST00000343687ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-intronENST00000560817ENST00000398437ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-intronENST00000560817ENST00000340588ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3CDSENST00000558828ENST00000398457ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000558828ENST00000462050ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000558828ENST00000347800ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000558828ENST00000398449ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000558828ENST00000361802ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-3UTRENST00000558828ENST00000343687ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-intronENST00000558828ENST00000398437ACSBG1chr15

78521562

-ABCG1chr21

43645835

+
intron-intronENST00000558828ENST00000340588ACSBG1chr15

78521562

-ABCG1chr21

43645835

+

Top

FusionProtFeatures for ACSBG1_ABCG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACSBG1

Q96GR2

ABCG1

P45844

Mediates activation of long-chain fatty acids for bothsynthesis of cellular lipids, and degradation via beta-oxidation.Able to activate long-chain fatty acids. Also able to activatevery long-chain fatty acids; however, the relevance of suchactivity is unclear in vivo. Can activate diverse saturated,monosaturated and polyunsaturated fatty acids.{ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ACSBG1_ABCG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ACSBG1_ABCG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ACSBG1_ABCG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ACSBG1_ABCG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABCG1C0009404Colorectal Neoplasms1CTD_human
TgeneABCG1C0022661Kidney Failure, Chronic1CTD_human
TgeneABCG1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneABCG1C0043094Weight Gain1CTD_human
TgeneABCG1C0525045Mood Disorders1PSYGENET