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Fusion gene ID: 4683 |
FusionGeneSummary for C12orf5_ZNF827 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C12orf5_ZNF827 | Fusion gene ID: 4683 | Hgene | Tgene | Gene symbol | C12orf5 | ZNF827 | Gene ID | 57103 | 152485 |
| Gene name | TP53 induced glycolysis regulatory phosphatase | zinc finger protein 827 | |
| Synonyms | C12orf5|FR2BP | - | |
| Cytomap | 12p13.32 | 4q31.21-q31.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fructose-2,6-bisphosphatase TIGARTP53-induced glycolysis and apoptosis regulatorfructose-2,6-bisphosphate 2-phosphataseprobable fructose-2,6-bisphosphatase TIGARtransactivated by NS3TP2 protein | zinc finger protein 827 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q17R98 | ||
| Ensembl transtripts involved in fusion gene | ENST00000179259, ENST00000537251, | ENST00000508784, ENST00000513320, ENST00000379448, ENST00000511534, | |
| Fusion gene scores | * DoF score | 5 X 2 X 3=30 | 10 X 4 X 7=280 |
| # samples | 5 | 10 | |
| ** MAII score | log2(5/30*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C12orf5 [Title/Abstract] AND ZNF827 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | C12orf5 | GO:0006003 | fructose 2,6-bisphosphate metabolic process | 19015259 |
| Hgene | C12orf5 | GO:0006974 | cellular response to DNA damage stimulus | 25928429 |
| Hgene | C12orf5 | GO:0030388 | fructose 1,6-bisphosphate metabolic process | 19015259 |
| Hgene | C12orf5 | GO:0043069 | negative regulation of programmed cell death | 23185017 |
| Hgene | C12orf5 | GO:0071279 | cellular response to cobalt ion | 25928429 |
| Hgene | C12orf5 | GO:0071456 | cellular response to hypoxia | 23185017 |
| Hgene | C12orf5 | GO:1903301 | positive regulation of hexokinase activity | 23185017 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-3B-A9HL-01A | C12orf5 | chr12 | 4430469 | + | ZNF827 | chr4 | 146744677 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000179259 | ENST00000508784 | C12orf5 | chr12 | 4430469 | + | ZNF827 | chr4 | 146744677 | - |
| In-frame | ENST00000179259 | ENST00000513320 | C12orf5 | chr12 | 4430469 | + | ZNF827 | chr4 | 146744677 | - |
| In-frame | ENST00000179259 | ENST00000379448 | C12orf5 | chr12 | 4430469 | + | ZNF827 | chr4 | 146744677 | - |
| 5CDS-intron | ENST00000179259 | ENST00000511534 | C12orf5 | chr12 | 4430469 | + | ZNF827 | chr4 | 146744677 | - |
| intron-3CDS | ENST00000537251 | ENST00000508784 | C12orf5 | chr12 | 4430469 | + | ZNF827 | chr4 | 146744677 | - |
| intron-3CDS | ENST00000537251 | ENST00000513320 | C12orf5 | chr12 | 4430469 | + | ZNF827 | chr4 | 146744677 | - |
| intron-3CDS | ENST00000537251 | ENST00000379448 | C12orf5 | chr12 | 4430469 | + | ZNF827 | chr4 | 146744677 | - |
| intron-intron | ENST00000537251 | ENST00000511534 | C12orf5 | chr12 | 4430469 | + | ZNF827 | chr4 | 146744677 | - |
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FusionProtFeatures for C12orf5_ZNF827 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C12orf5 | ZNF827 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May be involved in transcriptional regulation.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 961_972 | 759 | 995 | Compositional bias | Note=Poly-Ser |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 961_972 | 759 | 1976 | Compositional bias | Note=Poly-Ser |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 1019_1041 | 759 | 995 | Zinc finger | C2H2-type 8 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 1047_1069 | 759 | 995 | Zinc finger | C2H2-type 9 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 817_839 | 759 | 995 | Zinc finger | C2H2-type 4 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 845_867 | 759 | 995 | Zinc finger | C2H2-type 5 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 897_919 | 759 | 995 | Zinc finger | C2H2-type 6 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 929_952 | 759 | 995 | Zinc finger | C2H2-type 7 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 1019_1041 | 759 | 1976 | Zinc finger | C2H2-type 8 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 1047_1069 | 759 | 1976 | Zinc finger | C2H2-type 9 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 817_839 | 759 | 1976 | Zinc finger | C2H2-type 4 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 845_867 | 759 | 1976 | Zinc finger | C2H2-type 5 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 897_919 | 759 | 1976 | Zinc finger | C2H2-type 6 |
| Tgene | >ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 929_952 | 759 | 1976 | Zinc finger | C2H2-type 7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 311_354 | 759 | 995 | Compositional bias | Note=Pro-rich |
| Tgene | ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 311_354 | 759 | 1976 | Compositional bias | Note=Pro-rich |
| Tgene | ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 374_396 | 759 | 995 | Zinc finger | C2H2-type 1 |
| Tgene | ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 402_424 | 759 | 995 | Zinc finger | C2H2-type 2 |
| Tgene | ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000379448 | - | 6 | 15 | 433_455 | 759 | 995 | Zinc finger | C2H2-type 3 |
| Tgene | ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 374_396 | 759 | 1976 | Zinc finger | C2H2-type 1 |
| Tgene | ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 402_424 | 759 | 1976 | Zinc finger | C2H2-type 2 |
| Tgene | ZNF827 | chr12:4430469 | chr4:146744677 | ENST00000508784 | - | 6 | 15 | 433_455 | 759 | 1976 | Zinc finger | C2H2-type 3 |
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FusionGeneSequence for C12orf5_ZNF827 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_C12orf5_ENST00000179259_chr12_4430469_+_ZNF827_ENST00000508784_chr4_146744677_-_333aa MARFALTVVRHPFFSEDTFRQSPFTSNSKELLPSDSVLHGRISAPETEKIVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLH TEERKYKCHLCPYAAKCRANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVSHMSLHVDKEQWMFSI CCTACDFVTMEEAEIKTHIGTKHTGEDRKTPSESNSPSSSSLSALSDSANSKDDSDGSQKNKGGNNLLVISVMPGSQPSLNSEEKPEKGF >In-frame_C12orf5_ENST00000179259_chr12_4430469_+_ZNF827_ENST00000513320_chr4_146744677_-_333aa MARFALTVVRHPFFSEDTFRQSPFTSNSKELLPSDSVLHGRISAPETEKIVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLH TEERKYKCHLCPYAAKCRANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVSHMSLHVDKEQWMFSI CCTACDFVTMEEAEIKTHIGTKHTGEDRKTPSESNSPSSSSLSALSDSANSKDDSDGSQKNKGGNNLLVISVMPGSQPSLNSEEKPEKGF >In-frame_C12orf5_ENST00000179259_chr12_4430469_+_ZNF827_ENST00000379448_chr4_146744677_-_329aa MARFALTVVRHPFFSEDTFRQSPFTSNSKELLPSDSVLHGRISAPETEKIVLEAGNGLPSWKFNDQLFPCDVCGKVFGRQQTLSRHLSLH TEERKYKCHLCPYAAKCRANLNQHLTVHSVKLVSTDTEDIVSAVTSEGSDGKKHPYYYSCHVCGFETELNVQFVSHMSLHVDKEQWMFSI CCTACDFVTMEEAEIKTHIGTKHTGEDRKTPSESNSPSSSSLSALSDSANSKDDSDGSQKNKGGNNLLVISVMPGSQPSLNSEEKPEKGF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_C12orf5_ENST00000179259_chr12_4430469_+_ZNF827_ENST00000508784_chr4_146744677_-_999nt ATGGCTCGCTTCGCTCTGACTGTTGTCCGGCACCCTTTCTTTTCAGAAGACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAA CTGCTGCCCAGTGACTCCGTGCTGCACGGAAGAATATCAGCTCCAGAAACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCC TGGAAATTCAATGACCAGCTTTTTCCCTGTGACGTGTGTGGGAAAGTGTTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCAC ACAGAGGAAAGAAAATACAAATGCCACTTGTGCCCCTATGCTGCTAAGTGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTG AAGCTGGTGAGTACAGACACCGAGGACATTGTCAGCGCCGTCACCTCTGAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGT CACGTGTGTGGATTTGAGACCGAGCTCAATGTCCAGTTTGTCAGCCACATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATC TGCTGCACTGCCTGCGACTTCGTCACCATGGAGGAAGCAGAGATAAAGACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACC CCCAGCGAATCAAATAGCCCCTCTTCATCCTCCCTCTCAGCTCTGAGTGATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAA AACAAGGGCGGGAACAATCTGCTGGTCATCTCTGTCATGCCTGGGAGCCAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTC GAATGTGTTTTTTGCAACTTTGTCTGCAAGACGAAGAACATGTTTGAGCGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGT GATGTGTGCCACAAGTTCATGAAGACCCCCGAACAGCTGCTGGAGCATAAGAAATGCCACACTGTCCCCACCGGTGGGCTCAACTCAGGA >In-frame_C12orf5_ENST00000179259_chr12_4430469_+_ZNF827_ENST00000513320_chr4_146744677_-_999nt ATGGCTCGCTTCGCTCTGACTGTTGTCCGGCACCCTTTCTTTTCAGAAGACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAA CTGCTGCCCAGTGACTCCGTGCTGCACGGAAGAATATCAGCTCCAGAAACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCC TGGAAATTCAATGACCAGCTTTTTCCCTGTGACGTGTGTGGGAAAGTGTTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCAC ACAGAGGAAAGAAAATACAAATGCCACTTGTGCCCCTATGCTGCTAAGTGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTG AAGCTGGTGAGTACAGACACCGAGGACATTGTCAGCGCCGTCACCTCTGAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGT CACGTGTGTGGATTTGAGACCGAGCTCAATGTCCAGTTTGTCAGCCACATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATC TGCTGCACTGCCTGCGACTTCGTCACCATGGAGGAAGCAGAGATAAAGACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACC CCCAGCGAATCAAATAGCCCCTCTTCATCCTCCCTCTCAGCTCTGAGTGATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAA AACAAGGGCGGGAACAATCTGCTGGTCATCTCTGTCATGCCTGGGAGCCAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTC GAATGTGTTTTTTGCAACTTTGTCTGCAAGACGAAGAACATGTTTGAGCGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGT GATGTGTGCCACAAGTTCATGAAGACCCCCGAACAGCTGCTGGAGCATAAGAAATGCCACACTGTCCCCACCGGTGGGCTCAACTCAGGA >In-frame_C12orf5_ENST00000179259_chr12_4430469_+_ZNF827_ENST00000379448_chr4_146744677_-_987nt ATGGCTCGCTTCGCTCTGACTGTTGTCCGGCACCCTTTCTTTTCAGAAGACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAA CTGCTGCCCAGTGACTCCGTGCTGCACGGAAGAATATCAGCTCCAGAAACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCC TGGAAATTCAATGACCAGCTTTTTCCCTGTGACGTGTGTGGGAAAGTGTTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCAC ACAGAGGAAAGAAAATACAAATGCCACTTGTGCCCCTATGCTGCTAAGTGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTG AAGCTGGTGAGTACAGACACCGAGGACATTGTCAGCGCCGTCACCTCTGAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGT CACGTGTGTGGATTTGAGACCGAGCTCAATGTCCAGTTTGTCAGCCACATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATC TGCTGCACTGCCTGCGACTTCGTCACCATGGAGGAAGCAGAGATAAAGACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACC CCCAGCGAATCAAATAGCCCCTCTTCATCCTCCCTCTCAGCTCTGAGTGATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAA AACAAGGGCGGGAACAATCTGCTGGTCATCTCTGTCATGCCTGGGAGCCAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTC GAATGTGTTTTTTGCAACTTTGTCTGCAAGACGAAGAACATGTTTGAGCGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_C12orf5_ENST00000179259_chr12_4430469_+_ZNF827_ENST00000508784_chr4_146744677_-_5055nt GGGGAGGTAGCCCGCAGTGCAGGGGCAGCGCGGCGCGGGGCCACCGACGGGACGCGGCTCCGGGAACATGGCTCGCTTCGCTCTGACTGT TGTCCGGCACCCTTTCTTTTCAGAAGACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAACTGCTGCCCAGTGACTCCGTGCT GCACGGAAGAATATCAGCTCCAGAAACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCCTGGAAATTCAATGACCAGCTTTT TCCCTGTGACGTGTGTGGGAAAGTGTTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCACACAGAGGAAAGAAAATACAAATG CCACTTGTGCCCCTATGCTGCTAAGTGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTGAAGCTGGTGAGTACAGACACCGA GGACATTGTCAGCGCCGTCACCTCTGAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGTCACGTGTGTGGATTTGAGACCGA GCTCAATGTCCAGTTTGTCAGCCACATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATCTGCTGCACTGCCTGCGACTTCGT CACCATGGAGGAAGCAGAGATAAAGACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACCCCCAGCGAATCAAATAGCCCCTC TTCATCCTCCCTCTCAGCTCTGAGTGATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAAAACAAGGGCGGGAACAATCTGCT GGTCATCTCTGTCATGCCTGGGAGCCAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTCGAATGTGTTTTTTGCAACTTTGT CTGCAAGACGAAGAACATGTTTGAGCGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGTGATGTGTGCCACAAGTTCATGAA GACCCCCGAACAGCTGCTGGAGCATAAGAAATGCCACACTGTCCCCACCGGTGGGCTCAACTCAGGACAGTGGTGAGTTTCAGACTCCTC TAGGTGCCCATTCTGCATTTATTCCACCAACCGCCCCGCTGCCATGGAGTGCCACCTCAAGACCCACTACAAGATGGAGTACAAGTGCCG GATCTGCCAGACGGTGAAGGCCAACCAGCTGGAGCTGGAGACGCACACCCGGGAGCACCGCCTGGGCAACCACTACAAGTGCGACCAGTG CGGCTACCTGTCCAAGACCGCCAACAAGCTCATCGAGCACGTGCGCGTCCACACCGGGGAGCGGCCCTTCCACTGTGACCAGTGCAGCTA CAGCTGCAAGCGCAAGGACAATCTCAACCTGCACAAGAAGCTGAAGCACGCCCCACGCCAGACCTTCAGCTGCGAAGAGTGCCTGTTCAA GACCACACACCCTTTCGTCTTCAGCCGCCACGTCAAGAAGCACCAGAGTGGGGACTGCCCCGAGGAGGACAAGAAGGGCCTGTGTCCAGC CCCCAAGGAACCGGCCGGCCCGGGGGCCCCGCTCCTGGTGGTCGGGAGCTCCCGGAATCTCCTGTCTCCCCTGTCAGTTATGTCTGCCTC CCAGGCTCTGCAGACCGTGGCCCTGTCGGCAGCCCACGGCAGCAGCTCAGAGCCCAACCTGGCACTCAAGGCTTTGGCCTTCAACGGCTC CCCTTTGCGCTTTGACAAGTACCGGAACTCAGATTTTGCCCATCTCATTCCCTTGACAATGTTATACCCCAAGAACCACTTGGATCTCAC ATTCCACCCTCCCCGACCTCAGACTGCGCCTCCCAGCATCCCCTCACCCAAACACTCCTTCCTGGCCTATCTCGGACTGAGAGAAAGAGC AGAGACTGTCTGAGGGCAGCCATGTTCTGTACCAAAAACAGAGAGACAAAAGACAAAAAAAAAAAAAAAAACCACAAAACTTAAACACAA CCCCAGCAGGTGTATGTTGCTGCAAAACCTACAGACCCCGATGGGTCTGGAACATGTGTACTGTATATCTTTAGTAAGGAATAGAAAATT GGCTCTGTGTGTATACCTATTGCATTGACCTGAAAGCTGCTTTATCCAATCTTCAGAGAGGTGACCTACTGCATACTTCTACCTTCAGAG GCATGCCTCCCCAGCCACCCACTCCCACTCTCAGCCCTTCTCCGTACTTTTCTCTGAAAGGAATCTTGTCTTGTTAAACCCTAAAGAGAG TGTCCTTAATAGCAATCAGCACTTGTAAGCTTATATACTGGTGCATTTGGTTTTCTGTTGGGTGAATGCGGTGTGTGGGCGTTTGTGGAT TCTGAAAGAGAAAGCCGTGTGTCGTGTGCCATGACATTTCTATTGCACATTCTTTGTACTGGCTTCTTTAACAGCGATGAACGTTCTTTT CCCTCCTGGGTTGTTCATCCACGACAGTCTCTCCCTGTGCTCCTTCATCACCTTTCCCTCTCTCTTTGATGGCTACAGAGTGGTAGGGCC TGGTGCTTAGTCGATGAAGGAATGGTAGCCATCTACAGTGCTGCTGGAGATTTCCGCCAGAGCGCTGGAGACCTTGCGCTCAGATCTTCT CTGGTGATGAAGAGGCGAGGAATCAAGTGACTGATCTGGAAGAAATATCTCGCAGCACTGCAGCTAACATCACAGAACTTAAGTGTGTTT TGTGTGTGTGCCCACACGTAGACAAATGTGTACGGTGCACACACACAGTGCATCATTTTTTAAGGGCAGATTATATATATATATGAGATG TATTAATTCAGTGGTTACCATTTGTTTGCAGGAAAAAGAAATGTATGGGTGAAAAAATTTATGGTTGATAAATCCAGCCAAGGAGATTAA AAGGGGTTTGGATAAATTCTGGGTATAAATGCTCAGACTAAAAAAAAGAAATGGCAGTTTTGCACAGTGCTATGGTCTTGCACTAGTTTT TGTTTCTCATCTGAAAAAAAAAAAGTAAAATAAAAGGAAGAAAATGTACCTTTTTTATGGAATGAGTAGACTGTATGTTTGAAGATTTAG CCACAACCTCTTTGACATATAATGACGCAACAAAAAGGTGCTGTTTAGTCCTATGGTTCAGTTTATGCCCCTGACAAGTTTCCATTGTGT TTTGCCGATCTTCTGGCTAATCGTGGTATCCTCCATGTTATTAGTAATTCTGTATTCCATTTTGTTAACGCCTGGTAGATGTAACCTGCT AGGAGGCTAACTTTATACTTATTTAAAAGCTCTTATTTTGTGGTCATTAAAATGGCAATTTATGTGCAGCACTTTATTGCAGCAGGAAGC AGGTGTGGGTTGGTTGTAAAGCTCTTTGCTAATCTTAAAAAGTAATGGGTGATTTAAAAAGAAAAAAGGAAAAAAATCTTTGGCTGAATA TGTTCATTGCTTGTATTTTTAAAACAACAGAATTTCCAGTATGAAACAGGCTGAAAGAGCAGGAAGAAATGTTCTTTGTATAATAATGGG AAGTTTGGAATATAAAAGTTTATATATTATTTATCTATTGGAGAACTGGTGTACAGGAGGAACATTTTCTTACTGTGTTGCTGTTTTCCA TCATGTGTTATCCTAAGAGTTGGGGTTTTTTAAAATCTGTTTCACCAGGGGAAAATAAAAGCATCCCTAATGTTCTTCCTCTAGTCAGTT TGCTTTGCTGAAAGCTCCCTGGAAATTAGTACAGTTCTACAGGAAGCCAGAAGACTGTACTGTCTGTCCACACCATGGTCTCCTCAGTCC CCTCCACGCCAGCCCCTCTTCCCCACACCTAGTAGGTGTGCTACACCTCCCTTTGCCAGTCATCCCGCCATGGATGGGGAGCCTACTTGG TGCCCTGGCAAACCTGTTTACACTAAGGAGATGCCCACAGGGAGCGGGAAGCTCCCAAACCCTCAGTCATTCTCCAGCAGAGACCTTTGC TCTTGGCCAGGTTTGAAACGATGTTCAACCTCGCCACGTCAATGTCTCAGTAAAAGACACTATAGATAGTTATGGACAATACACTCCAAG AATACTGGGCTTATGGGTGGGTTGGTTTTTTGTTTTGTTTTGTTTTGTTTTCAAGTCATGTCTTTATCCCCATATAATGGAGAATGTGCC ACTTGGCTAATAATGTGTTTTCAAAACTACAAGTTCAGTGATGACAGGAAAGAGGGCTAAAGTAGTCCCACAGAGGCTGGTAGAAAAGGC GAATCACACTTAAGCACCAGCAGGTTAAAAACCTGAAAGGGTGGCCCTGACAATTCAGACTATAGGTTTTACAGCATGCCACTTGTGCAA TAGGAGGTCTAGGGTTGAAACTTTCAAGAACGAGAGGAGGTGAAGGAAGGAGACGTTTACTGCTCAAATGCCATGCATTTCACTGCTTGC CACTGAACTTGTATTTGAATGACTTAGTAATGCTTAATATAATTGGGCAACTTTTTTAGCACTTTGGAAAGAGTCATCAATCTTTCTGGT AAATTATAAAAGTTTTCTGAGTGAGAAAAGGTGTGTTTGGAGTTTGTTTGACTTTTTATATTATTATTGTTATTAATAAAGAAAAAAATC TACAGCATTTTTCAGACTCCACCCTAGAAAATATGTACCCCTGAATTTGGTTTGCAGTTTGATACTCAGGGAAGGATGTATTCCATAGAT ATCCTTTCCGTATAAAACACTAACATCTTTGAGAAATTCACCTACCAACTAACTTCAATTGTTGTCACTATGCATTCTTCAATGAAAACT AGCTTATTTTTCCATATAGTAATGCAGTTAGGGTTCTCAGCACTTTCTTTCTTCTATCCTTTTTTTAACTCTTCATATTATGTTCAGATG ATCATACTGTCAAGGTTTGTGTACATTACTGAAAATTTGTATTGTATAAAGCTTTTTGCATTACGAGGCTGTACAGGGTCATTTTGACAG TAACTGGTATATTCCTTTGCATCTTATGTTGCATTGCCAATTTCTAGTGTATCCAGTTTGAAAGTATAATATACTCTAATTAAAAAAAAA >In-frame_C12orf5_ENST00000179259_chr12_4430469_+_ZNF827_ENST00000513320_chr4_146744677_-_1953nt GGGGAGGTAGCCCGCAGTGCAGGGGCAGCGCGGCGCGGGGCCACCGACGGGACGCGGCTCCGGGAACATGGCTCGCTTCGCTCTGACTGT TGTCCGGCACCCTTTCTTTTCAGAAGACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAACTGCTGCCCAGTGACTCCGTGCT GCACGGAAGAATATCAGCTCCAGAAACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCCTGGAAATTCAATGACCAGCTTTT TCCCTGTGACGTGTGTGGGAAAGTGTTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCACACAGAGGAAAGAAAATACAAATG CCACTTGTGCCCCTATGCTGCTAAGTGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTGAAGCTGGTGAGTACAGACACCGA GGACATTGTCAGCGCCGTCACCTCTGAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGTCACGTGTGTGGATTTGAGACCGA GCTCAATGTCCAGTTTGTCAGCCACATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATCTGCTGCACTGCCTGCGACTTCGT CACCATGGAGGAAGCAGAGATAAAGACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACCCCCAGCGAATCAAATAGCCCCTC TTCATCCTCCCTCTCAGCTCTGAGTGATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAAAACAAGGGCGGGAACAATCTGCT GGTCATCTCTGTCATGCCTGGGAGCCAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTCGAATGTGTTTTTTGCAACTTTGT CTGCAAGACGAAGAACATGTTTGAGCGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGTGATGTGTGCCACAAGTTCATGAA GACCCCCGAACAGCTGCTGGAGCATAAGAAATGCCACACTGTCCCCACCGGTGGGCTCAACTCAGGACAGTGGTGAGTTTCAGACTCCTC TAGGTGCCCATTCTGCATTTATTCCACCAACCGCCCCGCTGCCATGGAGTGCCACCTCAAGACCCACTACAAGATGGAGTACAAGTGCCG GATCTGCCAGACGGTGAAGGCCAACCAGCTGGAGCTGGAGACGCACACCCGGGAGCACCGCCTGGGCAACCACTACAAGTGCGACCAGTG CGGCTACCTGTCCAAGACCGCCAACAAGCTCATCGAGCACGTGCGCGTCCACACCGGGGAGCGGCCCTTCCACTGTGACCAGTGCAGCTA CAGCTGCAAGCGCAAGGACAATCTCAACCTGCACAAGAAGCTGAAGCACGCCCCACGCCAGACCTTCAGCTGCGAAGAGTGCCTGTTCAA GACCACACACCCTTTCGTCTTCAGCCGCCACGTCAAGAAGCACCAGAGTGGGGACTGCCCCGAGGAGGACAAGAAGGGCCTGTGTCCAGC CCCCAAGGAACCGGCCGGCCCGGGGGCCCCGCTCCTGGTGGTCGGGAGCTCCCGGAATCTCCTGTCTCCCCTGTCAGTTATGTCTGCCTC CCAGGCTCTGCAGACCGTGGCCCTGTCGGCAGCCCACGGCAGCAGCTCAGAGCCCAACCTGGCACTCAAGGCTTTGGCCTTCAACGGCTC CCCTTTGCGCTTTGACAAGTACCGGAACTCAGATTTTGCCCATCTCATTCCCTTGACAATGTTATACCCCAAGAACCACTTGGATCTCAC ATTCCACCCTCCCCGACCTCAGACTGCGCCTCCCAGCATCCCCTCACCCAAACACTCCTTCCTGGCCTATCTCGGACTGAGAGAAAGAGC >In-frame_C12orf5_ENST00000179259_chr12_4430469_+_ZNF827_ENST00000379448_chr4_146744677_-_1953nt GGGGAGGTAGCCCGCAGTGCAGGGGCAGCGCGGCGCGGGGCCACCGACGGGACGCGGCTCCGGGAACATGGCTCGCTTCGCTCTGACTGT TGTCCGGCACCCTTTCTTTTCAGAAGACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAACTGCTGCCCAGTGACTCCGTGCT GCACGGAAGAATATCAGCTCCAGAAACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCCTGGAAATTCAATGACCAGCTTTT TCCCTGTGACGTGTGTGGGAAAGTGTTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCACACAGAGGAAAGAAAATACAAATG CCACTTGTGCCCCTATGCTGCTAAGTGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTGAAGCTGGTGAGTACAGACACCGA GGACATTGTCAGCGCCGTCACCTCTGAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGTCACGTGTGTGGATTTGAGACCGA GCTCAATGTCCAGTTTGTCAGCCACATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATCTGCTGCACTGCCTGCGACTTCGT CACCATGGAGGAAGCAGAGATAAAGACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACCCCCAGCGAATCAAATAGCCCCTC TTCATCCTCCCTCTCAGCTCTGAGTGATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAAAACAAGGGCGGGAACAATCTGCT GGTCATCTCTGTCATGCCTGGGAGCCAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTCGAATGTGTTTTTTGCAACTTTGT CTGCAAGACGAAGAACATGTTTGAGCGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGTGATGTGTGCCACAAGTTCATGAA GACCCCCGAACAGCTGCTGGAGCATAAGAAATGCCACACTGTCCCCACCGGTGGGCTCAAGTAAGGAAACTCAGGACAGTGGTGAGTTTC AGACTCCTCTAGGTGCCCATTCTGCATTTATTCCACCAACCGCCCCGCTGCCATGGAGTGCCACCTCAAGACCCACTACAAGATGGAGTA CAAGTGCCGGATCTGCCAGACGGTGAAGGCCAACCAGCTGGAGCTGGAGACGCACACCCGGGAGCACCGCCTGGGCAACCACTACAAGTG CGACCAGTGCGGCTACCTGTCCAAGACCGCCAACAAGCTCATCGAGCACGTGCGCGTCCACACCGGGGAGCGGCCCTTCCACTGTGACCA GTGCAGCTACAGCTGCAAGCGCAAGGACAATCTCAACCTGCACAAGAAGCTGAAGCACGCCCCACGCCAGACCTTCAGCTGCGAAGAGTG CCTGTTCAAGACCACACACCCTTTCGTCTTCAGCCGCCACGTCAAGAAGCACCAGAGTGGGGACTGCCCCGAGGAGGACAAGAAGGGCCT GTGTCCAGCCCCCAAGGAACCGGCCGGCCCGGGGGCCCCGCTCCTGGTGGTCGGGAGCTCCCGGAATCTCCTGTCTCCCCTGTCAGTTAT GTCTGCCTCCCAGGCTCTGCAGACCGTGGCCCTGTCGGCAGCCCACGGCAGCAGCTCAGAGCCCAACCTGGCACTCAAGGCTTTGGCCTT CAACGGCTCCCCTTTGCGCTTTGACAAGTACCGGAACTCAGATTTTGCCCATCTCATTCCCTTGACAATGTTATACCCCAAGAACCACTT GGATCTCACATTCCACCCTCCCCGACCTCAGACTGCGCCTCCCAGCATCCCCTCACCCAAACACTCCTTCCTGGCCTATCTCGGACTGAG |
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FusionGenePPI for C12orf5_ZNF827 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| C12orf5 | APP, UBE2L3, TSC2, RPL11, PCBP1, TKT, OFD1, PNPLA4, TWF1 | ZNF827 | PPP1CA, UBE2E1, ATP6V1E1, CHERP, VPS45, UNC80, HDAC1, GATAD2A, GATAD2B, RBBP7, RBBP4, CHD3, CHD4, MTA1, MTA2, MTA3, HDAC2, MCPH1, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for C12orf5_ZNF827 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for C12orf5_ZNF827 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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