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Fusion gene ID: 462 |
FusionGeneSummary for ACPP_OGT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACPP_OGT | Fusion gene ID: 462 | Hgene | Tgene | Gene symbol | ACPP | OGT | Gene ID | 55 | 8473 |
| Gene name | acid phosphatase, prostate | O-linked N-acetylglucosamine (GlcNAc) transferase | |
| Synonyms | 5'-NT|ACP-3|ACP3 | HINCUT-1|HRNT1|MRX106|O-GLCNAC|OGT1 | |
| Cytomap | 3q22.1 | Xq13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prostatic acid phosphataseTMPaseecto-5'-nucleotidaseprostatic acid phosphotasethiamine monophosphatase | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitO-GlcNAc transferase p110 subunitO-GlcNAc transferase subunit p110O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminy | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P15309 | O15294 | |
| Ensembl transtripts involved in fusion gene | ENST00000336375, ENST00000475741, ENST00000351273, ENST00000489084, | ENST00000373719, ENST00000373701, ENST00000498566, | |
| Fusion gene scores | * DoF score | 13 X 6 X 2=156 | 2 X 1 X 1=2 |
| # samples | 15 | 2 | |
| ** MAII score | log2(15/156*10)=-0.0565835283663674 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/2*10)=3.32192809488736 | |
| Context | PubMed: ACPP [Title/Abstract] AND OGT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACPP | GO:0046085 | adenosine metabolic process | 18940592 |
| Hgene | ACPP | GO:0051289 | protein homotetramerization | 10639192 |
| Tgene | OGT | GO:0006110 | regulation of glycolytic process | 22923583 |
| Tgene | OGT | GO:0006493 | protein O-linked glycosylation | 21240259|21285374|22923583|23222540|23352454|24474760 |
| Tgene | OGT | GO:0006915 | apoptotic process | 20824293 |
| Tgene | OGT | GO:0032868 | response to insulin | 18288188 |
| Tgene | OGT | GO:0035020 | regulation of Rac protein signal transduction | 18288188 |
| Tgene | OGT | GO:0043981 | histone H4-K5 acetylation | 20018852 |
| Tgene | OGT | GO:0043982 | histone H4-K8 acetylation | 20018852 |
| Tgene | OGT | GO:0043984 | histone H4-K16 acetylation | 20018852 |
| Tgene | OGT | GO:0045862 | positive regulation of proteolysis | 21285374 |
| Tgene | OGT | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23222540|23353889 |
| Tgene | OGT | GO:0046626 | regulation of insulin receptor signaling pathway | 18288188 |
| Tgene | OGT | GO:0048015 | phosphatidylinositol-mediated signaling | 18288188 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5512-01A | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000336375 | ENST00000373719 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| Frame-shift | ENST00000336375 | ENST00000373701 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| 5CDS-intron | ENST00000336375 | ENST00000498566 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| intron-3CDS | ENST00000475741 | ENST00000373719 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| intron-3CDS | ENST00000475741 | ENST00000373701 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| intron-intron | ENST00000475741 | ENST00000498566 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| intron-3CDS | ENST00000351273 | ENST00000373719 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| intron-3CDS | ENST00000351273 | ENST00000373701 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| intron-intron | ENST00000351273 | ENST00000498566 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| intron-3CDS | ENST00000489084 | ENST00000373719 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| intron-3CDS | ENST00000489084 | ENST00000373701 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
| intron-intron | ENST00000489084 | ENST00000498566 | ACPP | chr3 | 132077596 | + | OGT | chrX | 70782980 | + |
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FusionProtFeatures for ACPP_OGT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACPP | OGT |
| A non-specific tyrosine phosphatase thatdephosphorylates a diverse number of substrates under acidicconditions (pH 4-6) including alkyl, aryl, and acyl orthophosphatemonoesters and phosphorylated proteins. Has lipid phosphataseactivity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons.Generates adenosine from AMP which acts as a pain suppressor. Actsas a tumor suppressor of prostate cancer through dephosphorylationof ERBB2 and deactivation of MAPK-mediated signaling. | Catalyzes the transfer of a single N-acetylglucosaminefrom UDP-GlcNAc to a serine or threonine residue in cytoplasmicand nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539).Glycosylates a large and diverse number of proteins includinghistone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1(PubMed:26678539). Can regulate their cellular processes viacross-talk between glycosylation and phosphorylation or byaffecting proteolytic processing (PubMed:26678539). Probably byglycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing itsubiquitination (PubMed:26678539). Involved in insulin resistancein muscle and adipocyte cells via glycosylating insulin signalingcomponents and inhibiting the 'Thr-308' phosphorylation of AKT1,enhancing IRS1 phosphorylation and attenuating insulin signaling.Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity(PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complexthat is required for the regulation of the transcriptionalactivity of RRM1. Plays a key role in chromatin structure bymediating O-GlcNAcylation of 'Ser-112' of histone H2B: recruitedto CpG-rich transcription start sites of active genes via itsinteraction with TET proteins (TET1, TET2 or TET3)(PubMed:22121020, PubMed:23353889). As part of the NSL complexindirectly involved in acetylation of nucleosomal histone H4 onseveral lysine residues (PubMed:20018852). O-GlcNAcylation of'Ser-75' of EZH2 increases its stability, and facilitating theformation of H3K27me3 by the PRC2/EED-EZH2 complex(PubMed:24474760). Regulates circadian oscillation of the clockgenes and glucose homeostasis in the liver. Stabilizes clockproteins ARNTL/BMAL1 and CLOCK through O-glycosylation, whichprevents their ubiquitination and subsequent degradation. Promotesthe CLOCK-ARNTL/BMAL1-mediated transcription of genes in thenegative loop of the circadian clock such as PER1/2 and CRY1/2(PubMed:12150998, PubMed:18288188, PubMed:19377461,PubMed:19451179, PubMed:20018868, PubMed:20200153,PubMed:21285374, PubMed:15361863). O-glycosylates HCFC1 andregulates its proteolytic processing and transcriptional activity(PubMed:21285374, PubMed:28584052, PubMed:28302723).{ECO:0000269|PubMed:12150998, ECO:0000269|PubMed:15361863,ECO:0000269|PubMed:18288188, ECO:0000269|PubMed:19451179,ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:20018868,ECO:0000269|PubMed:20200153, ECO:0000269|PubMed:21285374,ECO:0000269|PubMed:22121020, ECO:0000269|PubMed:22923583,ECO:0000269|PubMed:23353889, ECO:0000269|PubMed:24474760,ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:28302723,ECO:0000269|PubMed:28584052}. Isoform 2: the mitochondrial isoform (mOGT) is cytotoxicand triggers apoptosis in several cell types including INS1, aninsulinoma cell line. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACPP_OGT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACPP_OGT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ACPP | ACPP, UBC, SHBG, MMRN1, DDX19B, RPS6KB2, TBC1D22B, FTH1, CDK15, CCDC103, CPLX3, FBXL4, AIRE, ZIC1, DUSP21, IL31RA, FCRL5, KIF3A, NPPA, HSF2, FCF1, LACC1, L2HGDH | OGT | NUP62CL, FIBP, CDK2, WRAP73, TRAK1, HCFC1, SIN3A, BAP1, BTRC, FBXW11, THAP3, THAP1, MGEA5, SAP25, NUP62, CSNK2A1, MAPT, YES1, KAT8, HDAC5, TAB1, PPP1CA, PPP1CB, RELA, NFATC1, SMURF1, FOXO4, UBL4A, ACTR2, AGFG1, ALAD, C14orf142, DBNL, GPN1, HSPBP1, LAP3, P3H1, LPP, PPME1, RPRD1B, SURF2, TOM1L1, WDR4, ZPR1, WWOX, HUWE1, PSG1, TET2, PHC3, NXF1, TRAK2, DDAH2, CREB3, THAP11, KCMF1, UNK, CRKL, FARSA, FARSB, GIPC1, PDXK, PSPH, TPD52L2, PAFAH1B2, NTRK1, CSNK2B, DYNLT1, AK1, KIF5B, RTFDC1, RBPJ, TCF4, ASXL1, ASXL2, KMT2E, USP7, KLF5, RC3H1, PHF8, KDM1B, CIART, HCFC1R1, HCFC2, THAP2, CAMK2D, UBC, UNC119, NPHP3, CYLD, TRIM25, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACPP_OGT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ACPP | P15309 | DB06688 | Sipuleucel-T | Prostatic acid phosphatase | biotech | approved|investigational |
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RelatedDiseases for ACPP_OGT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACPP | C3495559 | Juvenile arthritis | 1 | CTD_human |
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