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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4589

FusionGeneSummary for BZW2_CLCN3

check button Fusion gene summary
Fusion gene informationFusion gene name: BZW2_CLCN3
Fusion gene ID: 4589
HgeneTgene
Gene symbol

BZW2

CLCN3

Gene ID

28969

1182

Gene namebasic leucine zipper and W2 domains 2chloride voltage-gated channel 3
SynonymsHSPC028|MST017|MSTP017CLC3|ClC-3
Cytomap

7p21.1

4q33

Type of geneprotein-codingprotein-coding
Descriptionbasic leucine zipper and W2 domain-containing protein 2H(+)/Cl(-) exchange transporter 3chloride channel 3chloride channel protein 3chloride channel, voltage-sensitive 3chloride transporter ClC-3
Modification date2018052320180523
UniProtAcc

Q9Y6E2

P51790

Ensembl transtripts involved in fusion geneENST00000258761, ENST00000433922, 
ENST00000432311, ENST00000452975, 
ENST00000405202, ENST00000407633, 
ENST00000513761, ENST00000347613, 
ENST00000360642, ENST00000504131, 
ENST00000506924, 
Fusion gene scores* DoF score8 X 6 X 5=24036 X 4 X 19=2736
# samples 839
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(39/2736*10)=-2.81052220113629
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BZW2 [Title/Abstract] AND CLCN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLCN3

GO:1902476

chloride transmembrane transport

11274166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A18U-01ABZW2chr7

16685913

+CLCN3chr4

170601201

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000258761ENST00000513761BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000258761ENST00000347613BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000258761ENST00000360642BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000258761ENST00000504131BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-intronENST00000258761ENST00000506924BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000433922ENST00000513761BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000433922ENST00000347613BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000433922ENST00000360642BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000433922ENST00000504131BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-intronENST00000433922ENST00000506924BZW2chr7

16685913

+CLCN3chr4

170601201

+
3UTR-3CDSENST00000432311ENST00000513761BZW2chr7

16685913

+CLCN3chr4

170601201

+
3UTR-3CDSENST00000432311ENST00000347613BZW2chr7

16685913

+CLCN3chr4

170601201

+
3UTR-3CDSENST00000432311ENST00000360642BZW2chr7

16685913

+CLCN3chr4

170601201

+
3UTR-3CDSENST00000432311ENST00000504131BZW2chr7

16685913

+CLCN3chr4

170601201

+
3UTR-intronENST00000432311ENST00000506924BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000452975ENST00000513761BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000452975ENST00000347613BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000452975ENST00000360642BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000452975ENST00000504131BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-intronENST00000452975ENST00000506924BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000405202ENST00000513761BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000405202ENST00000347613BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000405202ENST00000360642BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-3CDSENST00000405202ENST00000504131BZW2chr7

16685913

+CLCN3chr4

170601201

+
5UTR-intronENST00000405202ENST00000506924BZW2chr7

16685913

+CLCN3chr4

170601201

+
intron-3CDSENST00000407633ENST00000513761BZW2chr7

16685913

+CLCN3chr4

170601201

+
intron-3CDSENST00000407633ENST00000347613BZW2chr7

16685913

+CLCN3chr4

170601201

+
intron-3CDSENST00000407633ENST00000360642BZW2chr7

16685913

+CLCN3chr4

170601201

+
intron-3CDSENST00000407633ENST00000504131BZW2chr7

16685913

+CLCN3chr4

170601201

+
intron-intronENST00000407633ENST00000506924BZW2chr7

16685913

+CLCN3chr4

170601201

+

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FusionProtFeatures for BZW2_CLCN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BZW2

Q9Y6E2

CLCN3

P51790

May be involved in neuronal differentiation.{ECO:0000250}. Mediates the exchange of chloride ions against protons.Functions as antiporter and contributes to the acidification ofthe endosome and synaptic vesicle lumen, and may thereby affectvesicle trafficking and exocytosis. May play an important role inneuronal cell function through regulation of membrane excitabilityby protein kinase C. It could help neuronal cells to establishshort-term memory. {ECO:0000269|PubMed:11967229}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BZW2_CLCN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BZW2_CLCN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BZW2BZW1, PSTPIP1, GSK3B, ELAVL1, VCP, FN1, EGFR, ABHD14A, CAPN1, CNBP, DFFA, EIF6, HSPA9, PFAS, CTSA, PPP5C, C11orf58, GINS3, PAFAH1B2, PHKG2, PTPLAD1, EIF2A, EIF2B1, EIF3A, STX12, RAB1B, CD68, GPR183, LYPD3, SCN2B, CYFIP1, EIF5, HSD17B10, STAG2, NTRK1, CDH1, PTPRE, MUL1, EXOG, NT5C3A, CANT1, ENDOD1, TMEM43, TMEM206, ZFPL1, SCCPDH, GYPB, MRS2, MAVS, OMA1, TVP23C, NXT1, RRAS, NRAS, VIPR2, SLC27A2, PTPRN, TPTE, SMDT1, EIF2B2, EIF2B4CLCN3CLCN3, SLC9A3R1, PDZK1, GOPC, CFTR, LGALS3, LGALS8, LGALS9, LYPD3, HSPB1, TMEM9B, GGA1, TPCN2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BZW2_CLCN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BZW2_CLCN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCLCN3C0017638Glioma1CTD_human
TgeneCLCN3C0038356Stomach Neoplasms1CTD_human
TgeneCLCN3C2931822Nasopharyngeal carcinoma1CTD_human